Lukas A. Basedow, PhD

📣 Noch 2 Tage bis zum Bewerbungsschluss!

Bitte teilen – wir freuen uns auf die Bewerbungen! 🤩

The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation - Nature Neuroscience Aarrestad et al. show that, in contrast to psychedelics, the nonhallucinogenic psychoplastogen tabernanthalog promotes neuroplasticity through 5-HT2AR activation without immediately increasing extrace...

Bit of a quiet landmark this study. Offers significant evidence to suggest non hallucinogenic psychedelic analogs could be effective as antidepressants. Amazing stuff.

Well, this preprint would agree with you: osf.io/preprints/ps...
"Contrary to prior hypothesis, PAT was no more effective than open-label tAD treatment (estimated difference: 0.3 favoring open-label tAD; 95% confidence interval: [-1.39, 1.98]; p=0.730)."

There is definitely an argument to be made that we basically induced an ASC through a setting fostering meditative processes which are reflected in the 5D-ASC scales. We're still collecting data though, so a comprehensive answer will have to wait a while :)

Huge congratulations to our two CRC members @labasedow.bsky.social and Marcel Wilhelm from @unimarburg.bsky.social for winning two out of four science slam prizes! 🥳🤯

Of course we also congratulate @ldruart.bsky.social and Pavel Goldstein for the other two awards - all super deserved! 🤩

Really happy to be able to present my Poster regarding placebo-induced psychedelic effects at #SIPSplacebo2025
Funded by the @sfb-trr-289.bsky.social

Really happy to have participated again. Always a fun challenge!
@sfb-trr-289.bsky.social @sipsplacebo.bsky.social
#SIPSplacebo2025

Huge thanks to Lene Vase for highlighting both our recent placebo meta-analysis and the patient advisory board ❤️

The meta-analysis: www.biorxiv.org/content/10.1...

The patient advisory board: treatment-expectation.de/projekte-peo...

@sipsplacebo.bsky.social
#SIPSplacebo2025

Glad to see this paper out finally. Well done @trpwolff.bsky.social for driving it!

I think this idea has potential for significant impact in psychedelic drug development.

/1 🧵 👇

📄 doi.org/10.1177/2050...

Research Associate in Psychology at University of Sheffield An opportunity for an academic position as a Research Associate in Psychology is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.

✨ Job opportunity! ✨ We're currently seeking a Research Associate in Psychology for a new project led by @fieldmatt.bsky.social which will use machine learning to develop a better understanding of why many people drop out of treatment for gambling problems. More project info at: bit.ly/45WEyVb

PCI Psychology is here!! 🎉🥳

After over a year of hard work by so many people, we are thrilled to announce that we are open for submissions! Join us in making publishing more efficient, equitable, and open: psych.peercommunityin.org
#PsychSciSky #scipub

An der @rptu.bsky.social wird eine neue W2-Professur "Klinische Psychologie und Psychopathologie" geschaffen 🎉

Wir freuen uns über zahlreiche Bewerbungen und stehen auf dem #dpk25 bei Fragen gerne zur Verfügung!

jobs.rptu.de/jobposting/0...

Gerne weiterteilen und geeignete Kandidat:innen darauf aufmerksam machen!
Neben Verfahrensoffenheit ist auch offen, ob Schwerpunkt auf Kinder & Jugendliche oder Erwachsene - oder eben über die Lebensspanne

Sporadic use of classic psychedelics and neuropsychological performance: A cross-sectional analysis Evidence on the neuropsychological consequences of classic psychedelics like psilocybin, LSD, and ayahuasca is conflicting, and little is known about …

Really proud that this paper got published: www.sciencedirect.com/science/arti...
While I was only involved peripherally in the final publication, this paper is the result of a project I started during my master thesis 8 years ago! It's great to see continuous collaboration result in a cool paper.

“We argue that high-quality collective outcomes are endangered not only by self-interested individual defectors, but by ‘cartels’ of mutually satisfied mediocrities.” 👀

I’ve often referred to Gambetta’s book in the context of academic dysfunction. Very excited to discover more relevant work!

Safety and Efficacy of Repeated Low-Dose LSD for ADHD Treatment in Adults This double-blind, placebo-controlled randomized clinical trial determines the safety and efficacy of repeated low doses of lysergic acid diethylamide (LSD) in reducing attention-deficit/hyperactivity...

Great to see a psychedelic null result published in JAMA Psychiatry! "[...], repeated low-dose LSD administration was safe in an outpatient setting, but it was not more efficacious than placebo in reducing ADHD symptoms." (Strong Placebo response as well!) jamanetwork.com/journals/jam...

Reviewer notes: That’s a very nice mediation analysis you have there. It would be a shame if something happened to it. Mediation analysis has gotten a lot of flak, including classic titles such as “Yes, but what’s the mechanism? (Don’t expect an easy answer)” (Bullock et al., 2010), “What mediation analysis can (not) ...

New blog post! In which I explain the issue with mediation analysis and sketch out one way to deal with the underlying causal inference problem -- in just a bit over 1,000 words!

If you have never found the time to read up on this, now is your chance.

www.the100.ci/2025/03/20/r...

🔥Frisch gedruckt im PTJ🔥: @tkaiser.science , Rafaële Huntjens und ich haben in dem Artikel gängige (Fehl-)Annahmen in der klinischen Praxis im Zusammenhang mit der
Dissoziativen Identitätsstörung (#DIS) aus Sicht der Wissenschaft näher beleuchtet. Ein Thread 🧵: 1/

Our first qualitative study on the Flotatation experience as Preprint: "Silence, darkness, and gravity: A qualitative analysis of individual experiences during Floatation-REST". By Kristin Schiffer, Eric Pfeifer, Christine Stolterfoth, and Marc Wittmann

osf.io/preprints/ps...

Psilocybin-assisted therapy for relapse prevention in alcohol use disorder: a phase 2 randomized clinical trial Despite the promising therapeutic effects of psilocybin, its efficacy in preventing relapse after withdrawal treatment for alcohol use disorder (AUD) …

Hi everyone, if you are interested in #psychedelic-assisted therapy, we just published a new study: www.sciencedirect.com/science/arti.... Congratulations to Dr. Nathalie Rieser, who has done a terrific job spearheading this project.

I waited for this paper by @robinawester.bsky.social, @ehrenthal-lab.bsky.social et al. to appear and finally, it's there. A mixed-methods survey on how German psychotherapists engage in personalized treatment selection.

The results are interesting.

It's out! Elated to share our latest work. I am incredibly proud of Ashley and the entire team. This study really brings together the best of everything we've been doing, and is the culimination of our research so far. It has everything - psychophysics, modelling, drug manipulation of intero!

A dual-pathway architecture for stress to disrupt agency and promote habit - Nature Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain path...

🚨📃New Wassum Lab Paper📃🚨

Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇

www.nature.com/articles/s41...

Free full text: rdcu.be/eaxEv

🏰 PhD position on computational modelling | collective dynamics | cultural evolution 🏰

Get in touch with any questions you might have and join me in beautiful Marburg!

stellenangebote.uni-marburg.de/jobposting/c... (Deutsch)

stellenangebote.uni-marburg.de/jobposting/3... (English)

Scientific publishing cannot be free but an annual $2.5 billion seems excessive to me

Stationäre Psychiatrie: Leitliniengerechte Behandlung erfordert mehr Personal Bei den derzeit geltenden Personalvorgaben f�r die station�re Psychiatrie handelt es sich um Mindestvorgaben. Eine Analyse zeigt, dass f�r eine leitliniengerechte Behandlung von psychisch kranken Mens...

"...ergibt sich [...] im Durchschnitt ein personeller Mehrbedarf im ärztlichen und pflegerischen Bereich von 103 Prozent..."
Ach...
#Psychotherapie #Psychiatrie
www.aerzteblatt.de/archiv/24254...

Missing outcome data in randomised clinical trials of psychological interventions: a review of published trial reports in major psychiatry journals - BMC Psychiatry Background Missing outcome data can pose a serious threat to the validity of randomised clinical trial results. We aimed to study the extent of missing outcome data in randomised clinical trials of ps...

"Missing outcome data in randomised clinical trials of psychological interventions: a review of published trial reports in major psychiatry journals"

Linking neural population formatting to function Animals capable of complex behaviors tend to have more distinct brain areas than simpler organisms, and artificial networks that perform many tasks tend to self-organize into modules (1-3). This sugge...

New results for a new year! “Linking neural population formatting to function” describes our modern take on an old question: how can we understand the contribution of a brain area to behavior?
www.biorxiv.org/content/10.1...
🧠👩🏻‍🔬🧪🧵
#neuroskyence
1/

How did people get significant positive effects for so long? Small groups (N<10 is typical), p-hacking, harking.
How much time, money have we wasted on that technique? (I was part of the problem)

I hope people starting Focused Ultrasound are taking notes (but I see the same mistakes being done)

Wow! I think this is one of the best (and most beautiful) demonstrations I've seen of the exquisite structure and specificity of neural circuits!