@tackle18.bsky.social
Interés en comprender, compartir y aprender. Hemato-Oncología 🦀, Terapia Celular, Enfermedades Infecciosas 🦠, Medicina de Precisión 🧬 Cuenta PERSONAL, mis opiniones son eso: mías Maradoniano
A genetic therapy has reversed aggressive & incurable blood cancers in ~64% of patients in a trial.
The treatment involves editing the DNA in white blood cells to transform them into a cancer-fighting "living drug".
🧪🩸🧬 #medsky
www.bbc.co.uk/news/article...
#ASH25 Among patients with #ChronicLymphocyticLeukemia, fixed-duration targeted treatment using venetoclax-based combinations was found to achieve efficacy comparable to #BTKi therapy, with 3-year PFS ranging from 79% to 81% across all treatment arms: https://ow.ly/LOkJ50XExRg
#HemeSky #OncSky
Excellent Review!!
Immune alterations in myeloma evolution and outcomes: quo vadis? buff.ly/6ft0xTG #hemesky
A rare T-cell lymphoma after chimeric antigen receptor (CAR) T-cell therapy for myeloma was linked to CCR4 overexpression and vector integration, which highlights the need for monitoring after CAR T-cell therapy. Read the full case details: nej.md/41fYX4v
#MedSky #Hematology #Genetics
In-vivo B-cell maturation antigen CAR T-cell therapy for relapsed or refractory multiple myeloma - The Lancet www.thelancet.com/journals/lan...
Antibiotic use: impact on the microbiome and cellular therapy outcomes
buff.ly/Awz7wZU #hemesky
In this 60-Second Journal Club, NEJM Editorial Fellow Abarna Pearl, MD, MPH, summarizes the BALANCE trial comparing antibiotic treatment for 7 versus 14 days in patients with bloodstream infections. Read the full article and accompanying Research Summary: nej.md/3Z5bTJD
#MedSky #IDSky
Perforin is responsible for creating a channel/pore (punching a hole) between cytolytic lymphocytes, natural killer cells and CD8 T cells, and their target cells, allowing for the delivery of apoptosis-inducing granzyme proteins. buff.ly/YFitped #hemesky
No doubts #EHA is the best congress of hematology ever.
EHA Highlights: First-in-Human Study of Trispecific Antibody JNJ-5322 Shows Promising Activity in Relapsed/Refractory Multiple Myeloma
oncodaily.com/oncolibrary/...
#OncoDaily #Oncology #Cancer #Health #Medicine #MedEd #MedOnc #MedNews #EHA #EHA2025 #MM #RRMM
Risk of SMN Low After CAR-T Therapy: The risk of secondary #myeloid #neoplasms (SMNs) following #CD19 #CARTcell therapy may be lower than expected. According to a retrospective study, SMNs occurred in 2.5% of patients after treatment with CAR T-cell therapy.
#HemeSky
For patients undergoing CD19-directed #CARTcell therapy, #itacitinib prophylaxis effectively reduced the incidence and severity of #cytokine release syndrome (CRS), with just 17.4% of patients experiencing grade ≥2 CRS compared with 56.5% on placebo: ow.ly/9y5l50W4mYU
#HemeSky #MedSky
Results from an MD Anderson study identified three subgroups of patients with large B-cell lymphoma who have different levels of benefit from CD19 CAR T cell therapy.
How the findings offer insights on the best potential clinical pathways: spr.ly/60174rfXF #EndCancer
A recent meta-analysis in JAMA Network Open evaluated cardiovascular risks in 1,528 adults receiving CAR T-cell therapy for advanced blood cancers.
@jama.com
#Onco404 #Cancer #Kanser #Hematology #CardioOncology #CARTCellTherapy #MetaAnalysis #MedResearch #MedSky #OncSky
There are so many ways to rev up our immune response against cancer. Here, the oncolytic viruses
www.cell.com/cancer-cell/...
In the BALANCE trial, patients with bacteremia were assigned to 7 or 14 days of appropriate antimicrobial therapy, and 7 days of therapy was found to be noninferior to 14 days. Full trial results and Research Summary: nej.md/3Z5bTJD
#MedSky #CriticalCare #IDSky
Today is World TB day. Here's a recent comprehensive review on therapeutic developments for tuberculosis and nontuberculous mycobacterial lung disease
www.nature.com/articles/s41...
rdcu.be/eeQ0m
The Pharmaceutical approach of obesity in children is a complete mistake, terrible results in a multi factorial disease.
Come together, really hard times for the science. | Science www.science.org/doi/10.1126/...
Restoration of the #immune function as a complementary strategy to treat #CLL effectively. This approach aims to achieve dual disease control by targeting both malignant B-cell activity and the often-compromised immune system in #CLL patients.
Eggs?
Hematopoietic stem cell transplant is a critical treatment for various cancers and other conditions.
This JAMA Insights discusses the process of allogeneic stem cell donation, including donor selection, preparation, and potential risks and benefits.
ja.ma/40911K8
Cytomegalovirus (CMV) is the leading cause of infectious birth defects and linked to many other morbidities such as with transplantation. For the first time after >50 years of pursuit, a vaccine is in reach jci.org/articles/vie...
Del gran Bukowski "No leaders please" Esto de las fechas "especiales" si tienen algo de bueno (probablemente lo único) es que son recordatorio de gratitud, reflexión, y sobre todo, de re invención a diferentes niveles, al no tenerlo en cuenta todo pierde sentido...
youtu.be/PLauo0Qx48k?...
Excelente
Un documental desgarrador, extraordinario #NoOtherLand. Siempre en @filmin.es
Ayuso es todo lo malo que te puedas imaginar, todo.
Whooping cough
La contaminación mata. #AirPollution