Florian Schueder

Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in Salmonella Typhimurium | PNAS Type III secretion systems (T3SS) are critical virulence machines in many Gram-negative bacteria, enabling hierarchical secretion of translocases f...

📄 New paper out!
Please check out our latest publication, where we show how the gatekeeper protein InvE orchestrates hierarchical type III secretion in Salmonella Typhimurium via oligomeric assembly. #T3SS #DNAPAINT

www.pnas.org/doi/10.1073/...

C-COMPASS: a user-friendly neural network tool profiles cell compartments at protein and lipid levels - Nature Methods C-COMPASS is an open-source software designed to predict the spatial cellular distribution of proteins and lipids from cellular organelle profiling using a neural network-based regression model.

I‘m excited to announce that our paper has just been published in 𝑁𝑎𝑡𝑢𝑟𝑒 𝑀𝑒𝑡ℎ𝑜𝑑𝑠.

Here, we provide a solution for analyzing subcellular proteomics datasets and extend it to predict lipid localizations as well.

#proteomics #lipidomics #bioinformatics #systemsbiology

www.nature.com/articles/s41...

Controllable Protein Design via Autoregressive Direct Coupling Analysis Conditioned on Principal Components We present FeatureDCA, a statistical framework for protein sequence modeling and generation that extends Direct Coupling Analysis (DCA) with biologically meaningful conditioning. The method can levera...

Here we are, trying to teach an old, but always fantastic dog (Direct Coupling Analysis) some new tricks! It learns them pretty well.
Together with @fcaredda.bsky.social @lgennai.bsky.social and bluesky-absent Andrea Pagnani.

www.biorxiv.org/content/10.1...

Ångström-resolution imaging of cell-surface glycans

Now published in Nature Nanotechnology! 🤩
@natnano.nature.com

www.nature.com/articles/s41...

🚨 2 × PhD positions @EPFL! 🚨
Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch
#PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT

Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ - Nature Communications A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give further insight into how Cohesi...

🔬🧬 New in @natcomms.nature.com‬: Nanoscale 3D DNA tracing in non‑denatured cells maps the #3Dgenome at nm‑resolution and reveals Cohesin‑dependent dynamic loops! 🚀 #OpenAccess 

www.nature.com/articles/s41...

@ellenberglab.bsky.social @jungmannlab.bsky.social
#Genomics #SuperResolution

Thank you Romain!

Thank you Yongdeng!!

Thank you Luciano!

Thank you Christophe!

Thank you Pierre!

Thank you Nike!

Big news: I’m joining EPFL as Tenure-Track Assistant Professor of Life Science Engineering!
Can’t wait to push super-resolution microscopy & spatial omics even further and build new collaborations in Lausanne. 🚀
#EPFL #SuperResolution #Microscopy #SpatialOmics #DNAPAINT

Growth in Low Carbon Conditions Reveals Amino-Acid-Coupled Iron Uptake Bacteria in nature encounter substrates at widely varying concentrations, yet studies of bacterial physiology have focused more on nutrient type than concentration, partly due to challenges in maintai...

The Stocker Lab’s Juanita Lara Gutierrez and colleagues discovered a new and highly interesting iron uptake mechanism in bacteria.
www.biorxiv.org/content/10.1...

"You'll be revisited by three spirits"

The spirits:

Elucidating subcellular architecture and dynamics at isotropic 100-nm resolution with 4Pi-SIM - Nature Methods The 4Pi-SIM microscope combines the benefits of structured illumination microscopy with 4Pi geometry for improved axial resolution, offering isotropic, multicolor super-resolution imaging of dynamic p...

Incredible new work from Yongdeng Zhang demonstrating live 4Pi SIM--and in two colors! www.nature.com/articles/s41...

I am very excited and deeply honored that our most recent work on #FLASHPAINT was highlighted as one of the methods to watch by @naturemethods.bsky.social' @ritastrack.bsky.social in the context of ‘spatial proteomics’ as Nature Methods' Method of the Year 2024. www.nature.com/articles/s41...

Would you mind adding me as well?

Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging Development of FLASH-PAINT enables rapid and efficient visualization of cellular organelles, using a potentially unlimited number of labels.

Please check out our (@bewersdorflab) latest work on #FLASHPAINT published in @CellCellPress.
#FLASHPAINT builds on #DNAPAINT and allows for fast and fluorogenic, highly multiplexed super-resolution imaging. cell.com/cell/fulltex...

Could you add me please?