Nick van Gastel

The #ISEH2025 🏯 program is here and packed with cutting-edge science. Hear from Scientific Program Chair @milsommick.bsky.social for a behind the scenes look at how it came together and what to expect in Kumamoto www.simplyblood.org

T-minus two days to snag a talk slot at ISEH 2025 via a late-breaking abstract submission

🚨 There is ONE WEEK left to submit a late-breaking abstract for #ISEH2025 🏯! Submit your research by 28 July for a chance at a short talk or poster presentation. www.iseh.org/2025abstracts

#ISEH2025 🏯 is just around the corner and hundreds of scientists will be heading to Kumamoto, Japan, for four days of education, networking, and sightseeing. Register by 7 August for the lowest rates to join us! www.iseh.org/2025Registration

The July #PreprintWatch features 25 fresh preprints that span hematopoietic development, leukemogenesis, and the latest in tech development. Plus, a video chat with @abattacks.bsky.social - one of our featured community submitters! Explore on www.simplyblood.org

Horizon Europe delivers €11 GDP return for every €1 invested Learn how Horizon Europe is driving innovation and growth across the EU, with up to €11 in GDP returns and sixfold societal benefits by 2045.

For every €1 invested in Horizon Europe programme, Europe is expected to get as much as €11 in GDP return

Source: www.innovationnewsnetwork.com/horizon-euro...

Research has an economic return multiplier >1. So taxes don't even really pay for research. Research more than pays for itself, the taxes are just used to kick-start the positive economic cycle. The more money invested in research, the better the economy.

New preprint from our lab! Given the importance of nucleotide synthesis for AML cells, and the fact that aspartate is essential for nucleotide synthesis, we wondered if exogenous aspartate uptake through EAAT transporters plays a role in this cancer.

The EAAT1 aspartate/glutamate transporter is dispensable for acute myeloid leukemia cell growth and response to therapy https://www.biorxiv.org/content/10.1101/2025.07.13.664609v1

Yet, we currently cannot exclude a role for this amino acid as nutrient for AML cells in the bone marrow, which contains high levels of aspartate. Congrats to first author Hernán Andres Tirado and all co-authors, and thanks to our funders! @uclouvain.bsky.social F.R.S.-FNRS, FCC, de Duve Institute

We found that AML cells only express EAAT1, but after extensive testing conclude that this transporter is not essential for AML cells. Moreover, exogenous aspartate is not needed for AML cell growth or response to chemotherapy in vitro.

New preprint from our lab! Given the importance of nucleotide synthesis for AML cells, and the fact that aspartate is essential for nucleotide synthesis, we wondered if exogenous aspartate uptake through EAAT transporters plays a role in this cancer.

Congrats Nina! I look forward to reading this in detail!

Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells - Nature Cell Biology Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline ...

🔥NEW paper from our lab! Ever wondered how the metabolite/lipid composition of human bone marrow HSCs changes during differentiation,aging,AML? Check our work www.nature.com/articles/s41... driven by the brilliant Marialena & Maricarmen with Jörg! @mpi-ie.bsky.social @ethz.ch @natcellbio.nature.com

Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity Challen and colleagues show that the clonal expansion of Dnmt3a-null HSCs in serial bone marrow transplantation assays is not dependent on the loss of DNA methylation functions of Dnmt3a. They identif...

Really fascinating work from Grant Challan's group reporting that increased HSC self-renewal seen with Dnmt3a knockout is potentially due to non-methyltransferase roles.

Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells - Nature Cell Biology Lalioti, Romero-Mulero et al. combine metabolomics, lipidomics and transcriptomics of haematopoietic stem and progenitor cells during differentiation, ageing and leukaemia, finding a role for choline ...

Really valuable resource in @natcellbio.nature.com from @ninacabezas.bsky.social and team - Metabolomic and lipidomic profiling of human hematopoietic stem and progenitor cells:

www.nature.com/articles/s41...

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

Proudly presenting Simon’s @simonsterson.bsky.social‬ paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8

Great opportunity! Are you a junior PI or senior postdoc attending #ISEH2025 in Kumamoto? This is a chance to receive direct feedback on your grant application (NIH, ERC, …) from top scientists in #Hematology!

And here it is! Our study in clonal hematopoiesis and Alzheimer’s disease — product of 5 years’ gestation. urldefense.proofpoint.com/v2/url?u=htt...

Didn’t get your abstract submitted in time? Late breaking submission has just opened

The Interview Spotlight Series continues with the 2025 Outstanding Mentor Award Winner, Prof. Teresa Bowman. ‪Prof. Bowman reflects on her mentoring style and highlights past mentors that have inspired her throughout her career. Watch the interview on www.simplyblood.org

‪The Special Issue New Culture Methods in Experimental Hematology covers novel co-culture approaches and mechanobiological efforts driving innovation. Reach the issue from guest editor @krikirschner.bsky.social‬ only on www.exphem.org/content/new_...

Happy to have been invited to guest edit this exciting special issue. Check it out!

a man with a beard is wearing a hat and a striped shirt and saying `` do you remember '' . ALT: a man with a beard is wearing a hat and a striped shirt and saying `` do you remember '' .

🧬 What if your blood cells remembered how their ancestors divided?

Our new preprint (www.biorxiv.org/content/10.1...) explores clonal memory in human blood stem cells — and how it breaks down in leukaemia.

📄 "Clonal memory of cell division..."

Greats times at the presidential evening #EHA2025! What an amazing conference with great science and meeting old and new friends! @PaoloGallipolli @dalessandrolab.bsky.social

Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...

🚨 Where does #lipid peroxidation kick off in #ferroptosis? 🔥Excited to reveal #ER- #mitochondria #contactsites as the ignition point of the lipid peroxidation cascade! Huge kudos to our Maria Livia Sassano @mariamls.bsky.social & our amazing collaborators who made this breakthrough possible!

On my way to #EHA2025 as well! Hope to see you there Charlie!

Metabolic adaptations direct cell fate during tissue regeneration - Nature Metabolic enzymes of the tricarboxylic acid cycle, such as 2-oxoglutarate dehydrogenase, are differentially expressed in absorptive and secretory lineages, guiding cell fate establishment and offering...

www.nature.com/articles/s41...

EHA 2025 annual meeting attendees, we have a great line up of speakers for this year's Mol. Hem. Workshop in Milan. Note the change of date time from the usual slot. This year on Thu 12th, starting at 13:30 in Brown Hall 3. Links to session in the thread below (1/4)

Session 1: Epigenetics and Metabolism
congress-apps.ehaweb.org/eha2025/en-G...