Yuning Hong

Have you ever thought of using a fluorescent probe to specifically enrich and profile proteins with disordered regions?

Read below about RUBICON (reactive unfolded protein-based identification of cysteine on enrichment), a new workflow which enables the identification of the disordered proteome!

🎆 New #ToolsOfTheTrade 🎆

@shouxiang-zhang.bsky.social & owyongtc.bsky.social ( @yuninghong.bsky.social lab @latrobeuni.bsky.social )
profile disordered proteins using a chemical tag. Check out the workflow and potential applications below!

🔗 go.nature.com/414Qtfv

OG paper: go.nature.com/4i3AGok

Check out this piece by @shouxiang-zhang.bsky.social and @owyongtc.bsky.social on Nat Rev Mol Cell Biol! @latrobeuni.bsky.social

New Online! Profiling the disordered proteome in cells using a chemical tag

Come join us for the Medicinal Chemistry & Chemical Biology Conference 2025 (MCCB 2025)

Darwin Australia 🐊

mccb2025.com.au

Hi #TeamMassSpec! #FeMS+ has joined BlueSky! Please share and get the word out so we can build up a base here.

Global analysis of endogenous protein disorder in cells Nature Methods - This article reports a method based on a bifunctional chemical probe called TME and a workflow named RUBICON to capture, enrich and profile endogenous disordered proteins in cells....

Very excited to share our work out at Nature Methods on a new method (RUBICON) based on a chemical probe to target in situ, enrich and profile endogenous disordered proteins in cells, including #IDPs and those that acquire disorder. #ozchem #proteostasis #TeamMassSpec #proteomics
rdcu.be/d1ru3