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Fabian Streit

@fstreit.bsky.social

psychologist | @zi_mannheim | psychiatric genetics | stress genomics of personality disorders http://www.zi-mannheim.de/pdgg

155 Followers  |  291 Following  |  8 Posts  |  Joined: 06.10.2023  |  2.0975

Latest posts by fstreit.bsky.social on Bluesky

The field of neuroscience views the goal of human genetics as "finding genes". This is an outdated view. In whole genome studies of rare variants, finding genes is the easy part. The more interesting and important goal is to map out the causal pathway from genes to brain function to cognitive traits

16.07.2025 14:47 β€” πŸ‘ 98    πŸ” 30    πŸ’¬ 2    πŸ“Œ 3
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Got prov. approval for 2 major grants in Neuro-AI & Dynamical Systems Reconstruction, on learning & inference in non-stationary environments, out-of-domain generalization, and DS foundation models. To all AI/math/DS enthusiasts: Expect job announcements (PhD/PostDoc) soon! Feel free to get in touch.

13.07.2025 06:23 β€” πŸ‘ 34    πŸ” 8    πŸ’¬ 0    πŸ“Œ 0
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Genome-wide Association Study Identifies SORCS3 as a Novel Susceptibility Locus for Panic Disorder in the FinnGen Study Panic disorder is an anxiety disorder with poorly understood etiology. Although twin studies suggest modest heritability (∼40%), few genetic variants have been associated with it. We carried out a gen...

I’m excited to share our genetic study on panic disorder in the FinnGen sample. We found a genomewide significant hit within the SORCS3 gene and showed that SORCS3 serum protein levels were 40% higher in panic disorder patients compared to controls medrxiv.org/cgi/content/...

10.07.2025 12:44 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

#ctglab is hiring! We have #vacancies! 2 PhD & 2 postdoc positions, in #statistical #genetics and/or #bioinformatics - if you like GWAS, method development and linking with biology - check these out πŸ‘‡

werkenbij.vu.nl/vacatures/tw...

werkenbij.vu.nl/vacatures/po...

werkenbij.vu.nl/vacatures/po...

24.05.2025 15:02 β€” πŸ‘ 4    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Great to see this paper finally online, and happy we could contribute (a bit) to it! It's a big progress in regard to variant discovery (especially for the other 4 Big 5) but Ted and team also ran a wide range of super interesting follow-up analyses, that showcase the potential of the results. πŸ₯³πŸ§¬

20.05.2025 13:21 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
Autism Working Group – PGC

We are currently looking for new collaborators with genotyping and autism data in order to increase our sample size for our next large-scale genome-wide meta-analyses of autism. Want to contribute? Contact us! πŸ“©

pgc.unc.edu/for-research...

14.05.2025 12:49 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
Sequence Language Models & Deep Learning in Genomics

🚨 I just released the alpha-version of my AI in Genomics textbook! It covers (so far!) sequence language models & deep learning for DNA/RNA/proteins. Check it out: biobook.michel.science

12.05.2025 12:25 β€” πŸ‘ 75    πŸ” 13    πŸ’¬ 1    πŸ“Œ 1

So depressing...

23.04.2025 17:44 β€” πŸ‘ 4    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Bold move 🀣

20.04.2025 16:51 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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πŸŽ‰Hello and welcome to the PGC Africa Working Group takeover πŸŽ‰
For the next 2 weeks, we will share with you exciting updates from @pgc-africa.bsky.social brought to you by @jaredgm.bsky.social and Ofure Ubah
1/4

15.04.2025 09:09 β€” πŸ‘ 6    πŸ” 4    πŸ’¬ 1    πŸ“Œ 1

Postdoc closing soon - two more days to apply for our statistical genetics role in antidepressant response at @kingsioppn.bsky.social

08.04.2025 05:40 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Intergenerational transmission of complex traits and the offspring methylome - Molecular Psychiatry Molecular Psychiatry - Intergenerational transmission of complex traits and the offspring methylome

Our new study in Molecular Psychiatry, in 1528 children and their parents (@ntrbiopsy.bsky.social) shows that indirect genetic effectsβ€”where parental genetics shape offspring traits via environmental influences (genetic nurture)β€”impact DNA methylation of children. doi.org/10.1038/s413... (1/5)

06.04.2025 14:07 β€” πŸ‘ 27    πŸ” 13    πŸ’¬ 1    πŸ“Œ 0

πŸŽ‰ Great news from @ebbsociety.bsky.social
πŸ‘ Congrats to our Chair, @francescacirulli.bsky.social, for receiving the Diversity Award in recognition of her dedication to fostering diversity and inclusion in research!
πŸ“…Join us in celebrating this achievement at the ALBA session at #EBBS2025

02.04.2025 15:47 β€” πŸ‘ 22    πŸ” 6    πŸ’¬ 2    πŸ“Œ 0
Brain Days Heidelberg Get ready to expand your research network at Brain Days Heidelberg -Keynote Talk- Hands-on-workshop and more...

🚨Attention research friends in Heidelberg/Mannheim, we have exiting news. You are warmly invited to join us for a day of networking and sharing science, the keynote will be given by
@gordonfeld.bsky.social ⭐!

Come and get your ticket at:
www.eventbrite.com/e/brain-days...

20.03.2025 09:14 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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GitHub - Ripkelab/ricopili: Main ricopili repo for public releases Main ricopili repo for public releases. Contribute to Ripkelab/ricopili development by creating an account on GitHub.

The Ripke lab has worked on a new stable release of RICOPILI! Updates include compatibility with GRCh38 and imputation using Minimac4. A software tarball and YAML file are provided to help resolve dependency issues:
github.com/Ripkelab/ric...
Any feedback is highly welcome!
@pgcgenetics.bsky.social

12.03.2025 17:03 β€” πŸ‘ 16    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0
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We asked three chairs of PGC Working Groups: what is the goal for their research this year? @niamhmullins.bsky.social, Barbara Franke and @egatkinson.bsky.social #womeninSTEM #InternationalWomensDay2025

06.03.2025 18:40 β€” πŸ‘ 14    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

It is wonderful to be able to share the latest PGC major depression GWAS that included results from our Australian Genetics of Depression Study. Large scale GWAS meta-analyses aren't possible without collaboration between hundreds of researchers and hundreds of thousands of study participants.

15.01.2025 12:05 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Postdoctoral Fellowship in Mental Health Research (272560) | University of Oslo Job title: Postdoctoral Fellowship in Mental Health Research (272560), Employer: University of Oslo, Deadline: Monday, February 24, 2025

Want to get out of Dodge? Do a postdoc @uio.no! You will be using the MoBa study and registers to study intergenerational transmission and GxE for #MentalHealth and #education using @behaviorgenetic.bsky.social and @pgcgenetics.bsky.social approaches. Please share!

www.jobbnorge.no/en/available...

14.01.2025 11:33 β€” πŸ‘ 26    πŸ” 27    πŸ’¬ 1    πŸ“Œ 0
Article screenshot of a genome-wide association study of major depression published in the journal Cell

Article screenshot of a genome-wide association study of major depression published in the journal Cell

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.

www.cell.com/cell/fulltex...

A thread 🧡:

14.01.2025 17:31 β€” πŸ‘ 76    πŸ” 25    πŸ’¬ 4    πŸ“Œ 10

πŸ™ Our collaborators (1/2) @evacschulte.bsky.social @psygenomics.bsky.social @annadocherty.bsky.social@klehto.bsky.social @ymilaneschi.bsky.social @jonicoleman.bsky.social @markjamesadams.bsky.social @cathrynlewis.bsky.social @docknowles.bsky.social @mcintosh2001.bsky.social @fstreit.bsky.social

14.01.2025 17:33 β€” πŸ‘ 8    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies Trans-ancestry GWAS of major depression identifies 697 genetic variants and 308 genes, implicating neural and molecular mechanisms and drug repurposing opportunities.

New study from the @pgcgenetics.bsky.social:

Multi-ancestry GWAS of MDD in over half a million cases and 4 million controls.

www.cell.com/cell/fulltex...

14.01.2025 16:10 β€” πŸ‘ 24    πŸ” 18    πŸ’¬ 2    πŸ“Œ 1
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Research Fellow (Statistician) – Eating Disorders Clinical Research Network at King's College London Recruiting now: Research Fellow (Statistician) – Eating Disorders Clinical Research Network on jobs.ac.uk. Click for details and explore more academic job opportunities on the top job board

Please apply for this postdoc analyst position in the UK's Eating Disorders Clinical Research Network. #eatingdisorders #treatment #epidemiology #genetics - DM if any questions www.jobs.ac.uk/job/DKR331/r...

02.12.2024 13:36 β€” πŸ‘ 14    πŸ” 19    πŸ’¬ 1    πŸ“Œ 1

It works for MedRxiv as well. That's really nice to see!

02.12.2024 13:53 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
A screenshot of a paper on bioarxiv illustrating the lack of blue sky share button!

A screenshot of a paper on bioarxiv illustrating the lack of blue sky share button!

Would you like to see @biorxivpreprint.bsky.social add a share to blue sky button?! I know I would! Share this post to let @richardsever.bsky.social @erictopol.bsky.social and others at bioarxiv know!

02.12.2024 12:10 β€” πŸ‘ 385    πŸ” 197    πŸ’¬ 9    πŸ“Œ 6
Personality Disorders Genomics Group

We are open to collaborations. If you are interested, find some info here: Personality Disorders Genomics Group zi-mannheim.de/pdgg.

30.11.2024 00:06 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Our study also links BPD genetics with personality traits e.g. showing a positive correlation with Neuroticism, and negative correlations with Agreeableness & Conscientiousness. We emphasize the need for larger samples, studies on diverse ancestries & including rare variants.

30.11.2024 00:06 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Strong genetic correlations were found between BPD and psychiatric conditions like PTSD, depression, ADHD, and antisocial behavior. Shared genetic risk with medical conditions further highlights the interplay between mental and physical health.

30.11.2024 00:06 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Borderline personality disorder is underresearched in genome-wide studies, but our findings confirm it as a polygenic disorder, much like other mental health conditions. GWAS approaches hold great promise for advancing our understanding of BPD.

30.11.2024 00:06 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Genome-wide association study of borderline personality disorder identifies six loci and highlights shared risk with mental and somatic disorders Environmental and genetic risk factors contribute to the development of borderline personality disorder (BPD). We conducted the largest GWAS of BPD to date, meta-analyzing data from 12,339 cases and 1...

Happy to see this finally online: we investigated the genetic association signal of Borderline Personality Disorder in a GWAS meta-analysis with >12,000 cases. We identified 6 risk loci, and investigated shared genetic risk using genetic correlations and PheWAS
www.medrxiv.org/content/10.1...

15.11.2024 19:56 β€” πŸ‘ 19    πŸ” 8    πŸ’¬ 1    πŸ“Œ 1

@fstreit is following 20 prominent accounts