Arnaud Krebs

Head, Advanced Genomics Technologies Core Facility (Ref. CF/26/01) - IRB Barcelona IRB Barcelona invites applications for the position of Head, Advanced Genomics Technologies Core Facility. The successful candidate will report to the Director, Technology Strateg...

🚨WE'RE RECRUITING AT @irbbarcelona.org !!!!

--- ADVANCED GENOMICS FACILITY MANAGER ---

An amazing opportunity to help us drive the fight against cancer and other aging-related diseases using Single-cell, Bulk and Spatial genomics!!!!

APPLY NOW!!!!

recruitment.irbbarcelona.org/jobs/7124180...

Come and join us at EMBL. Best way to get your scientific career started!

🤯🤯
#microsky #Phagesky #synbiosky

Very important work to reconcile canonical transcription initiation structures with the promoter diversity occurring in vivo. Some explanation on how the large majority of our promoters (TATA-less) ma initiate transcription through contacts downstream of the TSS.

Epigenetics that matters! Very cool work on hard to hard-to-access cell types . Finally some solid epigenetics examples that should be used in textbooks! Congrats to Mathieu and team @embl.org Rome!

This is nuts. Dead ringers fused. Cronenberg would have loved that.

Join @stirlingchurchman.bsky.social,
@moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...

Still time to apply until January, 19th!

The best chromatin kickstart pack you will find this year - please consider it if you want to get in the field or consolidate your skills. Hands on training and top notch speakers!

Programmatic design and editing of cis-regulatory elements The development of modern genome editing and DNA synthesis has enabled researchers to edit DNA sequences with high precision but has left unsolved the problem of designing these edits. We introduce Le...

After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out!

In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells.

www.biorxiv.org/content/10.1...

SET1/MLL complexes control transcription independently of H3K4me3 Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!

www.biorxiv.org/content/10.6...

Are you ready for the 17th edition of 'Transcription and chromatin'? Our conference remains a must-attend event for anyone engaged in the forefront of transcription research and we hope you can join us! 🧬

25 – 28 August 2026
Submit your abstract by 25 May: s.embl.org/trm26-01-bl

#EMBLTranscript

Summary - Summer School on Chromatin Biology: A Hands-On Expedition

👉 Chromatin Summer School 2026 – Apply Now!
Join us in Munich 17–29 August 2026 for an immersive program on chromatin biology:
🔬 Expert lectures
🧪 Hands-on training
🤝 Global networking
Open to 14 PhD students worldwide (sponsorship available)
👉 Apply here: bit.ly/4oGDR8f
#ChromatinBiology

Its out!!!

Please RT 📧
Registration open for ➡️"Summer School on Chromatin Biology" Our 2 weeks hands on expedition 🧪👩‍💻August 2026. 3. edition. Learn CUT@Tag, CUT@Run, ChIPseq, ATACseq AND to analyse your own data at @helmholtzmunich.bsky.social Daily letures by experts in the field !

▶️ shorturl.at/jrA8i

It's always exciting when the latest edition of JASPAR comes out. Great leadership by @amathelier.bsky.social and pleased to welcome @anshulkundaje.bsky.social to the journey. #Jaspar2026

academic.oup.com/nar/advance-...

Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs Low-affinity transcription factor (TF) motifs are an important element of the cis-regulatory code, yet they are notoriously difficult to map and mechanistically incompletely understood, limiting our a...

We are pleased to announce a new preprint by @mlweilert.bsky.social: “Widespread low-affinity motifs enhance chromatin accessibility and regulatory potential in mESCs” (www.biorxiv.org/content/10.1...). See summary and longer recap below:

(TLDR; low-affinity motifs matter as pioneers!)

Un gruyère suisse « parfait et inoubliable » sacré champion du monde des fromages Ce fromage provient de la fromagerie de montagne Vorderfultigen, en Suisse alémanique, spécialisée dans la production de gruyère AOP.

Je ne voudrais pas gacher l'enthousiasme a Tain l'hermitage, mais je ne suis pas sur que on soit encore remis de ca :) www.lemonde.fr/le-monde-pas...

Deadline is coming up soon!!

www.mdc-berlin.de/career/jobs/...

The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris).
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47

And the science is amazing! Apply!

Seminarankündigung des Max-Planck-Instituts Freiburg mit Thema zur DNA-Sequenz und Chromatin, Datum, Uhrzeit und Ort, Porträt von Philipp Korber. MPS: Philipp Korber - The role of DNA sequence, chromatin remodelers, barriers and their intrinsically disordered regions in nucleosome positioning Max Planck Seminar DATE: Nov 20, 2025 TIME: 01:00 PM SPEAKER: Philipp Korber AFFILIATION: Biomedical Center (BMC) of LMU Munich, Germany LOCATION: MPI-IE ROOM: Lecture Hall HOST: Nicola Iovino

This Thursday, we’re pleased to welcome Philipp Korber.
Prof Korber leads a research group on “Nucleosome Positioning & Remodeling in Yeasts” at the @bmc-lmu.bsky.social in Munich. His work has identified ATP-dependent chromatin remodelers as major determinants of nucleosome positioning.

Join us!

An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

EMBL-EBI / Embassy of France in London Internships In collaboration with the Embassy of France in London, we are offering a number of paid internships to computer-science, statistics and bioinformatics students.

Vous êtes étudiant(e) en informatique, ingénierie ou mathématiques dans une université ou une grande école ? La biologie et le fonctionnement du vivant vous intéressent ? Envie d'élargir vos horizons ?

Ce stage pourrait vous convenir.

www.ebi.ac.uk/about/jobs/i...

Sequential verification of transcription by Integrator and Restrictor Estell and Łazowski et al. show that Integrator and Restrictor form distinct pathways for early attenuation of RNA polymerase II: Integrator acts at the promoter-proximal pause site, whereas Restricto...

Ding ding! New Restrictor paper out showing that ZC3H4 affects transcription universally at a checkpoint downstream and distinct to Integrator!

Sequential verification of transcription by Integrator and Restrictor: Molecular Cell www.cell.com/molecular-ce...

This is a compact one compatible wit a train ride.

Promoter-proximal gatekeepers restrict pleiotropic enhancer inputs to achieve tissue specificity Developmental enhancers are central regulatory elements that can activate multiple genes, yet how they selectively regulate one gene over its neighbours remains unclear. Using the Drosophila twist E3 ...

Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?

Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...

Out now! 🎉 Check the thread & preprint to see why we think E–P specificity is real in mammals — and, well, a few other interesting things popped up too 👀
Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬

A genetic engineering tour de force by @blanka-majchrzycka.bsky.social. Systematic dissection of promoter function in relevant genomic context! Spoiler, promoter matters! Happy we could help on this!

Model organisms as platforms for training scientific minds

www.nature.com/articles/s41...