Fabian Streit

Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health - Nature Aging This genomic study of magnetic resonance imaging-based brain age in 56,348 people identifies 59 genetic loci, links brain aging to mental and physical health, and suggests high blood pressure and type 2 diabetes as causal factors of brain aging.

🧠 Why do some brains age faster than others?
🧬 Our new Nature Aging study of over 56,000 participants explores the genetics of the “brain age gap” — the difference between your brain’s biological and chronological age.
nature.com/articles/s43587-025-00962-7

Thread below 👇

Breaking the Norm: Population-Scale Normative Modeling of Brain Structure in Depression and Anxiety https://www.medrxiv.org/content/10.1101/2025.09.26.25336528v1

Breaking the Norm: Population-Scale Normative Modeling of Brain Structure in Depression and Anxiety | medRxiv www.medrxiv.org/content/10.1...

Genome-wide association study of borderline personality disorder identifies 11 loci and highlights shared risk with mental and somatic disorders We conducted the largest genome-wide meta-analysis of borderline personality disorder (BPD) to date, with a discovery sample of 12,339 cases and 1,041,717 controls, and a replication study of 685 case...

An updated preprint of our Borderline Personality Disorder GWAS is now online:
www.medrxiv.org/content/10.1...

The field of neuroscience views the goal of human genetics as "finding genes". This is an outdated view. In whole genome studies of rare variants, finding genes is the easy part. The more interesting and important goal is to map out the causal pathway from genes to brain function to cognitive traits

Got prov. approval for 2 major grants in Neuro-AI & Dynamical Systems Reconstruction, on learning & inference in non-stationary environments, out-of-domain generalization, and DS foundation models. To all AI/math/DS enthusiasts: Expect job announcements (PhD/PostDoc) soon! Feel free to get in touch.

Genome-wide Association Study Identifies SORCS3 as a Novel Susceptibility Locus for Panic Disorder in the FinnGen Study Panic disorder is an anxiety disorder with poorly understood etiology. Although twin studies suggest modest heritability (∼40%), few genetic variants have been associated with it. We carried out a gen...

I’m excited to share our genetic study on panic disorder in the FinnGen sample. We found a genomewide significant hit within the SORCS3 gene and showed that SORCS3 serum protein levels were 40% higher in panic disorder patients compared to controls medrxiv.org/cgi/content/...

#ctglab is hiring! We have #vacancies! 2 PhD & 2 postdoc positions, in #statistical #genetics and/or #bioinformatics - if you like GWAS, method development and linking with biology - check these out 👇

werkenbij.vu.nl/vacatures/tw...

werkenbij.vu.nl/vacatures/po...

werkenbij.vu.nl/vacatures/po...

Great to see this paper finally online, and happy we could contribute (a bit) to it! It's a big progress in regard to variant discovery (especially for the other 4 Big 5) but Ted and team also ran a wide range of super interesting follow-up analyses, that showcase the potential of the results. 🥳🧬

We are currently looking for new collaborators with genotyping and autism data in order to increase our sample size for our next large-scale genome-wide meta-analyses of autism. Want to contribute? Contact us! 📩

pgc.unc.edu/for-research...

🚨 I just released the alpha-version of my AI in Genomics textbook! It covers (so far!) sequence language models & deep learning for DNA/RNA/proteins. Check it out: biobook.michel.science

So depressing...

Bold move 🤣

🎉Hello and welcome to the PGC Africa Working Group takeover 🎉
For the next 2 weeks, we will share with you exciting updates from @pgc-africa.bsky.social brought to you by @jaredgm.bsky.social and Ofure Ubah
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Postdoc closing soon - two more days to apply for our statistical genetics role in antidepressant response at @kingsioppn.bsky.social

Intergenerational transmission of complex traits and the offspring methylome - Molecular Psychiatry Molecular Psychiatry - Intergenerational transmission of complex traits and the offspring methylome

Our new study in Molecular Psychiatry, in 1528 children and their parents (@ntrbiopsy.bsky.social) shows that indirect genetic effects—where parental genetics shape offspring traits via environmental influences (genetic nurture)—impact DNA methylation of children. doi.org/10.1038/s413... (1/5)

🎉 Great news from @ebbsociety.bsky.social
👏 Congrats to our Chair, @francescacirulli.bsky.social, for receiving the Diversity Award in recognition of her dedication to fostering diversity and inclusion in research!
📅Join us in celebrating this achievement at the ALBA session at #EBBS2025

🚨Attention research friends in Heidelberg/Mannheim, we have exiting news. You are warmly invited to join us for a day of networking and sharing science, the keynote will be given by
@gordonfeld.bsky.social ⭐!

Come and get your ticket at:
www.eventbrite.com/e/brain-days...

GitHub - Ripkelab/ricopili: Main ricopili repo for public releases Main ricopili repo for public releases. Contribute to Ripkelab/ricopili development by creating an account on GitHub.

The Ripke lab has worked on a new stable release of RICOPILI! Updates include compatibility with GRCh38 and imputation using Minimac4. A software tarball and YAML file are provided to help resolve dependency issues:
github.com/Ripkelab/ric...
Any feedback is highly welcome!
@pgcgenetics.bsky.social

We asked three chairs of PGC Working Groups: what is the goal for their research this year? @niamhmullins.bsky.social, Barbara Franke and @egatkinson.bsky.social #womeninSTEM #InternationalWomensDay2025

It is wonderful to be able to share the latest PGC major depression GWAS that included results from our Australian Genetics of Depression Study. Large scale GWAS meta-analyses aren't possible without collaboration between hundreds of researchers and hundreds of thousands of study participants.

Postdoctoral Fellowship in Mental Health Research (272560) | University of Oslo Job title: Postdoctoral Fellowship in Mental Health Research (272560), Employer: University of Oslo, Deadline: Monday, February 24, 2025

Want to get out of Dodge? Do a postdoc @uio.no! You will be using the MoBa study and registers to study intergenerational transmission and GxE for #MentalHealth and #education using @behaviorgenetic.bsky.social and @pgcgenetics.bsky.social approaches. Please share!

www.jobbnorge.no/en/available...

Article screenshot of a genome-wide association study of major depression published in the journal Cell

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.

www.cell.com/cell/fulltex...

A thread 🧵:

🙏 Our collaborators (1/2) @evacschulte.bsky.social @psygenomics.bsky.social @annadocherty.bsky.social@klehto.bsky.social @ymilaneschi.bsky.social @jonicoleman.bsky.social @markjamesadams.bsky.social @cathrynlewis.bsky.social @docknowles.bsky.social @mcintosh2001.bsky.social @fstreit.bsky.social

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies Trans-ancestry GWAS of major depression identifies 697 genetic variants and 308 genes, implicating neural and molecular mechanisms and drug repurposing opportunities.

New study from the @pgcgenetics.bsky.social:

Multi-ancestry GWAS of MDD in over half a million cases and 4 million controls.

www.cell.com/cell/fulltex...

Research Fellow (Statistician) – Eating Disorders Clinical Research Network at King's College London Recruiting now: Research Fellow (Statistician) – Eating Disorders Clinical Research Network on jobs.ac.uk. Click for details and explore more academic job opportunities on the top job board

Please apply for this postdoc analyst position in the UK's Eating Disorders Clinical Research Network. #eatingdisorders #treatment #epidemiology #genetics - DM if any questions www.jobs.ac.uk/job/DKR331/r...

It works for MedRxiv as well. That's really nice to see!

A screenshot of a paper on bioarxiv illustrating the lack of blue sky share button!

Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!

We are open to collaborations. If you are interested, find some info here: Personality Disorders Genomics Group zi-mannheim.de/pdgg.

Our study also links BPD genetics with personality traits e.g. showing a positive correlation with Neuroticism, and negative correlations with Agreeableness & Conscientiousness. We emphasize the need for larger samples, studies on diverse ancestries & including rare variants.