Andrey Klymchenko

Ready to fly back with @aklymchenko.bsky.social to Paris! Thanks to @faseborg.bsky.social and the organisers for the fantastic event!

Thanks Erdinc! I am also looking forward to starting this journey!

Great news: I received ERC Advanced grant #ERCAdG @erc.europa.eu CaptuRel! It aims at intelligent nanomaterials undergoing bioinspired cycle of capture and photorelease of bioactive molecules for sensing and controlling (bio)chemical gradients. Thanks to my Team, @cnrs.fr and @unistra.fr!

Today it is the MINT Day! A good occasion to share science and good moments together. We are really happy to welcome @aklymchenko.bsky.social to open this beautiful day! Thank you very much again for coming ☺️.

It was a great experience to participate in JCS2025 conference on supramolecular chemistry. Thanks @iwonanieren.bsky.social et al for the invitation and organization of this wonderful event!

Bürgenstock Conference by @swisschemistry.bsky.social was a truly amazing meeting with brilliant lectures and leading researchers in chemistry: @klanglab.bsky.social, JL Mascarenas, R Buller, @olallalab.bsky.social, D Hilvert, etc. It was an honor to present our work. A big thank to the organizers!

We thank our collaborator Arnaud Gautier and his team from @sorbonne-universite.fr for the precious contribution.

New preprint: we introduce peptide-functionalized fluorescent polymeric nanoparticles with stealth properties due to rather short polysarcosine peptides for targeting proteins on cell surface. Congrats to co-authors! @cnrs.fr @unistra.fr @agencerecherche.bsky.social
www.biorxiv.org/content/10.1...

We thank our collaborators Igor Khalin, Severin Filser and Nikolaus Plesnila @lmumuenchen.bsky.social for their precious contribution to in vivo imaging.

We revisited our #MemBright toolbox and report anionic cyanine membrane probes with improved properties that enable in vivo imaging of neurons in mice brain. Congrats & thanks to co-authors! Just out Anal. Chem. @acs.org :
pubs.acs.org/doi/10.1021/...
@cnrs.fr @unistra.fr @lmumuenchen.bsky.social

Cooperative effects in DNA-functionalized polymeric nanoparticles DNA-functionalized nanoparticles (NPs), called as spherical nucleic acids (SNA), attract strong attention due to their unique properties and numerous applications. In particular, DNA-functionalized dy...

New preprint alert: we found cooperative effects in DNA-functionalized polymeric nanoparticles, important for biosensing and diagnostics applications. Congrats and thanks to co-author Paraskevi Gaki.
@unistra.fr, @cnrs.fr, @bpifrance-officiel.bsky.social, #BrightSens
www.biorxiv.org/content/10.1...

Fluorescent Artificial Receptor for Dopamine based on Molecular Recognition‐driven Dynamic Covalent Chemistry in a Lipid Nanoreactor A dynamic artificial receptor is introduced that synergically combines molecular recognition with dynamic imine bond formation inside a lipid nanoreactor, triggering a fluorescence ratiometric respon....

Link to the article: onlinelibrary.wiley.com/doi/full/10....
Link to the cover: onlinelibrary.wiley.com/doi/10.1002/...

The cover (frontispiece) for our recent article on artificial receptor for neurotransmitter dopamine is finally out in @angewandtechemie.bsky.social. Thanks to Jurga Valanciunaite for the artwork!
Congratulations and thanks to the co-authors! @unistra.fr @cnrs.fr @agencerecherche.bsky.social

Packed room yesterday for a wonderful seminar from @aklymchenko.bsky.social from @cnrs.fr @unistra.fr #Fluorescence for #biomembranes #lipids #proteins
cbm.cnrs-orleans.fr/wp-content/u...

No, as I know, it was not recorded.

A deep dive into magic of biomembrane organization thanks to brilliant talk by @leventallab.bsky.social at PSL Chemical Biology meeting in Paris, @institutcurie.bsky.social, @cnrs.fr

Vers une détection ciblée des neurotransmetteurs : un récepteur artificiel pour la dopamine Les neurotransmetteurs ont un rôle clé dans le fonctionnement du cerveau et peuvent servir de biomarqueurs pour de nombreuses maladies neurologiques.

We thank @cnrs.fr for highlighting our work on the artificial receptor for dopamine, recently published in @angewandtechemie.bsky.social, in their news portal:
www.insb.cnrs.fr/fr/cnrsinfo/...

@cnrsbiologie.bsky.social @unistra.fr @cnrs-alsace.bsky.social

Measuring plasma membrane fluidity using confocal microscopy - Nature Protocols Membrane fluidity is a crucial feature in understanding cellular physiology. This protocol describes a robust pipeline for measuring plasma membrane fluidity using confocal imaging and new environment...

New paper out 🎇
It has been 13 years since @owenlabuob.bsky.social and co. published a stellar protocol on how to measure membrane order with smart probes! Since then, there has been new dyes, imaging modes and biology! We wrote a protocol for Nature Protocols:
www.nature.com/articles/s41...

Thank you!

It can be used for long-term cell tracking, co-culture of multiple cell populations, cell barcoading, magnetic cell manipulation, etc.

It means that the labelling is covalent, and unlike classical probes, MemGraft does not detach in biological media with serum, during permeabilizaion or in the presence of other cells.

Thank André for highlighting our work!

Congratulations and thanks to co-authors: Nathan Aknine and Rémi Pelletier. We acknowledge @unistra.fr, @cnrs.fr, @cnrs-alsace.bsky.social SysChem Graduate School, Laboratoire de Bioimagerie et Pathologies Illkirch, Fondation Jean-Marie Lehn, @agencerecherche.bsky.social

It is my first Bluesky post: I am thrilled that our work on MemGraft probes for “permanent” fluorescent labelling of plasma membranes is finally out in JACS Au! We established a concept of lipid-directed covalent labeling of plasma membranes. Open access article:
pubs.acs.org/doi/10.1021/...