Anand Padmanabhan

Third‐Generation Bruton tyrosine kinase Inhibitors for the Treatment of Monoclonal Gammopathy of Thrombotic Significance (MGTS) Click on the article title to read more.

Excited to publish on more treatment options for MGTS, a severe thrombotic disease. This study discusses the use of pirtobrutinib, a third-generation BTK inhibitor in the second case of "HIT-like" MGTS reported (1st case: Blood. 2023 Apr 6;141(14):1772-1776).

onlinelibrary.wiley.com/doi/10.1002/...

Mayo Clinic will be organizing this year‘s classical hematology conference in Arizona! If you work in this area or are curious to learn more about topics in this exciting field, join us! The link below provide more information and sign up instructions:

news.mayocliniclabs.com/mayo-clinic-...

Monoclonal Anti–Platelet Factor 4 Antibodies in Recurrent Pregnancy Loss | NEJM Two patients with monoclonal anti-PF4 antibodies, thrombosis, and chronic thrombocytopenia also had first-trimester pregnancy losses, findings that suggest a possible link between these antibodies ...

Are anti- platelet factor 4 antibodies a cause of recurrent miscarriage?
This data suggests they may be

www.nejm.org/doi/full/10....

Monoclonal Anti–Platelet Factor 4 Antibodies in Recurrent Pregnancy Loss | NEJM Two patients with monoclonal anti-PF4 antibodies, thrombosis, and chronic thrombocytopenia also had first-trimester pregnancy losses, findings that suggest a possible link between these antibodies ...

Along with collaborators at UT Southwestern Medical Center we report a study in the New England Journal of Medicine on the potential role of monoclonal anti-Platelet Factor 4 (PF4) antibodies in recurrent pregnancy loss. Larger studies to follow!

www.nejm.org/doi/full/10....

Great article in CAP TODAY on the expanding group of anti-PF4 disorders!! MGTS (monoclonal gammopathy of thrombotic significance) with its “flavors”, “HIT-like”, “VITT-like” & “non-HIT/VITT-like”, is going to be an important entity in the thrombophilia field!!
www.captodayonline.com/spectrum-of-...

Thanks to the Hematologist for spotlighting our work!!

'Unparalleled' snake antivenom made from man bitten 200 times Scientists hope to make a universal antivenom from the extraordinary blood of a man exposed to snake venom for decades.

The blood of a man who deliberately injected himself with snake venom for nearly 2 decades has led to an "unparalleled" antivenom, say scientists.

Antibodies found in his blood can protect against fatal doses from a wide range of species in animal tests.

🧪🩸🐍🐍🐍🐍
www.bbc.com/news/article...

Technology SpotlightUse of Mass Spectrometry to Study Antibody Clonality Leads to Identification of Novel Thrombophilia: Monoclonal Gammopathy of Thrombotic Significance Monoclonal gammopathy of clinical significance (MGCS) is a general descriptor of symptomatic diseases that are related to a monoclonal antibody (M-protein)

Excited to see technology developed by Dr. David Murray and I in the "Technology Spotlight" section of the "Hematologist". It helps detect a novel thrombophilia, MGTS. It is gratifying to see that this is providing answers to patients with this severe disorder.

ashpublications.org/thehematolog...

Investigation of Patient With Monoclonal Gammopathy of Thrombotic Significance Unmasks New Type of Platelet-Activating Anti-Platelet Factor 4 Antibody Kanack AJ, Leung N, Padmanabhan A. Diagnostic complexity in monoclonal gammopathy of thrombotic significance. N Engl J Med. 2024;391(20):1961-1963. PubMed

Thanks to the ASH for discussing a new flavor of anti-PF4 antibodies! This antibody we published on recently in the NEJM is neither HIT-like or VITT-like. Many thanks to @rapidnovor.bsky.social for their expertise! Here is the feature in the Hematologist:

ashpublications.org/thehematolog...

The new thrombophilia, MGTS gets more interesting, and complicated! Here is a new paper in NEJM from our group on the challenges of recognizing this disorder: www.nejm.org/doi/10.1056/...
Couple of other recent papers on MGTS: www.nejm.org/doi/full/10....
ashpublications.org/blood/articl...