Institut Necker Enfants Malades

[PUBLICATION] The @membramics-lab.bsky.social shows how Influenza A virus rewires ER lipid metabolism to promote vRNP egress.

👏🏼 Co-1st authors: Carla Alemany & @julianedagraca.bsky.social

journals.plos.org/plosbiology/...

w/ @institutpasteur.bsky.social & IPNP
@plosbiology.org

[PUBLICATION] NEW in @cp-cellreports.bsky.social
@julianedagraca.bsky.social et al. show that ER-endosome contacts act as hubs for phagophore formation during starvation.

📖 www.cell.com/cell-reports...
@membramics-lab.bsky.social

👏🏼 Proud to see @julianedagraca.bsky.social, former PhD student at INEM, honored with the 2025 Beth Levine Thesis Prize for her outstanding work on autophagy, supervised by Etienne Morel @membramics-lab.bsky.social.

[CAREER] A 3-year PhD position is open in Paris to explore how air pollution contributes to CKD. The project combines experimental and environmental science and is hosted by INEM & LISA.

📨 Apply by Sept 1.
🟢 Start Nov–Dec 2025.

www.institut-necker-enfants-malades.fr/offre-demplo...

🚨 We're hiring! INEM is recruiting a Group Leader in #Immunology. Join a vibrant biomedical research institute with strong clinical & academic links.

🗓 Apply by Sept 20, 2025

🔗 More info: institut-necker-enfants-malades.fr/careers

[PUBLICATION] New study with the Bharat lab @cellbiol-mrclmb.bsky.social reveals the structure of the Neisseria meningitidis filamentous phage MDAΦ. 🦠
Cryo-EM/ET show how phage bundling supports biofilm formation & pathogenesis.
@mathieucoureuil.bsky.social @pnas.org

www.pnas.org/doi/10.1073/...

[PUBLICATION] PIK3CA mutations in Schwann cells trigger neuropathy by disrupting nearby healthy tissues. This non-cell autonomous effect shifts local metabolism toward aerobic glycolysis. Early alpelisib treatment is key. | Canaud Lab @pnas.org
🔗https://www.pnas.org/doi/10.1073/pnas.2424867122

[PUBLICATION] Podocyte-specific YAP activation drives crescentic glomerulonephritis via cross-talk with parietal epithelial cells. 🌙
A study from @fabiolaterzi.bsky.social & @marco-pontoglio.bsky.social labs now out in Science Translational Medicine @science.org
👉 www.science.org/doi/10.1126/...

🗓️ Join us on July 4, for a #seminar with David Sabatini, group leader at @iocbprague.bsky.social.
Dr. Sabatini will explore nutrient sensing by the mTOR pathway. Don’t miss it! @mario-pende.bsky.social

[PUBLICATION] mTORC1 coordinates ependymal cell differentiation by regulating an alternative cell cycle and centrosomal proteins.
A new collaboration between the Pende and Spassky labs!

🔗 www.embopress.org/doi/full/10....
@mario-pende.bsky.social @ibensens.bsky.social ‪@emboreports.org

[PUBLICATION] First report of successful pregnancies after treatment with alpelisib for PIK3CA-related overgrowth spectrum.

➡️Fertility preserved
➡️No embryotoxicity
➡️Disease remained responsive after treatment pause

📖 Read more: www.nature.com/articles/s41...
@ejhg-journal.bsky.social‬

🗓️ Join us on June 20, for a #seminar with Jean-Emmanuel Sarry, team leader at CRCT Oncopole. Dr. Sarry will explore Mitohormesis and metabolic adaptations in response to therapeutic stress in acute myeloid leukemia. Don’t miss it!

🗓️ Join us on June 13, for a #seminar with Han Li, Principal Investigator and leader of the cellular plasticity in age-related pathologies group at @pasteur.fr. Prof. Li will explore senescence induced-cellular plasticity in health & disease. Don’t miss it! @mario-pende.bsky.social

✨ Calling all postdocs! The 2025-2026 #ParisPostdocs Seminars are now accepting applications.
Present your work, connect across 13 top Paris institutes — including INEM — and boost your visibility 🚀.

🗓️ Join us on Friday, June 6, for a #seminar with Elvira Mass, Head of the Department of Developmental Biology of the Immune System at LIMES Institute @unibonn.bsky.social. ‬
Prof. Mass will explore the developmental programming of tissue-resident macrophages. Don’t miss it!
@venteclefn.bsky.social

Join #ParisPostdocsSeminar this month to hear from our very own Laura Salavessa (@laurasalavessa.bsky.social) as she shares new insights on melanin transfer and uptake in keratinocytes.

📅 Tuesday, 27 May
🕚 11:00–12:00 CET
📍 Institut Pasteur – Amphitheatre Agnès Ullmann

🚨 We're hiring! The IMMEDIAB team is looking for:
🧪 1 Postdoc
🧬 1 Research Assistant / Bioinfo/ Tech
📍 Paris | Start Sept 2025
📄 Full details + apply: www.institut-necker-enfants-malades.fr/careers
@drfalzaid.bsky.social

[PUBLICATION] Treating patients with somatic PIK3R1 mutations using alpelisib leads to clinical and radiological improvement.
A promising step toward targeted therapy in PIK3R1-related disorders.
📄Read more: www.embopress.org/doi/full/10....
Canaud Lab @emboreports.org

🗓️ Join us on Friday, May 16, for a #seminar with Chantal Desdouets, Head of the "Genomic Instability, Metabolism, Immunity and Liver Tumorigenesis" team at @crcordeliers.bsky.social.
Dr. Desdouets will explore Polyploidy in chronic liver diseases. Don’t miss it! @goffinlab.bsky.social

🗓️ Join us for a special #seminar with Bing Su, Director of the Shanghai Institute of Immunology & Chair at Shanghai JiaoTong Univ. School of Medicine.
Prof. Su will explore Sin1-mTOR signaling in immune cell metabolism, growth & survival. Don't miss it! @venteclefn.bsky.social @upcite.bsky.social

🗓️ Join us on Monday, Apr 28, for a #seminar with Christopher Goodnow, Head of the Immunogenomics Lab at @garvaninstitute.bsky.social.
Prof. Goodnow will explore how B cell tolerance breaks and resists rituximab treatment. Don’t miss it! @matthieumahevas.bsky.social

🎉 Congrats to Khaled Tighanimine, former PhD student at INEM (supervised by @mario-pende.bsky.social & Stefano Fumagalli), awarded a @fondationarc.bsky.social Oberling-Haguenau Thesis Prize!
Proud to see his work recognised among this year’s #ARCTrophies winners 👏

🗓️ Join us Friday, Apr 25 for a #seminar with Brendan Manning — Professor and Chair of Molecular Metabolism at Harvard T.H. Chan School of Public Health.
He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social

🚨 Postdoc Opportunity

Join the "Host-Pathogen Integrative Biology" team at INEM to study endothelial microparticles in cardiovascular dysfunctions during bacterial sepsis.

🌐More info & application: institut-necker-enfants-malades.fr/offre-demplo...

@mathieucoureuil.bsky.social

🗓️ Join us on Friday, April 11, for a #seminar with Prof. Philippe Sansonetti @pasteur.fr on Gut dysbiosis and colorectal cancer.
Don’t miss this talk diving into how microbial imbalances shape cancer development — and how we move from observation to mechanistic insight.

🏆 Congrats to @julianedagraca.bsky.social! Former PhD student at INEM, Juliane has been awarded the 2025 Thesis Prize of the @clubexo-endo.bsky.social for her work on ER-endosome contact sites & autophagy regulation.
👏 Well done, Juliane! @membramics-lab.bsky.social

🗓️ Join us on Friday, April 4, for a #seminar with Dr. Meryem Baghdadi, new team leader at INEM (StemNest Lab), on "Stem cell regulation in homeostasis and disease."
Don't miss this talk exploring how stem cells maintain tissue balance — and what happens when this goes wrong!

🚨 New: Spleen-resident macrophages (MMMs) can directly activate CD8+ T cells to fight tumors – independently of dendritic cells. They use a vacuolar MHC-I pathway & need Batf3 for this antitumor response.
🧠 A game-changer for immunotherapy?

🔗 www.cell.com/immunity/abs... @cp-immunity.bsky.social

🗓️ Join us on Friday, March 28, for a #seminar with Dr. @goetzjacky.bsky.social (Centre de recherche en biomédecine de Strasbourg) on "Multi-modal tracking of metastasis: from priming to inhibitory targets."
🔍 A great chance to dive into new insights on cancer metastasis. @membramics-lab.bsky.social

🗓️ Join us on Friday, March 21, for a #seminar with Dr. Olivier Tabary on "ANO1: A new approach for cystic fibrosis — from basic science to translational studies."
Don't miss this opportunity to learn more about new therapeutic avenues in #CysticFibrosis research!