Scott Coyle

Final version of our paper on ciliary metachronal waves out now in Science Advances! doi.org/10.1126/scia...

This is the main thesis work of my PhD student Rebecca Poon, who caught many #platnereis larvae and tirelessly ablated them with a laser. THREAD

Join us ! We are looking for creative and motivated scientists at to join the group. We are recruiting candidates from various scientific backgrounds including, but not limited to: biophysics, physics, biochemi...

We have PhD and Postdoc positions open in our group. Join us in Lausanne to explore how cells pull off extreme shape changes and how cilia drive biological flows.

You can find more details on the projects available and how to apply in our website:

www.epfl.ch/labs/lpl/joi...

The Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social is hiring a tenure-track staff scientist in Computational Structural Biology (cryo-EM, cryo-ET, structural prediction methods, image analysis)!

More info here: apply.ista.ac.at/comp_structu...

MCDB Opens Search for Faculty | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB) MCDB welcomes applications at the Assistant Professor level from outstanding biological scientists in all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal le...

MCDB Assistant Professor Faculty Search. Please Repost!

Applications Due Oct 15th (TOMORROW!)

We welcome applications from all areas of physiology and neuroscience - spanning molecular, cellular, systems, and organismal levels.

More information can be found HERE:
lsa.umich.edu/mcdb/news-ev...

#Expansion #Microscopy #Atlas of #Microbial #Eukaryotes is getting up to speed.

We will be at full speed soon, but we are lucky to have a welcoming #protistology #community. Thx

🙏 to @Marine @fmikus.bsky.social @Julius & @Galina
⏭️Stop: @ccapoban.bsky.social
#ExpandThemAll #ExAME #ProtistsOnSky

The Thawani Lab at Columbia University The Thawani Lab at Columbia University describing their research on mobile genome, cryo-electron microscopy and genome engineering

Extremely excited to share that I’m joining Columbia University @columbiauniversity.bsky.social as an Assistant Professor!

We will explore how the mobile genome works—how transposons shape us, our DNA and how they can be harnessed to build useful technologies. #NewPI #RNAsky #TEsky

thawanilab.org

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.

Open access link below:
www.nature.com/articles/s41...

Here's a cool animated summary

Schematic of MAPK signalling in fission yeast, budding yeast and Metazoa. No MAPK scaffold was known for ERK-like MAPK in fission yeast, as opposed to budding yeast Ste5 and metazoan KSR1/2.

Mammalian cells have KSR, budding yeast has Ste5… and fission yeast has Sms1 as the MAPK scaffold for sexual reproduction!

Very excited to share my postdoc work where we discover that the hemi-arrestin Sms1 binds all components of the MAPK cascade, including ERK-like Spk1

doi.org/10.1101/2025...

Love #protists? Then you'd love this! Beautiful collection of hand-drawn critters represented here at the Oxford-Japan symposium on ethological dynamics in diorama environments sites.google.com/view/oxford-... #ciliates #testateamoeba #diatoms

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

Bioengineer Clifford Brangwynne wins Keio Medical Science Prize Japan’s Keio University awards the prize annually to honor contributions in medicine and life sciences. Brangwynne is being recognized for groundbreaking work that has opened up a new field of cell bi...

A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09...
#KeioMedicalSciencePrize

Looks like I am late to this party but have exciting news. I’ve been awarded an ERC Starting Grant to study #XtrmCells! Thankful to @erc.europa.eus for this opportunity, and to my collaborators, mentors, and group for their support. Looking forward to exploring the mechanics of these cells!

SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N

Eight Scientists Named 2025 Schmidt Polymaths to Tackle Breakthroughs in New Disciplines - Schmidt Sciences Schmidt Sciences announces next cohort of early-to mid- career scientists to each receive up to $2.5 million to pursue novel research. Media Contact: Carlie Wiener, cwiener@schmidtsciences.org NEW…

Congratulations to EMBO Young Investigator Uri Ben-David from Tel Aviv University, who has been named one of the 2025 Schmidt Polymaths by @schmidtsciences.bsky.social! 🧪 Uri will study human #aging through the lens of chromosomes.

www.schmidtsciences.org/eight-scient...
#award #genetics #GeneSky

MCDB Opens Search for Faculty | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB) MCDB welcomes applications at the Assistant Professor level from outstanding biological scientists in all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal le...

My MCDB dept is accepting applications for a faculty position at the Assistant Professor level!

Applications Due by October 15, 2025

We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.

lsa.umich.edu/mcdb/news-ev...

New Faculty Profile: Bryce LaFoya LaFoya, who joined the faculty in August 2025, will study neural stem cells and brain regeneration.

Welcome to Bryce LaFoya, who joins the UW–Madison Department of Biochemistry this month as an assistant professor! Learn more about his research, interests, and lab: biochem.wisc.edu/2025/08/21/n...

New Faculty Profile: Wei Wei Wei, who joined the faculty in August 2025, will explore how what we eat impacts our health.

Welcome to Wei Wei, who joins the Department of Biochemistry this month as an assistant professor! Learn more about his research, interests, and lab: biochem.wisc.edu/2025/08/05/n...

Folks the paper is on the cover of the latest issue of Science.

Figure legend: Categories and capabilities of smart microscopy systems integrating real-time image analysis and feedback control. Top: Smart microscopy workflows can be classified based on the driving logic behind decision-making: Event-driven (reacting to rare biological events), Outcome-driven (using feedback-control to steer biological systems toward a desired state), Quality-driven (optimizing signal quality or imaging metrics), and Information-driven (guided by models that predict which measurements/perturbations will yield the most informative data). Middle: Central feedback loop between the microscope and an image analysis system, which continuously exchanges images and commands to guide acquisition dynamically. Bottom: Key control actions enabled by smart microscopy: adjusting imaging modality (e.g. switching from brightfield to fluorescence, adjusting sampling rate), repositioning the field of view (e.g. tracking, drift correction), optimizing acquisition settings (e.g. adaptive optics), and performing photomanipulation (e.g. FRAP, ablation, optogenetics).

🔬🧠 Our paper on smart microscopy & the issue of interoperability! www.biorxiv.org/content/10.1... LONG THREAD WARNING: Smart microscopy uses real-time image analysis to automatically guide the acquisition or perturbation of the sample (closed feedback-control loop). Many applications exist:

Cells can form patterns within themselves just like embryos do. How? Connie Yan's new preprint shows how the anterior-posterior cytoskeleton pattern in Stentor is dictated by regionalized scaffolding proteins

www.biorxiv.org/content/10.1...

Position-specific frequency matrices can be used to calculate z-scores comparing enzyme-treated and control samples. The z-scores are plotted as heatmaps that represent an enzyme specificity profile.

New preprint: we developed a method that uses phosphoproteome-derived peptide libraries (PhosPropels) for deep specificity profiling of phosphatases and phospholyases www.biorxiv.org/content/10.1...

Want to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you!

embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

With @dudinlab.bsky.social
@embl.org @biology-unige.bsky.social @moorefound.bsky.social

We have a postdoc opening for a protistologist with biophysics inclinations to join our @hfspo.bsky.social project! (focus will be on characterising the morphology, ultrastructure and behaviour of excavates) #protistsonsky

Apply by Sept 17th (RTs appreciated!)
jobs.exeter.ac.uk/hrpr_webrecr...

Phenotypic landscape of an invasive fungal pathogen reveals its unique biology The construction and high-precision fitness profiling of a C. neoformans knockout library reveals a high-resolution functional map of its genome and allowed for the identification of fungal analogs of...

In today's issue of Cell-->if you are looking for a good distraction from the news (who isn't), check it out!
www.cell.com/cell/fulltex...

Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

Multi-million project to ‘crack the code’ of cilia – tiny structures with big impact on human health An international team of researchers, led by the University of Exeter, have been awarded a Wellcome Discovery Award grant of almost £5 million to investigate one of the body’s most fascinating microsc...

Excited to share that we have received significant funding from the @wellcometrust.bsky.social for a new interdisciplinary consortium project on #cilia coordination and function across scales and organisms! 🎉🥂@lsiexeter.bsky.social

news.exeter.ac.uk/living-syste...

Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior Nature Communications - Chromatin heterogeneity in the cell nucleus modulates the size, mobility, and formation of biomolecular condensates; decreasing chromatin heterogeneity correlates with...

Congrats to Jing @jesszhiyuezhao.bsky.social‬
& @dnamystrom.bsky.social‬ on cool manuscript!!! Reveals how cell nucleus is a heterogeneous material, w chromatin organization controlling formation & phase behavior of nuclear condensates. #CellBiology #Chromatin #PhaseSeparation rdcu.be/evWxR

Our new work understanding how phages are detected by the bacterial immune system is posted on bioRxiv! Check out Toni’s thread for a synopsis👇