Larissa Fischer @fislarissa

Latest posts by fislarissa.bsky.social on Bluesky

Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults. Fischer, Larissa; Adams, Jenna N; Molloy, Eóin N.; et al. Scientific reports Vol. 15, no. 1, p. 38499

New paper out: Longitudinal functional connectivity during rest and task is differentially related to Alzheimer's pathology and episodic memory in older adults.: Fischer, Larissa; Adams, Jenna N; Molloy, Eóin N.; et al.
Scientific reports Vol. 15, no. 1, p. 38499 Thanks for sharing! #dzne #papers

18.11.2025 12:28 — 👍 0 🔁 1 💬 0 📌 1

5/5 🧳

Our findings highlight region-specific differences in longitudinal rsFC strength between “normal” aging and early AD pathology and shed light on early changes in rsFC strength with AD pathology, which might already be disadvantageous for episodic memory performance in APOE4 carriers.

17.12.2024 17:49 — 👍 0 🔁 0 💬 0 📌 0

4/5💡

Longitudinal increase in rsFC strength between the anterior hippocampus and the superior precuneus is associated with higher early AD pathology. Higher rsFC strength was related to cognitive decline only in APOE4 carriers.

17.12.2024 17:49 — 👍 0 🔁 0 💬 1 📌 0

3/5 💡

Longitudinal decrease in rsFC strength within the posteromedial cortex and between the posterior hippocampus and the inferomedial precuneus was associated with “normal” aging. Pathology-independent lower rsFC strength was related to cognitive decline.

17.12.2024 17:49 — 👍 0 🔁 0 💬 1 📌 0

2/5 💡
In essence, hypoconnectivity was related to aging, hyperconnectivity was related to early Alzheimer’s pathology.
But which specific regions were involved?!

17.12.2024 17:49 — 👍 0 🔁 0 💬 1 📌 0

1/5 🔎
We investigated resting-state functional connectivity (rsFC) in episodic network regions over two years in cognitively normal amyloid- and tau-negative older adults (“normal” aging sample) and in older adults with CSF measurements (AD-biomarker sample).

17.12.2024 17:49 — 👍 0 🔁 0 💬 1 📌 0

I’m super happy about this project with Anne Maass, Jenna Adams, @sylviavilleneuve.bsky.social and the fantastic PREVENT-AD team!

17.12.2024 17:49 — 👍 1 🔁 0 💬 1 📌 0

Differential effects of aging, Alzheimer's pathology, and APOE4 on longitudinal functional connectivity and episodic memory in older adults Both aging and Alzheimer's disease (AD) affect episodic memory networks. How this relates to region-specific early differences in functional connectivity (FC), however, remains unclear. We assessed re...

Are you interested in distinguishing region-specific longitudinal changes in resting-state functional connectivity related to “normal” aging and to early Alzheimer’s pathology?
Then keep reading about your preregistered study and our fresh preprint! 🧠

www.biorxiv.org/content/10.1...

17.12.2024 17:49 — 👍 5 🔁 0 💬 1 📌 1

I‘m so proud of this team effort, thanks Nick for sharing it here! 😊

20.11.2024 21:19 — 👍 5 🔁 1 💬 0 📌 0

@fislarissa is following 20 prominent accounts

John Sutton
@suttonprofessor

Director, Centre for the Sciences of Place & Memory, Stirling Uni, Scotland. Skill, memory, embodied cognition, philosophy, cognitive history, cricket, music, collaboration, wayfinding. Leverhulme International Prof: johnsutton.net & placememory.net

Daniel Reznik
@reznikdan

Neuroscientist @ Max Planck (previously @ Harvard and @ TelAvivUni). Interested in many things, but trying to focus on anatomy and philosophy

Simon J. Schreiner
@sjschreiner

Neurologist & Neuroscientist. Head of Sleep Medicine, Dept. of Neurology, University Hospital Zurich. Researching Sleep & Neurodegeneration (Alzheimer & Parkinson) | Coffee aficionado | Dad | … https://scholar.google.ch/citations?user=Y7zDnWwAAAAJ&hl=de

Wiesje Pelkmans
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Jonas Schulte-Schrepping
@jsschrepping

PostDoc at Systems Medicine, DZNE, studying innate immunity and memory in the context of inflammatory challenges using (sc)Omics technologies and bioinformatics.

FOR 2812
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Our objective is to address fundamental questions about scenario construction during episodic memory recall.

Rik Ossenkoppele
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Kasia Mojescik
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Post-doc📍Memory Lab, University of Cambridge Check out our project: When Memories Come Alive 🧠 She/her

Alexa Pichet Binette
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Assistant professor @ University of Montreal | Neuroscience | Alzheimer's disease | Imaging | Biomarkers

Yara Yakoub
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PhD candidate @ McGill University

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Nils Briel
@nbriel

Neurology Resident @unispitalzuerich.bsky.social | PostDoc Fellow in Arosio Group @ethz.ch | Interested in biomarkers and molecular pathology of #Tauopathies, #HD and #ALS

Shahrdad Lotfipour, Ph.D.
@lotfipour

Associate Professor at UC Irvine studying translational drug addiction, mechanisms & therapeutics. Neuroscientist, Fulbrighter, 6x Marathoner (3:27:34). TEDx: youtu.be/Or7NeiJj2lw lotfipourlab.org UCIBTC.org

@judithmachts

@bjoernschott

psychiatrist / neuroscientist / DADDY. University Medical Center Göttingen & @dzne.science. #aging #Alzheimer's #PostCOVID #memory #MRI https://www.researchgate.net/profile/Bjoern-Schott

Dr Jose Bernal
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Junior (Assistant) Professor | AIBE@FAU | CSVD & Neuroimaging | He/him

Klara Gawor
@gawor-neuro

PhD candidate aiming to integrate more #DataScience into #Neuropathology | Alzheimer's disease and other neurodegenerative dementias | makes plots for fun 🙃

Rosanna Olsen
@rosannaolsen

Cognitive Neuroscientist; interested in understanding how memory changes as we age; I also love cats and running marathons Senior Scientist, Rotman Research Institute Associate Professor, Psychology, University of Toronto https://www.olsenmemorylab.com/

Sylvia Villeneuve
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Mike Yassa
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Neuroscientist | Entrepreneur | Author