Everett Moding, MD, PhD

We are thrilled to share that Everett Moding, MD, PhD, Assistant Professor of Radiation Oncology, has received a MERIT R37 Award from the NIH! This award is a long-term grant for investigators with outstanding research accomplishments and high productivity. Congratulations!

SCI member @everettmoding.bsky.social & others demonstrate that radiation therapy exerts selective pressures on undifferentiated pleomorphic sarcomas and suggest that targeting radioresistant subclonal populations could improve outcomes after radiotherapy. aacrjournals.org/cancerres/ar...

Congratulations to @everettmoding.bsky.social and colleagues for being featured online at the @theaacr.bsky.social for their study “Integrating ctDNA Analysis and Radiomics for Dynamic Risk Assessment in Localized Lung Cancer.”
aacrjournals.org/cancerdiscov...

Congrats again to Faith Ryu on the gorgeous cover and our amazing team in the lab (Erik Blomain, Shaghayegh Soudi, Ziwei Wang, Anish Somani, and many more!). Thank you to all of our collaborators and grant support for making this possible! (8/8)

Key takeaway ✅: We think targeting resistant subclones will be critical to improve the response of sarcomas and other cancers to radiotherapy, and we are optimistic that tools like ctDNA analysis can help us identify approaches to help radiation kill these cells. (7/8)

Finally, we demonstrated that circulating tumor DNA can accurately measure subclonal architecture and non-invasively monitor sarcoma evolution during radiotherapy. (6/8)

By analyzing genes mutated in radiosensitive subclones that contracted during radiotherapy, we observed an enrichment in mutations affecting the calcium signaling pathway. Inhibiting calcium transporters made sarcoma cells more sensitive to radiotherapy. (5/8)

Using metrics of genetic divergence between regions to measure selection pressure, we found that radiotherapy increased evolutionary selection and led to the expansion of resistant subclonal cancer cells. (4/8)

We observed evidence of strong selection during sarcoma development with most untreated UPS displaying initial linear evolution followed by branching evolution later in tumor development. (3/8)

We performed spatial and temporal genomic profiling of undifferentiated pleomorphic sarcomas (UPS) treated with or without radiotherapy to study sarcoma evolution. (2/8) aacrjournals.org/cancerres/ar...

First post on @bsky.app to share that our study made the cover of @theaacr.bsky.social Cancer Research! Congrats Faith Ryu on this beautiful artwork showing the effect of #radiotherapy on #sarcoma evolution. A 🧵 of key findings from the most recent story from the lab. (1/8)