Andrey Klymchenko

Andrey Klymchenko

@aklymchenko.bsky.social

CNRS senior researcher @unistra, @cnrs, @BrightSens Diagnostics, @AstraNICE. Working on fluorescent probes, organic nanoparticles, biomembranes, biosensing & bioimaging. #StandwithUkraine

234 Followers 173 Following 25 Posts Joined Feb 2025
5 months ago

Not yet, but we work on that.

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5 months ago

Thanks, it is rather for point of care applications, where one needs simple, fast, and inexpensive methods.

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6 months ago
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Just out in Nanoscale: we found cooperative effects in DNA-functionalized polymeric nanoparticles, important for biosensing & diagnostics. Congrats & thanks to Paraskevi Gaki & startup BrightSens Diagnostics. @unistra.fr, @cnrs.fr, @bpifrance-officiel.bsky.social, #iLab
pubs.rsc.org/en/content/a...

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6 months ago

We acknowledge the support from @agencerecherche.bsky.social, @erc.europa.eu , EIC FastComet, ITI SysChem, @unistra.fr, @cnrs.fr @cnrs-alsace.bsky.social. We thank all our colleagues who contributed to the research mentioned in this review!

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6 months ago
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Our review on light-harvesting nanomaterials for energy transfer & biosensing is out in Adv Mater! We analyzed literature on optical materials mimicking nature – chlorophyll in plants. Thanks & congrats to co-authors: Deep Biswas & Pascal Didier!
advanced.onlinelibrary.wiley.com/doi/full/10....

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7 months ago
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Ready to fly back with @aklymchenko.bsky.social to Paris! Thanks to @faseborg.bsky.social and the organisers for the fantastic event!

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8 months ago

Thanks Erdinc! I am also looking forward to starting this journey!

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8 months ago
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Great news: I received ERC Advanced grant #ERCAdG @erc.europa.eu CaptuRel! It aims at intelligent nanomaterials undergoing bioinspired cycle of capture and photorelease of bioactive molecules for sensing and controlling (bio)chemical gradients. Thanks to my Team, @cnrs.fr and @unistra.fr!

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8 months ago
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Today it is the MINT Day! A good occasion to share science and good moments together. We are really happy to welcome @aklymchenko.bsky.social to open this beautiful day! Thank you very much again for coming ☺️.

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9 months ago

It was a great experience to participate in JCS2025 conference on supramolecular chemistry. Thanks @iwonanieren.bsky.social et al for the invitation and organization of this wonderful event!

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10 months ago
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Bürgenstock Conference by @swisschemistry.bsky.social was a truly amazing meeting with brilliant lectures and leading researchers in chemistry: @klanglab.bsky.social, JL Mascarenas, R Buller, @olallalab.bsky.social, D Hilvert, etc. It was an honor to present our work. A big thank to the organizers!

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10 months ago

We thank our collaborator Arnaud Gautier and his team from @sorbonne-universite.fr for the precious contribution.

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10 months ago
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New preprint: we introduce peptide-functionalized fluorescent polymeric nanoparticles with stealth properties due to rather short polysarcosine peptides for targeting proteins on cell surface. Congrats to co-authors! @cnrs.fr @unistra.fr @agencerecherche.bsky.social
www.biorxiv.org/content/10.1...

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10 months ago

We thank our collaborators Igor Khalin, Severin Filser and Nikolaus Plesnila @lmumuenchen.bsky.social for their precious contribution to in vivo imaging.

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10 months ago
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We revisited our #MemBright toolbox and report anionic cyanine membrane probes with improved properties that enable in vivo imaging of neurons in mice brain. Congrats & thanks to co-authors! Just out Anal. Chem. @acs.org :
pubs.acs.org/doi/10.1021/...
@cnrs.fr @unistra.fr @lmumuenchen.bsky.social

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11 months ago
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Cooperative effects in DNA-functionalized polymeric nanoparticles DNA-functionalized nanoparticles (NPs), called as spherical nucleic acids (SNA), attract strong attention due to their unique properties and numerous applications. In particular, DNA-functionalized dy...

New preprint alert: we found cooperative effects in DNA-functionalized polymeric nanoparticles, important for biosensing and diagnostics applications. Congrats and thanks to co-author Paraskevi Gaki.
@unistra.fr, @cnrs.fr, @bpifrance-officiel.bsky.social, #BrightSens
www.biorxiv.org/content/10.1...

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11 months ago
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Fluorescent Artificial Receptor for Dopamine based on Molecular Recognition‐driven Dynamic Covalent Chemistry in a Lipid Nanoreactor A dynamic artificial receptor is introduced that synergically combines molecular recognition with dynamic imine bond formation inside a lipid nanoreactor, triggering a fluorescence ratiometric respon....

Link to the article: onlinelibrary.wiley.com/doi/full/10....
Link to the cover: onlinelibrary.wiley.com/doi/10.1002/...

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11 months ago
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The cover (frontispiece) for our recent article on artificial receptor for neurotransmitter dopamine is finally out in @angewandtechemie.bsky.social. Thanks to Jurga Valanciunaite for the artwork!
Congratulations and thanks to the co-authors! @unistra.fr @cnrs.fr @agencerecherche.bsky.social

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11 months ago

Packed room yesterday for a wonderful seminar from @aklymchenko.bsky.social from @cnrs.fr @unistra.fr #Fluorescence for #biomembranes #lipids #proteins
cbm.cnrs-orleans.fr/wp-content/u...

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1 year ago

No, as I know, it was not recorded.

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1 year ago
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A deep dive into magic of biomembrane organization thanks to brilliant talk by @leventallab.bsky.social at PSL Chemical Biology meeting in Paris, @institutcurie.bsky.social, @cnrs.fr

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1 year ago
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Vers une détection ciblée des neurotransmetteurs : un récepteur artificiel pour la dopamine Les neurotransmetteurs ont un rôle clé dans le fonctionnement du cerveau et peuvent servir de biomarqueurs pour de nombreuses maladies neurologiques.

We thank @cnrs.fr for highlighting our work on the artificial receptor for dopamine, recently published in @angewandtechemie.bsky.social, in their news portal:
www.insb.cnrs.fr/fr/cnrsinfo/...

@cnrsbiologie.bsky.social @unistra.fr @cnrs-alsace.bsky.social

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1 year ago
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Measuring plasma membrane fluidity using confocal microscopy - Nature Protocols Membrane fluidity is a crucial feature in understanding cellular physiology. This protocol describes a robust pipeline for measuring plasma membrane fluidity using confocal imaging and new environment...

New paper out 🎇
It has been 13 years since @owenlabuob.bsky.social and co. published a stellar protocol on how to measure membrane order with smart probes! Since then, there has been new dyes, imaging modes and biology! We wrote a protocol for Nature Protocols:
www.nature.com/articles/s41...

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1 year ago

Thank you!

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1 year ago

It can be used for long-term cell tracking, co-culture of multiple cell populations, cell barcoading, magnetic cell manipulation, etc.

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1 year ago

It means that the labelling is covalent, and unlike classical probes, MemGraft does not detach in biological media with serum, during permeabilizaion or in the presence of other cells.

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1 year ago

Thank André for highlighting our work!

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1 year ago

Congratulations and thanks to co-authors: Nathan Aknine and Rémi Pelletier. We acknowledge @unistra.fr, @cnrs.fr, @cnrs-alsace.bsky.social SysChem Graduate School, Laboratoire de Bioimagerie et Pathologies Illkirch, Fondation Jean-Marie Lehn, @agencerecherche.bsky.social

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1 year ago
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It is my first Bluesky post: I am thrilled that our work on MemGraft probes for “permanent” fluorescent labelling of plasma membranes is finally out in JACS Au! We established a concept of lipid-directed covalent labeling of plasma membranes. Open access article:
pubs.acs.org/doi/10.1021/...

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