Institut Cochin

Registration is now open for the Cochin #QuPath training course for the manipulation of Fluo or color pyramid images, #histology or #microscopy, with the application of #deeplearning
November 5, 2025
November 12, 2025
@institutcochin.bsky.social
institutcochin.fr/formation-co...

The IMAG'IC team is back to offer you the "Introduction to the Use of #ImageJ" training course.
October 24, 2025: Session in French
October 29, 2025: Session in English
institutcochin.fr/formations/f...

@institutcochin.bsky.social
@upcite.bsky.social
@inserm.fr

Tumor specific regulation of T cell exhaustion can be targeted for immunotherapy Persistent exposure to antigen during chronic infection or cancer renders T cells dysfunctional. The molecular mechanisms regulating this state of exhaustion are thought to be common in infection and ...

Seminar on October 9 at noon by Grégory Verdeil (Department of Oncology, Univ of Lausanne): Tumor specific regulation of T cell exhaustion can be targeted for immunotherapy
institutcochin.fr/agenda/tumor...
@cnrs-idf-villejuif.bsky.social
@inserm.fr
@upcite.bsky.social
@cnrsbiologie.bsky.social

Registration for the symposium Institut Cochin "Long COVID and other post-acute infections: from symptoms to mechanisms" is open
🗓️ Dec. 5, 2025
📍Institut Cochin, Paris
📧 symposium.u1016@inserm.fr
Information: institutcochin.fr/en/animation...
@cnrsbiologie.bsky.social
@inserm.fr
@upcite.bsky.social

We just launched the 2025/2026 series of the #PPS! 🚀

Check our October newsletter and save the dates 🗓️ see you at @institutcochin.bsky.social, @pasteur.fr, @institutcurie.bsky.social, @ibps.bsky.social, @upcite.bsky.social, @institutducerveau.bsky.social & @ijmonod.bsky.social !

#parispostdocs

Plot twist: homologous recombination promotes cancer development The prevailing view considers homologous recombination to be a tumour-suppressing mechanism. However, a re-analysis of data and concepts published in the journal Oncogene concludes that, in fact, homo...

In a review article published in the Journal #Oncogene, Bernard Lopez proposes that #RAD51 -mediated homologous recombination is a Pro-tumour driver pathway, contradicting the generally accepted dogma
institutcochin.fr/en/news/plot...
@cnrsbiologie.bsky.social @inserm.fr @upcite.bsky.social

The Candida Corkscrew: A Morphological Strategy of Epithelial Invasion The opportunistic human fungal pathogen Candida albicans displays a high degree of morphological plasticity, with the ability to switch between at least 7 different forms, depending on its environment...

Seminar on October 2 at noon by Emma Agnew (Fungal Biology and Pathogenicity Laboratory, Dept of Mycology, @pasteur.fr, Paris)The Candida Corkscrew: A Morphological Strategy of Epithelial Invasion
institutcochin.fr/en/agenda/ca...
@cnrsbiologie.bsky.social @inserm.fr @upcite.bsky.social

Our Jove video is finally out! Watch us try our best to look natural while reading the script 🤭

#vascular #imaging #bonemarrow #leukemia #intravital #twophoton #passarolab @institutcochin.bsky.social @imag-ic.bsky.social

app.jove.com/v/67332/intr...

Raphaël Scharfmann receives the Albert Renold price from the EASD Raphaël Scharfmann has been nominated for the Albert Renold Award (2025) from the European Association for the Study of Diabetes e.V. (EASD) The Albert Renold Award recognizes outstanding achievement ...

Congratulations to Raphaël Scharfmann, research director at @institutcochin.bsky.social, who received the Albert Renold Award (2025) from the European Association for the Study of Diabetes.
institutcochin.fr/en/news/raph...
@inserm.fr
@upcite.bsky.social
@cnrs-idf-villejuif.bsky.social

Phospholipase A1A deficiency shapes the Immune cell profile and oxidative responses of phagocytes in a mouse model of psoriasis

Seminar on September 18 at noon by Sylvain Bourgoin (Laval University, Québec, Canada): Phospholipase A1A deficiency shapes the Immune cell profile and oxidative responses of phagocytes in a mouse model of psoriasis
institutcochin.fr/en/agenda/ph...

Consultez le programme complet de la #FDS2025 à l' @institutcochin.bsky.social :https://institutcochin.fr/lanimation/science-societe/fete-science/fete-science-2025

Dominant negative mutations in ADA2 deficiency Human ADA2 (adenosine deaminase 2) deficiency (DADA2) is an inborn error of immunity with a broad clinical phenotype, which encompasses vasculopathy and hemato-immunological features. Diagnosis is bas...

Seminar on Sept. 12 at 11:30 by Isabelle Meyts (KU Leuven, Belgium) Title: Dominant negative mutations in ADA2 deficiency
institutcochin.fr/en/agenda/do...
@cnrs-idf-villejuif.bsky.social
@cnrsbiologie.bsky.social
@inserm.fr
@upcite.bsky.social

Do not hesitate to register for Sept 18. Please repost this message.

Reduced ATP turnover during hibernation in relaxed skeletal muscle Hibernating brown bears, due to a drastic reduction in metabolic rate, show only moderate muscle wasting. Here, we evaluate if ATPase activity of resting skeletal muscle myosin can contribute to this ...

Tuesday, Sept. 16, seminar at noon by Bert Blaauw (Veneto Inst. of Molecular Medicine, Univ of Padova, Italy): Reduced ATP turnover during hibernation in relaxed skeletal muscle
institutcochin.fr/en/agenda/re...
@inserm.fr @cnrs-idf-villejuif.bsky.social @cnrsbiologie.bsky.social @upcite.bsky.social

Registration for the symposium Institut Cochin "Long COVID and other post-acute infections: from symptoms to mechanisms" is open
🗓️ Dec. 5, 2025
📍Institut Cochin, Paris
📧 symposium.u1016@inserm.fr
Information: institutcochin.fr/en/animation...
@cnrsbiologie.bsky.social
@inserm.fr
@upcite.bsky.social

Seminar on Sept. 11 at noon by Alvaro Lladser (Fundacion Ciencia & Vida, U. San Sebastián): Dissecting the crossroads of circulating and tissue-resident T cells in solid tumors
institutcochin.fr/en/agenda/di...
@upcite.bsky.social @cnrsbiologie.bsky.social @cnrs-idf-villejuif.bsky.social @inserm.fr

🦠🦠🦠New paper out in JBC! Argonaute 1 contributes to HIV-1 transcriptional silencing. doi.org/10.1016/j.jb...
Collaboration between the Host-Virus Interaction & Rétrovirus, infection & latency teams @institutcochin.bsky.social @inserm.fr @cnrs.fr @upcite.bsky.social ⬇️

It is tomorrow ⬇️

Seminar on Tuesday August 26 at 10:00 am, by Vijay KUCHROO (@harvardmed.bsky.social & Brigham and Women's Hospital, Boston, US)
Title: Checkpoint Molecules, Tregs and Induction of Anti-tumor Immunity
institutcochin.fr/en/agenda/ch...
@inserm.fr @cnrsbiologie.bsky.social
@upcite.bsky.social

Seminar on Tuesday August 26 at 10:00 am, by Vijay KUCHROO (@harvardmed.bsky.social & Brigham and Women's Hospital, Boston, US)
Title: Checkpoint Molecules, Tregs and Induction of Anti-tumor Immunity
institutcochin.fr/en/agenda/ch...
@inserm.fr
@cnrs-idf-villejuif.bsky.social
@upcite.bsky.social

Still 1 month to submit your abstract! Don’t miss the chance to participate in our next #POHaD symposium. Join us onsite/virtually on Oct 16th, 2025 at @institutcochin.bsky.social (Paris 🇫🇷). Registration is free but mandatory 🗓️
@juliecocquet.bsky.social #epigenetics #dohad #offspringhealth

See the great program of our symposium "Long COVID and other post-acute infections: from symptoms to mechanisms".
🗓️ December 5, 2025
📍 Institut Cochin, Paris 14
📧 symposium.u1016@inserm.fr
Information: institutcochin.fr/en/animation...
@cnrsbiologie.bsky.social @inserm.fr @upcite.bsky.social

JCS poster - Phagocytosis at a glance

In their Cell Science at a Glance article and poster, @manondepierre.bsky.social, @chiarapompili.bsky.social and @florenceniedergang.bsky.social @institutcochin.bsky.social take us through the key features of #phagocytosis.

journals.biologists.com/jcs/article/...

Who said research was boring?
At #passarolab @institutcochin.bsky.social même une visite ministérielle devient un moment de bonne humeur 😄 Merci pour cette belle discussion sur #ouverture #mobilité & #integration … dans un labo où la diversité internationale est déjà une réalité au quotidien 🌍

Check this symposium that @albiglero.bsky.social and I will organise with GdR Repro @gdr-reproduction.bsky.social
October 16 @Institut Cochin @institutcochin.bsky.social but also online! Don't hesitate to register, submit an abstract, and spread the word #epigenetics #reproduction #DOHaD #POHaD

!

Congratulations Roy, Well deserved!

Congratulations Roy!

Hyperactivation of DNA repair by the AKT1/PKB oncogene generates genetic instability Defects in DNA damage responses induce genetic instability. A study published in Nucleic Acids Res. shows that, mirroring their hyperactivation, also induces genomic rearrangements. Combining global a...

Publication in Nucleic Acid Research: Bernard Lopez's team demonstrates a new role for the #AKT1/PKB oncogene: it induces genetic rearrangements by overstimulating DNA repair via phosphorylation of MRE11, a key protein in DNA damage signaling.
institutcochin.fr/en/hyperacti...

SAVE THE DATE: Symposium Institut Cochin "Long COVID and other Post-Acute Infections: from symptoms to mechanisms" on December 5, 2025 at @institutcochin.bsky.social in Paris.
institutcochin.fr/en/animation...

@cnrsbiologie.bsky.social @inserm.fr @upcite.bsky.social

Maîtriser la fin de la transcription : un mécanisme clé pour préserver l'intégrité du génome La transcription des gènes est un processus qui permet de copier l’information génétique contenue dans l’ADN sous forme d’ARN.

Maîtriser la fin de la transcription : identification d'un mécanisme clé pour préserver l'intégrité du génome par @fabiennebejjani.bsky.social ! 🧬

🤝 @cnrs-idf-villejuif.bsky.social‬ @inserm.fr‬ @upcite.bsky.social‬ @institutcochin.bsky.social‬

buff.ly/5hyNH7E