Gomes Lab

So proud of Felicia Lazure, who spearheads our studies on aging and lung cancer, for her American Lung Association Catalyst Award. Thank you for the continued support of our studies @moffittnews.bsky.social #proudPI

Super proud of @standrapela.bsky.social, this just cements what I have known all along, you have a bright future ahead of you! #proudPI

Cancer progression through the lens of age-induced metabolic reprogramming - Nature Reviews Cancer In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.

Super excited to share our newest piece out today @natrevcancer.nature.com linking age-induced metabolic reprogramming to cancer development. www.nature.com/articles/s41...

A big thank you to all the co-authors and collaborators on this study for their contributions to bring this to the finish line! @standrapela.bsky.social
@gomeslab.bsky.social
@jaguirreghisolab.bsky.social
And the majority not on BlueSky!

Aging directs the differential evolution of KRAS-driven lung adenocarcinoma Lung adenocarcinoma (LUAD), the most common histological subtype of lung cancer( [1][1], [2][2] ), is a disease of the elderly, with an average age of diagnosis of about 70 years of age( [3][3] ). Old...

So happy to share the newest pre-print from the lab where we show that old age significantly changes the traits that evolve in established lung adenocarcinoma. This work sheds light into the importance of modeling age-related cancers in the context of old age. www.biorxiv.org/content/10.1...

You cannot underestimate all the positive and long-term benefits of having a supportive #mentor

One could argue this is at least as important as the research topic 🧪

Do choose wisely..

#MentoringMonth

🔔 We're hiring a Research Technician to join our team!
The ideal candidate will be down to work with mice and human tissues, be available to join us for at least two years, and enjoy being a part of an ambitious research team.

Apply here: correialab.com/join-the-team/
Funded by La Caixa Foundation

Happy Holidays from the Gomes Lab 🎄🎅

Great idea Sandy :) can you add me as well?

Congratulations @standrapela.bsky.social, very well deserved #ProudPI

For a starter package on Cancer and Aging 👇🏻 Thanks Sandy ☺️

Join us in Boston! The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health has just opened a Jr. Faculty search. Apply by January 15, 2025 at academicpositions.harvard.edu/postings/14371

Normal breast tissues harbour rare populations of aneuploid epithelial cells - Nature Using single-cell DNA sequencing we show that most healthy women harbour rare populations of aneuploid epithelial cells with copy number alteration events in their breast tissue that expand and accumu...

new out in Nature www.nature.com/articles/s41...

So proud of our student Devesh and postdoc @standrapela.bsky.social representing our lab at #AACRtumorenviron24

🦋Introductory post 🦋

The Metastasis Research Society (MRS) is a professional society for metastasis researchers. The MRS is dedicated to promoting research into all aspects of metastasis, and the exchange of information amongst key stakeholders including scientists, clinicians & patients.

Epigenetic scars of Brca1 loss point toward breast cancer cell of origin - Nature Genetics The two-hit hypothesis suggests that a second mutation is necessary for cancer development in cells with a defective tumor-suppressor gene, such as BRCA1. However, a study now shows that the loss of j...

Check out our News and views on @carman-mc-li.bsky.social cool study about the molecular regulation of Brca1 deficiency mammary oncogenesis - with Steven Lewis www.nature.com/articles/s41...

We had a lot of fun conceptualizing and writing this perspective. If you want to know more about metabolism and cancer dormancy check it out 👇🏻

Mind blowing talk by James DeGregori on viral infection, awakening, and maintenance of metastatic outgrowth. Not good news for those of us that have had multiple Covid-19 infections.

#AACRtumorenviron24

Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...

Super cool work from @vonmeyennlab.bsky.social www.nature.com/articles/s41...

Let's start the week at Bluesky with an updated Starter Pack V3.0 #metabolism and #mitochondrialbiology are super strong here!

go.bsky.app/VavECSX

Thank you Marcelo :)

Thank you Nima :)

Can you add me as well please?

And of course a big thank you to all our collaborators in this project :) #teamwork

Methylmalonic acid is exhausting! The story of an age-related metabolite that suppresses anti-tumor immunity Methylmalonic acid (MMA) is a metabolite known to promote tumor progression within tumor cells but its impact on anti-tumor immune cells has not been studied. Here, we reveal a previously unknown immu...

Here is a breakdown of our findings by Joanne herself communities.springernature.com/posts/methyl...

Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity - Oncogene Oncogene - Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity

Super happy to share our lab new paper spearheaded by graduate student Joanne Tejero describing a role for the age-induced oncometabolite methylamlonic acid in promoting T cell exhaustion and contributing to lung cancer immune evasion. www.nature.com/articles/s41...

Hi Christian, can you add me to this awesome starter pack please?