Stella Hurtley

My choice this week in @science.org
www.cell.com/cell-reports...

Epithelial tension controls intestinal cell extrusion Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...

I was on vacation when this one went live - relatively new in @science.org
Epithelial tension controls intestinal cell extrusion | Science www.science.org/doi/10.1126/...

Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos Although specific transcription factors (TFs) are known to regulate cell fate decisions, the degree to which they can stimulate formation of specific cell organelles is less clear. We used a multiomic...

I was on vacation when this one went live - relatively new in @science.org
Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos | Science www.science.org/doi/10.1126/...

Re-upping this - applications will close - open to UK-based people too!!!

Do you love science but want to leave the bench? This could be what you’re looking for.
Send us your cv and a cover letter.
Join us in Cambridge UK or Washington DC.
Apply early and before 22 September.

Come join us @science.org. We’re looking for a new editor to look after infectious disease and microbiome submissions.
Check out this Associate or Senior Editor opportunity recruiting.ultipro.com/AME1123ASEM/...

My choice this week in @science.org
www.cell.com/cell/abstrac...

A protein tunnel helps stressed lysosomes swell The endoplasmic reticulum donates lipids through a tunnel-like protein to help lysosomes expand

www.science.org/doi/10.1126/...

LYVAC/PDZD8 is a lysosomal vacuolator Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...

New in @science.org with a related Perspective
LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...

How a Ph.D. is like riding a bike This researcher struggled in grad school—until he embraced it as a time for learning

New in @science.org a really helpful metaphor for many life stages!
How a Ph.D. is like riding a bike | Science | AAAS www.science.org/content/arti...

Mitochondria hoard folate to starve a parasite Metabolic immunity contributes to cells’ defenses against Toxoplasma gondii

www.science.org/doi/10.1126/...

Mitochondria protect against an intracellular pathogen by restricting access to folate As major consumers of cellular metabolites, mitochondria are poised to compete with invading microbes for the nutrients that they need to grow. Whether cells exploit mitochondrial metabolism to protec...

Check out this paper and its related Perspective in @science.org
Mitochondria protect against an intracellular pathogen by restricting access to folate | Science www.science.org/doi/10.1126/...

Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex Malaria parasite fertilization occurs in the midgut of a female Anopheles mosquito. Blocking fertilization within the mosquito can prevent malaria transmission. Plasmodium falciparum Pfs230 and Pfs48/...

Online now in @science.org
Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex | Science www.science.org/doi/10.1126/...

Silencing mitochondrial gene expression in living cells Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, the central mechanis...

Just out in @science.org
Silencing mitochondrial gene expression in living cells | Science www.science.org/doi/10.1126/...

My choice this week in @science.org
www.cell.com/cell-host-mi...

A hypoxia-responsive tRNA-derived small RNA confers renal protection through RNA autophagy Transfer RNA-derived small RNAs (tsRNAs, or tDRs) perform a range of cellular functions. Here, we showed that a hypoxia-induced tDR, derived from the 3′ end of tRNA-Asp-GTC (tRNA-Asp-GTC-3′tDR), activ...

In First Release @science.org this week
A hypoxia-responsive tRNA-derived small RNA confers renal protection through RNA autophagy | Science www.science.org/doi/10.1126/...

Organelles share the load Peroxisome-mitochondria contact sites manage mitochondrial oxidative stress

Organelles share the load | Science www.science.org/doi/10.1126/...

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science www.science.org/doi/10.1126/...

Congratulations to all the winners! @djenetbousbaine.bsky.social; Ayele Argaw-Denboba; Mohammad Arifuzzaman

Illuminating microbial dark matter: Dietary alterations uncover microbial regulation of immunity and metabolism Dietary alterations uncover microbial regulation of immunity and metabolism

Illuminating microbial dark matter: Dietary alterations uncover microbial regulation of immunity and metabolism | Science www.science.org/doi/10.1126/...

The gut microbiome–germline axis: Does a prospective father’s gut microbiota matter? Does a prospective father’s gut microbiota matter?

The gut microbiome–germline axis: Does a prospective father’s gut microbiota matter? | Science www.science.org/doi/10.1126/...

The vaccine we all wear: Skin microbiota can be engineered into topical vaccines Skin microbiota can be engineered into topical vaccines

Check out the Noster prize winning essays @science.org The vaccine we all wear: Skin microbiota can be engineered into topical vaccines | Science www.science.org/doi/10.1126/...

My choice this week in @science.org
doi.org/10.1083/jcb....

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell ...

Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch | Science www.science.org/doi/10.1126/...

Another post that didn't happen whilst I was on vacation - my choice in @science.org a couple of weeks ago
www.nature.com/articles/s41...

Rewriting the rules of cell division Microtubules get help from actin filaments during mitosis

And see related Perspective
www.science.org/doi/10.1126/...

Actin organizes chromosomes and microtubules to ensure mitotic fidelity in the preimplantation embryo Following fertilization, the preimplantation embryo undergoes successive rounds of cell division and must accurately propagate the genetic material to ensure successful development. However, early mam...

Better late than never! I was on vacation when this one came out in @science.org
Actin organizes chromosomes and microtubules to ensure mitotic fidelity in the preimplantation embryo | Science www.science.org/doi/10.1126/...

My choice this week in @science.org
10.1016/j.cell.2025.02.033
Pierre Stallforth and colleagues

The complex role of brain cilia in feeding control Variants in a ciliary receptor are associated with obesity

www.science.org/doi/10.1126/...

GPR45 modulates Gαs at primary cilia of the paraventricular hypothalamus to control food intake The melanocortin system centrally regulates energy homeostasis, with key components such as melanocortin-4 receptor (MC4R) and adenylyl cyclase 3 (ADCY3) in neuronal primary cilia. Mutations in MC4R a...

Check out this intriguing paper and its related Perspective in @science.org
GPR45 modulates Gαs at primary cilia of the paraventricular hypothalamus to control food intake | Science www.science.org/doi/10.1126/...