Adrian Woolfson

Lab-grown genomes set to transform human DNA Research shows synthetic chromosomes can be transferred to human cells with potential to improve viral resistance

www.ft.com/content/8b06...

Growing the UK’s Modern Industrial Bioeconomy

bbia.org.uk/wp-content/u...

Transplant of human chromosomes marks first step in genome synthesis project - MRC Laboratory of Molecular Biology Researchers in the LMB’s PNAC Division detail a new pipeline to implant human chromosomes into mouse cells and back again without genomic damage, marking an important step towards the overall goal of ...

Remarkable work by Julian Sale and Jason Chin at the LMB, in Cambridge. Congratulations! The delivery of rewritten chromosomes is the key bottleneck in constructing an artificial human genome. This is huge!

www2.mrc-lmb.cam.ac.uk/transplant-o...

High-fidelity human chromosome transfer and elimination The synthesis of human genomes and other gigabase-scale genomes will require new strategies. Here, we realized key steps in our pipeline for building synthetic human chromosomes. We established: (i) t...

Here is the paper:

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The secret language of cells — and how to "speak" it What if medicines could "speak" directly to your cells? Protein designer and TED Fellow Chris Bahl introduces a new generation of miniproteins: AI-designed medicines that can deliver detailed instruct...

www.ted.com/talks/chris_...

Atom-level enzyme active site scaffolding using RFdiffusion2 - Nature Methods RFdiffusion2, an extension of the RFdiffusion framework, builds de novo enzyme active sites using atom-level functional group constraints.

And the companion paper in Nature Methods - a unified foundational model for designing proteins that interact with DNA, RNA, small molecules and other proteins

www.nature.com/articles/s41...

Computational design of metallohydrolases - Nature A generative artificial intelligence-powered method enables de novo design of highly active enzymes based on information about the geometry of residues in the active site, without requiring protein ba...

RFdiffusion generates new enzymes that work efficiently straight out of the computer. An astonishing result with great implications.

www.nature.com/articles/s41...

Scientists achieve breakthrough on quantum signaling A tiny device that entangles light and electrons without super-cooling could revolutionize quantum tech in cryptography, computing, and AI.

This could be hugely consequential

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Can We Build A Human? Professor Brian Cox and our expert panel explore the frontier of human bioengineering and building, replacing, and enhancing our bodies.   Will we ever have bionic brains and cloned humans? Is there ...

www.lnk.to/AQOSBioengin...

What’s Special about Life? Bulk Orchestration and the Rulial Ensemble in Biology and Beyond Stephen Wolfram shares his early findings from researching a general characterization of what happens in systems that exhibit "bulk orchestration" and discovers that there is in fact a certain univers...

The orchestration of life

writings.stephenwolfram.com/2025/11/what...

Laboratory of Evolutionary Design Developing biological AI for human good at Stanford University

A brilliant place to do a PhD at the epicenter of bioconvergence

evodesign.org

Do you have his contact details?

Estimation and mapping of the missing heritability of human phenotypes - Nature WGS data were used from 347,630 individuals with European ancestry in the UK Biobank to obtain high-precision estimates of coding and non-coding rare variant heritability for 34 co...

Eking out the ‘missing heritability’ of GWAS. Shining a light on the genomes ‘dark matter’

www.nature.com/articles/s41...

Inventor Mark Kokoris on Roche’s New Sequencing by Expansion The biggest story in sequencing this year lives up to the hype.

Personally I can’t get enough of SBX. This time from the inventor himself!

www.mendelspod.com/p/inventor-m...

Really looking forward to reading it. The Cobb book has primed me for it!

We’re all in this writing game together! I will plan for WSJ. As long as you get it to me in a timely manner, I can more or less guarantee that for you.

Nice quote from Bragg. He makes a good point about their youth also. Something that one doesn’t always think about. It really was quite remarkable.

A multimodal whole-slide foundation model for pathology - Nature Medicine Pretrained using 335,645 whole-slide images, a foundation model is developed to provide representations for slide- and patient-level tasks. It is capable of performing clinical tasks and generating re...

Phenomenal work! AI models trained on pathology slides using TITAN.

www.nature.com/articles/s41...

Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells Abstract. Human trisomy 21, responsible for Down syndrome, is the most prevalent genetic cause of cognitive impairment and remains a key focus for prenatal

Extraordinary paper showing how an extra copy of chromosome 21 can be deleted in both stem cells and skin cells in Down’s syndrome trisomy 21 cells using CRISPR-cas9 edits. A real tour de force.

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Maybe WSJ

I look forward to reviewing it! Make sure I get a bound proofs copy ahead of time

My pleasure

Reporter’s Notebook: Is Intellia’s Patient Death the Nail in the Coffin for Cas9? In light of the recent tragedy, many wonder if Intellia's program is the only one affected or if all Cas9-based CRISPR therapies are at risk.

www.insideprecisionmedicine.com/topics/preci...

NSCEB report on the future of biotechnology

www.biotech.senate.gov/wp-content/u...

Computational enzyme design by catalytic motif scaffolding - Nature A hybrid machine learning and atomistic modelling strategy enables one-shot design of efficient enzymes to catalyse diverse biological and non-biological chemical transformations.

Computational enzyme design

www.nature.com/articles/s41...

On the design of artificial flowers

nph.onlinelibrary.wiley.com/doi/10.1111/...

Teens may have come up with a new way to detect, treat Lyme disease using CRISPR gene editing To compete at iGEM, a sort of science Olympics, teens at a Georgia high school set their sights on finding a better way to detect and treat Lyme disease. Their approach uses CRISPR gene editing.

www.cbsnews.com/news/teens-m...

Daphnia water fleas with embryos (left) and eggs (right)

Hyperdimensional computing: A fast, robust, and interpretable paradigm for biological data Advances in bioinformatics are primarily due to new algorithms for processing diverse biological data sources. While sophisticated alignment algorithms have been pivotal in analyzing biological sequen...

journals.plos.org/ploscompbiol...

The circular argument behind spider and silkworm silk mechanical properties Comparative studies of silk mechanical properties often highlight spider silk as superior to silkworm silk, but such claims are frequently based on in…

Correcting the misconception that spider silk is the toughest biological material on Earth. Apparently it is in fact bagworm silk that deserves that accolade!

www.sciencedirect.com/science/arti...