Bertoglio lab (FMC/UFSC)

PV - Oligodendrocyte Interactions in the Infralimbic Cortex Promote Extracellular Plasticity after Safety Learning Safety learning is mediated by the infralimbic region (IL) of the medial prefrontal cortex, but its cellular mechanisms are poorly understood. Here we show that safety learning improves cognitive flex...

PV - Oligodendrocyte Interactions in the Infralimbic Cortex Promote Extracellular Plasticity after Safety Learning
www.biorxiv.org/content/10.1...

Backward Conditioning Reveals Flexibility in Infralimbic Cortex Inhibitory Memories While the infralimbic cortex (IL) is recognized as critical for behavioral inhibition, the content of the inhibitory memories stored in this region remains elusive. To probe this content, we examined ...

Backward Conditioning Reveals Flexibility in Infralimbic Cortex Inhibitory Memories
www.biorxiv.org/content/10.1...

A synaptic mechanism for encoding the learned value of action-derived safety Motivated behavior is often framed in terms of biologically grounded outcomes, such as food or threat. Yet many motivated actions, like the pursuit of safety or agency, depend on outcomes that lack ex...

A synaptic mechanism for encoding the learned value of action-derived safety
www.biorxiv.org/content/10.1...

A reciprocal interplay between 5-HT2A and mGlu5 receptors underlies neuroplasticity The serotonin (5-HT)2A receptor is the primary target of numerous psychoactive drugs including serotonergic psychedelics, and mediates psychedelics-induced neuroplasticity, but the signaling mechanism...

A reciprocal interplay between 5-HT2A and mGlu5 receptors underlies neuroplasticity
www.biorxiv.org/content/10.1...

Electrophysiological effects of psilocybin co-administered with midazolam The serotonergic psychedelic psilocybin induces glutamatergic neural plasticity and profoundly alters consciousness. Midazolam, a benzodiazepine and positive allosteric modulator of GABAA receptors, b...

Electrophysiological effects of psilocybin co-administered with midazolam
www.biorxiv.org/content/10.1...

A common denominator: PTSD, rapid eye movements, and fear extinction | PNAS A common denominator: PTSD, rapid eye movements, and fear extinction

A common denominator: PTSD, rapid eye movements, and fear extinction
www.pnas.org/doi/10.1073/...

Variability in threat processing is related to endogenous butyrate levels in healthy men
doi.org/10.1016/j.bi...

The ventral midline thalamus: participation in neurological and neuropsychiatric disorders
doi.org/10.1016/j.ne...

PET imaging evidence of HDAC6 suppression in the amygdala across species in PTSD - Molecular Psychiatry Molecular Psychiatry - PET imaging evidence of HDAC6 suppression in the amygdala across species in PTSD

PET imaging evidence of HDAC6 suppression in the amygdala across species in PTSD
www.nature.com/articles/s41...

Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function The dorsal and ventral hippocampus have distinct processing properties, but it remains unclear if interneuron subtypes differ in connectivity along the dorsoventral axis. Oriens lacunosum-moleculare ...

Differentiated Presynaptic Input to OLMɑ2 Cells Along the Hippocampal Dorsoventral Axis: Implications for Hippocampal Microcircuit Function
onlinelibrary.wiley.com/doi/10.1002/...

Brain Organoids in the Study of Psychiatric Disorders This article discusses the use of brain organoids in modeling the biological mechanisms of psychiatric disease.

Brain Organoids in the Study of Psychiatric Disorders
jamanetwork.com/journals/jam...

Influence of environmental conditions and seasonality on the metabolome and lipidome of Psychotria viridis leaves The metabolic pathways presenting significant variation in response to seasonality were associated with energy production through the biosynthesis and consumption of carbohydrates. In contrast, the b...

DMT concentrations did not exhibit any significant statistical variation across the studied conditions...
doi.org/10.1111/tpj....

Open-source, high performance miniature 2-photon microscopy systems for freely behaving animals - Nature Communications Madruga and colleagues present an open-source, miniature 2-photon microscope that can fit on a mouse’s head. Using this system, the authors perform high-resolution brain activity measurements in fine ...

Open-source, high performance miniature 2-photon microscopy systems for freely behaving animals
www.nature.com/articles/s41...

Chronic stress in mice: how gut bacteria influence gene activity in key brain neurons - Translational Psychiatry Translational Psychiatry - Chronic stress in mice: how gut bacteria influence gene activity in key brain neurons

Chronic stress in mice: how gut bacteria influence gene activity in key brain neurons
www.nature.com/articles/s41...

The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation - Nature Neuroscience Aarrestad et al. show that, in contrast to psychedelics, the nonhallucinogenic psychoplastogen tabernanthalog promotes neuroplasticity through 5-HT2AR activation without immediately increasing extrace...

The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation
www.nature.com/articles/s41...

Evidence of Disrupted Hippocampal Gray- and White-Matter Development in Adolescent Anxiety Disorders, Independent From Early-Life Stress
onlinelibrary.wiley.com/doi/10.1002/...

Molecular and cellular rhythms in excitatory and inhibitory neurons in the mouse prefrontal cortex Abstract. While previous studies have found rhythms in gene expression in the prefrontal cortex (PFC), the contribution of different cell types and potenti

Molecular and cellular rhythms in excitatory and inhibitory neurons in the mouse prefrontal cortex
academic.oup.com/cercor/artic...

DNA methylation regulates the extinction of fear memory
doi.org/10.5498/wjp....

Fear extinction using a conditioned stimulus that was temporally proximal to the unconditioned stimulus reduces physiological and subjective return of fear
doi.org/10.1016/j.br...

Encoding-retrieval similarity reveals distinct neural reinstatement of safety memories following counterconditioning in PTSD
doi.org/10.1016/j.bp...

Dual lineage origins contribute to neocortical astrocyte diversity - Nature Communications Astrocytes display diverse molecular and functional features in the brain, but the developmental origins of this heterogeneity are not well understood. Here, the authors show that two separate progeni...

Dual lineage origins contribute to neocortical astrocyte diversity
www.nature.com/articles/s41...

A role for the thalamus in danger evoked awakening during sleep - Nature Communications The extent to which the sleeping brain can discern safety from danger is poorly understood. In mice, the authors show that centro-medial thalamic neurons detect threat-related sounds and selectively t...

A role for the thalamus in danger evoked awakening during sleep
www.nature.com/articles/s41...

Effect of ketamine and esketamine on RNA expression and its relevance for depression: a systematic review Treatment-resistant depression (TRD) remains a challenge in psychiatry, necessitating novel therapeutic strategies beyond traditional monoaminergic an…

Effect of ketamine and esketamine on RNA expression and its relevance for depression: a systematic review
www.sciencedirect.com/science/arti...

Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state Optogenetic manipulations and neural circuit interrogation reveal that dorsal raphe dopamine circuits can emulate different facets of a loneliness-like state, including prosociality, aversion, and vig...

Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state
elifesciences.org/articles/105...

Effects of naturalistic doses of cannabis edibles on cognition and association with blood THC - Psychopharmacology Background Smoked cannabis is known to have effects on cognitive function. The use of edibles is on the rise yet there are few studies of the effects of edibles on cognitive function. Further, most st...

Effects of naturalistic doses of cannabis edibles on cognition and association with blood THC
link.springer.com/article/10.1...

Rapid deep brain chemogenetics: Minimally invasive, genetically targeted deep brain stimulation is achieved using ultrasound-activated nanocrystals Minimally invasive, genetically targeted deep brain stimulation is achieved using ultrasound-activated nanocrystals

Rapid deep brain chemogenetics: Minimally invasive, genetically targeted deep brain stimulation is achieved using ultrasound-activated nanocrystals
www.science.org/doi/10.1126/...

Serotonin 2A (5-HT2A) receptor as evolving biological target: function, structure, ligands and role in the therapy of neuropsychiatric diseases. The serotonin 5-HT2A receptor is a G-protein-coupled receptor that plays a critical role in numerous physiological processes within the central nervou…

5-HT2A receptor as evolving biological target: function, structure, ligands and role in the therapy of neuropsychiatric diseases
www.sciencedirect.com/science/arti...

Long-lived cellular molecules in the brain In long-lived mammals, including humans, brain cell homeostasis is critical for maintaining brain function throughout life. Most neurons are generated during development and must maintain their cellul...

Long-lived cellular molecules in the brain
www.cell.com/trends/neuro...

Control Group Outcomes in Psilocybin, SSRI, or Esketamine Trials for Depression This meta-analysis compares depression rating outcomes among patients receiving control treatments in randomized clinical trials of psilocybin vs trials of selective serotonin reuptake inhibitors (SSR...

Control group outcomes in trials of psilocybin, SSRIs, or esketamine for depression: A meta-analysis
doi.org/10.1001/jama...

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus - Nature Neuroscience The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...

An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus
www.nature.com/articles/s41...