Jake Yeston

A Metro train in a festive red white and green candy themed wrap

Good morning from the holiday candy Metro train 🍬

A trio of AI methods tackles enzyme design RFdiffusion2, RFdiffusion3, and Riff-Diff each solve different structural problems in computational enzyme design

Three new papers report improvements to enzyme design using diffusion models, a class of generative artificial intelligence algorithms that add and then subtract noise. cen.acs.org/physical-che... #chemsky 🧪

Boxing up the NSF at Eisenhower Av for the forced relocation. Boxes have “Details Matter” signage.

NSF

- Forced reorg

- POs down ~ 40% (DRP, most rotators not renewed, retirements)

- Forced move (and we have to pack and clean) to a building with no furniture, little to no conference space for panels, inadequate 🛜, …)

I personally love the boxes they gave us for packing.
“Details matter” 🙃

🤪

I’ve seen this photo a zillion times and I mostly focus on how he has a nice belt.

I think the upshot of this thread is we should all move to Philly. Great food scene there!

Do I show up at your job and complain that the goods and services have prices?

Starting tomorrow- join us for the ultimate organic reaction bracket #ReactionRunoff hosted by the ACS Organic Division @organicdivision.org
Round 1 from Dec 10-11 and new rounds every 2 days
#ChemSky #ChemChat
#AmplifyOrganic

Well that was 2025 in Pharma, and what a year it turned out to be

a little girl wearing a happy new year crown says i 'm wearing the hat where 's the party ALT: a little girl wearing a happy new year crown says i 'm wearing the hat where 's the party

Photoredox and electrochem like

And if you’re ready for the holidays, but also looking for something that’s a little bit different, tickets are on sale now for our concert next week! They’re selling fast so get them today at our website Alexandriachoralsociety.org

Abigail Adams, 1776

founders.archives.gov/documents/Ad...

This is so gross for so many reasons, but especially because John Adams was more progressive about women than any of the other founders.

A new #ScienceRobotics study describes an interlaced origami-based structure that enables mobile robots to extend arms to press elevator buttons or form frames to support heavy 3D printing systems. https://scim.ag/44sUi0D

CDC Panel’s Hepatitis B Vaccine Vote Undid Decades of Progress In a stunning decision that defies all expert advice and scientific evidence, the influential group that shapes US vaccine policy will no longer recommend that all infants receive the hepatitis B vacc...

For my latest @opinion.bloomberg.com, I wrote about this week's ACIP meeting-- yes, the CDC panel's terrible hep B vaccine decision, but the simple strategy RFK's handpicked members are using to sow confusion and distrust in vaccines. (🎁 link)

I yelled so loud I kinda passed out.

The light of the nine lives!

It's a meownorah!

A Chanukkah menorah with a different colored ceramic cat under each of the nine candle holders. The cat under the shamash is sitting on a little cat tree.

New menorah just dropped🤩

bsky.app/profile/jake...

bsky.app/profile/jake...

🙄

Well done Hoosiers!!

Someone please make Sam a caipirinha

Spelling Bee really should not take the word it took today if it doesn’t take cachaça

Missed this the first time—it’s an all-timer!

Reupping for no reason.

Za’atar bagel with cream cheese, lox, cucumber, lemon and dill. Dopest Dough!
(cc: @jakeyeston.bsky.social)

I miss the bagel feed

too soon