Dr. Dale Bredesen

Those who ate the most riboflavin (vitamin B2) cut their dementia risk in half compared to those who ate the least in a new longitudinal study. Folate (B9) and vitamin B6 also reduced risk. https://www.eatingwell.com/riboflavin-for-lower-dementia-risk-study-11824281

Increasing daytime sleepiness and worsening circadian rest-activity rhythms were associated with a higher risk of dementia. This tiredness could be a symptom of an energy imbalance, where your brain demands more than it is being supplied. https://www.neurology.org/doi/10.1212/WNL.0000000000213403

Women are more likely to develop Alzheimer’s-related dementia than men, but a new study has found that men have higher hospitalization and mortality rates than women following a dementia diagnosis, even after adjusting for age and comorbidities. https://www.medpagetoday.com/neurology/dementia/116964

A precise, personalized brain stimulation was found to ease depression rapidly, and even reduced anxiety. The connection between mental health and dementia means this research is worth following. https://newatlas.com/mental-health/hd-tdcs-brain-stimulation-precise-depression/

In a new preprint, Dr. Ram Rao found that the ReCODE protocol significantly reduced depression scores in patients with cognitive impairment.

Read on to learn why ReCODE helps: https://www.apollohealthco.com/precision-medicine-protocol-shows-dual-benefits-improved-cognition-and-reduced-depression/

A recent study has found that high sugar intake can increase your risk of dementia by as much as 43%. Researchers also found that genetics can influence these numbers even further. But we already knew that, didn’t we? https://www.eatingwell.com/sugar-dementia-risk-study-11787744

We’ve highlighted the link between pollution/toxins and Alzheimer’s for years. Please take precautions, avoid polluted air when possible, use HEPA filters (or similar) in your home, and detox when air quality is low. https://jamanetwork.com/journals/jamaneurology/article-abstract/2838665

An antiparasitic used to treat pinworm can help lower the tau levels in mice. The drug targets misshapen nuclear speckles and restores their shape, reducing tau levels without causing cellular stress. https://today.ucsd.edu/story/antiparasitic-drug-shows-power-against-alzheimers-and-dementia

Join Judy Benjamin and me this Monday, September 29th at 11:00 am PT as we go LIVE to celebrate Judy’s incredible 2,000-mile milestone on her walk across America.

To sign up for the webinar, click here: https://us02web.zoom.us/webinar/register/WN_UsefeGqwRTu1XnlFUw905Q#/registration

Recent research from Brazil showed those consuming the greatest amount of these sweeteners experienced a 62% faster cognitive decline. https://www.medscape.com/viewarticle/sugar-substitutes-not-so-sweet-brain-health-2025a1000nes

Can exercise prevent or help treat cancer? According to new research, yes. The study found that a single exercise session of resistance or high-intensity interval training increased anti-cancer myokines and reduced the growth of cancer cells. Wow. https://pmc.ncbi.nlm.nih.gov/articles/PMC12259798/

According to Dariush Mozaffarian, the best vegetable (or really, fruit) for heart health is the avocado. It can help lower LDL cholesterol, and provides healthy fiber, potassium, & antioxidants. https://www.realsimple.com/the-one-vegetable-for-better-heart-health-according-to-a-cardiologist-11774184

Looking for a way to put all of your dementia-fighting skills to work? Visiting new locations stimulates your brain, gets you moving, and helps keep you social, helping to keep your brain sharp. https://nypost.com/2025/08/12/health/your-summer-travel-could-be-helping-you-prevent-dementia-heres-how/

A new analysis of the efficacy of lecanemab and donanemab found a high likelihood that the antibodies had no effect for those with 2 copies of APOE4. Given the higher risk of side effects, they recommend these individuals should not receive the treatment. https://pubmed.ncbi.nlm.nih.gov/40225236/

Herpes simplex virus type 1 is becoming an established risk factor for dementia, and evidence is building that treatment with antivirals for various infections may reduce dementia risk. https://www.medscape.com/viewarticle/can-preventing-treating-herpes-reduce-dementia-risk-2025a1000kna

A heart drug slowed accumulation of phosphorylated tau protein-217 (p-Tau 217) in those with cardiovascular disease in a new trial. While the drug targets cholesterol, much of the benefit may simply come from improved cardiovascular health. https://www.medpagetoday.com/meetingcoverage/aaic/116765

A combination of epigallocatechin gallate and nicotinamide can increase clearance of amyloid beta, improve energy metabolism, and reduce oxidative stress. https://news.uci.edu/2025/08/06/uc-irvine-researchers-find-combination-of-natural-compounds-for-brain-cleaning/

A decades-long study has found that superagers can have brains similar to those of people 30 years younger. The thing they seemed to have in common was active social lives (another recommendation of our protocol). https://www.popularmechanics.com/science/health/a65632918/superagers-brains/

Surprisingly, nighttime light doesn’t just ruin your sleep - it can disrupt your body in many other ways that also increase your risk of cognitive decline and dementia. https://scitechdaily.com/the-surprising-ways-nighttime-light-wrecks-your-brain-and-body/

We’ve long documented that reducing stress has cognitive benefits, but how do you actually do it? The Independent documents four easy techniques that are worth a try. https://www.independent.co.uk/health-and-fitness/four-brain-hacks-stress-reduction-vagus-reset-b2806735.html

New research has found that COVID-19, as well as a bacterium causing pneumonia (Chlamydia pneumoniae), can increase your risk of dementia. In our protocol, we include treatment of such infections. https://medicalxpress.com/news/2025-07-links-covid-bacterial-infection-alzheimer.html

I recommend our KetoFLEX 12/3 program, but a recent study found that the other four diets listed above can also reduce your risk of dementia. https://www.sciencealert.com/major-study-links-4-healthy-diets-with-up-to-28-lower-dementia-risk

Researchers found that grandparents who spend a moderate amount of time caring for their grandchildren had a 24% less likely chance of developing dementia. https://www.mcknights.com/news/moderate-amount-of-caring-for-grandchildren-protects-against-dementia-in-seniors-new-study-finds/

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August 4th, 2025 will forever be known as Dr. Judy Benjamin Day in Austin, Texas! https://youtube.com/shorts/UuDxZgumSfQ?si=ZnSJd0GcU1mE1xaU

New research has found that loss of visual sensitivity can predict dementia 12 years before diagnosis (one surprise in this work—watching TV or reading books was associated with reduced risk). https://www.sciencealert.com/your-vision-can-predict-dementia-12-years-before-a-diagnosis-study-discovers

A new study has found that fasting produces ketones like β‑hydroxybutyrate that attach themselves to misfolded proteins and steer them to the brain’s recycling system. https://www.earth.com/news/ketone-bodies-compound-produced-during-fasting-improves-brain-health/

Join Dr. Dale Bredesen and Judy Benjamin on Tuesday, August 5th at 1:30pm PT to celebrate Judy reaching the halfway mark of her inspiring walk across America. Register here: https://us02web.zoom.us/webinar/register/WN_jnKH1ZkTSG2yS8otnlfdQw#/

Cycling during middle age can significantly lower your risk of developing several different types of dementia. Great to see that so much new research is confirming what we’ve been saying for over a decade. https://www.thecooldown.com/outdoors/cycling-reduces-risk-dementia-brain-health-study/

Achieving an Ageless Brain is profoundly influenced by what you eat. Real Simple highlighted 6 foods centenarians almost never eat, and their list aligns well with KetoFLEX 12/3. https://www.realsimple.com/foods-centenarians-rarely-eat-8737190

Looking forward to joining The DNA Company for a webinar because they understand that your genes are not your destiny! Come join us for this talk on the role of APOE, our research, and how you can protect yourself. https://us02web.zoom.us/webinar/register/WN_kIlN9pf7S6yQ_vMJtQF6ZA