Bertoglio lab (FMC/UFSC)

Locus coeruleus-amygdala circuit disrupts prefrontal control to impair fear extinction
doi.org/10.1073/pnas...

The dynamic basis of G-protein recognition and activation by a GPCR - Nature Conventional and time-resolved cryo-electron microscopy reveal how NTSR1 dynamically engages and releases different G proteins, capturing over 20 intermediates and uncovering key mechanistic step...

The dynamic basis of G-protein recognition and activation by a GPCR
www.nature.com/articles/s41...

Deconstruction of a memory engram reveals distinct ensembles recruited at learning - Nature Neuroscience Pouget et al. identified distinct CA1 neuron ensembles active during specific moments of fear learning and uncovered the core engram essential for memory formation.

Deconstruction of a memory engram reveals distinct ensembles recruited at learning
www.nature.com/articles/s41...

The impact of dendritic mitochondrial heterogeneity on synapse function Mitochondria are energy- and metabolite-producing organelles that are differentially distributed throughout neuronal axons and dendrites to meet unique energy demands. Emerging evidence indicates that...

The impact of dendritic mitochondrial heterogeneity on synapse function
www.cell.com/trends/neuro...

Functional selectivity of cannabinoids at CB1 receptors
doi.org/10.1016/j.ej...

The role of amygdala GABA neurons in controlling stress and reproduction in female mice
www.nature.com/articles/s41...

The emergence of neuropsychiatric symptoms in preclinical Alzheimer’s disease: An emotion regulation perspective Turnbull and colleagues propose an emotion regulation (ER) process-oriented framework for understanding the emergence of neuropsychiatric symptoms (NPSs) in preclinical Alzheimer’s disease (AD), highl...

The emergence of neuropsychiatric symptoms in preclinical Alzheimer’s disease: An emotion regulation perspective
www.cell.com/neuron/fullt...

Cannabis and Mental Health This Review summarizes the current evidence on the effects of cannabis on commonly encountered mental health conditions and provides clinicians with basic information about cannabis pharmacology and b...

Cannabis and Mental Health: A Review
doi.org/10.1001/jama...

Confronting mortality: A meta-analysis and systematic review of psychedelic experiences and death anxiety
doi.org/10.1177/0269...

Directional dynamics in the entorhinal cortex of male mice driven by behavioral constraints
www.nature.com/articles/s41...

Effects of doxycycline on intrusive experimental trauma memory: a pre-registered, randomized double-blind placebo-controlled trial
www.nature.com/articles/s41...

“Beyond the Toad’s Kiss: Mapping Acute 5-MeO-DMT Effects on Brain Connectivity Across Sex and Dose Using Awake Rat Neuroimaging” 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a potent serotonergic psychedelic with rapid therapeutic potential for depression and anxiety disorder…

Beyond the Toad’s Kiss: Mapping Acute 5-MeO-DMT Effects on Brain Connectivity Across Sex and Dose Using Awake Rat Neuroimaging
www.sciencedirect.com/science/arti...

Efficacy and risks of psychedelics in treatment of posttraumatic stress disorder: A systematic review AbstractPurpose. The purpose of this review is to evaluate which psychedelics have the most efficacy data to support their use in the treatment of posttrau

Efficacy and risks of psychedelics in treatment of PTSD: A systematic review
doi.org/10.1093/ajhp...

Acute and long-term psychiatric consequences of synthetic cannabinoids and related novel psychoactive substances: A systematic review
doi.org/10.1016/j.ps...

Corticotropin-releasing factor and somatostatin neurons in the central amygdala mediate dynamic defensive behaviors during fear extinction Traumatic experiences can result in heightened fear responses to trauma-associated stimuli. These symptoms can be difficult to extinguish, so identifying neuronal targets for facilitating fear extinct...

Corticotropin-releasing factor and somatostatin neurons in the central amygdala mediate dynamic defensive behaviors during fear extinction
doi.org/10.1523/jneu...

Fear extinction induces maladaptive generalization via noradrenergic and GABAergic systems | PNAS Exposure therapy for anxiety disorders relies on fear extinction to reduce pathological fear responses. Here, we show that while effective at dimin...

Fear extinction induces maladaptive generalization via noradrenergic and GABAergic systems
doi.org/10.1073/pnas...

Investigational drugs in PTSD | Neuropsychopharmacology share.google/c0JvpTfGjQWq...

The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression - Molecular Psychiatry Molecular Psychiatry - The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression

The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression
www.nature.com/articles/s41...

Mitochondrial dynamics in neurodevelopment and neurodevelopmental disorders - Nature Reviews Neuroscience Mitochondria make essential contributions to neural development. Zhao and colleagues provide an overview of the mechanisms that regulate mitochondrial biogenesis, degradation, remodelling and transpor...

Mitochondrial dynamics in neurodevelopment and neurodevelopmental disorders
www.nature.com/articles/s41...

Cannabidiol reduces the latency for the behavioral effect of escitalopram in chronically stressed male mice: involvement of NAPE-PLD expressed in parvalbumin-positive interneurons and the prefrontal cortex
www.sciencedirect.com/science/arti...

The Adrenal is Doing What it’s Supposed to Do, You Just Don’t Understand it Exposure to early life adversity is thought to induce long-term alterations in the hypothalamic-pituitary-adrenal (HPA) axis activity and regulation, …

The Adrenal is Doing What it’s Supposed to Do, You Just Don’t Understand it
www.sciencedirect.com/science/arti...

Circadian changes in CA1 LTP are driven by shifts in excitation–inhibition balance and reverse direction after puberty in mice. Long-term potentiation (LTP), the best-characterized form of Hebbian synaptic plasticity, is well known to be under strong circadian regulation. In mice and rats, both nocturnal species, most studies ...

Circadian changes in CA1 LTP are driven by shifts in excitation–inhibition balance and reverse direction after puberty in mice
www.jneurosci.org/content/earl...

A repeated low-dose regimen of MDMA has transient next-day effects on locomotor activity, anxiety-like behavior, and brain serotonin levels, with no effect on anhedonia-like behavior, in both female a... Psychopharmacology - MDMA (3–4 methylenedioxymethamphetamine) assisted psychotherapy has gained considerable attention as a potential adjuvant therapy for post-traumatic stress disorder...

A repeated low-dose regimen of MDMA has transient next-day effects on locomotor activity, anxiety-like behavior, and brain serotonin levels, with no effect on anhedonia-like behavior, in both female and male rats
link.springer.com/article/10.1...

A neuromodulatory circuit-to-molecular pathway for reformatting aversive memories during recall Tan et al. identify a neuromodulatory circuit-to-molecular pathway in rats that updates aversive memories when they are recalled. Noradrenaline from the locus coeruleus triggers synapse-to-nuclear tra...

Excited to share our new paper:
We uncover a locus coeruleus→amygdala circuit linking β-adrenergic signaling to transcription regulation in defined amygdala cells during memory reconsolidation—+ stress or elevated noradrenergic signaling at recall can strengthen memory.
www.cell.com/neuron/abstr...

Ayahuasca, DMT, and Mental Health: A Current Review of Scientific Studies - Current Addiction Reports Current Addiction Reports - Summarizes preclinical and clinical evidence on ayahuasca—a traditional Amazonian brew combining N, N-Dimethyltryptamine (DMT) and β-carbolines—in...

Ayahuasca, DMT, and Mental Health: A Current Review of Scientific Studies
link.springer.com/article/10.1...

A Promise Without Panacea: Psychedelic-Assisted Therapies in Modern Psychiatry Psychedelic-assisted therapies have re-emerged as a subject of increasing scientific and clinical interest in psychiatry, particularly in the context of persistent treatment gaps for conditions such a...

A Promise Without Panacea: Psychedelic-Assisted Therapies in Modern Psychiatry
doi.org/10.7759/cure...

Peripheral nerve stimulation using tDCS can enhance reconsolidation but cannot mitigate retrieval-induced forgetting
doi.org/10.1016/j.bi...

Redefining the central pattern generator for vertebrate locomotion - Nature Reviews Neuroscience The neuronal circuits that comprise the spinal cord central pattern generator (CPG) orchestrate the rhythmic and coordinated motor activity that underlies locomotion. El Manira describes recent advances in our understanding of the organization and operation of the CPG, highlighting findings that have revealed its distributed, modular and adaptable nature.

Redefining the central pattern generator for vertebrate locomotion
www.nature.com/articles/s41...

ACC in complex associative learning: monitoring action state and action content
elifesciences.org/reviewed-pre...