Suel-Kee Kim

In a new @natcomms.nature.com study, @yaleneuro.bsky.social's Nicola Micali from the Rakic lab, alongside a team of researchers @prbb.org, found that many genes 🧬 linked to mental illness 🧠 are turned ON in neural stem cells as early as the first trimester.👶

#aECM (apical extracellular matrix) is a subset of #ECMatrix that is distinct from stromal matrices or basement membranes. Anybody out there studying #mucins #ZPproteins #cuticle #glycocalyx #surfactant or the like? We need to find each other and start talking!

There is so much cool #aECM work going on but most of the researchers don’t know or talk to each other; this is an attempt to change that! Link below

Human-specific features of the cerebellum and ZP2-regulated synapse development Understanding the unique features of the human brain compared to non-human primates has long intrigued humankind. The cerebellum refines motor coordination and cognitive functions, contributing to the...

Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions. www.biorxiv.org/content/10.1...

NEXT TUE: DDD seminar, Sept. 16, 2025 @ 1PM Eastern US:
Continuing our focus on early fate decisions and CNS regionalization, next Tuesday Sept. 16th at 1PM Eastern US time, Gaurav Rathore (from Angete Kirkeby's group) will share his recent work. seminar info: carlocolantuoni.org/seminar.

Developmental Diversity in a Dish Seminar Series - YouTube A virtual seminar series focusing on stem cell models and functional variation across human iPSC lines. Monthly virtual seminar series, held on one Tuesday o...

today's discussion of CNS regionalization and its modeling in vitro is now online at:
www.youtube.com/playlist?lis...

Linking alterations in precursor cells of brain 🧠 formation with the origin of #neuropsychiatricdiseases

#bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social

www.researchmar.net/news/742/lin...

Early developmental origins of cortical disorders modeled in human neural stem cells Nature Communications - The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem...

Excited to share our latest work, spearheaded by my brilliant student Xoel Mato and co-led by Nicola Micali. After years of sweat, intense weekly meetings, and meticulous discussion of every panel, we learned a lot from each other. Grateful for the journey!

@researchmar.bsky.social
rdcu.be/evCaU

Early developmental origins of cortical disorders modeled in human neural stem cells - Nature Communications The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem cells, revealing vulnerabi...

Excited to share our latest work, Mato-Blanco et al., nature.com/articles/s41.... Thanks to the incredible collaboration with Nicola Micali, Rakic lab, Sestan lab, Vaccarino lab
@yaleneuro.bsky.social @santperelab.bsky.social @carlocolantuoni.bsky.social

NEXT TUE: DDD seminar, July 8, 2025 @ 1PM Eastern US: Dr. Alessandro Vitriolo @alessandrovitriolo.bsky.social‬ (Lab of Dr. Giuseppe Testa) “Regulatory logic of human cortex evolution by combinatorial perturbations”. seminar info: carlocolantuoni.org/seminar [repost to spread the word]

Competing Programs Shape Cortical Sensorimotor-Association Axis Development The neocortex is organized along a dominant sensorimotor-to-association (S-A) axis, anchored by modality-specific primary sensorimotor areas at one end and transmodal association areas that form distr...

Thrilled to present MIND!

A model for how the sensorimotor–association axis of the neocortex develops.

Huge thanks to the incredible multidisciplinary team who made this happen.

www.biorxiv.org/content/10.1...

NEXT TUE: DDD seminar, June 10, 2025 @ 1PM Eastern US: Dr. Magdalena Sutcliffe (lab of Dr. M Lancaster @lancasterlab.bsky.social) “Epigenetic restoration of differentiation competency via reversal of epiblast regionalisation”. seminar info: carlocolantuoni.org/seminar [repost to spread the word]

Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1

Developmental Diversity in a Dish Seminar Series - YouTube A virtual seminar series focusing on stem cell models and functional variation across human iPSC lines. Monthly virtual seminar series, held on one Tuesday o...

The recording of today's DDD seminar by Dr. Ron McKay “Origin and consequences of genetically distinct behaviors in human neural stem cells” is now online at: www.youtube.com/playlist?lis...

A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas.
We built an interactive browser to explore the spatial data: walshlab.org/research/cor...
Paper link below 👇

NEXT TUE: DDD seminar, May 6, 2025 @ 1PM Eastern US: Dr. Ron McKay “Origin and consequences of genetically distinct behaviors in human neural stem cells”. seminar info: carlocolantuoni.org/seminar [repost to spread the word]

NEXT TUE: DDD seminar, Apr. 1, 2025 @ 1PM Eastern US: Dr. Jason Stein steinlab.bsky.social “Modeling genetics altering human cortical structure”. seminar info: carlocolantuoni.org/seminar [repost to spread the word]

Specification of claustro-amygdalar and palaeocortical neurons and circuits - Nature A conserved gene regulatory network involving SOX4, SOX11 and TFAP2D shapes the development of excitatory neurons in ventrolateral pallium and their connectivity with the prefrontal cortex.

Navjot Kaur
I am thrilled to share our latest paper from Sestan lab on the development of the claustro-amygdalar complex, is published at nature.com/articles/s41.... A big thank you to all our collaborators and mentors.
@marinap63.bsky.social

📢The YC-SCAN² has awarded 14 grants 💰 to researchers, including @yaleneuro.bsky.social's Nicola Micali & @mhigley.bsky.social 👨‍🔬🥼, for their work focused on understanding the impact of cannabinoids on neurodevelopment!

Read More Here 👇