Have to say, I am tempted to do a second PhD!
27.10.2025 09:17 β π 3 π 0 π¬ 0 π 0@tomayates.bsky.social
Epidemiology, infection https://profiles.ucl.ac.uk/37299-tom-yates/about
Have to say, I am tempted to do a second PhD!
27.10.2025 09:17 β π 3 π 0 π¬ 0 π 0When trains are pricier than planes, thereβs a heavy social, financial and environmental cost
24.10.2025 06:05 β π 26 π 14 π¬ 0 π 1Good this, from @kenanmalik.bsky.social 
Given status quo is unacceptable, the international community must apply overwhelming pressure to ensure one of the two potential solutions comes to pass
Cross community organising, of the kind @standing-together.bsky.social undertake, also important
One reason why the government is in a mess is that βis that true tho?β doesnβt get anywhere near enough weight against βwhat do the public think?β
23.10.2025 09:46 β π 305 π 84 π¬ 15 π 1π Thinking about a PhD in clinical trial #methodology?
We have two funded PhD opportunities for students passionate about trial design and statistical methods:
β’	One in estimands
β’	One in non-inferiority trials
π More info and how to apply here: buff.ly/lCpqcF6
@mrcnihrtmrp.bsky.social
βModerna is still developing the CMV vaccine for patients undergoing a bone marrow transplant.β www.statnews.com/2025/10/22/m...
22.10.2025 20:20 β π 1 π 2 π¬ 0 π 0I think there are major advantages to the approach
Why expect optimal duration to be a standard number of days, e.g. 3, 5, 7, 10, 14, etc?
With DURATIONS, even if you don't manage to prove non inferiority of e.g. 7 days, top end of the confidence interval can still allow you to shorten treatment
Mushrooms
Mushrooms
Mushrooms
Mushroom
18.10.2025 18:54 β π 3 π 0 π¬ 0 π 0Perhaps, but Matteo published the DURATIONS design paper 7 years ago now
What if the optimal duration turns out to be e.g. 10 days?
Why are we still doing duration A vs duration B trials?
18.10.2025 12:32 β π 0 π 0 π¬ 1 π 0Table showing marginal tax rates, excluding employer NI, existing and after proposed 2p cut in National Insurance and 2p rise in Income Tax: UK excluding Scotland
Switching 2p from National Insurance to Income Tax would raise Β£6 billion while protecting pay packets.
The increase in the state pension would mean that all pensioners with incomes below Β£40,000 would still be better off next year than this year. 
Read 'Call of duties' now β€΅οΈ buff.ly/BKL1NyD
Scenario I'm considering has patient on long course of cefazolin for another indication
13.10.2025 18:21 β π 0 π 0 π¬ 1 π 0What do we think about cefazolin for late latent syphilis? @drmichaelmarks.bsky.social 
#IDsky
Good listen
12.10.2025 08:25 β π 5 π 2 π¬ 0 π 0NEW EDITORIAL!
Me, @drjesspotter.bsky.social and Rouxjeane Venter argue
- that rapid near patient DST should be developed alongside new RRTB treatment regimens
- for changes in the design of Phase 3 treatment trials
- we must oppose unprecedented cuts to research funding and development assistance
NEW EDITORIAL!
Me, @drjesspotter.bsky.social and Rouxjeane Venter argue
- that rapid near patient DST should be developed alongside new RRTB treatment regimens
- for changes in the design of Phase 3 treatment trials
- we must oppose unprecedented cuts to research funding and development assistance
I think people with a CFS label most likely have a mix of different pathology
I think psychiatric and physical illness are equally 'real'
I think these findings won't replicate
Or possibly these are biomarkers common to many different illnesses, perhaps the downstream consequences of inactivity
Young lives cut short on an unimaginable scale: the 18,457 children on Gazaβs list of war dead
08.10.2025 07:51 β π 309 π 232 π¬ 22 π 26Even if you disregard likely overfitting, the tiny validation sample and whether the outcome is pathophysiologically coherent, what is this test for? 
You don't need a Β£1000 test to distinguish folk with profound fatigue from people with normal activity levels - you can just ask them
Reform UKβs ex-leader in Wales Nathan Gill pleads guilty to bribery charges
26.09.2025 12:11 β π 155 π 103 π¬ 23 π 39Powell or Phillipson? I am leaning Powell
26.09.2025 20:44 β π 0 π 0 π¬ 0 π 0I have no idea. The press release suggests two different dosing strategies were tried
25.09.2025 15:00 β π 1 π 0 π¬ 0 π 0There is a press release
uniqure.gcs-web.com/news-release...
Sham procedures are certainly done to robustly evaluate surgical interventions - you can blind patient and have blinded outcome assessors
Or a blinded MAMS-ROCI across a wide range of doses could have been done - a completely flat dose response curve would suggest no biological activity
I think the regulator/REC dropped the ball
This exercise reduced equipoise without generating sufficient data to allow intervention to be confidently rolled out
To roll out expensive invasive intervention in perpetuity, we really need to know how well it works
For me, the key question is whether that journey includes a trial demonstrating definitively whether the intervention does more good than harm
25.09.2025 08:07 β π 3 π 0 π¬ 0 π 0I am not sure data of that kind can be sufficiently robust to roll out an invasive intervention without an RCT
25.09.2025 08:06 β π 1 π 0 π¬ 0 π 0Cohort of 29 compared to a propensity score matched group of comparator patients
Unclear from press release whether RCT will be required by regulator
Clear potential for harm - drug instilled during a lengthy neurosurgical procedure
Thoughts? #medsky #statsky
I don't know if those data exist. Will be mix of leaving and not starting research track. The consultant contract partly compensates trainees who delay completing training due to dual specialty or less than full time working, but there is no such protection for time spent in research.
23.09.2025 19:00 β π 0 π 0 π¬ 0 π 0The average main applicant who received a visa 2019-2023 made about 45% more than the average person in the UK. The average dependent who received a visa 2019-2023 made about 25% less than the average person in the UK. The average person who received a humanitarian visa made about 33% less than the average person in the UK. When we take a weighted average of all categories of 2019-2023, the average new migrant who arrived 2019-2023 made Β£24,881 in FY 2023-2024. This is about 4% more than average earnings - even when I have made optimistic assumptions about native-born earnings and excluded any self-employment income for migrants. It is difficult to see how admitting people who outearn the native-born would be catastrophic for public finances, particularly given that the British state need not pay to educate them. The data certainly does not seem to suggest this cohort is a βticking time bombβ for British public finances
There are actually credible and competent analysts looking at the data. 
www.laurenpolicy.com/p/are-recent...