Arthur Mortha

https://ilc6vancouver.com/

What's up?

SCIENTIST – Developmental, Stem Cell & Cancer Biology Program - Toronto (City), Ontario (CA) job with The Hospital for Sick Children - Developmental & Stem Cell Biology Program | 12848200 Discovery-based and/or translational research using model organism genetics and/or stem cell and organoid platforms to study paediatric cancer.

Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...

Our department is hiring a cancer immunologist (tenure track assistant professor)!

🚨Job posting! #UMassAmherst Department of Veterinary and Animal Sciences is hiring a TT faculty member in #Immunology. Both fundamental and translational areas considered. Please spread the word!
careers.umass.edu/amherst/en-u...

Happy to share new work from #theonlylabever, lead by the phenomenal @sltai.bsky.social - who developed a tool to study the biology of ILC3s, identifying their role in controlling CSF2-dependent myeloid cells. 🤗
@mucosalimmunol.bsky.social @societymucosalimm.bsky.social
OA: doi.org/10.1016/j.mu...

Happy to share that my first first-authored paper is finally out in @mucosalimmunol.bsky.social in time for the long weekend!
This work would not have been possible without the current and past members of @theonlylabever.bsky.social
Check it out here:
www.sciencedirect.com/science/arti...

Group 3 innate lymphoid cell-derived CSF2 tunes homeostasis of tissue macrophages and neutrophils Mucosal surfaces are complex ecosystems that rely on continuous communication between host and the inhabiting microbiota to sustain immune balance and health. The vast complexity of microbial communit...

Group 3 innate lymphoid cell-derived CSF2 tunes homeostasis of tissue macrophages and neutrophils from @sltai.bsky.social @theonlylabever.bsky.social and colleagues: www.mucosalimmunology.org/article/S193...

New Postdoc position as part of the recently awarded MRC Core in Exposome Immunology, led by Jo Konkel here @lydiabeckeriii.bsky.social. Job ad and more info below:
www.jobs.manchester.ac.uk/Job/JobDetai...

www.bmh.manchester.ac.uk/research/ins...

This one is going to be amazing! The 6th International Conference on Innate Lymphoid Cells.
ilc6vancouver.com
Mark your calendars, tell your friends and share widely please. 😘
#immunosky #2026ILC6 #ILC6Vancouver #ILC6

Amyloid-β-driven Alzheimer’s disease reshapes the colonic immune system in mice Makhijani et al. investigate the colonic immune landscape in the 5XFAD model, showing a reduction in CXCR4+ antibody-secreting cells and a concomitant increase in brain CXCL12. Dietary intervention wi...

Amyloid-β-driven Alzheimer’s disease reshapes the colonic immune system in mice: Cell Reports www.cell.com/cell-reports...

The gut immune system is altered in mouse model of Alzheimer’s, providing a new target for therapeutics Feeding the animals a high fiber diet reduced Alzheimer’s-related frailty including tremor.

Is brain/gut axis a superhighway for immune response to #Alzheimers? Study in @cellpress.bsky.social shows immune cells use that route in mouse models. Feeding animals high fiber diet reduced AD-related frailty. Congrats Dr. Winer, Dr. Makhijani, & Dr. Andersen
www.buckinstitute.org/news/the-gut...

In our latest work we've explored associations between the fecal bile acid pool and helminth infection status in school aged children in Uganda. Have a read and see what we found!

Regulation of inflammatory responses by pH-dependent transcriptional condensates BRD4 functions as an intracellular pH sensor through a conserved histidine-rich intrinsically disordered region. Inflammation-associated acidification triggers a pH-dependent switch in transcriptional...

pH controls inflammatory response through transcriptional condensates...but how? Read all about the mechanism here -> ‪
@xuzhoulab.bsky.social
www.cell.com/cell/fulltex...
www.nature.com/articles/s41...
www.preprintclub.com/preprint-rev...
@preprintclub.bsky.social

HBD.

Happy 🇨🇦 day! 😘

Single-celled organisms set for greater role in gut health Long cast as villains, some protists, such as Blastocystis, are potentially beneficial to human health.

www.nature.com/articles/d41...

🇨🇦🚨Job Alert🚨🇨🇦
Canada Excellence Research Chair (C$5 or C$10M, 8 yr budget)
U Toronto, Dept of Biochem/LabMedPath
*Was just told they're looking for a structural biologist using cryoEM* (related to infectious disease?)
Are you an established PI ready to move to 🇨🇦?
research.utoronto.ca/funding-oppo...

Canadian Excellence Research Chair (CERC) in Human Immunology Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Are you an established PI that studies the human immune system and looking for a change of location? If the answer is yes, #McGill has an amazing opportunity to provide long-term funding at a world class institution. Apply now!!!! Please repost!!! mcgill.wd3.myworkdayjobs.com/en-US/McGill...

My Canadian university, Queen's, is offering TWENTY 4-year funded PhDs (40k CAD/yr) for a student of ANY citizenship who has been accepted at a top 100 US university but have had offer rescinded OR are reconsidering offer due to US policy.
Details found here👇

www.queensu.ca/grad-postdoc...

Why is Dr. Arthur Mortha's lab called @theonlylabever.bsky.social?

Find out in our latest episode, and learn about his work on ILCs and their interactions with the #microbiome!

Listen now: bit.ly/43NmHO0

Global evolution of inflammatory bowel disease across epidemiologic stages - Nature An analysis of data from 522 population-based studies encompassing 82 global regions and spanning more than a century (1920–2024) shows spatiotemporal transitions across epidemiologic stages 1 to 3 of...

Open-access @nature.com paper from GIVES21 consortium and IOIBD, co-led by Siew Ng and I, funded by @helmsleytrust.bsky.social, reveals the global evolution of IBD across epidemiologic stages. Co–first authors: Dr. Hracs and Dr. Windsor, @ucalgary.bsky.social. www.nature.com/articles/s41...

“America First” Will Destroy U.S. Science The U.S. government has sought to restrict immigration under the “America First” doctrine. These policies severely harm American science by stripping it of talent and eliminating a major driver of its...

25 years ago, I came to Stanford on a J1 visa and worked so hard to be worthy of that privilege. Today, I lead Immunology at Mount Sinai and I am the one who feel privileged when brilliant international trainees chose to join us.

The nervous system comprises the CNS and associated sensory nerves (blue) and the autonomic nervous system, which includes sympathetic and parasympathetic nerves (red) and the ENS (purple). The immune system is composed of cells that span the entire body. This includes the meningiocranial immune system, which comprises immune cells important for neural development, brain repair, and brain border protection. Repeated exposure to allergens at mucosal sites (for example, lung, skin, and gut) can trigger local type 2 immunity. Type 2 immune cells signal to neurons across the periphery and brain through cytokines, whereas neurons signal to immune cells via neurotransmitters and neuropeptides. This is not an exhaustive list of cellular players, given that other tissue resident cells (e.g., fibroblasts and glial cells) may also respond to these signals.

In a new #ScienceImmunology Review, researchers discuss how interactions between the nervous and immune systems could impact neurological disorders and allergy-related behaviors like food avoidance. scim.ag/4mpgzE5

📢📢📢Link here!
The #NIH town hall is tomorrow 1-2 PM ET. I hope someone asks, "When will you comply with the name and email signature block mandates?"

Robbie Jin & Tracy McGaha discuss a study from @raquelbuj.bsky.social @airdlab.bsky.social reporting that Cdkn2alow tumours impair macrophage phagocytosis by depriving them of zinc

Congratulations team King! 🥳

Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...

#WeekendRead! #NotAllFatIsEqual! @lexiong.bsky.social Seillet &co show @cp-immunity.bsky.social that #diet saturated fatty acids rapidly impair (while unsaturated fatty acids favor via lipid droplets) IL22 production by ILC3 supporting dysbiosis & gut permeability, exacerbating inflammation!

Check out our feedback on this #preprint 📚 📚📚

www.preprintclub.com/preprint-rev...

A pan-cancer atlas of T cell targets T-cell-based immunotherapies have revolutionized cancer treatment, yet only a minority of patients respond to these approaches, significantly constrained by the limited knowledge of tumor-specific ant...

Tomorrow, in #PreprintClubHub1 MD Anderson’s own Ben Shrank will present a #preprint about a pan-cancer T-cell target atlas for the identification of tumour-specific antigens. 🍳 🎯 🌎

www.biorxiv.org/content/10.1...

Maternal immune activation imprints a regulatory T cell deficiency in offspring that drives an autism-like phenotype Maternal immune activation (MIA) triggers an IL-17-driven autism spectrum disorder (ASD) in mouse and human offspring. While regulatory T cells (Tregs) regulate Th17 cells, their involvement in MIA an...

In our Wednesday #DoubleFeatureEvent, Toronto’s Madhieh Golzari will present a #preprint about how maternal immune activation imprints a regulatory #T-cell deficiency that drives an autism-like phenotype in offspring. 🤰🤰🤰

www.biorxiv.org/content/10.1...