Duke Genomics

From one to many gene therapies Instead of making one-off treatments, industrialized gene therapy might be able to treat multiple diseases.

Gene therapy is rapidly changes with new technologies and abilities. An article in Nature goes through some of these updates, including work by our own Charlie Gersbach:
www.nature.com/articles/d41...
#genetics #genetherapy #DukeUniversity

North Carolina Businessman and Philanthropist David Murdock Dies at 102 The Duke Clinical and Translational Science Institute (CTSI) and Duke Health mourn the passing of David H. Murdock, a visionary philanthropist and the namesake of the MURDOCK Study, who died at the ag...

A life well lived. Thank you, David Murdock, for all you have given to Duke University and the MURDOCK Study.
ctsi.duke.edu/news/north-c...

From Data to Decisions: A Model for Returning Individual Results to Research Participants Duke researchers have developed a model for how to effectively communicate research results to patients and help empower them towards their health and medical choices.

Returning research results to clinical study participants has not been the norm, even for those with abnormal findings. The paradigm, though, is shifting, with #ROR becoming not only a scientific responsibility but also an ethical imperative.
medschool.duke.edu/news/data-de...

Congratulations to Anne West on being awarded a distinguished professorship.
Dr. West is now the George Barth Geller Distinguished Professor of Neurobiology.
today.duke.edu/2025/03/duke...

Congratulations to Greg Crawford on being awarded a distinguished professorship.
Dr. Crawford is the Wilburt C. Davison Distinguished Professor in Pediatrics
today.duke.edu/2025/03/duke...

Congratulations to Gregory Wray for receiving the Gordon G. Hammes Faculty Teaching Award
medschool.duke.edu/news/duke-un...

Celebrating TIME100 Health 2025’s Most Influential Leaders in Oncology - OncoDaily Celebrating TIME100 Health 2025’s Most Influential Leaders in Oncology / Abasi Ene-Obong, AmirAli Talasaz, Andre Esteva, Andrea Cercek, Arianna Huffington,

Shelley Hwang was named on this year's TIME100 Health 2025 List for Cancer Innovators as a pioneer for less invasive treatments for early-stage breast cancer, challenging traditional approaches to surgery and radiation.
oncodaily.com/blog/time100...

Sequencing & Genomic Technologies director Devjanee Swain Lenz will join QIAGEN for a live webinar on May 12 at 11 AM to discuss how to set up your microRNA sequencing project for success.
duke.is/2/3rky
#RNA #sequencing #miRNA

OneDukeGen Overview YouTube video by Duke Center for Precision Health

The OneDukeGen research study is working to build a healthier future for everyone. By studying blood or saliva for #genetic material collected from 150,000 people, researchers can better understand how our #genes affect our #health.
www.youtube.com/watch?v=9gwD...

A great opportunity!

PGC Pilot Grants Invest in the Future of Science The Precision Genomics Collaboratory (PGC) is committed to supporting graduate students in scientific and educational efforts that bolster their graduate training experiences.

To date, we've given out nearly 100 student pilot grants. Here's how some of them have used these funds to enhance their educational and professional experiences: medschool.duke.edu/blog/pgc-pil...

Duke is one of the largest biomedical research enterprises in the country. A cut of this magnitude (15%cap on F&As) would result in thousands of lost jobs at Duke & potentially tens of thousands across NC.
Sources: medschool.duke.edu/about-us/fac... & www.unitedformedicalresearch.org/nih-pdf/?sta...

Advancing Prenatal, Postnatal Care Through Early Genetic Insight Pregnancy is exciting and terrifying. Expectant mothers picture their lives when they are finally able to hold the baby growing inside of them in their own arms. But many also worry about making sure ...

Jennifer Cohen helped develop a treatable fetal findings list that uses genetic testing results during pregnancy to treat in utero or prepare to treat immediately following birth. This may improve care for mothers and babies and help deliver more healthy babies.

ctsi.duke.edu/blog/advanci...

PGC Faculty Among Those Awarded Distinguished Professorships Duke University has awarded distinguished professorships to 31 faculty members and will recognize them in a ceremony at the Washington Duke Inn on May 14. Among those awarded are four Precision Genomi...

Congrats to all of the newest distinguished professors at Duke, especially the 4 in the Precision Genomics Collaboratory.
medschool.duke.edu/blog/pgc-fac...

Join leading experts for a deep dive into the intersection of proteomics, transcriptomics, & Alzheimer’s drug discovery. This webinar explores the data pipeline fueling breakthroughs in personalized medicine, accelerating efficiency, & enhancing accuracy in dementia research.
zoom.us/webinar/regi...

Project Baseline Study Watch Resting Heart Rate Correlates with ECG A study found that resting heart rate measured with an investigational watch worn during the Project Baseline Health Study correlated strongly with electrocardiography (ECG), considered the gold stand...

Precision Genomics Collaboratory Director Svati Shah was part of a team that found resting heart rate measured with an investigational watch worn during the Project Baseline Health Study strongly correlated with electrocardiography (ECG), considered the gold standard.
ctsi.duke.edu/news/project...

The Clinical Microbiome This joint Collection invites submissions of cutting-edge translational and clinical research, including microbiome-based diagnostics, therapeutics, ...

📢Excited to announce a new collection open for submission - The Clinical Microbiome. 💉🦠
Led by @naturecomms.bsky.social with participation from @naturemedicine.bsky.social, @naturemicrobiol.bsky.social, and @commsmed.bsky.social
Details:
www.nature.com/collections/...

#Microsky #MicrobiomeSky

Endothelial SHANK3 regulates tight junctions in the neonatal mouse blood-brain barrier through β-Catenin signaling - Nature Communications This study reveals that SHANK3 deficiency in brain endothelial cells disrupts BBB function during the neonatal period through β-Catenin imbalance, leading to ASD-related neuronal and behavioral abnorm...

Excited to share exciting new work from my former postdoc, Il Hwan Kim. His study reveals that SHANK3, an ASD-risk gene, is expressed in brain endothelial cells and plays a crucial role in maintaining tight junction integrity at the blood-brain barrier.

www.nature.com/articles/s41...

This blog commemorates today's #RareDiseaseDay with a selection of articles, collections, clinical study registrations and blog posts chosen by our publishers: http://spklr.io/633282U5e

Two Duke Nephrologists Elected to American Society for Clinical Investigation Two Duke Department of Medicine faculty members, physician-scientists Opeyemi A. Olabisi, MD, PhD, and Tomokazu Souma, MD, PhD, are among the 2025 researchers elected to the American Society for Clini...

Congratulations to Drs. Olabisi and Souma for being elected into the American Society for Clinical Investigation!

medicine.duke.edu/news/two-duk...

New Grant to Address Hidden Hypoxemia Pulse oximetry has long been trusted as a key diagnostic tool. However, for patients with darker skin tones, this technology may not be accurate. A new grant aims to fix that.

Pulse oximetry monitors oxygen levels in patients, but for those with darker skin tones, the equipment isn't always reliable. A. Ian Wong and team received a $3.4M to develop methods and technology to improve the accuracy of pulse oximetry. ctsi.duke.edu/blog/new-gra...

Activating Complex Regions of the Genome to Treat Rare Diseases | Duke Pratt School of Engineering Researchers find a master epigenetic switch that activates silenced genes to compensate for their missing counterparts in a rare genetic disease called Prader-Willi syndrome

Researchers find a master #epigenetic switch that activates silenced genes to compensate for their missing counterparts in a rare genetic disease called #Prader-Willi syndrome
pratt.duke.edu/news/crispr-...
#epigenome #genomics #CRISPR

What Comes Next: Genomics and Precision Health Dr. Svati Shah, a leader in cardiovascular genetics at Duke, directs the OneDukeGen program, aiming to sequence 150,000 patients to identify actionable genetic variants. Her vision is a future where g...

Genomics and Precision Health, in the words of PGC Director, Svati Shah:
"That’s my dream: Instead of the trial-and-error way we currently practice medicine, we’ll have a much more precise way that we deliver care and, hopefully, prevent disease entirely." medschool.duke.edu/news/what-co...

EXTENDing Hope: Artificial Wombs for Safer Neonatal Development For expectant mothers, going into labor early can be terrifying. Premature babies are at an increased risk for serious health problems. The earlier a baby is born, the higher risk of health challenges...

An artificial womb holds promise for helping premature babies face less health risks. New research from Duke and CHOP show that in animal models, the EXTEND artificial womb model is both safe and effective. Read more: medschool.duke.edu/blog/extendi...

Reaching New Heights in Cancer Care Patients with ductal carcinoma in situ (DCIS) are usually treated with surgery and radiation, even though it may not develop into invasive breast cancer. Dr. Shelley Hwang recently presented a study s...

Early in her career, surgical oncologist Shelley Hwang questioned the practice of treating patients diagnosed with certain breast cancer with mastectomies or lumpectomies. Now, she's showing less aggressive alternatives may be available
medschool.duke.edu/stories/reac...

Highlights from the 4th Annual Genomics Scientific Retreat The Duke School of Medicine Precision Genomics Collaboratory (PGC) held the fourth annual Genomics Scientific Retreat on December 13 in the Trent Semans Center Great Hall.

What a better way to introduce ourselves here than by sharing a wrap-up of our #Genomics Scientific Retreat? The day featured two keynote speakers, 13 short talks, and almost 30 posters: medschool.duke.edu/blog/highlig...