Arnaud Krebs

And the science is amazing! Apply!

Seminarankündigung des Max-Planck-Instituts Freiburg mit Thema zur DNA-Sequenz und Chromatin, Datum, Uhrzeit und Ort, Porträt von Philipp Korber. MPS: Philipp Korber - The role of DNA sequence, chromatin remodelers, barriers and their intrinsically disordered regions in nucleosome positioning Max Planck Seminar DATE: Nov 20, 2025 TIME: 01:00 PM SPEAKER: Philipp Korber AFFILIATION: Biomedical Center (BMC) of LMU Munich, Germany LOCATION: MPI-IE ROOM: Lecture Hall HOST: Nicola Iovino

This Thursday, we’re pleased to welcome Philipp Korber.
Prof Korber leads a research group on “Nucleosome Positioning & Remodeling in Yeasts” at the @bmc-lmu.bsky.social in Munich. His work has identified ATP-dependent chromatin remodelers as major determinants of nucleosome positioning.

Join us!

An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

EMBL-EBI / Embassy of France in London Internships In collaboration with the Embassy of France in London, we are offering a number of paid internships to computer-science, statistics and bioinformatics students.

Vous êtes étudiant(e) en informatique, ingénierie ou mathématiques dans une université ou une grande école ? La biologie et le fonctionnement du vivant vous intéressent ? Envie d'élargir vos horizons ?

Ce stage pourrait vous convenir.

www.ebi.ac.uk/about/jobs/i...

Sequential verification of transcription by Integrator and Restrictor Estell and Łazowski et al. show that Integrator and Restrictor form distinct pathways for early attenuation of RNA polymerase II: Integrator acts at the promoter-proximal pause site, whereas Restricto...

Ding ding! New Restrictor paper out showing that ZC3H4 affects transcription universally at a checkpoint downstream and distinct to Integrator!

Sequential verification of transcription by Integrator and Restrictor: Molecular Cell www.cell.com/molecular-ce...

This is a compact one compatible wit a train ride.

Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...

Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?

Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...

Out now! 🎉 Check the thread & preprint to see why we think E–P specificity is real in mammals — and, well, a few other interesting things popped up too 👀
Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬

A genetic engineering tour de force by @blanka-majchrzycka.bsky.social. Systematic dissection of promoter function in relevant genomic context! Spoiler, promoter matters! Happy we could help on this!

Model organisms as platforms for training scientific minds

www.nature.com/articles/s41...

Early career group leaders We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

Unique opportunity to get hands on experience at post-doc+ level in cutting edge environment!

📢We're #hiring Group Leaders!

Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.

🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines

Apply by Nov. 4👉 https://janelia.link/groupleader

Two more days to apply for the VBC PhD program! Join us in beautiful Vienna to explore exciting scientific questions under fantastic mentorship and in an outstanding training environment!

Great news. Congrats!

Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.

🧵1/ Excited to share our new paper introducing a new #singlecell assay: scTF-seq, a high-throughput single-cell approach to explore how transcription factor (TF) dose shapes cell identity and reprogramming outcomes. 🔗 www.nature.com/articles/s41... Big congrats to the entire team @EPFL & @SIAT_China

Congratulations! nice to see this out!

We're growing the VIB.AI Machine Learning Unit, and we're hiring!

📌 Head of the Machine Learning Unit
📌 LLM Engineer

Both roles are based in Leuven, Belgium, at the heart of a thriving research ecosystem.
https://vib.ai/en/opportunities#/job-list
Apply by October 31st.

#Jobalert 🚨: Please RT !
Looking for a #PhD student for exciting project on the interphase between epigenetics and cellular metabolism:
How do (nuclear) metabolic enzymes reguate chromatin function ?
#epigenomics, #epigenetics, #metabolism
www.helmholtz-munich.de/en/ife/job-o...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

✨Exciting news: the main story of my PhD is out in Science!

Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.

📖 Read the full story here: www.science.org/doi/10.1126/...

Spectacular work Christine & co! Congrats! Happy to see this out.

Have you ever wondered how the exact location of a gene affects it's activity?

The main story of my PhD deals with exactly that question, and is now published in Science! ✨
www.science.org/doi/10.1126/...

My amazing co-author and friend @mathiaseder.bsky.social summarized the highlights for you

🤞

This feeling usually precedes an emergency call from the kita or school :)

Join EMBL AI!

We have ambitious plans to transform life sciences research through AI.

Interested in using ML/AI to solve complex interdisciplinary challenges?

We’re looking for two senior leaders based at EMBL Heidelberg👇

We're getting started in ~90 minutes!

In addition to watching the seminars, remember you can join us on Discord to chat about transcription and chromatin whenever you want! discord.com/invite/dXqT89r

FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics The FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics will take place 19–22 October 2026 in Budapest, Hungary. Here we give a taste of the scientific content, flag some of the speaker...

Do not forget to apply to the FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics (19–22 October 2026, Budapest, Hungary. Will be a great meeting as always. Check out the site: network.febs.org/posts/febs-a...

Check it out, Chromatin Kids!

Chromatin remodeller does stuff to Transcription Factors!

Functions where it is seldom seen!

Both decreases and increases chromatin accessibility!

How cool is that?

Excited to share another new preprint from our lab in which we developed a cluster-based phasing strategy using long read nano-NOMe-seq data to link distinct CTCF binding states—captured at the single molecule level—to the transcriptional status of genes: biorxiv.org/content/10.1...

Become our colleague at @fmiscience.bsky.social! The FMI is a very special place to start your lab: a vibrant international institute with world-class research groups and facilities, core funding, fantastic trainees, great colleagues😅, and a collegial culture. Get in touch if you're interested!