Tony Gamble

After 10 years of work, a complete telomere-to-telomere gap-free genome for C. elegans finally exists: it has 106 Mb rather than the textbook 100.3 Mb, and up to 366 additional genes.
genome.cshlp.org/content/35/8...

GitHub - lh3/longdust: Identify long STRs, VNTRs, satellite DNA and other low-complexity regions in a genome Identify long STRs, VNTRs, satellite DNA and other low-complexity regions in a genome - lh3/longdust

Longdust, a new tool to identify highly repetitive STRs, VNTRs, satellite DNA and other low-complexity regions (LCRs). Similar to SDUST but for long regions.
github.com/lh3/longdust

Hi #Botany2025 - In my quest to never do flow cytometry again, I am collecting sequence data (radseq, target enrichment, WGS, ect.) with confirmed ploidal level. If you have samples, reach out!

Radiation with reproductive isolation in the near-absence of phylogenetic signal Phenotypic diversification and reproductive isolation may unfold in the near-absence of phylogenetic signal.

Been waiting on a hamlet phylogeny (Hypoplectrus spp.) They have a beautiful mating ritual where they loop around each other floating up - then go down switch sexes and do the dance again.

Also notable / 300+ genomes can’t resolve the relationships of 19 species!

www.science.org/doi/10.1126/...

The gene regulatory landscape driving mouse gonadal supporting cell differentiation Multiomics analysis revealed the regulatory elements and transcription factors responsible for gonadal sex determination.

1/n Very excited to share our recent paper published on
@ScienceAdvances
where we dissect the gene regulatory landscape guiding mouse sex determination!
science.org/doi/10.1126/...
A huge well done to @IsabelleStevant.genomic.social.ap.brid.gy, Meshi and Elisheva who spearhead this project!

A 3d rendering of a CT scan of a Rio Cauca caecilian with transparent body and bone colored skeleton, showing 7 baby caecilians inside, each rendered in a different color - counter-clockwise from tail to head - red, orange, yellow, green, light blue, dark blue, purple.

Say hello to Florida's newest established species, Typhlonectes natans - the Rio Cauca Caecilian! You can read about their relative abundance, distribution, & natural history, in our brand new paper:

journals.ku.edu/reptilesanda...

Here is one individual I CT scanned that had 7 babies inside!

Faceted plot with panels for Atlanta, Pittsbrugh, and Houston. Focal counties (Dekalb, Alleghany, and Houston) are outlined. Surrounding counties are shaded by future estimated annual economic loss due to the proposed cap on indirect costs based on commuter flows that connect to a focal county (indicated by light pink outline).

#SCIMaP estimates current & future economic losses in local communities across the US (counties & Congressional Districts). We explain our approach in a new preprint: www.medrxiv.org/content/10.1...

(w @joshuasweitz.bsky.social @asinclair.bsky.social @cl10.bsky.social)

a photo of governor ventura smiling excitedly

Excited to share our new paper in #MolEcol on sex chromosome evolution in African killifish! 🐟 A great collaboration with @alexandrsember.bsky.social . We uncovered ≥4 sex chromosome turnovers across Nothobranchius spp. using cytogenetics & genomics.
👉 onlinelibrary.wiley.com/doi/10.1111/...

Amid Fear of Retaliation, N.S.F. Workers Sign Letter of Dissent

“More than 140 employees of the National Science Foundation have signed a letter denouncing what they described as efforts to undermine one of the country’s main science funding agencies. … Out of fear of retaliation, all but one of the employees’ signatures are redacted.”

I just can’t believe it! My dear dear friend Ozzy has passed away only weeks after our show at Villa Park.

📣 Check out the latest preprints related to Tokay gecko welfare!

1. Is physical closeness a good measure for pair bond strength? doi.org/10.32942/X2F...

2. How do incubation environment and social rearing influence development?
doi.org/10.32942/X2T...

Stay tuned for more coming soon!

A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...

Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...

Graphical overview of the biological foundations of the proposed approach.

Application of SCINKD to identify XY chromosomes in the Christmas island skink

Application of SCINKD to identify previously unannotated sex chromosomes in the Lesser electric ray.

🚨Preprint🚨

Sex chromosome identification & genome curation from a single individual with SCINKD
www.biorxiv.org/content/10.1...

Incredible work led by @drpintothe2nd.bsky.social in collaboration w/ @drsimonegable.bsky.social @stuartvnielsen.bsky.social @tonygamble.bsky.social SE Keating & CH Smith

Photo of a Sasquatch wearing sunglasses and playing saxophone

Photo of a Sasquatch wearing sunglasses and playing saxophone along with a human man singing

Photo of a male Sasquatch with a saxophone next to a female Sasquatch wearing a hat

Photo of a Sasquatch playing saxophone in a crowd with a handsome, bearded man in the foreground pointing at the Sasquatch.

Ain’t no party like a Saxsquatch party! #Summerfest 🎵
@saxsquatch-music.bsky.social

The band Tripping Daisy performing live

Live performance of the band Tripping Daisy. Singer Tim DeLaughter is holding an orange & red sign that says, “tripping Daisy”above his head.

Photo of two men with guitars. John Oates is on the left.

Photo of Richard Marx playing guitar and singing live. His hair looks great!

Music from the 80s & 90s was well represented at Milwaukee’s #SummerFest this 4th of July 🎵
Tripping Daisy, John Oates, & Richard Marx all sounded great!

Photo of a smiling man (Ike Reilly) playing an electric guitar

Photo of the band Ike Reilly Assassination playing live

Photo of a man (Ike Reilly) wearing sunglasses and playing acoustic guitar

Photo of the band Ike Reilly Assassination playing live

The Ike Reilly Assassination brought the goods to their Milwaukee show! #SummerFest 🎵

Drones spelling the word “sausage” in the evening sky. The “USA” in “sausage” is emphasized. I guess you can’t spell sausage without USA.

A sausage made of illuminated drones floats in the evening sky.

A drone show where the drones have formed Milwaukee’s Hoan Bridge with a drone sausage floating above it.

This was the most #Milwaukee 4th of July drone show imaginable. There is none more Milwaukee. #Summerfest

Photo of a brown tree frog (Pengyilleyia peronii) on a brown tree trunk.

Really nice paper! It’s so much work to do a big revision like this.

Hello, Pengyilleyia peronii!

🐸🧪

🚨🐸 Frog Nerds Assemble 🐸🚨

Recently we published a paper on the phylogenetics and taxonomy of Australia and New Guinea's tree frogs, the Pelodryadidae.

Link here: tinyurl.com/4udpmxsm

What does this mean for you Litoria-lovers?
There's a whole bunch more names to use!

Let me explain ...

New Handbook Aims to Protect Scientists From Autocratic Threats - Inside Climate News Scientists, experts say, need to help protect democracy, “the system of government in which science, health and humanity are most likely to thrive.”

"New Handbook Aims to Protect Scientists From Autocratic Threats--Scientists, experts say, need to help protect democracy" by Bob Berwyn for @insideclimatenews.org: insideclimatenews.org/news/0407202...

I don’t think anyone is prepared for what they just did w/ ICE.

This is not a simple budget increase. It is an explosion - making ICE bigger than the FBI, US Bureau of Prisons, DEA,& others combined.

It is setting up to make what’s happening now look like child’s play. And people are disappearing.

Screen shot of a phone with an alert that says, “Emergency Alert ON-GOING TACTICAL SITUATION - RESIDENTS TO SHELTER IN PLACE”

I guess I’m awake now #Milwaukee #Shorewood

Foundations: please step up and take over the Biodiversity Heritage Library (BHL). This is an absolutely essential scanned archive of all of the old journals and books from the 1500s to about 1920. Has been indispensable for my research.
about.biodiversitylibrary.org/call-for-sup...

Let’s be very clear: even if you are not a Medicaid recipient, cuts to the program will impact you.

Without Medicaid funds, rural hospitals, maternity wards, and nursing homes will be shuttered.

Having private health insurance won’t do you much good when there’s nowhere to go.

A USB stick attached to a keychain that says, “Sequencher Gene Codes Corporation“

I miss spending thousands of dollars for a Sequencher license key 😢

The two Mesquite logos. At left, a mesquite tree leaf is against a black background. At right, a leaf is against a blue sky and sun.

Mesquite 4.0 released! A major update — many new features, small and large (phylogenomics, visualizations, workflow management, &c). Check out the trailer video: www.mesquiteproject.org.

Come discuss in our new Google Group (groups.google.com/g/mesquite-project). @bembidion.bsky.social ‬🧪 #evolbio

☝🏼 @baldwin.senate.gov

‘This is bull——”: National Science Foundation employees protest HUD's takeover Dozens of National Science Foundation employees crowded the agency’s headquarters in Alexandria, Virginia, Wednesday to protest the news that the Department of Housing and Urban Development, or HUD, w...

Another day testing the limits of resilience.

The Alexandria NSF building was designed for the NSF merit review process (gold standard), complete with a floor devoted to panels.

Now we aren’t allowed to have in person panels.

The loss of US science leadership will haunt this country for decades.

Sara Lipshutz presents her multivariate view of sex including gametes, genetics, anatomy, hormones, brains, and behavior

Thomas Sanger demonstrates that sex is not a developmental binary and is both extremely complex and dynamic

Amazing symposium on Sex and Gender at #Evol2025 So grateful to all the speakers for bringing us together to think about how to teach and communicate these complex topics @jacanamama.bsky.social Thomas Sanger @bio-eddy.bsky.social @cissyballen.bsky.social