Tom Yates

Nurses are right to demand more

You can donate to the RCN strike fund here

@stellacreasy.bsky.social

I live in Britain; I grew up in Israel. It’s painful to say, but we need real UK sanctions to save Gaza | Yair Wallach Symbolic gestures and empty statements are no longer enough. In Israel’s globalised economy, here’s what will shift public opinion, says says senior lecturer in Israeli studies Yair Wallach

By continuing business as usual, Israel’s international partners are allowing the Israeli government to continue with its genocidal campaign with no consequences beyond symbolic gestures of disapproval and statements.
The time to act is now - me @theguardian.com

www.theguardian.com/commentisfre...

It is very hard to see how the UK government can sign this statement, which makes it absolutely clear that it recognises that Israel is committing - as a matter of state policy - deliberate and systematic war crimes, without at a minimum cutting all military cooperation with Israel.

The upcoming NIRVANA study will randomise these folk to valganciclovir or placebo to test safety, with a view to a phase 3 trial powered for mortality.

Text from British National Formulary advising against giving various sulfonamide antibiotics with methenamine due to risk of crystalluria. Manufacturer advises avoid. Severity: severe. Evidence: theoretical.

Clinical pharmacology friends, how likely is it that patients would develop sulfamethoxazole crystals in urine if given prophylactic doses of co-trim PLUS methenamine? The case reports I have seen are all patients on high dose co-trim

#IDSky #ClinPharm

SNAP trial update

➡️ The DSMC provided a recommendation to close the ADJUNCTIVE domain (Clindamycin), due to a statistical trigger for futility being met.

#IDsky

Perhaps unsurprising - force of infection will be high in this age group and setting, so we expect lots of primary CMV in a very immunocompromised population

I am told the CHAMPS post mortem studies also found lots of CMV

Wow, maybe there is something to this CMV thing!

Indirect effects, do you think, or are we missing loads of CMV pneumonitis in paediatric AHD?

Can't believe the EMPIRICAL study showing reduced MORTALITY in kids with pneumonia given valganciclovir didn't get an oral! Come on #IAS2025. This is a VERY important finding.

Francois Venter | Slow motion denialism: Our leaders are allowing the HIV response to collapse South Africa is staging a sequel to Mbeki-era denialism, only this time, the science, solutions, and costs are clearer, argues Professor Francois Venter.

MUST READ | South Africa is staging a sequel to Mbeki-era denialism, only this time, the science, solutions, and costs are clearer, argues Professor @francoisventer.bsky.social‬. @groundup.org.za

www.spotlightnsp.co.za/2025/07/16/f...

Thanks, you may be right

Intervention an alternative to long term antibiotic

Authors suggest biological explanations for why UTIs more common in Hiprex arm, averaged over 6m 'treatment' and 6m post treatment periods

But wonder if it is just that those failing in placebo arm started LT antibiotics

Actions - such as diverting ODA funding to pay for defence spending - have consequences

@stellacreasy.bsky.social

Well, if the goal is number of papers, then absolutely!

Struggling to understand how 12m analysis accounted for fact that more women randomised to 6m of placebo were started on suppressive antibiotics (4.5%) than women randomised to 6m Hiprex (2.4%)

Presumably these were the women most vulnerable to UTI recurrence

#Estimands @brennankahan.bsky.social

Reweighting UK Biobank corrects for pervasive selection bias due to volunteering AbstractBackground. Biobanks typically rely on volunteer-based sampling. This results in large samples (power) at the cost of representativeness (bias). Th

There are going to be an awful lot of analyses that need redone when people finally accept that collider bias is a major issue in unweighted analyses of UKBB data

I have seen it used for treatment in UK - often in folk who struggle to stick to oral regimens

And I understand it is used for treatment quite a bit in Spain

Yes, though over time, and with sufficient coverage, might select for lencapavir resistant strains at community level

Do you know what the genetic barrier to resistance is?

I think this could be game changing in communities with very high HIV incidence

#IDSky #EpiSky

With a few caveats, I think this is broadly fair - we really need to address barriers to embedding RCTs in routine clinical care

Adding AI watermark to latest paper...

Free speech for all! Except for Bob Vylan | The Observer Outrage over band's chants shows how meaning of incitement has been expanded

“What such cases expose is the way that expanding the meaning of incitement has become a means for greater policing of speech.” My ‪@theobserveruk.bsky.social‬ column: observer.co.uk/news/columni...

Has anyone in the UK yet got access to urine LAM? Why is this so hard?

#IDSky

Primary efficacy endpoints in phase 3 non-inferiority trials to establish new tuberculosis treatment regimens should only include microbiological outcomes Treatment regimens for tuberculosis remain protracted and burdensome, both for patients to adhere to and for health-care providers to administer. Particularly, many current regimens for drug-resistant...

Nice thread

Me and @danieljgrint.bsky.social discussed this recently, with a focus on TB trials

The power argument doesn't hold if measuring a risk difference percent

Genius from my old mate Frank

The Guardian view on Palestine Action: if red paint is terrorism, what isn’t? | Editorial Editorial: Labelling direct action as an act of terror criminalises dissent, chills speech and redefines nuisance as extremism under the banner of national security

The Guardian view on Palestine Action: if red paint is terrorism, what isn’t? | Editorial

A military official stands behind a podium and says, “We have no concrete idea what we did, what comes next, or what it means for the globe, but other than that it was a spectacular military success!”

Today’s Daily Cartoon, by Lars Kenseth. #NewYorkerCartoons

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As every vegetarian who grew up in the 1990s knows, Bean Feast is delicious. But surely this is taking things too far!