I think there are major advantages to the approach
Why expect optimal duration to be a standard number of days, e.g. 3, 5, 7, 10, 14, etc?
With DURATIONS, even if you don't manage to prove non inferiority of e.g. 7 days, top end of the confidence interval can still allow you to shorten treatment
19.10.2025 08:09 β π 1 π 0 π¬ 0 π 0
Mushrooms
Mushrooms
Mushrooms
Mushroom
18.10.2025 18:54 β π 1 π 0 π¬ 0 π 0
Perhaps, but Matteo published the DURATIONS design paper 7 years ago now
What if the optimal duration turns out to be e.g. 10 days?
18.10.2025 14:01 β π 0 π 0 π¬ 1 π 0
Why are we still doing duration A vs duration B trials?
18.10.2025 12:32 β π 0 π 0 π¬ 1 π 0
Table showing marginal tax rates, excluding employer NI, existing and after proposed 2p cut in National Insurance and 2p rise in Income Tax: UK excluding Scotland
Switching 2p from National Insurance to Income Tax would raise Β£6 billion while protecting pay packets.
The increase in the state pension would mean that all pensioners with incomes below Β£40,000 would still be better off next year than this year.
Read 'Call of duties' now β€΅οΈ buff.ly/BKL1NyD
13.10.2025 15:15 β π 12 π 9 π¬ 0 π 0
Scenario I'm considering has patient on long course of cefazolin for another indication
13.10.2025 18:21 β π 0 π 0 π¬ 1 π 0
What do we think about cefazolin for late latent syphilis? @drmichaelmarks.bsky.social
#IDsky
13.10.2025 16:27 β π 0 π 0 π¬ 1 π 0
Good listen
12.10.2025 08:25 β π 4 π 2 π¬ 0 π 0
Priorities in addressing rifampicin resistant TB
Progress in testing and trial design are needed
Rifampicin is a critical component of tuberculosis (TB) treatment regimens. Recent positive developments in rifampicin resistant TBβthe emergence of ne...
NEW EDITORIAL!
Me, @drjesspotter.bsky.social and Rouxjeane Venter argue
- that rapid near patient DST should be developed alongside new RRTB treatment regimens
- for changes in the design of Phase 3 treatment trials
- we must oppose unprecedented cuts to research funding and development assistance
11.10.2025 09:29 β π 6 π 4 π¬ 0 π 0
Priorities in addressing rifampicin resistant TB
Progress in testing and trial design are needed
Rifampicin is a critical component of tuberculosis (TB) treatment regimens. Recent positive developments in rifampicin resistant TBβthe emergence of ne...
NEW EDITORIAL!
Me, @drjesspotter.bsky.social and Rouxjeane Venter argue
- that rapid near patient DST should be developed alongside new RRTB treatment regimens
- for changes in the design of Phase 3 treatment trials
- we must oppose unprecedented cuts to research funding and development assistance
11.10.2025 09:29 β π 6 π 4 π¬ 0 π 0
I think people with a CFS label most likely have a mix of different pathology
I think psychiatric and physical illness are equally 'real'
I think these findings won't replicate
Or possibly these are biomarkers common to many different illnesses, perhaps the downstream consequences of inactivity
08.10.2025 23:26 β π 1 π 0 π¬ 0 π 0
Young lives cut short on an unimaginable scale: the 18,457 children on Gazaβs list of war dead
The childrenβs names below appear on a list of victims of Israelβs offensive in Gaza, maintained by health authorities in the territory. As of the end of July it ran to 60,199 names, of whom 18,457 were under 18s. Far from comprehensive, the list does not include the thousands still buried under the rubble of destroyed buildings, as well as the warβs many indirect victims
As of the end of July there were 18,457 children named on the long official list of Palestinian victims of Israelβs war in Gaza. Over almost two years, that is equivalent to bombs, bullets and shells killing a boy or girl every hour of every day.
In reality the deaths are not spaced out so evenly. Siblings, cousins and playmates are often killed together, by an airstrike or artillery shell. Even children shot by snipers or quadcopters are sometimes brought into hospitals in groups, doctors say. Continue reading...
Young lives cut short on an unimaginable scale: the 18,457 children on Gazaβs list of war dead
08.10.2025 07:51 β π 307 π 232 π¬ 21 π 26
Even if you disregard likely overfitting, the tiny validation sample and whether the outcome is pathophysiologically coherent, what is this test for?
You don't need a Β£1000 test to distinguish folk with profound fatigue from people with normal activity levels - you can just ask them
08.10.2025 17:47 β π 6 π 0 π¬ 1 π 0
Powell or Phillipson? I am leaning Powell
26.09.2025 20:44 β π 0 π 0 π¬ 0 π 0
I have no idea. The press release suggests two different dosing strategies were tried
25.09.2025 15:00 β π 1 π 0 π¬ 0 π 0
There is a press release
uniqure.gcs-web.com/news-release...
25.09.2025 14:36 β π 0 π 0 π¬ 0 π 0
Sham procedures are certainly done to robustly evaluate surgical interventions - you can blind patient and have blinded outcome assessors
Or a blinded MAMS-ROCI across a wide range of doses could have been done - a completely flat dose response curve would suggest no biological activity
25.09.2025 14:23 β π 0 π 0 π¬ 1 π 0
I think the regulator/REC dropped the ball
This exercise reduced equipoise without generating sufficient data to allow intervention to be confidently rolled out
To roll out expensive invasive intervention in perpetuity, we really need to know how well it works
25.09.2025 13:34 β π 1 π 0 π¬ 1 π 0
For me, the key question is whether that journey includes a trial demonstrating definitively whether the intervention does more good than harm
25.09.2025 08:07 β π 3 π 0 π¬ 0 π 0
I am not sure data of that kind can be sufficiently robust to roll out an invasive intervention without an RCT
25.09.2025 08:06 β π 1 π 0 π¬ 0 π 0
Cohort of 29 compared to a propensity score matched group of comparator patients
Unclear from press release whether RCT will be required by regulator
Clear potential for harm - drug instilled during a lengthy neurosurgical procedure
Thoughts? #medsky #statsky
24.09.2025 19:01 β π 12 π 4 π¬ 4 π 0
I don't know if those data exist. Will be mix of leaving and not starting research track. The consultant contract partly compensates trainees who delay completing training due to dual specialty or less than full time working, but there is no such protection for time spent in research.
23.09.2025 19:00 β π 0 π 0 π¬ 0 π 0
The average main applicant who received a visa 2019-2023 made about 45% more than the average person in the UK.
The average dependent who received a visa 2019-2023 made about 25% less than the average person in the UK.
The average person who received a humanitarian visa made about 33% less than the average person in the UK.
When we take a weighted average of all categories of 2019-2023, the average new migrant who arrived 2019-2023 made Β£24,881 in FY 2023-2024. This is about 4% more than average earnings - even when I have made optimistic assumptions about native-born earnings and excluded any self-employment income for migrants.
It is difficult to see how admitting people who outearn the native-born would be catastrophic for public finances, particularly given that the British state need not pay to educate them. The data certainly does not seem to suggest this cohort is a βticking time bombβ for British public finances
There are actually credible and competent analysts looking at the data.
www.laurenpolicy.com/p/are-recent...
23.09.2025 06:55 β π 57 π 23 π¬ 3 π 0
I don't think that is true for medically trained folk
The current generation exit medical school with ~100k debt
There will generally be clinical work available, to pay bills
Choosing academic path means losing Β£10ks in pay
23.09.2025 06:46 β π 0 π 0 π¬ 1 π 0
Maybe not a priority, though I'd point out govt are also opening new prisons, extending freeze on fuel duty, maintaining tax relief for rich pensioners, etc
Leaving things as they are will mean docs from less affluent backgrounds will be underrepresented in next generation of clinical academics
22.09.2025 21:27 β π 0 π 0 π¬ 1 π 0
There is a big financial penalty to pursuing a clinical academic career - delay to CCT (consultant salary), loss of out of hours supplements whilst on research blocks
Unless this can be addressed, it will increasingly become a choice restricted to doctors from wealthy families
22.09.2025 07:05 β π 5 π 1 π¬ 1 π 0
Results of polling initiated by Compass:
- 92% of Labour Party members support the public ownership of essential utilities.
- 91% support taxing the wealth of the richest in our society.
- 84% support an end to the two-child benefit limit.
There's overwhelming support amongst Labour's membership for a more radical offer on democracy, the economy, child poverty & more.
We believe the voices of radical realists, the vast majority of the Labour Party, must be heard and heeded.
Join us: mainstreamlabour.org/get-involved
09.09.2025 09:12 β π 17 π 8 π¬ 3 π 3
Assistant Professor, Case Western Reserve University (CCLCM). Staff Biostatistician, Cleveland Clinic.
Epidemiologist interested in causal inference, infectious disease, trial design
https://christopherbboyer.com/about.html
#causalsky #statssky #episky
Professor of Epidemiology Harvard Chan SPH, Director, @ccdd-hsph.bsky.social. Views my own.
Labour & Co-op MP for Manchester Central | contact@lucypowell.org.uk
https://www.lucyfordeputy.co.uk/
Economist; professor; health policy and decision science. Advocate for high quality, affordable #HigherEd. Georgetown and UW-Madison alum. Personal views only. #AcademicSky #EconSky #Bayesian
https://orcid.org/0000-0002-9790-2988
Healer, teacher, fighter, mother, comrade, singer . Working with amazing friends to slay dragons and make the world more fair CMO@PIH
Politics Professor, University of Manchester.
Author of "The British General Election of 2024", "The British General Election of 2019" & "Brexitland"
My Substack, "The Swingometer", is here: https://swingometer.substack.com/
https://www.robertford.net/
The home for Labourβs radical realists - united by values, driven by change.
Join us to unlock the transformative potential of the Labour Party.
http://mainstreamlabour.org/
MP for Norwich South βThe ultimate hidden truth of the world is that it is something we make and could just as easily make differentlyβ - David Graeber
Scottish Green Councillor for Shetland South.
Scotlandβs most northerly paediatrician.
Wealth tax, wolves and wokery.
Journalist. Editor of @londoncentric.media, a modern news outlet covering London in the old-fashioned way: www.londoncentric.media
Writes the most popular UK politics Substack (samf.substack.com)
Sunday Times bestselling book "Failed State" out now. (An Economist and Financial Times Book of the Year for 2024).
Senior fellow: Institute for Government
Sitting on the sidelines is for Waldorf and Statler. Promoted by Tim Dexter on behalf of Labour both at 23 Orford Rd E17 9NL.
Streptococcal and Infectious Diseases research at Imperial College London- and Infectious Diseases Physician
Infectious Disease Epidemiologist at University of Cambridge
Infection and Immunity | Vaccines and Antibodies | Strep A and rheumatic fever | Research scientist and Associate Professor in Aotearoa New Zealand
Wellcome Career Development Fellow, University of Sheffield and the Florey Institute working on streptococci. #SpyLab #StrepA
Prof @McGillU. Albert Boehringer I Chair. I'm here for talk about study design, good pizza, snow sports, cycling, soccer (#cfmtl and #fulhamfc), and work-life balance. Would rather be outside.