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@anomanellore.bsky.social

22 Followers  |  36 Following  |  3 Posts  |  Joined: 03.03.2025  |  1.7867

Latest posts by anomanellore.bsky.social on Bluesky

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Community-Acquired Respiratory Virus Infections: A Threat to Long-Term Survivors After Allogeneic Stem Cell Transplant? Studies on late community-acquired respiratory virus (CARV) infections in long-term allogeneic hematopoietic stem cell transplantation (allo-HCT) survivors are scarce, creating knowledge gaps on the epidemiology, risk of progression to lower respiratory tract disease (LRTD), and conditions linked...

Community-Acquired Respiratory Virus Infections: A Threat to Long-Term Survivors After Allogeneic Stem Cell Transplant?

#IDSky

12.10.2025 18:12 β€” πŸ‘ 3    πŸ” 3    πŸ’¬ 0    πŸ“Œ 7
Toxoplasma qPCR Kinetics to Guide Preemptive Treatment of Toxoplasmosis After Allogeneic Hematopoietic Stem Cell Transplantation Recent European Conference on Infections in Leukemia (ECIL) guidelines recommend a quantitative polymerase chain reaction (qPCR) guided preemptive treatment approach to toxoplasmosis in seropositive recipients of allogeneic hematopoietic cell transplantation (allo-HCT). Although qPCR might serve as a sensitive tool for early Toxoplasma detection, its role in treatment follow-up remains unknown.MethodsWe analyzed the qPCR kinetics of allo-HCT recipients experiencing either Toxoplasma infection (TI, n = 71) or disease (TD, n = 14) in relation to different parameters. We included 85 patients with available qPCR values expressed as quantitative cycle (Cq) from 4 large hematological centers from 2009 to 2023, and kinetic analysis was performed in a selection of 74 patients screened at least weekly with blood qPCR. Day 0 (D0) was the day of anti-Toxoplasma treatment start or (when untreated) day of diagnosis.ResultsTime to qPCR negativity was inversely proportional to the Cq value at D0 (P = .0063). Not reaching negativity at D10 was associated with a significantly higher mortality at D30 (P = .023). Patients with a high D0-parasitic load and patients with TD showed slower clearance (P < .001, P = .032). Time to negativity was not significantly different for patients started on prophylactic versus curative doses as first-line treatment regimen (P = .16).ConclusionsThis study underscores the predictive value of qPCR kinetics monitoring in allo-HCT patients with toxoplasmosis. With the aforementioned risk factors, clinicians can identify patients at high risk for worse outcome. Our results support to consider a therapeutic change or reinforcement if the parasitic load does not decrease after 10 days, supplementing existing clinical guidelines.

Study of 85 allo-HCT patients showed qPCR negativity time linked to initial Cq value (P = .0063). Not reaching negativity by D10 increased 30-day mortality (P = .023). High D0 load slowed clearance (P < .001).

#idsky

10.10.2025 18:00 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Home - Doctor Fungus Welcome to Doctor Fungus! An Educational Website of theMycoses Study Group Education and Research Consortium (MSGERC) Β  [View Legal Information] Where to Start Mycology Case of the Month An Introducti...

There’s now an app for all things fungi πŸ¦ πŸ„
Dr. Matthew Pullen, Assistant Professor at the University of Minnesota, helped launch Dr Fungusβ€”a free app that brings the trusted resource to your phone.

Explore fungal infections, antifungal treatments, and case-based learningβ€”all in one place.

07.10.2025 13:09 β€” πŸ‘ 39    πŸ” 14    πŸ’¬ 2    πŸ“Œ 2
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Highlights of ESCMID Global 2025 The 35th Congress of the European Society of Clinical Microbiology and Infectious Diseases was held in Vienna, Austria, from April 11 to 15, 2025. Syeda Saleha Hassan reports.

Proud to see key antifungal advances featured in The Lancet Infectious Diseases highlights of #ESCMIDGlobal2025.
@rosannesprute.bsky.social presented global candidiasis guidelines; I shared FURI study results on ibrexafungerp efficacy.
πŸ‘‰ The Lancet article: www.thelancet.com/journals/lan...

08.10.2025 11:19 β€” πŸ‘ 7    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
Blood cultures contain populations of genetically diverse Candida albicans strains that may differ in echinocandin tolerance and fitness It is unknown whether within-patient Candida albicans diversity is common during bloodstream infections (BSIs).MethodsWe determined whole genome sequences of 10 C. albicans strains from blood cultures (BCs) in each of 4 patients. We performed detailed phenotypic studies on strains from 1 patient.ResultsBCs in 3 patients contained mixed populations of strains that differed by large-scale genetic variants, including chromosome (Chr) 5 or 7 aneuploidy and Chr1 loss of heterozygosity (n=1 each). In patient M, Chr7 trisomy (Tri7) strains were attenuated for hyphal and biofilm formation in vitro, due at least in part to NRG1 over-expression. Nevertheless, representative Tri7 strain M1 underwent filamentation during disseminated candidiasis (DC) in mice. M1 was more fit than euploid strain M2 during DC and mouse gastrointestinal colonization, and in blood ex vivo. M1 and M2 exhibited identical echinocandin minimum inhibitory concentrations, but M2 was more tolerant to micafungin in vitro. Furthermore, M2 was more competitive with M1 in mouse kidneys following micafungin treatment than it was in absence of micafungin. Tri7 strains represented 74% of patient MÒ€ℒs baseline BC population, but euploid strains were 98% of the population after 3d of echinocandin treatment. Findings suggest that echinocandin tolerant, euploid strains were a subpopulation to more fit Tri7 strains at baseline and then were selected upon echinocandin exposure.ConclusionsBCs in some patients are comprised of diverse C. albicans populations not recognized by the clinical lab, rather than single strains. Clinical relevance of C. albicans diversity and echinocandin tolerance merits further investigation.

In 4 patients, 10 strains of 🦠 *C. albicans* were analyzed. 3 had mixed strains; 74% were Tri7 before echinocandin, dropping to 2% after 3 days. Echinocandin tolerance needs more study.

#idsky

01.10.2025 12:30 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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From earlier this week: A MRSA strain emerged ~2009 in Brooklyn, NY that is now a major cause of skin infections in the US.

Bo Shopsin & team discover a prophage-encoded methyltransferase that increases virulence by promoting biofilm formation in a mouse infection model:
buff.ly/g0i2DGm

27.09.2025 12:04 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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A MRSA strain emerged ~2009 in Brooklyn, NY that is now a major cause of skin infections in the US.

Bo Shopsin & team discover a prophage-encoded methyltransferase that increases virulence by promoting biofilm formation in a mouse infection model: buff.ly/tbvVWoG

22.09.2025 13:20 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 2    πŸ“Œ 0
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Denmark close to wiping out leading cancer-causing HPV strains after vaccine roll-out A nationwide study suggests infections with human papillomavirus (HPV) types 16 and 18 have been virtually eliminated since vaccination began in 2008 – protecting even unvaccinated women.

I am here to say vaccines are awesome because guess what Denmark is close to completely eliminating the two most dangerous HPV strains (serotype 16 and 18) and with the cervical cancer.I think that is bloody AMAZING!!!!
bit.ly/4pbHxjT

08.09.2025 21:52 β€” πŸ‘ 1011    πŸ” 276    πŸ’¬ 11    πŸ“Œ 15
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CBS video and text: NIH whistleblower Jeanne Marrazzo details clash over childhood vaccines with Trump administration: "We became inconvenient"

πŸ‘‰ cbsn.ws/3IcWNwc

09.09.2025 02:13 β€” πŸ‘ 7    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Florida moves to end all school vaccine mandates, first in nation to do so β€” The Washington Post Florida Surgeon General Joseph A. Ladapo criticized school vaccine mandates, which every state has, and likened them to slavery.

This is where we are?

Sadly, yes. We vilify that which protects our children. Truly dystopian.

apple.news/AljZtI59wQ8S...

03.09.2025 18:57 β€” πŸ‘ 18    πŸ” 6    πŸ’¬ 3    πŸ“Œ 0
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Opinion | We Ran the C.D.C.: Kennedy Is Endangering Every American’s Health

www.nytimes.com/2025/09/01/o...

04.09.2025 13:52 β€” πŸ‘ 0    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Whistle-Blower Complaints Detail Tension Over Vaccines at N.I.H.

Whistle-Blower Complaints Detail Tension Over Vaccines at N.I.H. www.nytimes.com/2025/09/04/h....

04.09.2025 21:54 β€” πŸ‘ 1    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Will the C.D.C. Survive?

Will the C.D.C. Survive? www.nytimes.com/2025/08/29/h... I think it will survive but not thrive. CDC rapidly loosing its leadership and relevance nationally and globally. In the short term State and local health departments will be critical for public health.

30.08.2025 06:54 β€” πŸ‘ 14    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0

This is truly a CMV superstar lineup- looking forward to watching this recording!

30.08.2025 14:18 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Great summary slide by @jobadd.bsky.social

22.08.2025 18:09 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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AJT’S new ID blog, TxIDExchange, is dedicated to sharing the latest ID updates, research, and guidelines relevant to the transplant community. We’re soliciting blog posts and comments from you and your colleagues and encourage you to participate.

ajt-transplant-id-exchange.squarespace.com

10.07.2025 19:21 β€” πŸ‘ 9    πŸ” 8    πŸ’¬ 0    πŸ“Œ 1
Is it time for transplant centers to formalize standards like trauma centers? Transplant centers hold the key to accelerating organ use and transplanting more patients more efficiently. However, not all transplant procedures are…

Intriguing proposal by Becker et alia to stratify transplant centers, like trauma hospitals, into levels I, II, and III, assigning patients, organs, and resources accordingly. doi.org/10.1016/j.aj...

08.08.2025 23:27 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Former surgeon general: The CDC shooting must be a wakeup call β€œWhen influential figures amplify falsehoods, they legitimize the anger that leads to violence,” writes former Surgeon General Jerome Adams.

www.statnews.com/2025/08/09/c...

10.08.2025 14:32 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Dr. Robert (Bob) Rubin Transplant ID Award Recipient for 2025 is the amazing @kottonnelson.bsky.social !!! #TxID #MedEd @astinfo.bsky.social

04.08.2025 18:35 β€” πŸ‘ 29    πŸ” 8    πŸ’¬ 0    πŸ“Œ 1
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Broad-spectrum antibiotics for moderately immunocompromised patients with CAP: An overdone practice A study in CID examined broad-spectrum antibiotics in moderately immunocompromised patients with community-acquired pneumonia

Moderate immunocompromise (even if overly broadly defined) should not buy you vanc + antipseudomonal for CAP: my latest @idsainfo.bsky.social Journal Club review:

www.idsociety.org/science-spea...

04.08.2025 16:22 β€” πŸ‘ 12    πŸ” 5    πŸ’¬ 0    πŸ“Œ 1
Visual abstract showing inferior early fungicidal activity (primary endpoint) and csf sterility at 2 weeks (secondary endpoint) in experimental arm, no difference in survival (secondary endpoint)

Visual abstract showing inferior early fungicidal activity (primary endpoint) and csf sterility at 2 weeks (secondary endpoint) in experimental arm, no difference in survival (secondary endpoint)

Evaluating the Use of Lower Dose Flucytosine for the Treatment of Cryptococcal Meningitis: A Clinical Trial

Compared to historical controls w/ standard 100 mg/kg flucytosine dose, a CM regimen w/ low dose (60 mg/kg) flucytosine had inferior CSF fungal clearance

academic.oup.com/cid/advance-...

08.08.2025 12:51 β€” πŸ‘ 11    πŸ” 8    πŸ’¬ 0    πŸ“Œ 0
Cover of The Lancet's July 26, 2025 issue. Quote on cover reads: "It is time to reposition transplantation not as a niche intervention, but as a strategic health system functionβ€”one that must align with global goals regarding NCDs, climate resilience, and pandemic preparedness."

Cover of The Lancet's July 26, 2025 issue. Quote on cover reads: "It is time to reposition transplantation not as a niche intervention, but as a strategic health system functionβ€”one that must align with global goals regarding NCDs, climate resilience, and pandemic preparedness."

Organ transplantation saves lives 🫁

Yet, according to WHO, only 10% of the global need for transplants is being met.

In our latest issue, a Comment introduces the ESOT transplant–Lancet Commission on Transplantation.

➑️ tinyurl.com/ccysxrux

25.07.2025 07:54 β€” πŸ‘ 13    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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Weekly Screening of Circulating Mucorales DNA and early treatment in Severely Burned Patients Improves Survival: Real-Life Bi-center Experience in France Early serum Mucorales DNA detection in severely burned patients enables faster diagnosis of invasive wound mucormycosis, reducing 100-day mortality, partic

Weekly Screening of Circulating Mucorales DNA and early
treatment in Severely Burned Patients Improves Survival:
Real-Life Bi-center Experience in France

Emmanuale Faure... Alexandre Alanio and @sarah-delliere.bsky.socialΒ 

#IDSky #MedMycoSky #IDDx

academic.oup.com/cid/advance-...

31.07.2025 14:01 β€” πŸ‘ 22    πŸ” 11    πŸ’¬ 1    πŸ“Œ 0
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Liver transplantation in Candida endocarditis–induced acute-on-chronic liver failure This case report details the clinical course of a 35-year-old patient with decompensated liver cirrhosis due to primary sclerosing cholangitis awaitin…

#Open Access! "Liver transplantation in Candida endocarditis–induced acute-on-chronic liver failure" by Allgeier et al. doi.org/10.1016/j.aj...

28.07.2025 11:02 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Great to see this work be published, it has been such a wonderful opportunity to be involved with the #IMPACC network - these important findings re immune response to #COVID will be useful for future pandemics especially for vulnerable populations @ast-idcop.bsky.social @niaidnews.bsky.social

29.07.2025 22:28 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
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Letermovir prophylaxis guided by cytomegalovirus cell-mediated immunity improves the outcomes of allogeneic hematopoietic stem cell transplant recipients The control of cytomegalovirus (CMV) reactivation after allogeneic hematopoietic stem cell transplantation (allo-HSCT) depends heavily on the reconstitution of CMV-specific cell-mediated immunity (CMI).

Letermovir prophylaxis guided by cytomegalovirus cell-mediated immunity improves the outcomes of allogeneic hematopoietic stem cell transplant recipients

βœ… Just Accepted
#IDSky

30.07.2025 18:58 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
American Society for Transplantation and Cellular Therapy Series #11: Updated Cytomegalovirus Guidelines in Hematopoietic Cell Transplant and Cellular Therapy Recipients The Practice Guidelines Committee of the American Society of Transplantation and Cellular Therapy partnered with the society’s Transplant Infectious Diseases Special Interest Group to update its previ...

Check out newπŸ”₯
American Society for Transplantation Updated Cytomegalovirus Guidelines in Hematopoietic Cell Transplant and Cellular Therapy Recipients www.astctjournal.org/article/S266...
#IDsky #TxID #IDOnc

23.07.2025 15:50 β€” πŸ‘ 3    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Advanced Fellowship in Transplant Infectious Diseases (TID) Explore our one-year Advanced Fellowship in Transplant Infectious Diseases, offering expert training across Columbia, Weill Cornell, and NewYork-Presbyterian.

Excited to announce a new opportunity for those interested in advancing their careers in TID! Columbia and Cornell now offer a combined advanced TID fellowship! Check us out and apply! @rosypriya.bsky.social @txidfellows.bsky.social
www.infectiousdiseases.cuimc.columbia.edu/education/ad...

16.07.2025 19:40 β€” πŸ‘ 4    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Oncologists need to see antimicrobial resistance as a cancer care delivery crisis Oncologists must join the global fight against microbial resistance.

Insightful opinion piece.
www.statnews.com/2025/07/16/c...

16.07.2025 13:27 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Graphical abstract

Graphical abstract

Improved consistency of Candida auris colonization screening with an anterior nares and hands composite sample

From CDC’s Mycotic Diseases Branch

Open access
academic.oup.com/cid/article/...

Read commentary by @drrossanarosa.bsky.social

academic.oup.com/cid/advance-...

11.07.2025 14:03 β€” πŸ‘ 12    πŸ” 2    πŸ’¬ 1    πŸ“Œ 1

@anomanellore is following 20 prominent accounts