Great read by @alexkwan.bsky.social on how fundamental neuroscience research has paved the way for new drug development.
I’d also highlight orexin’s role in sleep–wake regulation and the upcoming wave of dual orexin receptor antagonists (DORAs) for sleep disorders (& soon agonists for narcolepsy).
That's all!
More bangers from Judge Young in the thread below. And check out my story for the full low-down on what happened yesterday — and what led up to this moment.
www.nature.com/articles/d41...
in any case, what result/outcome would proof that dendrites have credit signals combining such a behavior and dendritic activation?
Lets suppose you have an animal that has learned association A, needs to learn association B and then go back to A. overactivating the dendrites might speed up the transition from A to B but maybe at cost of „overwriting“ part of the „dendritic representation“ of A due to too much plasticity.
Does neural computation feel like something? In our new paper, we explore a paradox: if you replay all the neural activity of a brain—every spike, every synapse—does it recreate conscious experience?
🧠 doi.org/10.3389/fnin...
New #NeuroAI #compneurosky preprint! To better understand how target-directed learning works in the brain, we sought to engineer an artificial neural network capable of solving complex image classification tasks that comprises only experimentally-supported biological building blocks. (1/15)
Maybe I am wrong but this recent study of ours might indicate that both interneurons and dendrites might play a role (with a certain regulatory interdependence) in concepts like the ones you are discussing here.
www.biorxiv.org/content/10.1...
The book sounds very exciting! Is there going to be an audiobook version of it? :)
Our new paper is out in Science.
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
Baclofen, a GABAB receptor agonist, impairs motor learning in healthy people and changes inhibitory dynamics in motor areas https://www.biorxiv.org/content/10.1101/2025.03.27.645701v1
🥰 updated my perspective on building more adaptive AI with neuroscience inspired brain-like agentic systems.
If of interest, I hope it’s a nice review of adaptive behavior in neuro, cutting edge AI, and my proposal for an updated merger: arxiv.org/abs/2411.15234
New glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain! www.addgene.org/browse/artic...
*Please repost* @sjgreenwood.bsky.social and I just launched a new personalized feed (*please pin*) that we hope will become a "must use" for #academicsky. The feed shows posts about papers filtered by *your* follower network. It's become my default Bluesky experience bsky.app/profile/pape...
Tuft dendrites in frontal motor cortex enable flexible learning https://www.biorxiv.org/content/10.1101/2025.03.13.642781v1
Was just going to advertise another awesome summer course for people starting their labs: safelabs.info -- related to the one we are organizing compneurosci.com/Neuro4Pros/i... - if you have a new lab this is a good year.
