Dr. Sedona Murphy

Open Call for Expressions of Interest in Max Planck Directorships: Expressions of interest can be submitted until 31 October 2025.

Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.

Thrilled to share our work using live imaging to understand how Epiblast (future embryo proper) and Primitive Endoderm (future extraembryonic tissues) cell fates segregate in the preimplantation mouse embryo. Gargantuan effort led by amazing @rpkimyip.bsky.social, David Denberg and Denis Faerberg!

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Excited to share a new preprint from the lab!

This (doi.org/10.1101/2025...) and an earlier one (doi.org/10.1101/2025...) mark my lab's first steps into studying how Polycomb modifications get established in early Drosophila development.
🧵 1/10

Buildings on the Lawrence Berkeley National Lab campus, with the San Francisco Bay and the Golden Gate Bridge in the background. It's sunset time, the sky is orange. On the left is the Integrative Genomics Building (IGB), which houses the JGI, NMDC and KBase. On the right is the BioEPIC building.

🧬 @jgi.doe.gov is hiring! We're seeking an Advanced Analysis Manager to lead data infrastructure and software engineering supporting the generation, analysis, and dissemination of genomics data

Hybrid | SF Bay Area | Apply by Aug 7

jobs.lbl.gov/jobs/advance...

@biosci.lbl.gov @berkeleylab.lbl.gov

Head of the Cell Biology and Biophysics Unit The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...

EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Mount Holyoke College in lovely western Massachusetts is hiring a tenure-track neuroscientist. Amazing students and fantastic faculty support - please share!
mtholyoke.wd5.myworkdayjobs.com/en-US/Extern...

Great opportunity! The Uni Vienna has launched a call (APART) for 4-funding for outstanding postdocs from a US institution. The host lab has to nominate by 1 August a candidate for further selection. Anyone interested in our work please contact me by email with CV/motivation letter. Hurry up!

How can we identify novel regulators of germ layer differentiation and body patterning? I am happy to announce that my preprint using single-cell CRISPR screens in gastruloids to answer this question is now online! Thank you to the rest of the @sendoellab.bsky.social and all coauthors!

Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications!

We are looking for creative, innovative scientists asking fundamental questions in any area of biology.

Join our vibrant, collaborative, and supportive community!

aprecruit.ucsf.edu/JPF05702

We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...

And another opportunity! Any postdocs looking forward to start your lab on a tenure track? Supportive environment, great core facilities and an outstanding PhD program.

How do chromatin remodelers use #IDRs to find TF binding partners? In our new Molecular Cell paper, we show that β-catenin is an adaptor that links SWI/SNF (cBAF) subunit ARID1A with binding partners via IDR-domain interactions.
www.cell.com/molecular-ce...

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress SPIDR, a massively multiplexed method that simultaneously maps dozens of RNA-binding proteins to their RNA targets at single-nucleotide resolution, uncovers new RNA-protein interactions and provides c...

www.cell.com/cell/fulltex...

Science philanthropy faces a new reality As the ground under American science shifts in troubling and unpredictable ways, questions have arisen as to how philanthropies should respond. Having recently led a private foundation that supports s...

"the persistent exclusion of those who have been marginalized historically is a stain on America’s scientific community" Whether or not funders describe their support as DEI, "they should be at least as courageous... as their grantees are." www.science.org/doi/10.1126/...

Just published: The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

A global temporal chromatin program, operating across the CNS, directs binding of specific spatial TFs & hence when/where neurons & glia are born

authors.elsevier.com/sd/article/S...

We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity!
www.nature.com/naturecareer...

Gene regulatory networks and essential transcription factors for de novo-originated genes Nature Ecology & Evolution - A combination of computational methods applied to single-cell RNA sequencing data and genetic experiments shows that a small number of transcription factors are...

Our latest paper is out: rdcu.be/ev6Ym — one of my favorite projects. It began about 8 years ago when Nobel laureate Torsten Wiesel asked me: what transcription factors regulate new genes? I had no idea then. Now we have some answers.

Congrats on these beautiful papers! Excited to read the finished products 😊

We are looking for a student to continue our work on chromatin evolution:
www.nature.com/articles/s41...
www.biorxiv.org/content/10.1...

The project with @seanamontgomery.bsky.social will focus on chromatin state readers across eukaryotes.

More info: recruitment.crg.eu/content/jobs...

Just a few more days until the deadline!

If you're planning to apply to Bio-based PhD programs this year, considering joining us at the Biology Preview Program where we'll walk you through the PhD application process and help you polish you application materials!

Apply here: bit.ly/4n4Nxtu

A shotgun approach for highly multiplexed mammalian metabolic engineering Mammalian metabolic engineering is critical to advancing basic biology, bioproduction, and cell therapy. However, as pathway complexity increases, so does the size of both the combinatorial design spa...

Excited to share our work with @julietrolle.bsky.social & Jef Boeke.

We developed a 'shotgun' method to screen millions of synthetic metabolic pathways to enable mammalian cells to grow without two essential nutrients for the first time in >500 million years!

doi.org/10.1101/2025...

Thread...

New preprint in collaboration with the Faryabi lab: Optical Looping Interactive Viewing Engine (OLIVE), a web-based tool designed for high-throughput chromatin tracing data that functions similarly to genome browsers. If you work with these data, give a try: www.biorxiv.org/content/10.1...

Excited to share that our latest story on Restrictor is out now in @genesdev.bsky.social!! Big thank you to my fellow co-first author Hanneke, Karen @adelmanlab.bsky.social and co-authors Nathalie and Allison!

H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing Forebrain The PRC1 complex regulates developmental gene expression in mammals by ubiquitinating histones (H2AK119ub) and nucleating repressive chromatin interactions. Human genetic data and functional experimen...

Excited to share our hot-off-the-press @biorxivpreprint.bsky.social
that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬
www.biorxiv.org/content/10.1...

Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

A little belated posting, but we (Emily Navarrete, Leonid Mirny, me) have an updated preprint in collaboration the Ines Drinnenberg, Héloïse Muller, José Gil Jr, + others on the strange and striking compartmentalization of silkworm chromatin: www.biorxiv.org/content/10.1...

Happy to announce a new preprint from my lab looking in to the establishment of polycomb domains in early fly development and contributions from pioneer factors Zelda and GAGA-factor.

Long-read transcriptome assembly reveals vast isoform diversity in the placenta associated with metabolic and endocrine function The placenta plays a critical role in fetal development and mediates maternal metabolic effects on offspring health outcomes. Despite its importance, the placenta remains understudied in large-scale g...

🧬🚨PREPRINT🚨- The first placental isoform reference from long-read seq & supporting data! We demonstrate how tissue-specific assembly improves transcript quantification with short-read data from multi-ancestry birth studies & reveals placenta-mediated effects of gestational diabetes on birth weight🫄

A dream come true: my first first-author publication! 🧬 🎉 Working to unravel the mysteries of long-range gene regulation has been an incredible journey. Endless gratitude to Evgeny, the lab, and all of the amazing collaborators who helped make this happen 🙌