Michael Wilson

Survey Challenge

Hey ALS/MND peeps! Quick mission for you as I know how much you enjoy clicking buttons. Please take this 2025 Fundamental Rights Survey for people with ALS/MND, caregivers, and blood relatives. Open to all around the world.

survey.alchemer-ca.com/s3/50360855/...

More like "conservative guys over 40"

Social media data can be informative, but extremely limited.

FDA Patient-Focused Drug Development: Workshop

COI - Concepts of Interest
MAH - Meaningful Aspects of Health
COA - Clinical Outcome Assessment

Takeaway is FDA very interested in including patient experience data, but is very challenging. These should be part of trial design.

a man with a mustache is making a funny face and saying i 'm biting my tongue . ALT: a man with a mustache is making a funny face and saying i 'm biting my tongue .

Some days this is hard

seekingalpha.com/news/4485598...

So there blaming the Citizen's Petition on lack of trial funding and falling off the NASDAQ?

This isn’t just in a galaxy far, far away.

"Of all the things at risk, the loss of an objective reality is perhaps the most dangerous. The death of truth is the ultimate victory of evil. When truth leaves us...we become vulnerable to the appetite of whatever monster screams the loudest."

- Mon Mothma, Andor S2E9

Maybe we can find someone to bring in some drama!?

@lynnbr2.bsky.social @alsadvocacy.bsky.social

🤣🤣😂😅

So NfL is listed as pre-specified key secondary endpoint for Tofesen in clinical trial site. NfL not listed on site for Nurown, but is in SAP as pre-specified other secondary/exploratory endpoint. Not sure if FDA weights those differently, but I think the %NfL drop between the two was biggest thing.

ChatGPT - NurOwn Approval vs Cancer Drugs Shared via ChatGPT

Did a deeper dive and added this article:

-Seems virtually all AA are based on pre-specified surrogates, not post-hoc alone. Including all from Table 2.

-Some cancer drugs were approved without confirmatory trials already underway, but this was the minority.

Full chat: chatgpt.com/share/687692...

ChatGPT thoughts...

chatgpt.com/s/t_687691d7...

The real purpose of the scientific method is to make sure nature hasn’t misled you into thinking you know something you actually don’t know.

- Robert M. Pirsig

Cassidy was the deciding vote to confirm RFK Jr. based on a promise not to fire the panel. Maybe confirmation promises aren’t enough when there is ZERO accountability!

Very exciting series!

I'm excited for tonight! #ThunderUp

a mascot for the oklahoma city thunder stands in a bathroom ALT: a mascot for the oklahoma city thunder stands in a bathroom

#ThunderUp

Swearing in with one hand, pulling the rug with the other.

Andy Buckley Obituary June 3, 2025 - Davenport Family Funeral Homes And Crematory View Andy Buckley's obituary, send flowers, find service dates, and sign the guestbook.

RIP, friend! You might be the funniest person I ever met. Gonna miss our banter.

You endured a lot of hate from some in the ALS community because they disagreed with you. I'm sorry for getting you involved in that, but you handled it like a champ.

#ALSobit

www.davenportfamily.com/obituaries/a...

That was a tough loss…Congrats on Game 1!

Nothing says 'defender of democracy' like wielding the weapon of a Sith Lord. So...no Star Wars nerds on his staff?

May the 4th be with you my fellow #ALSWarriors!