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Michael Love

@mikelove.bsky.social

Genetics, bioinformatics, comp bio, statistics, data science, open source, open science!

6,851 Followers  |  1,754 Following  |  545 Posts  |  Joined: 27.08.2023  |  2.0603

Latest posts by mikelove.bsky.social on Bluesky

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Enabling Discovery Through Genomics (EDGE)

The new Enabling Discovery through GEnomics (EDGE) Program page is posted. Please contact us at BIOEDGE@nsf.gov if you have questions. www.nsf.gov/funding/oppo...

08.12.2025 21:00 β€” πŸ‘ 80    πŸ” 53    πŸ’¬ 1    πŸ“Œ 2

Ten years ago I had sent off my applications for faculty positions and found out that I was getting an interview with Chapel Hill Biostatistics.

08.12.2025 21:58 β€” πŸ‘ 21    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Let us know, e.g. @stemang.bsky.social or I if you have any ideas for something to post re: use cases for tidyomics to share or to develop.

08.12.2025 17:29 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

tidyomics project πŸ”› R-bloggers!

www.r-bloggers.com/2025/10/the-...

Thanks to @stemang.bsky.social, Maria Doyle @bioconductor.bsky.social, @jhsanchez.bsky.social, Mengyuan Shen, Jonathan Carroll and others in tidyomics for testing and getting this up and running

08.12.2025 17:28 β€” πŸ‘ 17    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0

Impressive!

04.12.2025 12:12 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines Feng et al. present the first genome-scale CRISPR interference perturbation map with scRNA-seq readout across many genetic backgrounds in human pluripotent cells, pioneering population-scale CRISPR pe...

Happy to see this out now in Cell Genomics: A genome-scale single-cell CRISPRi map of trans gene regulation across human pluripotent stem cell lines: www.cell.com/cell-genomic...

03.12.2025 09:17 β€” πŸ‘ 26    πŸ” 9    πŸ’¬ 3    πŸ“Œ 1
Terence Tao on the cosmic distance ladder
YouTube video by 3Blue1Brown Terence Tao on the cosmic distance ladder

www.youtube.com/watch?v=YdOX...

03.12.2025 15:36 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

en.wikipedia.org/wiki/Hertzsp...

03.12.2025 00:57 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
"Hertzsprung–Russell diagram. A plot of luminosity (absolute magnitude) against the colour of the stars ranging from the high-temperature blue-white stars on the left side of the diagram to the low temperature red stars on the right side."

"Hertzsprung–Russell diagram. A plot of luminosity (absolute magnitude) against the colour of the stars ranging from the high-temperature blue-white stars on the left side of the diagram to the low temperature red stars on the right side."

Is this the coolest scatterplot?

03.12.2025 00:57 β€” πŸ‘ 35    πŸ” 0    πŸ’¬ 2    πŸ“Œ 0
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The most-cited neuroscience papers from the past 30 years Highly cited papers reflect the surge in artificial-intelligence research in the field and other technical advances.

Pretty neat to see our paper - led by @kr-maynard.bsky.social @lcolladotor.bsky.social on the 2021 list of most cited neuroscience papers πŸ§ πŸ”¬πŸ§ͺ

www.thetransmitter.org/publishing/w...

01.12.2025 12:57 β€” πŸ‘ 34    πŸ” 7    πŸ’¬ 1    πŸ“Œ 1

As promised, a longer thread on what I consider to be some of the most interesting and important contributions of this paper (1/10)

01.12.2025 21:20 β€” πŸ‘ 13    πŸ” 7    πŸ’¬ 1    πŸ“Œ 2
STATGEN 2026: Conference on Statistics in Genomics and Genetics STATGEN 2026: Conference on Statistics in Genomics and Genetics, May 18-20, 2026. ASA Section on Statistics in Genomics and Genetics.

Consider submitting an abstract for an invited talk or poster at STATGEN 2026 by December 15th!

Amazing keynote speakers and statistical leaders in #genetics and #genomics! πŸ‘

Hope to see you there! statgen26.emory.edu

πŸ§ͺ 🧬 πŸ–₯️ 🧠 #statssky #imaging #SingleCell #spatial #omics #DigitalPathology

01.12.2025 18:25 β€” πŸ‘ 10    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

A nice paper on distilling AI-based splicing models into much simpler additive models:

"[...] the distilled models achieve this without modeling RNA structure or feature interactions, indicating that [AI]-based splicing models recognize exons primarily through simple additive sequence features."

02.12.2025 00:53 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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High-quality mouse reference genomes reveal the structural complexity of the murine protein-coding landscape Helmy et al. provide a collection of high-quality mouse reference genomes. They were able to resolve some of the most complex regions among mouse genomes that are involved in immune defense. These fin...

High-quality mouse reference genomes [PacBio Long Read genomes of 17 strains] reveal the structural complexity of the murine protein-coding landscape, Cell Genomics. www.cell.com/cell-genomic... Genomes and annotations here: projects.ensembl.org/mouse_genomes/

02.12.2025 04:30 β€” πŸ‘ 28    πŸ” 9    πŸ’¬ 1    πŸ“Œ 0
https://ds.dfci.harvard.edu/postdocs/

πŸ“’ We are taking applications for our Postdoctoral Fellows Program at Harvard/DFCI!

πŸ”ΉJoin a research group in our department
πŸ”ΉCo-mentoring opportunities with 2+ faculty
πŸ”ΉCollaborate with investigators beyond our department
πŸ”ΉSalary starts at $75K

Apply here: t.co/B7SLZzQFKu

01.12.2025 18:59 β€” πŸ‘ 8    πŸ” 17    πŸ’¬ 0    πŸ“Œ 0
Intro to Bedder – The Quinlan Lab

We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #π—―π—²π—±π˜π—Όπ—Όπ—Ήπ˜€! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.

1/n

02.12.2025 02:28 β€” πŸ‘ 281    πŸ” 139    πŸ’¬ 5    πŸ“Œ 10
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⏰ Only a few hours left to register!

Don’t miss today’s Bioconductor Seminar Series session:
β€œDeep-learning-based Gene Perturbation Effect Prediction Does Not Yet Outperform Simple Linear Baselines.”

πŸ—“οΈ December 2, 2025
πŸ•’ 9PM CET / 3PM EST / 12PM PST

πŸ‘‰ Register here: dfci.zoom.us/webinar/regi...

02.12.2025 07:00 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
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Observational epidemiological studies can mitigate genetic confounding with the genetic relatedness matrix Observational studies are commonly used in psychology and epidemiology to identify risk factors correlated with health outcomes. However, these studies are vulnerable to confounding when shared geneti...

Excited to share work from my postdoc with @docedge.bsky.social and collaborators Matt Pennell and @jgschraiber.bsky.social, newly out over the weekend: www.biorxiv.org/content/10.1... (1/6)

01.12.2025 19:09 β€” πŸ‘ 60    πŸ” 28    πŸ’¬ 2    πŸ“Œ 2
EIPOD-LinC Fellowship Programme – Postdoctoral Programme

Join EMBL's Interdisciplinary Postdoc Programme!
3 years funding, self-designed interdisciplinary project co-led between EMBL PI and PI in one of EMBL's actual, prospect or associate member states.

In particular: AI&Theory, use mathem. models, physics principles and AI

www.embl.org/about/info/p...

01.12.2025 11:00 β€” πŸ‘ 20    πŸ” 21    πŸ’¬ 2    πŸ“Œ 0
Validate User

Excited to share that our article on accurate sample deconvolution of pooled snRNA-seq data using sex-dependent gene expression patterns is live on NAR Genomics and Bioinformatics! πŸŽ‰

Check it out here: doi.org/10.1093/narg...

#NARGenomicsandBioinformatics #snRNAseq #Genomics #Bioinformatics

26.11.2025 17:44 β€” πŸ‘ 13    πŸ” 7    πŸ’¬ 1    πŸ“Œ 2
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Metabolites are not genes β€” avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pathway analysis in metabolomics often yields misleading or nonsensical results.

#Throwback πŸ§ͺ

COMMENT | Metabolites are not genes β€” avoiding the misuse of pathway analysis in metabolomics

KS Lee, X Su & T Huan

30.11.2025 19:01 β€” πŸ‘ 34    πŸ” 10    πŸ’¬ 0    πŸ“Œ 0
Figure 1. Proteome compleasm scores for predicted transcripts by annotation method for vertebrates. The score is calculated as 1 βˆ’ (number missing BUSCOs/total number of BUSCOs searched).

Figure 1. Proteome compleasm scores for predicted transcripts by annotation method for vertebrates. The score is calculated as 1 βˆ’ (number missing BUSCOs/total number of BUSCOs searched).

Joint distributions of number of predicted CDSs (normalized by number of NCBI predictions) over median predicted CDS length (nor- malized by median NCBI CDS length) for the reference species for each taxonomic group we examined, as well as M. musculus. Dotted lines indi- cate equivalence to NCBI annotation, such that methods that are closest to the intersection of those lines best approximate CDS length and number of NCBI annotations. A β€œP” indicates that the method only makes protein- coding predictions.

Joint distributions of number of predicted CDSs (normalized by number of NCBI predictions) over median predicted CDS length (nor- malized by median NCBI CDS length) for the reference species for each taxonomic group we examined, as well as M. musculus. Dotted lines indi- cate equivalence to NCBI annotation, such that methods that are closest to the intersection of those lines best approximate CDS length and number of NCBI annotations. A β€œP” indicates that the method only makes protein- coding predictions.

Building better genome annotations across the tree of life
genome.cshlp.org/content/35/5...
TOGA, BRAKER3, and the RNA-seq assembler StringTie are top performers when benchmarking 12 different methods for 21 different species spanning vertebrates, plants, and insects.

30.11.2025 23:17 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
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PanSN-spec: Pangenome Sequence Naming
github.com/pangenome/Pa...

30.11.2025 23:24 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

SuSiE 2.0: improved methods and implementations for genetic fine-mapping and phenotype prediction https://www.biorxiv.org/content/10.1101/2025.11.25.690514v1

28.11.2025 10:46 β€” πŸ‘ 19    πŸ” 8    πŸ’¬ 0    πŸ“Œ 0
Portrait photo Katy BΓΆrner

Portrait photo Katy BΓΆrner

πŸ“£ Listen to the BIH Lecture " Multiscale Human Reference Atlas - An Ontological Bridge Between Anatomy and Disease" by Stiftung CharitΓ© visiting fellow Prof. Dr. @katyborner.bsky.social.

πŸ“… December 5, 2025, 12:00 - 1:00 pm, online via Zoom

➑️ tinyurl.com/4p9cjhph

Foto Β© Andreas Bueckle

28.11.2025 09:22 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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GitHub - BiocPy/GenomicRanges: Container class to represent genomic locations and support genomic analysis Container class to represent genomic locations and support genomic analysis - BiocPy/GenomicRanges

The GenomicRanges (github.com/BiocPy/GenomicRanges) package for Python got a major speed boost (v0.7.0+) thanks to Aaron’s blazing-fast C++ nclist interval indexing!

#Bioinformatics #Genomics #Bioconductor

25.08.2025 03:56 β€” πŸ‘ 14    πŸ” 3    πŸ’¬ 1    πŸ“Œ 1

I am very excited to share this book! It has been so much to collaborate on the project. We hope you find it useful!

21.11.2025 22:11 β€” πŸ‘ 22    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

We are excited to share our online book and preprint on β€œOrchestrating Spatial Transcriptomics Analysis with Bioconductor”!

22.11.2025 12:38 β€” πŸ‘ 18    πŸ” 12    πŸ’¬ 1    πŸ“Œ 0

Many people hours, calls and messages later: OSTA is now β€œin (pre)print”, though the real thing lives at bioconductor.org/books/OSTA.

Check it out, get in touch. We welcome any feedback, suggestions, wishes (& contributions).

It’s been a joy working with you @estellayixingdong.bsky.social!

21.11.2025 17:31 β€” πŸ‘ 39    πŸ” 24    πŸ’¬ 1    πŸ“Œ 4
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Representing EuroBioC2026 at the @abacbs.bsky.social Conference this week.

The next European @bioconductor.bsky.social Conference will be in Turku, Finland!

#ABACBS2025
#EuroBioC2026

25.11.2025 22:33 β€” πŸ‘ 15    πŸ” 8    πŸ’¬ 0    πŸ“Œ 0

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