🗓️📍Save the date for UCSF PROPEL’s 6th Annual Symposium on June 1st!!
🧑🔬🧫Come support and celebrate our scholars as they present research talks and posters!
We look forward to seeing you there!
My goodness SF is beautiful. I had never seen a night rainbow before!!! #doLookUp
Happy to share new manuscript I completed with @ee-reh-neh.bsky.social & @davisjmcc.bsky.social back in Melbourne. The work originally conceived by @ijbeasley.bsky.social focuses on how we can reconcile and meta-analyse eQTL studies across studies cohorts and ancestries. doi.org/10.64898/202...
David Botstein has passed away. A true pioneer in the genetics and biotechnology industry, known methods to map genes. While at Stanford he collaborated with Pat Brown in microarrays, co-founded the Gene Ontology and became the CSO of Calico. He worked again with Pat Brown at Impossible Foods. RIP.
1. Kevin Gross and I have a new paper out today PLOS Biology.
We used economic models based around screening games and the market for unpaid labor to highlight a meltdown cycle threatening peer review.
"In particular, these models highlight a pernicious feedback loop: increasing submissions to top journals exhausts the pool of suitable peer reviewers, resulting in lower quality peer reviews that encourage yet more authors to take a chance on submitting their paper to a prestigious venue."
www.biorxiv.org/content/10.6...
Glad to see this paper out.
I attended Prof. Gürsoy's talk during last year's probgen and the claims were scary. You can literally reverse-engineer GWAS summary statistics and public single-cell RNA-seq data to identify subjects.
We have posted data providing real-time measurement of human neutralizing antibody landscape to seasonal influenza.
Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization, & can inform choice of strains for next vaccine.
Can we simulate realistic evolutionary trajectories and “replay the tape of life”? In this work, we propose a flexible, generalizable deep learning framework for modeling how the entire protein sequence evolves over time while capturing complex interactions across sites. 1/n
doi.org/10.64898/202...
🚨 Proud to share that our paper on the genetic links between type 2 diabetes (T2D) and hypertension is now published in @natcomms.nature.com!
We dissect the genetic relationship between T2D and hypertension and show it is not driven by a single shared pathway. 🧬
(1/N)
My colleagues at @sfsu.bsky.social used 3 decades of data to show that students with low undergrad GPA have equal PhD completion rates compared to students with high GPA. @sfstatebio.bsky.social
journals.plos.org/plosone/arti...
Sad. We are a country in decline www.chronicle.com/article/has-... #gradschool #phd
So excited to have this study live! Lead by @ee-reh-neh.bsky.social's teram and in collaboration with an incredible team at MRIN in Indonesia. This is the culmination of ~5 years of work including a ton of effort in the field. Really proud of how this came together!
www.biorxiv.org/content/10.6...
Very nice work led @drghawkes.bsky.social,
showing convergence between rare and common genetic
associations, using whole-genome sequencing data to evaluate the
contribution of rare non-coding variants for commonly studied anthropometric traits 🧪🧬
www.nature.com/articles/s41...
Science Bluesky is now much better than Science Twitter is… but I still miss peak pre-pandemic Science Twitter.
My daughter Maya, who had to wear a scoliosis brace for 2 years, wants to connect with other teens who live with invisible diseases. www.under-the-iceberg.com/about
“Success in US science has come from sustained funding and welcoming the best talent from around the world, yet both of these advantages are in decline”
www.science.org/doi/10.1126/...
We are in the middle of MCB graduate admissions interviews. It has renewed my sense of hope—there are so many bright, empathic and resilient young people ready to help advance knowledge and make a difference.
It took scientists 11 years to compute 1-2/3=1/3
Balancing selection alert!! 🧬🧪
New preprint where we try to quantify how likely (or rather, unlikely) it is for balancing selection to maintain stable polymorphism, and how easy (or rather, challenging) it is to identify its signatures in genomes.
#Popgen #MolecularEvolution #EvoBio #Science
A new preprint from the lab, with postdoc @deboraycb.bsky.social and collaborators @aidaandres.bsky.social and Tim Connallon:
“Characterising the detectable and invisible fractions of genomic loci under balancing selection”
www.biorxiv.org/content/10.6...
Thinking of doing something similar. How did you structure it?
Hey MD/PhD-bound Scholars 👋 Prepare for MSTP Program applications with PROPEL! This is an opportunity you don't want to miss!
📆 Feb 6 – Sign up for AMCAS essay reviews by MSTP grad students (QR code)
📆 Feb 13 – Submit essay draft for review
📆 Feb 20 – Receive Feedback
PEQG! My favorite conference ever*. Single session, fantastic talks, great discussions. Only once every 2 years. And in the best conference location too! Abstract deadline coming up Feb 5!
*Disclosure: I am required to say it's the best conference because it is and I told my mom I wouldn't lie.
The meeting will take place at the gorgeous IslandWood Resort on Bainbridge Island, a short ferry ride from downtown Seattle.
Registration is free. We will cover travel and lodging for graduate students, and at least partially subsidize those costs for postdocs and assistant professors.
Excited to share our new preprint from the @arbelharpak.bsky.social Lab!
How do recruitment into genetic studies and study characteristics impact what we infer about the genetic bases of traits, and what are the consequences? (1/21)
www.biorxiv.org/content/10.6...
How well does TWAS estimate a gene’s direction of effect on a trait? We think of this as an important stress-test for the accuracy of TWAS.
In a new pre-print, we find that TWAS gets the sign wrong around 20-30% of the time!
doi.org/10.64898/202...
1/n
Here's my latest contribution to the @nytimes "Lost Science" series. Brenna Henn's sweeping study of African genetics has been frozen. Gift link: nyti.ms/3Ypmm1A
Oh come on… it is January SECOND. Who ALREADY broke our cluster?? #Wyntoff
