Laura

Jane Goodall: A Life in Pictures

RIP Jane Goodall.. www.nytimes.com/2025/10/01/s...

☀️ We are happy to have Jente Meijer from the Bonn–Melbourne Joint PhD Program visiting us in Bonn this week! ☀️
Her talk “Towards precision psychiatry using multi-view clustering approaches” was a wonderful opportunity to learn how machine learning can be applied in psychiatry. 🎓🧠💻

Former NIH Director Francis Collins retires suddenly, makes plea to protect agency staff Geneticist abruptly announced his resignation over the weekend

www.science.org/content/arti...

Stop the CDU demanding information from NGOs that impinge on their freedom of speech, including the freedom to attend anti-right demos despite govermental funding - please sign the petition: weact.campact.de/petitions/sc...

Interesting new preprint:

Polygenic contributions to lithium augmentation outcomes in antidepressant non-responders with unipolar depression: www.medrxiv.org/content/10.1...

Systematic assessment of COVID-19 host genetics using whole genome sequencing data Author summary After infection with SARS-CoV-2, symptoms vary widely. On average, individuals who are older, males and those with certain comorbidities tend to be more severely affected by COVID-19. A...

Happy to share our newest work on #covid19 #hostgenetics ! An analysis of >1000 whole genomes with @kuludwig.bsky.social and Axel Schmidt at University of Bonn and Uniklinik Bonn, the DeCOI consortium and many colleagues from around Germany & beyond. #plospathogens
journals.plos.org/plospathogen...

✨Psygenomics Lab escapes the psych ward! ✨

We had a lot of fun at our early Christmas outing at the psychiatry-themed escape room! 🧠🕵️‍♀️🎄

Happy new year! (It‘s been a while since I enjoyed the vast horizons on bluesky…)

Phenotype integration improves power and preserves specificity in biobank-based genetic studies of m... Phenotype imputation increases the effective sample size of major depressive disorder cases in UK Biobank, enhancing study power and polygenic risk score (PRS) accuracy. A new pleiotropy metric enable...

New paper by Andy Dahl and I on phenotype integration improving GWAS power while preserving specificity is now out in Nature Genetics 🧬🎉 thank you all collaborators and reviewers!

www.nature.com/articles/s41...

My current view of psychological/psychiatric science: we have to be an order of magnitude more ambitions about the quality and quantity of the data we collect; in order to answer questions that are an order of magnitude more modest than the questions we think we can answer.

Patient with Progressive Supranuclear Palsy Initially Diagnosed as Anxiety and Depression La parálisis supranuclear progresiva (PSP) incluye un amplio espectro de síndromes relacionados con trastornos del movimiento y el comportamiento. Los…

Does anyone happen to have access to this article? www.sciencedirect.com/science/arti...

Non-coding rare variant associations with blood traits on 166,740 UK Biobank genomes https://www.biorxiv.org/content/10.1101/2023.12.01.569422v1 Large biobanks with whole-genome sequencing now enable the association of non-coding rare variants w

Non-coding rare variant associations with blood traits on 166,740 UK Biobank genomes https://www.biorxiv.org/content/10.1101/2023.12.01.569422v1

War’n Witz, ich habe als Ärztin und Wissenschaftlerin in Vollzeit gar keine Zeit zum Puzzeln. Finde die Verallgemeinerung, dass die Ärzteschaft es schuld ist, weil sie‘s ja besser wissen sollte und generell uninformiert/ignorant sei, dennoch recht verletzend. Aber egal, glaubt eh jeder was er will.

Klar, Studien lesen ist schön & sinnvoll, aber es stellt sich die Frage nach dem Wann wenn man im Hamsterrad namens Gesundheitssystem steckt. Es sei mir verziehen, dass ich in meiner „Freizeit“ nicht noch 1000 Studien lese, sondern mal mit meinem Sohn puzzle. Aber ich trag Maske, falls das hilft..

Learning few-shot imitation as cultural transmission - Nature Communications The modelling of human-like behaviours is one of the challenges in the field of Artificial Intelligence. Inspired by experimental studies of cultural evolution, the authors propose a reinforcemen...

No, I didn’t get everything… www.nature.com/articles/s41...

@nbkroemer.bsky.social Congratulations on your DGPPN prize!

100BPM - der Rhythmus der Herzdruckmassage 100BPM - der Rhythmus der Herzdruckmassage · Playlist · 86 songs · 324 likes

The BeeGees are not your thing? Well, the German Society for Anaesthesiology and the Professional Association of German Anaesthesiologists have created a Spotify playlist of songs suitable for keeping pace with the 100bpm needed for CPR: www.daebl.de/SR59. (Source: Deutsches Ärzteblatt)

Genomic Medicine in 2023 In the broad sense, the term "genomic medicine" encompasses various approaches and techniques that involve the analysis of biologically relevant molecules within an individual's genome. While genome s...

Genomic Medicine in 2023 open.substack.com/pub/albertvi...

Sorry I forgot to put “only” in quotation marks. Whether 10s or 100s of millions, it’s millions too many…

Oh don’t. I got initial symptoms a month ago, and still have ups and downs. Currently down again with sore throat, headache, fatigue, depression, emotional instability. 2nd infection, 3 vaccinations. I know, only a month, but worried it won’t go away anymore…any thoughts on what helped in your case?

Long COVID: major findings, mechanisms and recommendations - Nature Reviews Microbiology Long COVID is an often debilitating illness of severe symptoms that can develop during or following COVID-19. In this Review, Davis, McCorkell, Vogel and Topol explore our knowledge of long COVID and ...

Well, only at least 65 million according to the following review, so I guess you could accuse the op of exaggerating… www.nature.com/articles/s41...

Heritability of complex traits in sub-populations experiencing bottlenecks and growth https://www.biorxiv.org/content/10.1101/2023.11.23.568467v1 Populations that have experienced a bottleneck are regularly used in Genome Wide Association Studies

Heritability of complex traits in sub-populations experiencing bottlenecks and growth https://www.biorxiv.org/content/10.1101/2023.11.23.568467v1

Massive genetic study finds genes linked to cannabis addiction Data from more than one million genomes offer fresh insights into excessive cannabis use and its relationship to other diseases. Data from more than one million genomes offer fresh insights into exces...

🧪 Study of over a million genomes reveals links between specific genomic regions and cannabis addiction. These regions also relate to schizophrenia & lung cancer. Further, a two-way relationship between heavy cannabis use and schizophrenia is identified, highlighting potential mutual influence. 🩺🧬🖥️

Treatment of 95 post-Covid patients with SSRIs - Scientific Reports Scientific Reports - Treatment of 95 post-Covid patients with SSRIs

Wichtige Beobachtungsstudie bei PCS: Antidepressiva aus der Gruppe der SSRI, die Serotonin erhöhen, führten bei 90% zu Besserung
Hier die klinische Studie:
www.nature.com/articles/s41...

Another one for the „to read“-list: Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes

jamanetwork.com/journals/jam...

The diffuse inflammation of the brain in symptomatic people with Long Covid by PET scans, with matched controls, and correlation with their blood inflammatory biomarkers
www.biorxiv.org/content/10.1...

www.pnas.org/doi/full/10....
The immune cell census in the human body! These ~2 trillion cells collectively weigh ~1.2 kg, 40% are lymphocytes, 10% macrophages

Special collection of 21 papers showcasing a multi-omics analysis of the human brain at the cell-type level: www.science.org/collections/...

Metabolomic Biomarker Signatures for Bipolar and Unipolar Depression This diagnostic study evaluates a reproducible metabolomic biomarker signature in patient dried blood spots that differentiates bipolar disorder from major depr

Interesting study on distinguishing bipolar disorder, currently depressed, from major depressive disorder, which is obviously rather relevant in everyday clinical work.. jamanetwork.com/journals/jam...

Dopaminergic systems create reward seeking despite adverse consequences - Nature In Drosophila, a subpopulation of reward-encoding dopaminergic neurons antagonizes punishment-encoding neurons and can override punishment or hunger cues in favour of reward-seeking behaviour.

It took us 11 years but: Dopaminergic systems create reward seeking despite adverse consequences

www.nature.com/articles/s41...