Stella Hurtley

Independent nuclear and organellar mechanisms determine apicoplast fate in malaria parasites

My choice this week in @science.org
@florentin-lab.bsky.social
doi.org/10.1083/jcb....

Termination of the integrated stress response Stress responses enable cells to detect, adapt to, and survive challenges. The benefit of these signaling pathways depends on their reversibility. The integrated stress response (ISR) is elicited by p...

Final version out now in @science.org
Termination of the integrated stress response | Science www.science.org/doi/10.1126/...

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...

Out now in @science.org
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...

Bacteria gain a firm hold in the airways Pathogenic Bordetella avoid clearance from airways by hanging on to microtubules of ciliated cells

www.science.org/doi/10.1126/...

Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization Pathogenic Bordetella bacteria use protein adhesins to infect the ciliated respiratory epithelia of vertebrate hosts. In this work, we show that the filamentous hemagglutinin FhaB adhesin of Bordetell...

Just published in @science.org with related Perspective by Françoise Jacob-Dubuisson.
Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization | Science www.science.org/doi/10.1126/...

My choice this week in @science.org
Multiscale mitochondrial cristae remodeling links Opa1 downregulation to reduced OXPHOS capacity in aged hearts

10.1073/pnas.2508911123

DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...

Out now in @science.org
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...

Please share widely!

It's here!
bit.ly/4bWOJfn

The position is open to applicants able to work in our Washington, DC or Cambridge, UK office or remotely from select states.

Application Process
Submit a resume and cover letter outlining qualifications and interest in the position by February 27, 2026. Applications are reviewed on a rolling basis. A Recruiter will contact you with next steps if you are selected for an interview.

Minimum Requirements
PhD in relevant discipline.
Several years of post-doctoral research experience.
Proven track record of publishing high-quality research papers in scientific journals.

What You'll Do
Manage the evaluation, review, and editing of submitted manuscripts in the field of next generation medicine.
Represent Science at scientific meetings nationally and internationally and visit scientists with the goal of recruiting the best papers to Science.

Science is looking for an Editor to handle research in the area of next-generation medicine, to identify, assess and select research papers that use system approaches (including application of AI to large data sets) to advance bench to bedside biomedical research and therapeutics development.

We're looking for a new editor with experience in Next Generation Medicine. Are you ready to leave the bench (or bedside) and help us identify the best science for publication in @science.org
Send your CV and cover letter explaining why you're a good fit for the role.
bit.ly/4bWOJfn

Look out for an exciting job opening coming up at Science - anyone interested in Next Generation Medicine? @science.org
We'll be posting the ad soon! .. Watch this space!

Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development Zygotic genome activation (ZGA) failure leads to developmental arrest and poses a clinical challenge to women’s fertility. We observed that human embryos arresting at the eight-cell ZGA stage exhibite...

Out now in @science.org Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development | Science www.science.org/doi/10.1126/...

My choice last week in @science.org
www.nature.com/articles/s41...
Caitlin E. Cornell, Aymeric Chorlay, Deepak Krishnamurthy, Nicholas R. Martin, Lucia Baldauf & Daniel A. Fletcher

If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 yrs don’t forget to apply for the NOSTER & @science.org Microbiome Prize! Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: buff.ly/5GKZgUN

A little bit late after #cellbio2025. My choice last week in @science.org
www.nature.com/articles/s41...

Looking forward to #cellbio2025
I’ll be at there for @science.org
Find me Monday and Tuesday 2:30-3:30pm at the Science/AAAS
Booth #325

Nucleotides on the frontline: Nucleotide-centric defense systems reveal a core principle in bacterial antiviral immunity Nucleotide-centric defense systems reveal a core principle in bacterial antiviral immunity

GENOMICS, PROTEOMICS, & SYSTEMS BIOLOGY
Nucleotides on the frontline: Nucleotide-centric defense systems reveal a core principle in bacterial antiviral immunity
www.science.org/doi/10.1126/...

Balancing between evolutionary rescue and extinction: The adaptive potential of reef-building corals in a warming world The adaptive potential of reef-building corals in a warming world

ECOLOGY & ENVIRONMENT
Balancing between evolutionary rescue and extinction: The adaptive potential of reef-building corals in a warming world
www.science.org/doi/10.1126/...

Oncogenes out of context: Cancer genes break free from the regulatory constraints of chromosomes Cancer genes break free from the regulatory constraints of chromosomes

CELL & MOLECULAR BIOLOGY
Oncogenes out of context: Cancer genes break free from the regulatory constraints of chromosomes
www.science.org/doi/10.1126/...

The missing piece: Solving the 50-year puzzle of BMP synthesis in neurodegeneration Solving the 50-year puzzle of BMP synthesis in neurodegeneration

Congratulations to all the winners of the @science.org and SciLifeLab prize - Uche Medoh, King L. Hung, Liam Lachs, and Nitzan Tal
MOLECULAR MEDICINE
The missing piece: Solving the 50-year puzzle of BMP synthesis in neurodegeneration | Science www.science.org/doi/10.1126/...

Prize winners harness interdisciplinary tools to investigate climate apathy and human health | American Association for the Advancement of Science (AAAS)

www.aaas.org/news/prize-w...

Congratulations to our two NOMIS & Science Grand Prize Winners @rachitdubey.bsky.social and Jiacheng Miao whose essays just published in @science.org
www.science.org/content/page...

The normalization of (almost) everything: Our minds can get used to anything, and even crises start feeling normal Our minds can get used to anything, and even crises start feeling normal

Honored and excited to share that I am the winner of Nomis & Science Young Explorer Award!!

Also thrilled to share that my article describing my research is out now in @science.org today!

The normalization of (almost) everything www.science.org/doi/10.1126/...

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Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex The microprotein adipogenin (Adig) is predominantly expressed in adipose tissues. Here, we found that Adig interacts with seipin to form a stable, rigid complex. We present the structure of the seipin...

www.science.org/doi/10.1126/...