(@anomanellore) — Bluesky Profile

3 months ago

The role of CMV-specific cellular immunity in transplant recipients with letermovir prophylaxis: to be determined

✅ Just Accepted
🔗 https://bit.ly/4oqR2dv

4 4 0 0

3 months ago

An Analysis of Cytomegalovirus-Specific Cell-Mediated Immunity in a Phase 3, Randomized, Placebo-Controlled Trial of Letermovir Prophylaxis in Cytomegalovirus-Seropositive Recipients of an Allogeneic Hematopoietic Cell Transplant

✅ Just Accepted
https://bit.ly/3Xvuu00

0 2 0 0

4 months ago

New study shows antagonism between olorofim and voriconazole in vitro, suggesting this may be a class effect

academic.oup.com/jac/advance-... #MedMycoSky #TxID #IDSky

11 6 0 1

4 months ago

Figure Panel A shows the iodophor treatment timeline and nasal sampling timepoints. Panel B displays a dot plot of C. auris nasal bioburden at each timepoint and Panel C displays a dot plot of changes in C. auris bioburden for culture-based sampling which occurred on Days 1, 5, and 9. Each dot represents a participant. A box is drawn around the median bioburden or change in bioburden. Nasal bioburden was assessed as follows: 0 = no growth; 1 = few (1-2 isolated colonies); 2 = 1+ (growth in first quadrant only); 3 = 2+ (growth into second quadrant); 4 = 3+ (growth into third quadrant); and 5 = 4+ (growth in all quadrants, high burden).

Nasal iodophor to reduce Candidozyma auris nasal carriage in nursing home residents

Intriguing pilot study (n=27) that treated C auris-colonized NH residents with intranasal iodophor bid x 5d. Intervention assoc w decreased C auris burden, some were decolonized

academic.oup.com/ofid/advance...

3 3 1 0

4 months ago

Community-Acquired Respiratory Virus Infections: A Threat to Long-Term Survivors After Allogeneic Stem Cell Transplant? Late community-acquired respiratory virus (CARV) infections in long-term allogeneic hematopoietic stem cell transplantation (allo-HCT) survivors carry sign

Community-Acquired Respiratory Virus Infections: A Threat to Long-Term Survivors After Allogeneic Stem Cell Transplant?

#IDSky

3 3 0 7

4 months ago

[Articles] Vaccine effectiveness of a bivalent respiratory syncytial virus (RSV) pre-F vaccine against RSV-associated hospital admission among adults aged 75–79 years in England: a multicentre, test-negative, case–control study This study provides evidence that the RSV pre-F vaccine is highly effective against RSV-associated hospital admissions, including exacerbations of chronic disease, and in adults with immunosuppression.

Study shows RSV pre-F vaccine is highly effective against RSV hospital admissions, including chronic disease exacerbations & in immunosuppressed adults. 📊💉

#idsky

1 1 0 0

4 months ago

Done!

0 1 0 0

4 months ago

Volume 232 Issue Supplement_3 | The Journal of Infectious Diseases | Oxford Academic An official journal of the Infectious Diseases Society of America. Publishes research results on microbiology, immunology, and epidemiology; pathogenesis, diagnosis, and treatment of infectious diseas...

Excited to see the “Advances in Influenza Therapeutics” supplement out in @jidjournal.bsky.social - led by Fred Hayden and Rich Whitley, this supplement reviews what we know about antivirals and how they should be used for influenza.

academic.oup.com/jid/issue/23...

5 3 1 0

4 months ago

Highway to the donor danger zone? Please join the #TxID crew Tues 8am in B312 for 'Should I Take This Donor?' 🤔 w donor-derived infx experts Stephanie Pouch and Emily Blumberg dropping knowledge on all your donor-related q's ♥️ 🫁 🫘 @aneeshkmehta.bsky.social #IDSky @idweek.bsky.social #IDWeek2025

5 2 0 0

5 months ago

Community-Acquired Respiratory Virus Infections: A Threat to Long-Term Survivors After Allogeneic Stem Cell Transplant? Studies on late community-acquired respiratory virus (CARV) infections in long-term allogeneic hematopoietic stem cell transplantation (allo-HCT) survivors are scarce, creating knowledge gaps on the epidemiology, risk of progression to lower respiratory tract disease (LRTD), and conditions linked...

Community-Acquired Respiratory Virus Infections: A Threat to Long-Term Survivors After Allogeneic Stem Cell Transplant?

#IDSky

3 3 0 7

5 months ago

Toxoplasma qPCR Kinetics to Guide Preemptive Treatment of Toxoplasmosis After Allogeneic Hematopoietic Stem Cell Transplantation Recent European Conference on Infections in Leukemia (ECIL) guidelines recommend a quantitative polymerase chain reaction (qPCR) guided preemptive treatment approach to toxoplasmosis in seropositive recipients of allogeneic hematopoietic cell transplantation (allo-HCT). Although qPCR might serve as a sensitive tool for early Toxoplasma detection, its role in treatment follow-up remains unknown.MethodsWe analyzed the qPCR kinetics of allo-HCT recipients experiencing either Toxoplasma infection (TI, n = 71) or disease (TD, n = 14) in relation to different parameters. We included 85 patients with available qPCR values expressed as quantitative cycle (Cq) from 4 large hematological centers from 2009 to 2023, and kinetic analysis was performed in a selection of 74 patients screened at least weekly with blood qPCR. Day 0 (D0) was the day of anti-Toxoplasma treatment start or (when untreated) day of diagnosis.ResultsTime to qPCR negativity was inversely proportional to the Cq value at D0 (P = .0063). Not reaching negativity at D10 was associated with a significantly higher mortality at D30 (P = .023). Patients with a high D0-parasitic load and patients with TD showed slower clearance (P < .001, P = .032). Time to negativity was not significantly different for patients started on prophylactic versus curative doses as first-line treatment regimen (P = .16).ConclusionsThis study underscores the predictive value of qPCR kinetics monitoring in allo-HCT patients with toxoplasmosis. With the aforementioned risk factors, clinicians can identify patients at high risk for worse outcome. Our results support to consider a therapeutic change or reinforcement if the parasitic load does not decrease after 10 days, supplementing existing clinical guidelines.

Study of 85 allo-HCT patients showed qPCR negativity time linked to initial Cq value (P = .0063). Not reaching negativity by D10 increased 30-day mortality (P = .023). High D0 load slowed clearance (P < .001).

#idsky

0 1 0 0

5 months ago

Home - Doctor Fungus Welcome to Doctor Fungus! An Educational Website of theMycoses Study Group Education and Research Consortium (MSGERC) [View Legal Information] Where to Start Mycology Case of the Month An Introducti...

There’s now an app for all things fungi 🦠🍄
Dr. Matthew Pullen, Assistant Professor at the University of Minnesota, helped launch Dr Fungus—a free app that brings the trusted resource to your phone.

Explore fungal infections, antifungal treatments, and case-based learning—all in one place.

43 16 2 2

5 months ago

Highlights of ESCMID Global 2025 The 35th Congress of the European Society of Clinical Microbiology and Infectious Diseases was held in Vienna, Austria, from April 11 to 15, 2025. Syeda Saleha Hassan reports.

Proud to see key antifungal advances featured in The Lancet Infectious Diseases highlights of #ESCMIDGlobal2025.
@rosannesprute.bsky.social presented global candidiasis guidelines; I shared FURI study results on ibrexafungerp efficacy.
👉 The Lancet article: www.thelancet.com/journals/lan...

7 4 0 0

5 months ago

Blood cultures contain populations of genetically diverse Candida albicans strains that may differ in echinocandin tolerance and fitness It is unknown whether within-patient Candida albicans diversity is common during bloodstream infections (BSIs).MethodsWe determined whole genome sequences of 10 C. albicans strains from blood cultures (BCs) in each of 4 patients. We performed detailed phenotypic studies on strains from 1 patient.ResultsBCs in 3 patients contained mixed populations of strains that differed by large-scale genetic variants, including chromosome (Chr) 5 or 7 aneuploidy and Chr1 loss of heterozygosity (n=1 each). In patient M, Chr7 trisomy (Tri7) strains were attenuated for hyphal and biofilm formation in vitro, due at least in part to NRG1 over-expression. Nevertheless, representative Tri7 strain M1 underwent filamentation during disseminated candidiasis (DC) in mice. M1 was more fit than euploid strain M2 during DC and mouse gastrointestinal colonization, and in blood ex vivo. M1 and M2 exhibited identical echinocandin minimum inhibitory concentrations, but M2 was more tolerant to micafungin in vitro. Furthermore, M2 was more competitive with M1 in mouse kidneys following micafungin treatment than it was in absence of micafungin. Tri7 strains represented 74% of patient Mâ€™s baseline BC population, but euploid strains were 98% of the population after 3d of echinocandin treatment. Findings suggest that echinocandin tolerant, euploid strains were a subpopulation to more fit Tri7 strains at baseline and then were selected upon echinocandin exposure.ConclusionsBCs in some patients are comprised of diverse C. albicans populations not recognized by the clinical lab, rather than single strains. Clinical relevance of C. albicans diversity and echinocandin tolerance merits further investigation.

In 4 patients, 10 strains of 🦠 *C. albicans* were analyzed. 3 had mixed strains; 74% were Tri7 before echinocandin, dropping to 2% after 3 days. Echinocandin tolerance needs more study.

#idsky

0 1 0 0

5 months ago

From earlier this week: A MRSA strain emerged ~2009 in Brooklyn, NY that is now a major cause of skin infections in the US.

Bo Shopsin & team discover a prophage-encoded methyltransferase that increases virulence by promoting biofilm formation in a mouse infection model:
buff.ly/g0i2DGm

3 2 1 0

5 months ago

A MRSA strain emerged ~2009 in Brooklyn, NY that is now a major cause of skin infections in the US.

Bo Shopsin & team discover a prophage-encoded methyltransferase that increases virulence by promoting biofilm formation in a mouse infection model: buff.ly/tbvVWoG

4 2 2 0

6 months ago

Denmark close to wiping out leading cancer-causing HPV strains after vaccine roll-out A nationwide study suggests infections with human papillomavirus (HPV) types 16 and 18 have been virtually eliminated since vaccination began in 2008 – protecting even unvaccinated women.

I am here to say vaccines are awesome because guess what Denmark is close to completely eliminating the two most dangerous HPV strains (serotype 16 and 18) and with the cervical cancer.I think that is bloody AMAZING!!!!
bit.ly/4pbHxjT

1,006 272 11 15

6 months ago

CBS video and text: NIH whistleblower Jeanne Marrazzo details clash over childhood vaccines with Trump administration: "We became inconvenient"

👉 cbsn.ws/3IcWNwc

7 4 0 0

6 months ago

Florida moves to end all school vaccine mandates, first in nation to do so — The Washington Post Florida Surgeon General Joseph A. Ladapo criticized school vaccine mandates, which every state has, and likened them to slavery.

This is where we are?

Sadly, yes. We vilify that which protects our children. Truly dystopian.

apple.news/AljZtI59wQ8S...

18 6 3 0

6 months ago

Opinion | We Ran the C.D.C.: Kennedy Is Endangering Every American’s Health

www.nytimes.com/2025/09/01/o...

0 2 0 0

6 months ago

Whistle-Blower Complaints Detail Tension Over Vaccines at N.I.H.

Whistle-Blower Complaints Detail Tension Over Vaccines at N.I.H. www.nytimes.com/2025/09/04/h....

1 2 1 0

6 months ago

Will the C.D.C. Survive?

Will the C.D.C. Survive? www.nytimes.com/2025/08/29/h... I think it will survive but not thrive. CDC rapidly loosing its leadership and relevance nationally and globally. In the short term State and local health departments will be critical for public health.

14 3 1 0

6 months ago

This is truly a CMV superstar lineup- looking forward to watching this recording!

0 1 0 0

6 months ago

Great summary slide by @jobadd.bsky.social

4 2 1 0

8 months ago

AJT’S new ID blog, TxIDExchange, is dedicated to sharing the latest ID updates, research, and guidelines relevant to the transplant community. We’re soliciting blog posts and comments from you and your colleagues and encourage you to participate.

ajt-transplant-id-exchange.squarespace.com

9 8 0 1

7 months ago

Is it time for transplant centers to formalize standards like trauma centers? Transplant centers hold the key to accelerating organ use and transplanting more patients more efficiently. However, not all transplant procedures are…

Intriguing proposal by Becker et alia to stratify transplant centers, like trauma hospitals, into levels I, II, and III, assigning patients, organs, and resources accordingly. doi.org/10.1016/j.aj...

0 1 0 0

7 months ago

Former surgeon general: The CDC shooting must be a wakeup call “When influential figures amplify falsehoods, they legitimize the anger that leads to violence,” writes former Surgeon General Jerome Adams.

www.statnews.com/2025/08/09/c...

0 0 0 0

7 months ago

Dr. Robert (Bob) Rubin Transplant ID Award Recipient for 2025 is the amazing @kottonnelson.bsky.social !!! #TxID #MedEd @astinfo.bsky.social

29 8 0 1

7 months ago

Broad-spectrum antibiotics for moderately immunocompromised patients with CAP: An overdone practice A study in CID examined broad-spectrum antibiotics in moderately immunocompromised patients with community-acquired pneumonia

Moderate immunocompromise (even if overly broadly defined) should not buy you vanc + antipseudomonal for CAP: my latest @idsainfo.bsky.social Journal Club review:

www.idsociety.org/science-spea...

12 5 0 1

7 months ago

Visual abstract showing inferior early fungicidal activity (primary endpoint) and csf sterility at 2 weeks (secondary endpoint) in experimental arm, no difference in survival (secondary endpoint)

Evaluating the Use of Lower Dose Flucytosine for the Treatment of Cryptococcal Meningitis: A Clinical Trial

Compared to historical controls w/ standard 100 mg/kg flucytosine dose, a CM regimen w/ low dose (60 mg/kg) flucytosine had inferior CSF fungal clearance

academic.oup.com/cid/advance-...

11 8 0 0