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Scott Coyle

@cellraiser.bsky.social

signaling systems and protein circuitry. reimagining what cells can be. fun posts only. Assistant Professor: @uwbiochem | Postdoc: @stanford @prakashlab | Ph.D.: @ucsf Wendell Lim @CDI_UCSF

1,441 Followers  |  580 Following  |  66 Posts  |  Joined: 12.10.2023  |  1.7778

Latest posts by cellraiser.bsky.social on Bluesky

Proud and excited to share our work with the community! Helen @helenfoster.bsky.social Foster et al. study how #cilia axonemes are built. πŸ‘€ Don't miss the gorgeous and insightful movies by @margotriggi.bsky.social, they really show our discoveries in full action!

www.biorxiv.org/content/10.6...

09.02.2026 20:03 β€” πŸ‘ 74    πŸ” 26    πŸ’¬ 3    πŸ“Œ 1

Thank you @mollyherring.bsky.social for the stunning showcase 😍

Like what you see? Come ExM with us! Let’s flood the internet with microbial marvels 🦠

#ProtistsOnSky #MicroEvoSky πŸ§ͺπŸ”¬πŸŒ

@dudinlab.bsky.social @centriolelab.bsky.social @moorefound.bsky.social @embl.org @erc.europa.eu @embo.org

04.02.2026 20:43 β€” πŸ‘ 99    πŸ” 31    πŸ’¬ 2    πŸ“Œ 2

If you're interested in the regulation and/or evolution of complex cell behavior, this could serve as an opportunity to join our lab as a postdoc. I would be happy to consult on proposal development if we've got a good alignment of goals, skills, and interests. DMs or emails welcome.

06.02.2026 18:23 β€” πŸ‘ 2    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

Thx for @mollyherring.bsky.social for featuring our recent work with @centriolelab.bsky.social and our quest with @gautamdey.bsky.social & the support of the @moorefound.bsky.social to look for the beauty in every #eukaryote out there using #Expansion #Microscopy #UExM

04.02.2026 19:30 β€” πŸ‘ 42    πŸ” 17    πŸ’¬ 0    πŸ“Œ 1

Now in print at ACS Synbio! Introducing Aviatar: a concept for inducible translocation to any cell compartment using only a 1-component probe
pubs.acs.org/doi/10.1021/...

02.02.2026 12:21 β€” πŸ‘ 19    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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EiraBio

Our company has a new name, Eira Bio (www.eirabio.com) (formerly K2 Therapeutics), but the same important mission to apply our advanced synthetic biology, directed evolution, and protein design technologies to discover and develop next-generation antibody-based medicines for a range of diseases!

01.02.2026 12:43 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

Our new paper just out!
pubs.acs.org/doi/10.1021/...

31.01.2026 13:53 β€” πŸ‘ 13    πŸ” 9    πŸ’¬ 2    πŸ“Œ 0
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SynBYSS The International SynBYSS Conference is focused on bringing together the synthetic biology community with the explicit goal of developing young...

#SynBYSS conference is scheduled on Jun 8-11, 2026 in Barcelona. Given the 100-year celebration of Architect Gaudi in Barcelona, we suggest early booking of hotels.
Details can be found: www.jcvi.org/events/synbyss (speakers, abstract submission & registration)
@jcvi.org @marcguellc.bsky.social

31.01.2026 12:00 β€” πŸ‘ 9    πŸ” 7    πŸ’¬ 1    πŸ“Œ 0
Harnessing Higher-Dimensional Fluctuations in an Information Engine We study the optimal performance of an information engine consisting of an overdamped Brownian bead confined in a controllable, $d$-dimensional harmonic trap and additionally subjected to gravity. The...

Out in @physrevlett.bsky.social: @sfuphysics.bsky.social postdoc Antonio PatrΓ³n Castro (in tight collaboration with my colleague John Bechhoefer) pushes our information engine to higher dimensions!
doi.org/10.1103/xwjd...

28.01.2026 17:19 β€” πŸ‘ 5    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
Spindles lacking Ase1 adapt more resiliently to compressive force from the nuclear envelope than normal spindles.

Spindles lacking Ase1 adapt more resiliently to compressive force from the nuclear envelope than normal spindles.

Taylor proudly holds a troll doll named Thelonius she has adopted as a lab mascot, along with a copy of her preprint!

Taylor proudly holds a troll doll named Thelonius she has adopted as a lab mascot, along with a copy of her preprint!

Final model figure of our manuscript indicates that compression force from the nuclear envelope regulates spindle biochemistry.

Final model figure of our manuscript indicates that compression force from the nuclear envelope regulates spindle biochemistry.

We've got a new preprint posted, you can read all about it (and see a picture of our recently adopted lab mascot) here: eltinglab.github.io/news/taylorB...

The bottom line of this work is that we reveal new ways that S. pombe spindle biochemistry is regulated by force from the nuclear envelope.

27.01.2026 23:09 β€” πŸ‘ 10    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
CytoTape in a neuron

CytoTape in a neuron

Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...

26.01.2026 20:49 β€” πŸ‘ 58    πŸ” 19    πŸ’¬ 4    πŸ“Œ 3

Alex Pretti was a colleague at the VA. We hired him to recruit for our trial. He became an ICU nurse- I lover working with him. He was a good kind person who lived to help and these fuckers executed him.

White. Hot. Rage.

24.01.2026 19:31 β€” πŸ‘ 60698    πŸ” 18942    πŸ’¬ 1407    πŸ“Œ 742

"Use it or lose it." This is great advice for exercise, but when cells need to slow down or go dormant, they need to store ribosomes to recover growth in the future. They use hibernation factors to do this. Here is our latest story on how archaea hibernate ribosomes (1/7):
doi.org/10.64898/202...

20.01.2026 15:53 β€” πŸ‘ 37    πŸ” 14    πŸ’¬ 1    πŸ“Œ 1
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Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production - Nature Metabolism Hexokinase detachment from the outer mitochondrial membrane is shown to support aerobic glycolysis in cancer cells. Differential localization of the HK1 isoform to the outer mitochondrial membrane, co...

Latest collection of papers on mitochondria in health and disease! #MitochondrialDisease #week3

biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

www.nature.com/articles/s42...

18.01.2026 12:36 β€” πŸ‘ 18    πŸ” 10    πŸ’¬ 1    πŸ“Œ 0
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a woman says " would you like to join us " with her eyes closed ALT: a woman says " would you like to join us " with her eyes closed

πŸ“’ Open faculty position – Origins of Life
We have an opening in our section at the University of Geneva! πŸ§¬πŸš€

SPREAD THE WORD

Apply here: jobs.unige.ch/www/wd_porta...

16.01.2026 17:49 β€” πŸ‘ 45    πŸ” 39    πŸ’¬ 1    πŸ“Œ 1

Yet another fantastic study by my amazing colleague @jasonrcantor.bsky.social -- the spatiotemporal organization of glycolytic machinery / ATP production at play here is so interesting. Congrats to @thebiokimist.bsky.social and the team on a beautiful paper!

16.01.2026 16:44 β€” πŸ‘ 7    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧡

16.01.2026 16:26 β€” πŸ‘ 55    πŸ” 27    πŸ’¬ 3    πŸ“Œ 2
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Membrane editing with proximity labeling reveals regulators of lipid homeostasis - Nature Chemical Biology Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.

Thrilled to share our latest study, led by @reikatei.bsky.social, in @natchembio.nature.com! We began by asking a simple questionβ€”how do cells know if they have too much of a lipid in a particular membrane, and how do they respond to rectify this imbalance?
www.nature.com/articles/s41...
More info πŸ‘‡

07.01.2026 14:59 β€” πŸ‘ 154    πŸ” 61    πŸ’¬ 7    πŸ“Œ 7
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Memory from variability: Heritable short-term cellular memory emerges from stochastic biochemical reaction networks Cells exhibit a mysterious form of selective heritable short-term memory, influencing outcomes as diverse as cell fate decisions in embryos and environmental responses in cancer cells and bacteria. He...

Thrilled that the lab's first @hhmijanelia.bsky.social project is up on bioRxiv! Story behind the story to follow. www.biorxiv.org/content/10.6...

02.01.2026 20:54 β€” πŸ‘ 24    πŸ” 10    πŸ’¬ 0    πŸ“Œ 0
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New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides πŸ§ͺhttps://www.biorxiv.org/content/10.64898/2025.12.17.694899v1

21.12.2025 03:58 β€” πŸ‘ 33    πŸ” 14    πŸ’¬ 2    πŸ“Œ 0
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New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations!

pubs.acs.org/doi/full/10....

17.12.2025 15:24 β€” πŸ‘ 27    πŸ” 11    πŸ’¬ 2    πŸ“Œ 1
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🚨New preprint(1/2)! We show that RTK fusion oncoproteins broadly suppress EGFR signaling. How? Sequestration of adapters as the shared principle.

Led by superb PhD student Carol Gao.

www.biorxiv.org/content/10.1...

Implications for drug tolerance/resistance, and includes one big surprise🫧.πŸ‘‡

16.12.2025 12:05 β€” πŸ‘ 19    πŸ” 18    πŸ’¬ 2    πŸ“Œ 1
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Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!

GRS will be on June 5-6, 2027

GRC will be from June 6-11, 2027

Block off your calendars Prokaryotic Cell Biologists!

More details to come! Please repost!

12.12.2025 14:58 β€” πŸ‘ 61    πŸ” 37    πŸ’¬ 3    πŸ“Œ 2
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#Cellbio2025 come see the latest from the lab, including on opto/thermogenetics, condensates, RTK fusions, stress granules, biosensors of clustering. Talks and posters today and tomorrow!

08.12.2025 12:12 β€” πŸ‘ 8    πŸ” 6    πŸ’¬ 1    πŸ“Œ 1
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Come work with us! We are looking for a postdoc in #philbio or #philphysics to work on an interdisciplinary project that adopts the lens of self-organization & active matter to explore the boundary between living & nonliving systems www.kuleuven.be/personeel/jo... #academicsky #philjobs #HPS #evosky

08.12.2025 11:21 β€” πŸ‘ 58    πŸ” 37    πŸ’¬ 2    πŸ“Œ 3
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Cells can hunt prey, solve mazes, and learn from past experience. Does this mean they can think, at some level? Find out more at our upcoming session on "Cell Behavior and Cognition" at the ASCB/EMBO #cellbio2025 meeting, Saturday 1-3 pm rm 115.

05.12.2025 14:36 β€” πŸ‘ 70    πŸ” 16    πŸ’¬ 4    πŸ“Œ 1

Thanks Claudia ! Full credit to Maggie for making the story so epic in scope. Also: will you be at ASCB this year? Hope to see you again some time soon

03.12.2025 19:31 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

So happy to announce our new preprint, β€œA geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63Β°C (145Β°F) πŸ”₯ - a new record for euk growth!
#protistsonsky 🧡

25.11.2025 20:41 β€” πŸ‘ 492    πŸ” 163    πŸ’¬ 16    πŸ“Œ 31
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Our new preprint describes Plasmodium NEK4 as a key regulator coupling meiotic initiation and morphogenesisβ€”a critical step for malaria transmission. This involves MTOC-driven nuclear movement strikingly analogous to "horsetail" movement in fission yeast.
www.biorxiv.org/content/10.1...

24.11.2025 16:07 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

Wow! Remarkably complete story on the logic of phenotypic plasticity in a predatory protist - congrats @cellraiser.bsky.social et al!

18.11.2025 20:52 β€” πŸ‘ 25    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0

@cellraiser is following 20 prominent accounts