Inna Nechipurenko

Experience-dependent reconfiguration of thermoreceptors regulates neuronal response plasticity Harris, Dutta, et al. find that experience-dependent plasticity in the activation threshold of the AFD thermosensory neurons is mediated by modulating warm and cold thermoreceptor levels at the sensor...

Our first 2026 paper is out @currentbiology.bsky.social!
👏 to @nathancsharris.bsky.social (now Asst Prof, GA State) and PD Priya Dutta.

Here we show how transcriptional and trafficking pathways coordinate thermoreceptor levels to precisely modulate response plasticity
www.cell.com/current-biol...

Congrats to all! 🎉

Friends! I am so happy to share our new preprint!

Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago.

How do animals like C. elegans sense it fast and escape?

www.biorxiv.org/content/10.6...

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In #GENETICS, @inechipurenko.bsky.social and colleagues studied the effects of mutations in the GNAI1, a G protein–coupled receptor gene, identifying their effects on ciliogenesis in human cells and #Celegans. buff.ly/MF1bSVn

Thank you! We are excited to get this story out.

More new science from the lab! Led by @nathancsharris.bsky.social (now at GA State) and PD Priya Dutta.

We describe how experience tunes the ratios of functional receptors in a single sensory neuron via coordinating transcriptional and post-transcriptional mechanisms to drive response plasticity.

C. elegans Community Mentor Match 2024 feedback survey Thank you for providing feedback about your experiences as a mentee, mentor, and peer group member in this year's C. elegans Community Mentor Match program! Please skip questions that are not relevan...

Worm people: Were you a mentor, mentee, or in a peer-mentoring group in the C. elegans Mentor Match program last year? We need your feedback!

Please fill out this quick survey to help us evaluate the program and improve it for the coming year.

forms.gle/KKDtZwFdEzjP...

Synthetic GPCRs for programmable sensing and control of cell behaviour - Nature Modular synthetic G-protein-coupled receptors with nanobody-based ligand-recognition domains can be designed and used to programme transgene expression, real-time fluorescence or endogenous G-protein ...

Amazing new work from the lab of @aliceyting.bsky.social @stanfordmedicine.bsky.social @stanfordbiosci.bsky.social, engineered GPCRs for ligand-activated cell responses

www.nature.com/articles/s41...

Cilia structure and intraflagellar transport differentially regulate sensory response dynamics within and between C. elegans chemosensory neurons The relative contributions of intraflagellar transport (IFT) and cilia structure to sensory neuron responses remains unclear. This study reveals unexpected complexity in the contribution of IFT and ci...

🧪 Lab's latest!! Work by PD (and now PI) Alison Philbrook.
C. elegans sensory neurons have gorgeous #cilia. We’ve always thought that a) no cilia = no sensory responses, & b) no IFT = no cilia. Punchline is we thought wrong. Read paper for more!
#neuroscience
journals.plos.org/plosbiology/...

Hey bluesky friends! We are hiring a tenure-track faculty with a focus on human-plant interactions 🌱

Get this: we want graduating PhDs and early postdocs to apply! 🤯

We really want candidates that'll advance diversity, equity, and inclusion. I am in the search committee. Contact me if interested!

Congratulations, Piali!!! That’s terrific!

Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans - Natu... To overcome challenges posted by vast number of GPCR genes and redundancy, the authors disrupted nearly all GPCR-encoding genes in C. elegans, enabling effective examination of GPCR signaling and offe...

All #Celegans peeps! Drawing your attention to this really amazing tour-de-force from Changchun Chen's lab (with a small contribution from us). An incredible resource of strains with combos of 1654 GPCRs KO'd. Deals with the issue of gene duplication and redundancy.
www.nature.com/articles/s41...

Nanometer-scale views of visual cortex reveal anatomical features of primary cilia poised to detect ... bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Another spectacular paper about cilia and their structural and positional diversity in the brain. Wonder why oligodendrocytes and microglia don't have 'em but astrocytes do.
From Carolyn Ott at Janelia
🧪 🧠🟦
www.biorxiv.org/content/10.1...

Aging folks, my university is hiring!

We really want candidates that'll advance diversity, equity, and inclusion. Please share widely and feel free to ask me any questions!

Abstract submission for #TAGC24 is open now through Nov 9! Topics include Neurogenetics, Genomes & Genomics, Ecological Genetics, plus model organism meetings, amazing keynotes, industry sessions, career/networking events & much more.
genetics-gsa.org/tagc-2024/ab...

bioRxiv goes big on Bluesky: accounts for all subject categories now available (Please Reskeet) connect.biorxiv.org/news/2023/09...

Move to Massachusetts? It’s been 70s and grey pretty much every weekend this summer

Lily Jan and Eve Marder to receive 2023 Pearl Meister Greengard Prize - News Groundbreaking neuroscientists Lily Jan and Eve Marder will jointly receive the 2023 Pearl Meister Greengard Prize, an award which recognizes outstanding women scientists. The award will be presented ...

Two groundbreaking women neuroscientists. Eve has been an incredible mentor and friend and support system over my time at Brandeis. Congrats to Eve and Lily!
www.rockefeller.edu/news/34584-l...