Adrian Woolfson (@adrianwoolfson) — Bluesky Profile

7 hours ago

How to Design Antibodies A step-by-step guide to making de novo binders.

www.asimov.press/p/antibody-d...

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15 hours ago

Want to hack your body with peptides? If only the science agreed Performance-enhancing peptides are increasingly popular among fitness enthusiasts and biohackers, despite limited human testing and potential health risks.

www.economist.com/science-and-...

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1 day ago

Secrets of evolution found in ancient plant DNA | Cold Spring Harbor Laboratory You’ve heard of deep space, but what about deep time? Today’s geneticists and evolutionary biologists can extend their investigations further back in time than ever imagined. Still, many mysteries rem...

www.cshl.edu/secrets-of-e...

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3 days ago

Great to see the Spanish version of my book On the Future of Species

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3 days ago

Bringing the genetically minimal cell to life on a computer in 4D We present a whole-cell spatial and kinetic model for the ∼100 min cell cycle of the genetically minimal bacterium JCVI-syn3A. We simulate the complet…

www.sciencedirect.com/science/arti...

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5 days ago

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish - Nature Aging Characterizing molecular aging features is crucial for understanding systemic and local factors contributing to the aging process. Here Costa, Chen et al. performed RNA sequencing on 13 tissues across...

www.nature.com/articles/s43...

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1 week ago

Genome modelling and design across all domains of life with Evo 2 - Nature Evo 2 is an artificial intelligence-based biological foundation model trained on 9 trillion DNA base pairs spanning all domains of life that predicts functional properties from genomic sequences and p...

www.nature.com/articles/s41...

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1 week ago

The MicrobeAtlas database: Global trends and insights into Earth’s microbial ecosystems MicrobeAtlas (www.microbeatlas.org) is an integrated, reference-based resource for truly planet-wide microbiomics, analyzing hundreds of thousands of microbial lineages across diverse environments, co...

www.cell.com/cell/fulltex...

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1 week ago

The Accidental Architect of Globalisation: How One Man’s Thirteen-Year Odyssey Changed the World Beyond Borders: The 13-Year Journey That Bridged East and West and Forever Changed the Course of History

medium.com/time-chronic...

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1 week ago

Too rare to be random: genetic finding suggests previously unrecognized path of mutagenesis We report a previously undescribed genotypic configuration identified in twins with HNRNPU-related neurodevelopmental disorder. Both twins have two closely spaced mosaic variants on the same allele th...

www.medrxiv.org/content/10.6...

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1 week ago

Functional landscape of non-canonical open reading frames in coordinating cell fate The human genome harbors thousands of unannotated short open reading frames (sORFs) with the potential to encode microproteins, yet their physiologica…

www.sciencedirect.com/science/arti...

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1 week ago

AI can write genomes — how long until it creates synthetic life? The Evo2 genomic language model can generate short genome sequences, but scientists say further advances are needed to write genomes that will work inside living cells.

www.nature.com/articles/d41...

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1 week ago

Matching sounds to shapes: Evidence of the bouba-kiki effect in naïve baby chicks Humans across multiple languages spontaneously associate the nonwords “kiki” and “bouba” with spiky and round shapes, respectively, a phenomenon named the bouba-kiki effect. To explore the origin of t...

www.science.org/doi/10.1126/...

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1 week ago

Evo 2: One Year Later | Arc Institute Now published in the journal Nature, the DNA foundation model is showcasing the power of open and collaborative science

arcinstitute.org/news/evo-2-o...

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1 week ago

Genome modelling and design across all domains of life with Evo 2 - Nature Evo 2 is an artificial intelligence-based biological foundation model trained on 9 trillion DNA base pairs spanning all domains of life that predicts functional properties from genomic sequences and p...

www.nature.com/articles/s41...

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1 week ago

Highly mutagenic continuous evolution in E. coli using a Φ29-based orthogonal replication system - Nature Biotechnology Mutational rates of bacterial evolution are increased using an error-prone orthogonal system.

www.nature.com/articles/s41...

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1 week ago

Transposable elements in the dark genome - Nature Biotechnology Transposable elements (TEs), such as retrotransposons and endogenous retroviruses, are increasingly recognized for their important roles in genome function and impact on disease development. Residing ...

www.nature.com/articles/s41...

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1 week ago

Beyond Mendel: a call to revisit the genotype–phenotype map through new experimental paradigms Abstract. The long-standing notion that genotypes map to phenotypes through simple one gene–one trait relationships continues to shape both research in the

academic.oup.com/genetics/adv...

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1 week ago

A symbiotic origin of the ribosome? Abstract. The origin of life is one of the great mysteries of science. Of the multiple unsolved problems, the origin of the translation system (the means b

academic.oup.com/pnasnexus/ar...

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1 week ago

Rapid directed evolution guided by protein language models and epistatic interactions Protein engineering is limited by the inefficient search through a high-dimensional sequence space to find combinations of synergistic mutations. Traditional approaches use stepwise mutation stacking,...

www.science.org/doi/10.1126/...

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1 week ago

www.nyu.edu/about/news-p...

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1 week ago

Good to see that On The Future of Species has been named FT Book of the Week. Thanks to Clive Cookson, Senior Science Writer at the Financial Times, for his thoughtful review.

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1 week ago

Three-dimensional genome reorganization foreshadows zygotic genome activation in Drosophila - Nature Genetics Pico-C, a low-input Micro-C approach, reveals that dynamic three-dimensional genome folding precedes zygotic genome activation in Drosophila.

www.nature.com/articles/s41...

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1 week ago

The Rockefeller University » Scientists map how aging reshapes cells across the entire mammalian body

www.rockefeller.edu/news/39031-s...

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1 week ago

AI and the problems of protein folding – Soft Machines, by Richard Jones

softmachines.org?p=3258

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1 week ago

Generative AI for synthetic biology: Designing biological parts, circuits, and genomes The convergence of generative AI and synthetic biology is transforming biological design, enabling the de novo creation of biological parts and systems with predictable, programmable function. Kim et ...

www.cell.com/cell-systems...

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1 week ago

‘An AlphaFold 4’ — scientists marvel at DeepMind drug spin-off’s exclusive new AI Isomorphic Lab’s proprietary drug-discovery model is a major advance, but scientists developing open-source tools are left guessing how to achieve similar results.

www.nature.com/articles/d41...

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1 week ago

Foundational AI Models to Accelerate Biological Discovery Berkeley Lab is helping build AI models for autonomous research that will enable prediction and precise design of biological systems.

newscenter.lbl.gov/2026/02/02/f...

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1 week ago

Ancient bacteria strain discovered in ice cave is resistant to some modern antibiotics | CNN In a cave in Romania, scientists found a bacterial strain entombed in ice that is resistant to 10 modern antibiotics. But it may also help fight superbugs.

www.cnn.com/2026/02/20/s...

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2 weeks ago

On the Future of Species — unnatural selection Geneticist and entrepreneur Adrian Woolfson argues that genome engineering and AI will let us design organisms beyond nature’s limits

Good review of ‘On the future of species’ in today’s FT

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