Callirhoé

PFAS in eye drops are here.
The data is not.

Patients deserve informed consent.
Clinicians deserve evidence.
Regulators must stop confusing usefulness with safety. They must protect long-term ocular health.

If you have dry eye disease, you already navigate pain, disability, and medical gaslighting.

You shouldn’t have to wonder if your eye drops contain chemicals designed to last forever.

Innovation must not outpace knowledge especially on the cornea.

The history of ophthalmology is full of “safe” excipients later found harmful (ex : benzalkonium chloride, still used despite numerous studies).

PFAS are not ordinary molecules.
They are:
- persistent
- stable
- insufficiently studied in the eye

No one is asking to ban innovation.
We’re asking for:

• transparency on fluorinated excipients
• long-term ocular toxicology
• human pharmacokinetics
• non-PFAS alternatives

Basic science, not blind trust.

Regulatory plot twist:
In the EU, PFAS can be banned in consumer goods unless proven necessary in pharmaceuticals.

So if industry claims these fluorinated solvents are “essential,” they get a pass even without long-term safety data.

That’s regulatory capture, not precaution.

Effects of Perfluorobutylpentane (F4H5) on Corneal Endothelial Cells - PubMed <span><b>Purpose</b>: To evaluate the effects of perfluorobutylpentane (F4H5) on corneal endothelial cell density (ECD) and morphology using a porcine corneal endothelial organ culture model. <b>Materials and methods</b>: "Split corneal buttons" were cultivated for 15 days (d) after incubation in F4H5 (15</span> …

One lab study showed that after 60 minutes of direct exposure, PFAS-based solvents altered corneal endothelial cells.

Not proof of harm in real use,
but proof that these substances are not biologically inert.

That alone should trigger more research.
pubmed.ncbi.nlm.nih.gov/30892089/

Animal studies show these molecules can remain on the eye for hours and reach Meibomian glands for 24h+.

In humans?
No long-term pharmacokinetics.
No chronic exposure data.
No safety thresholds.

We approved first, asked questions later.

Key issue: persistence.
PFAS are designed to resist breakdown. Once in the environment or the body, they tend to stay.

So what happens when you put a persistent molecule on a highly vascularized mucosal surface… every day… for years?

We don’t know. And that’s the problem.

These formulations use semifluorinated alkanes (SFA), a subgroup of PFAS, as solvents or even active ingredients.

Why? They allow water-free eye drops that spread well and increase drug penetration.
Dry eye patients love them.

But loving something is different from understanding it.

PFAS are now in some eye drops.
Yes , the “forever chemicals” you’ve heard about in water, packaging, and cosmetics have quietly entered ophthalmology.

Innovation? Maybe.
Precaution? Not so much.

Do you think doing it on gofundme would help ? I wonder if the fact that it's a French non profit platform probably unknown could be an obstacle.

Campagne de dons : Soutien pour un traitement contre des douleurs très sévères Soutien pour un traitement contre des douleurs très sévères

I’m struggling with constant pain. I need an anti-CGRP medicine (€280/month) that France hasn’t reimbursed yet, lagging behind in innovative therapies.
On a disability pension, I can’t afford it alone.
Any help, a donation or RT, means the world. Thanks a lot 💙
www.we-solidaire.com/fr/collecte/...

Wrapped from Spotify : "46 top fan de Nicolas Britell dans le monde"

I might be a little obsessed ... To the point of being #46 in the world for this artist (who composed most of the music for Andor).

michael sheen @michaelsheen En réponse à @youryurigoddess So this is a big bird saying - we had a screening last night. I laughed and I cried. There'll be bits you absolutely love and there'll be things you'll argue about of course. It should have been 6 episodes but it's not. Thank God for what it is. Brilliantly directed, beautiful performances, fantastic new looks, incredible work all round. And there's nightingales.

To all Good Omens fans 👇👇

Campagne de dons : Soutien pour un traitement contre des douleurs très sévères Soutien pour un traitement contre des douleurs très sévères

I’m struggling with constant pain. I need an anti-CGRP medicine (€280/month) that France hasn’t reimbursed yet, lagging behind in innovative therapies.
On a disability pension, I can’t afford it alone.
Any help, a donation or RT, means the world. Thanks a lot 💙
www.we-solidaire.com/fr/collecte/...

December 1 is symbolic, but the reality remains.

Long COVID is here, shaping lives and society. Ignoring it doesn’t make it disappear, it allows preventable harm to accumulate and exposes the cost of absent public-health policies, chronic underinvestment in medical research, and systemic ableism.

- Recognition of long COVID (and chronic post-viral conditions) by health and social systems as disability, as chronic illness deserving rights and support.

- Public policies centering disability justice, universal care access, and structural prevention rather than individual burden.

What to demand and fight for now:

- Clean air and ventilation standards in public spaces (workplaces, schools, transit).

- More public investment in long COVID (and all illnesses for that matter) research, diagnostics, treatments.

The narrative must shift:
From “resilience as a personal virtue” which blames bodies for their limits, to acknowledging COVID’s long-term impact as a population-wide health crisis.

Long COVID is a disabling condition on its own terms, with consequences that affect individuals and society alike.

Ignoring long COVID doesn’t make it disappear. It deepens inequalities: those with means may manage, those without become invisible, excluded, impoverished, disabled without support.
This is ableism by default, institutional abandonment made systemic.

We need structural, collective responses: clean air and ventilation, quality public healthcare, universal access to long-term care, social support systems that treat chronic illness and disability as a human and social issue, not a personal failure.

So far, prevention and care have mostly meant: vaccination, personal protection, and occasional masking. Those matter but they are not enough.

The danger now lies in normalization: treating COVID as “just another virus,” a part of “living with it.”

That framing shifts responsibility onto individuals and hides a growing, structural public health crisis.

The consequences are wide-ranging and often multi-systemic: chronic fatigue, respiratory issues, autonomic dysfunction, neurological disorders, cardiovascular problems...

For many, COVID did not end with a “mild case.” It began a chronic condition.

Long COVID is not limited to a certain age or “risk group.” It affects people across ages and prior health status.

The virus doesn’t discriminate, and neither should our concern.

Global Prevalence of Long COVID, Its Subtypes, and Risk Factors: An Updated Systematic Review and Meta-analysis - PubMed Long COVID is globally prevalent after a severe acute respiratory syndrome coronavirus 2 infection, highlighting a continuing health challenge. The heterogeneity of estimates across populations argues the need for well-designed follow-up studies that use consistent measures and are globally represen …

A recent mega-meta-analysis (429 studies, 2021-2024) estimates a global pooled Long-COVID prevalence of ~36% (95% CI: 33–40%) among people with confirmed infection.
This is not a fringe phenomenon. It touches tens or hundreds of millions worldwide.
pubmed.ncbi.nlm.nih.gov/41018705/

December 1, 2019 : the first known case of COVID-19.
More than six years later, SARS-CoV-2 is still circulating. Its long-term effects are not “in the past.” They accumulate, quietly and often invisibly.

Un signe de plus qu’on pense que l’argent n’est pas donné aux pauvres pour les aider mais pour qu’ils se conforment à nos attentes : ça ne devient pas leur argent, ça reste notre argent, qui doit nous servir à nous.

Un des points de mon bouquin Où va l’argent des pauvres

Bougeons nous à gauche. Le fascisme est plus qu'à notre porte, il sera la à la prochaine élection si nous n'avons pas réussi d'ici là:
-a reconquérir des électorats en se remettent en cause
-a sortir des candidats type Glucksmann ou Mélenchon, l'un n'étant pas de gauche, l'autre si problématique..

Voi-lààà.
Y a jamais eu de pacifisme à avoir quand, la porte à coté, des gens se prennent une agression imperialiste fasciste.