The difference between #techbio and #biotech is hubris. Where #techbio believes biological mystery can be overcome by more data and that the underlying mechanism is unimportant, #biotech (and it's children #synbio #engbio) believes that the mechanism itself will lead to new wonders

China's biotech boom is threatening US drugmakers' dominance In 2019, Stanford University professor Irv Weissman and a colleague published a paper that represented a new way to target some aggressive cancers. Shortly after, they did what many researchers ...

My latest is an in-depth look at China's scientific rise unnerving the US biotech industry. A 🧵:

endpts.com/chinas-drug-...

Anything for the people I love!!

🤣

Homeward bound. Farewell city by the bay and #JPM2025

The Biotech CEO Sisterhood stood out at #JPM2025 today. Proud to be an ally! #allyship

Semper Maior: Pumping up the candor — RApport Wouldn’t it be better if everyone in our ecosystem were candid with one another? After all, within companies it’s common to encourage everyone to speak their minds. If you see a problem, call it out;...

Biotech on Bluesky get a look first.

RA Capital’s annual thoughts on how biotech can better (Semper Maior; always better). This one explore how we can elicit more candor. Some stories, too.

And tons of top-down data analyzing 2024 performance & setup for 2025.

rapport.bio/all-stories/...

Biotech on Bluesky, I’m sharing with you first.

RA Capital just launched Biotech Unveiled, a free online course our team created.

Learn at own pace. Covers fundamentals of how insurance + investment direct R&D. Essential knowledge for leaders.

racap.thinkific.com/courses/biot...

Re-upping this reply thread from last night. Drugs don't come from nowhere, folks. And we're not ripping off the NIH, either.

Is it just me or is the biggest biotech / Pharma deal news this week going to be Centerview selling a stake?

Michael Caine Loves 'The Muppet Christmas Carol' as Much as You Do God bless us, every one! But especially Michael Caine.

He did it because he had a seven-year old daughter who had never seen one of his films and he wanted to make something she could see. He also said “I’m going to play this movie like I’m working with the Royal Shakespeare Company” www.gq.com/story/michae...

Great to have y’all here. 👍

Six Childhood Scourges We’ve Forgotten About, Thanks to Vaccines Most Americans, including doctors, have no memory of the devastating diseases that routinely threatened children until the 1960s.

New York Times

‘Six Childhood Scourges We’ve Forgotten About, Thanks to Vaccines

Most Americans, including doctors, have no memory of the devastating diseases that routinely threatened children until the 1960s.’

Biotech in 2024: A retrospective 2024 is coming to a close and it is time to look at how biotech performed this year. Was it a triumph or a year of cautious optimism?

Time for a recap of what happened in #biotech this year. #biosky #chemsky

Kudos to both Vijay and Vineeta!

@lisamjarvis.bsky.social’s editorial on the shocking murder of UnitedHealth Insurance’s CEO is a must read, and masterclass on balanced perspectives. The health insurance “industry” has a basic economic principle incompatible with others in the ecosystem. Collect premiums, don’t pay claims.

Read further and found this alternative suggested by the strike organizers. Yoink!!

@dereklowe.bsky.social honing in on the same bottom line message from @wpwalters.bsky.social @prof-ajay-jain.bsky.social

it's so true and hits so hard:

Between the earthquake/tsuanmi scare, the UnitedHealthcare shooting and the South Korea martial law stuff this week, it feels like Bluesky is getting more and more critical mass around breaking events that made Twitter so sticky and useful.

Congratulations!! So well deserved!

You may not understand why, but the healthcare insurance and PBM contracts YOU have signed for Tesla, SpaceX , @X, along with CEOs of other big companies , have more impact on healthcare costs and quality of care in this country, than anything you can do with DOGE

Computational Care

DiffDock, a new diffusion-based ligand docking program, made s big splash earlier this year. But it’s apparently not all it’s claimed to be:

Sometimes the combination of arrogance and ignorance is breathtaking. Yes, US health care has high admin costs; that's because it relies so much on private insurers. Govt-run health insurance has much lower overhead

@lifescivc.bsky.social blog on Atlas Venture's recent fundraising is a master class in biotech venture capital financial metrics. A must read.
lifescivc.com/2024/12/atla...

I’ve worked with Ramy for years, and I completely agree that the overhype doesn’t help make medicines any faster. AI is a great tool, it’s not a solution in and of itself.

Eli Lilly’s Zepbound Beats Novo Nordisk’s Wegovy in First Head-to-Head Study People who took Zepbound lost 17 pounds more on average after 72 weeks of treatment than those who were given Novo Nordisk’s drug.

The fight between Eli Lilly and Novo Nordisk over the booming obesity drug market is intensifying now that manufacturing has ramped up. This Lilly-sponsored study is one jab.

This whole thread. The beauty of this platform…

Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera Proteolysis targeting chimera (PROTAC) degraders are typically bifunctional with one E3 ligase ligand connected to one target protein ligand via a linker. While augmented valency has been shown with t...

Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera | Collaboration with @georgwinter.bsky.social and Kristin Riching labs. Now published in Journal of the American Chemical Society @acsjacs.bsky.social pubs.acs.org/doi/10.1021/...

Pretty darn cool. Kudos to the labs.