Dr. Ina Klockner🧬👩‍🔬🔬

Therapeutic approaches for nonsense mutations in CFTR - PubMed This manuscript reviews recent developments in suppressing nonsense mutations in the CFTR gene. Nonsense mutations lead to premature termination codons (PTCs)-UAG, UGA, or UAA- that cause the…

Hot off the press from the @korostelevlab.bsky.social: Therapeutic approaches for nonsense mutations in CFTR

buff.ly/zeUPNLl #RNA #RNATherapeutics @UMassChan.bsky.social

1/10
I am truly honored to receive the Hilde Mangold Award from @gfeev.bsky.social!

Mangold’s classic transplantation experiments transformed developmental biology and our understanding of self-organization. I am grateful to be associated with this legacy!

🌍 It’s #RareDiseaseDay 2026! 💜

Today we stand with the 300 million people living with a rare disease. Together, we’re showing our colours, raising awareness, and inspiring change by talking about what equity means to us.

👉 Read more: https://go.rarediseaseday.org/NEWS

🎉New paper (co-author) in Reproduction 🎉

We characterize human QRICH2, a sperm-specific, conserved protein essential for normal sperm structure and function, with potential as a non-hormonal male contraceptive target.
Check the full article 👉
doi.org/10.1093/repr...
#MaleContraception #ReproBio

🔬Join our #ReproductionMS seminar with Dr.
@maikbischoff.bsky.social on "Coiling a Duct: How Mesenchymal Cells Sculpt Male Reproductive Organ Architecture" this Wednesday, 11 February 12pm CET. DM for Zoom details.

🧬 𝗡𝗲𝘄 𝘆𝗲𝗮𝗿, 𝗻𝗲𝘄 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗵𝗼𝗿𝗶𝘇𝗼𝗻𝘀! 🧠❤️
Two new research groups have joined our institute – and we’re excited to welcome them!

𝗣𝗦: 𝗞𝗮𝗿𝗶𝗻 𝗶𝘀 𝗵𝗶𝗿𝗶𝗻𝗴! Take a look at her job openings here: lnkd.in/gGQimf8

Oh hi Mark! Thanks for reposting :)

PhD position available 🔬📝

🔥last day to submit your application!
stellen.uni-muenster.de/jobposting/d...

Thank you for reaching out and for sharing about your son.

The biosensor that the team developed is a research tool that scientists use to study how variants (mutations) of a gene related to AS (Ube3a) work. It isn’t something used directly in patients or for diagnosis.

Warm regards,
Ina

A luminescence-based biosensor to measure endogenous UBE3A activity Loss- and gain-of-function (LOF and GOF) mutations in the E3 ubiquitin ligase UBE3A cause distinct neurodevelopmental disorders. The AZUL domain of UB…

New biosensor💥

🎯precisely measures endogenous UBE3A activity with super high sensitivity

📌providing a powerful tool for studying Angelman syndrome & advancing therapeutic development for UBE3A-related disorders

link to study:
www.sciencedirect.com/science/arti...

Ontogeny of the spinal cord dorsal horn The dorsal horn of the mammalian spinal cord is organized into laminae where each layer is populated by different neuron types, has distinctive circuit connections, and plays specialized roles in beha...

Excited to share @rbrianroome.bsky.social ‘s beautiful paper on development of the dorsal horn of the mouse spinal cord @science.org

This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.

www.science.org/doi/10.1126/...

SUN5 forms a regular protein lattice reinforcing the sperm head-tail junction Linker of nucleo- and cytoskeleton (LINC) complexes reside in the nuclear envelope, the double-membrane surrounding the nucleus, where they establish a physical bridge between nucleus and cytoplasm. L...

I am happy our recent study on the human sperm head-tail junction is now online. We find that SUN5 form an hexagonal lattice at the nuclear membrane, rationalising how mutations in SUN5 lead to infertility. Great work of @cryonas.bsky.social !
www.biorxiv.org/content/10.1...

There is still over a week left to apply.
Please send your documents to maik.bischoff@uni-muenster.de

#eNeuro: Ringelberg et al. identify a key role for excitatory neuron loss of UBE3A in motor, innate, and sleep behavioral phenotypes of Angelman syndrome model mice.
https://doi.org/10.1523/ENEURO.0453-24.2025

3′UTR shortening alleviates miRNA repression of mRNAs critical for muscle stem cell differentiation - The EMBO Journal Alternative polyadenylation (APA) modulates gene expression by altering 3′ untranslated region (3′UTR) length. Although 3′UTR lengthening typically accompanies cell differentiation, we unexpectedly ob...

Hong Cheng and collaborators show how alternative polyadenylation can facilitate muscle differentiation and regeneration: 3’UTR shortening of differentiation-gene mRNAs alleviates their repression by myomiR muscle-specific miRNAs
link.springer.com/article/10.1...

Here we compare the ultra-compact Calm1 promoter with the widely used hSyn promoter for targeting human neurons using AAV-mediated delivery. Our findings show that Calm1 is a promising alternative for neuronal gene delivery and in the future development of clinical interventions for brain disorders.

Compact Calm1 promoter enables AAV mediated neuron-targeted expression in human iPSC-derived brain organoids - Scientific Reports Scientific Reports - Compact Calm1 promoter enables AAV mediated neuron-targeted expression in human iPSC-derived brain organoids

New paper out 🔥!

Small promoter, big potential🧬 We show that the ultra-compact Calm1 promoter efficiently targets human neurons in brain organoids and is a promising alternative to hSyn for AAV gene delivery.

Huge thanks to everyone who contributed to this work!
🧠 📄: www.nature.com/articles/s41...

1/2 A special #FluorescenceFriday for me! 🌈
Live muscle precursors on a pupal fly testis (Lifeact-eGFP, 🔥-depth-coded).

It's special because this is on the poster for the @sfb1348.bsky.social Meeting in May — my first time being featured as a speaker on a poster! 😀

Feeling very grateful & excited!

So excited to share this as a new junior PI:

My brand-new lab website! 🎉🪰🌀
www.bischofflab.com

Please pass it on to young, motivated researchers looking for PhD positions 😊

And for the #FluorescenceFriday community: don’t miss the SciArt Gallery!

#CellBio #DevBio #PhDjob #PhDposition #Science

A developmental atlas of zebrafish gills links early vascular patterning to adult architecture Summary: An atlas of zebrafish gill vasculature reveals developmental asymmetries and shows how early vascular patterning shapes filaments and lamellae and is reflected in adult gill architecture.

Amazing paper with gorgeous imaging 🔥
from @mathpreu.bsky.social

journals.biologists.com/dev/article/...

Can't believe it — my first‑author paper is out and my image graces the cover of @dev-journal.bsky.social 🎉

Here, we reveal how early developmental programs shape and maintain #zebrafish gill architecture throughout life
🔗 journals.biologists.com/dev/issue/15...

#FluorescenceFriday #LifelongDevSI

A developmental atlas of zebrafish gills links early vascular patterning to adult architecture

Read this #LifelongDevSI #OA Research Article by Mathieu Preußner @mathpreu.bsky.social, Virginie Lecaudey @vlecaudey.bsky.social and colleagues:

journals.biologists.com/dev/article/...

My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing
🔵 lifeact &
🔴 RFP-nls

Honored & grateful to receive an honorable mention at @healthcare.nikon.com Nikon Small World 🌍🔬✨

🔗 www.nikonsmallworld.com/galleries/20...

#NikonSmallWorld #Microscopy #ScienceArt

1/12 A very special moment for me! 🎉

My first paper as corresponding author—a @jcb.org Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes.

rupress.org/jcb/article/...

#cellbio #devbio #science

🧵for details

New perspective by @maikbischoff.bsky.social & @mayorlab.bsky.social about how mesenchymal cells use contact-dependent rules to generate swarm-like behaviors, patterns & organ forms. rupress.org/jcb/article/...

#CellBio #CellMigration #Morphogenesis #Development #Science

We’re excited to announce the launch of our new website at angelman.org! 🎉 Our updated site features easy navigation and filters that help you find the resources, clinics, research, and support you need on any device. Check it out!➡️ angelman.org

A Boa Constrictor brain-derived cell expressing a viral glycoprotein (magenta) and stained for actin (yellow) and DNA (white).

#FluorescenceFriday

Added!

Sure! I will add you ASAP 🙂

FINALLY out in #Science Advances! 🎉
3 years of hard work, a fantastic team — and I’m proud to be first and co-corresponding author!

It's about Plexin signaling driving collective cell migration & organ sculpting. Check out the videos 😀

www.science.org/doi/10.1126/...

#DevBio #CellBio #Microscopy