🧠 Is Alzheimer’s really a disease of misfolded proteins—or a crisis of cellular energy?
For decades, the dominant theory of Alzheimer’s disease has focused on the growth of amyloid plaques. But a growing body of research points to a different culprit that may come earlier: mitochondrial dysfunction
For years, midlife weight gain in women was blamed on a simple drop in estrogen. But new research shows it’s far more complex—and it at least partially starts in the brain.
1. 🧠 What if Alzheimer’s isn’t caused by plaques at all—but by an energy crisis inside your brain cells?
The research of Dr. Francisco Gonzalez-Lima on mitochondrial dysfunction in AD—and the potential of methylene blue to restore neuronal energy—you see a radically different framing of the disease
In this episode of The Science Club, Dr. Rich LaFountain delves into the intricacies of body composition and BMI, discussing his extensive research and experience in the field.
www.youtube.com/watch?v=4WD...
New Research Review: SGLT2 Inhibitors as Metabolic Senolytics: Clearing Senescent Cells to Combat Pathological Aging
gethealthspan.com/science/art...
🧬 Why are geroscientists interested in SGLT2 inhibitors for longevity?
Approved for Type II Diabetes, these drugs differ from Metformin or Acarbose. They prevent glucose reabsorption in kidneys, leading to the excretion of 70-90g of glucose daily.
Here's why longevity researchers are intrigued. 👇
We often neglect the 'boring' items that matter the most:
Sleep
Eat real foods
Move mostly easy, occasionally hard.
Community & Belonging
Stress & Rest go hand in hand
Have something that:
-You can win at
-Makes you feel alive
-Expands your perspective
I am always shocked at the number of bizarre things people do to "optimize" their health and longevity and yet they don't exercise regularly, sleep 7-9 hours, eat fruits and veggies, build intimate bonds and community, or ever relax.
They obsess over the 0.1% but not the 99.9%.
🚨 🚨 SGLT-2 Inhibitors in Aging and Healthspan: Surprising Mechanistic Insights Into Adipose Tissue Reduction, Lean Mass Preservation, and Longevity by @dantawfik and Shriya Bakhshi
hspan.io/t7CsFO
🚨 🚨 New Research Review: The Metabolic Basis of Neurodegeneration: The Glucose Paradox of Fueling Cognition and Driving Decline
hspan.io/lE3MqR
🚨🚨 New Research Review: The Role of Urolithin A in Enhancing Mitochondrial Biogenesis and Muscle Function: Mechanistic and Clinical Insights: hspan.io/l9d6jR
Do you share these goals? Then tell me and I'll add you to the list: go.bsky.app/E2oy2jV
Hi Peter. I’m working on translation longevity with Healthspan.
This story knocked the wind out of me and i hope esquire paid this man.
www.esquire.com/news-politic...
Wonderful results: The combination of nivolumab and ipilimumab in patients with metastatic colorectal cancer led to 24-month progression-free survival of 72%, as compared with 14% with chemotherapy: nej.md/4eGp1tj
I use typefully
Stress + Rest = Growth.
Stress:
•Just-manageable challenges
•Think 7 out of 10
•Ask yourself, "What is the next logical step?"
Rest:
•Switch away from primary task
•Transition out of fight-flight stress response
•Sleep (for body AND mind)
Balance these. Simple as that.
New Research Review: The Surprising Role of Rapamcyin in Treating Long COVID and Post-Viral Symptoms: https://hspan.io/j5Cyvz
If you’re not participating in structured exercise, consuming a high-protein diet may cause some level of metabolic damage in the long term due to impaired insulin sensitivity, increased insulin-glucagon, and impaired suppression of hepatic glucose production.
Exercise prevented all the negative effects associated with high-protein diets.
While the human and animal data suggest that increased protein intake is bad for metabolic health, some people consuming the highest protein levels–athletes–are metabolically very healthy.
Notably, the high-protein diet, when combined with exercise training, resulted in greater gains in lean mass, with no impairments to glycaemic control or the accumulation of fat mass observed in the non-exercise, high-protein group.
In @michaelamrd’s low-protein vs high-protein investigation, they had an additional two groups which consumed the same low/high protein diets but with the addition of resistance-type exercise.
The reduced mTOR activity still results in increases in muscle protein synthesis and increased muscle mass over time.
It’s worthy of note those adults that reported the greatest gains in muscle mass actually observed the greatest inhibition of genes related to mTOR.
A common misconception is a desire to repeatedly initiate mTOR activity to maximize muscle growth.
Although acute exercise increases mTOR & muscle protein synthesis, repeated chronic exposure to resistance training actually results in a decrease in mTOR activity over time.
The increased body mass and adiposity also resulted in a 22% increase in fasting blood glucose and a 35% reduction in glycaemic control in response to a glucose tolerance test.
What's causing this increase in adiposity and elevated glucose levels?
Notably, high-protein diets caused an +635% increase in body mass.
Although this was due to gains in muscle mass, but also fat mass (+212%), and in particular white adipose tissue (+106%) and liver mass.
The representative dietary protein intake in the average 80kg US male would be ~43g of protein (0.5g/kg) & ~231g of protein per day (2.8g/kg).
As a result, there were some quite distinct differences between the two diets.
Michaela’s recent work (published here https://www.biorxiv.org/content/10.1101/2022.10.18.512689v1.full.pdf) probed the effects of a low-protein diet (7% of caloric intake) and a high-protein diet (37% of caloric intake) with and without progressive resistance-type exercise.
A main hypothesis of her work from @LammingLab is the restriction of dietary protein and BCAA’s results in a reduced expression of mTOR activity, resulting in improvements in metabolic health, disease prevention, and increased lifespan.
As a Ph.D. candidate at the @lamminglab, @michaelamrd's research has begun to unravel the physiological role of protein and BCAA restriction, and even the restriction of certain amino acids within the diet to enhance body composition, metabolic health, and longevity.
