IonOptix

A recent study links N-terminal acetylation dysregulation to cardiac arrhythmia and cardiomyopathy. Using patient-derived iPSC-CMs and the IonOptix Calcium & Contractility System, researchers uncovered how NatA mutations disrupt cardiac function. shorturl.at/onfeK

Bloodborne pancreatic amylin may impair cerebral Aβ clearance, contributing to Alzheimer's pathology. Using the IonOptix Vessel Diameter System, researchers showed how amylin affects vascular tone and Aβ pathways. shorturl.at/aH1XN

Loss of Snord116 protects cardiomyocyte kinetics during ischemic stress Loss of Snord116, a non-coding RNA, causes Prader Willi Syndrome (PWS), a complex disorder with circadian, metabolic, neurologic, and cardiovascular p…

Loss of Snord116 improves cardiomyocyte performance during ischemic stress. Using living myocardial slices and the IonOptix Cardiac Slice System, researchers showed improved contractility and kinetics during ischemia–reperfusion injury. shorturl.at/nc9o0

A Nature study shows iPSC-CM maturation can be significantly improved by combining metabolic media, nanopatterning, and electrostimulation. Using the IonOptix C-Pace, researchers achieved more adult-like structure, function, and drug response. shorturl.at/DUbfl

Stretch-mediated β₂-adrenergic signaling in cardiomyocytes depends on caveolae. Using the IonOptix CytoCypher MultiCell, researchers showed stretch increases contractility and cAMP via β₂AR—not β₁AR—and is lost when caveolae are disrupted. shorturl.at/AgbtN

Mechanical loading reveals hidden cardiomyocyte stiffness in cardiometabolic disease. Using IonOptix MyoStretcher and Calcium & Contractility systems, researchers found HFSD-fed mice had stiffer cells and slower Ca²⁺ decay—signs of diastolic dysfunction. shorturl.at/xDazR

Shortening the thick filament by partial deletion of titin's C-zone alters cardiac function by reducing the operating sarcomere length range Titin's C-zone is an inextensible segment in titin, comprised of 11 super-repeats and located in the cMyBP-C-containing region of the thick filament. Previously we showed that deletion of titin's supe...

A recent study reveals how a titin mutation alters thick filament length, driving dilated cardiomyopathy. Using the IonOptix MyoStretcher and CytoCypher MultiCell Systems, researchers measured changes in force, sarcomere length, and calcium handling. shorturl.at/H9b2r

Researchers modeled hypertrophic cardiomyopathy using human cardiac organoids derived from hiPSC-CMs carrying the MYBPC3 D389V variant. Using the IonOptix CytoCypher MultiCell System, they measured faster contractility and calcium kinetics. shorturl.at/rKqnN

Rbm20 antisense oligonucleotides alleviate diastolic dysfunction in a mouse model of cardiometabolic heart failure (HFpEF) AbstractAims. Heart failure with preserved ejection fraction (HFpEF) is prevalent, deadly, and difficult to treat. Risk factors such as obesity and hyperte

In this Cardiovascular Research study, researchers used IonOptix’s MyoStretcher and MultiCell systems to assess stiffness and calcium handling in cardiomyocytes. Targeting titin isoforms via Rbm20-ASO reduced stiffness and improved diastolic function. shorturl.at/UCf89

Researchers used IonOptix cardiomyocyte systems to study GPR41 function. Butyrate reduced cell shortening and Ca²⁺ transients in WT but not GPR41−/− mice, implicating GPR41 in modulating inotropy via cAMP signaling and SERCA2a activity.
Read more: shorturl.at/9TEEr

Such a pleasure to have Hanan from @ionoptix.bsky.social to come to FSU to help us setup this Ca2+ and contrqctility system to assess #cardiomyocyte function 🔬🧫🫀

Calcium transient imaging using an @ionoptix.bsky.social setup. On the bottom of the screen we can the pretty cardiomyocyte "beating". 🧪

Researchers used IonOptix cardiomyocyte systems to study GPR41 function. Butyrate reduced cell shortening and Ca²⁺ transients in WT but not GPR41−/− mice, implicating GPR41 in modulating inotropy via cAMP signaling and SERCA2a activity.
Read more: shorturl.at/9TEEr

Researchers used the IonOptix CytoCypher MultiCell to compare calcium handling and contractility in hiPSC-cardiomyocytes with or without sympathetic neurons. Coculture enhanced inotropy, chronotropy, and structure—supporting improved maturation. shorturl.at/fldct

Researchers feature IonOptix systems while highlighting the value of intact cardiomyocytes and tissue slices in HFpEF research. Preserving native environments yields more physiologically relevant insights than skinned preps.
Read more: shorturl.at/bK3pU

An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency | American Journal of Physiology-Heart and Circulatory Physiology | American Physiological Society The incidence of heart failure with preserved ejection fraction (HFpEF) in women significantly increases following menopause. This trend cannot solely be attributed to chronological aging, as evidence...

Using the IonOptix MyoStretcher, researchers revealed that diastolic dysfunction in a novel ovary-intact HFpEF mouse model stems from increased stiffness in ventricular myocytes—highlighting a link between menopause and HFpEF.
Read more: shorturl.at/T7gse

Microtubule destabilization with colchicine increases the work output of myocardial slices Cardiac microtubules have recently been implicated in mechanical dysfunction during heart failure. However, systemic intolerance and non-cardiac effec…

In this Journal of Molecular and Cellular Cardiology Plus publication from researchers at UVM, Hancock et al. demonstrate a novel method utilizing living myocardial slices to model early and late stage diastole using their IonOptix Cardiac Slice System. shorturl.at/4ShI6