Kevin Mitchell

Kevin Mitchell

@wiringthebrain.bsky.social

Neurogeneticist interested in the relations between genes, brains, and minds. Author of INNATE (2018) and FREE AGENTS (2023)

36,023 Followers 2,220 Following 3,162 Posts Joined Sep 2023
2 hours ago

I presumed the pull quote here was parody, but no…

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11 hours ago
A male elephant seal laying in short grass with a beach in the background. Its head is lifted and mouth is wide open as it lets out an aggressive call. A portrait of a male elephant seal sitting up relaxed. It’s long snout is draped down its face, looking like a muppet

Inside you there are two Elephant Seals 🐘 🦭
#mammals #seals

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13 hours ago
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Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

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2 hours ago
US eases Russian oil sanctions to tackle spiralling prices
The US will allow countries to buy Russian oil stranded at sea, as the Trump administration scrambles to stabilise a rise in global energy prices caused by the war against Iran.

When you thought things could not get any worse. Dizzying feedback loops of ridiculousness

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2 hours ago

Cellular morphology emerges from polygenic, distributed transcriptional variation https://www.biorxiv.org/content/10.64898/2026.03.12.711281v1

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15 hours ago
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Seal and sea lion brains have evolved to support volitional control of vocal behavior and learning Seals and sea lions have highly developed volitional breathing control, to which the phocid seals add vocal production learning, including mimicry. In this work, using histology and ex vivo diffusion ...

Vocal production learning is a key ability enabling spoken language, but is not itself unique to humans, having been documented in (e.g.) some bird, bat, & seal species. A new study of pinnipeds in @science.org 👇 finds they have neural adaptations supporting voluntary control of vocalizations.
🦭💬🧪

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4 hours ago
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In an Irish Atlantic rainforest, a 'wolf' oak: the term for a tree much older than those all around.

A grandmother tree, progenitor and nurturer of the ecosystem, she very possibly grew when – even because – wolves still hunted these parts.

A nice twist on the word.

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10 hours ago
YouTube
Kevin Mitchell discusses the Hype and Myths around Autism and the Gut Microbiome YouTube video by Decoding the Gurus

Our interview with Kevin Mitchell (@wiringthebrain.bsky.social) on the hype surrounding Gut microbiome research is now up on ze YouTube. youtu.be/edeeGrCygPg

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17 hours ago
Nancy Lurie Marks Prize for Autism Research
Huda Y. Zoghbi
HHMI Investigator
Baylor College of Medicine

Celebrating #HHMIInvestigator Huda Zoghbi, recognized by the Lurie Autism Institute for her ground-breaking discovery that mutations in the MECP2 gene cause Rett syndrome (an autism-related neurodevelopmental disorder) — work that continues to transform autism research today: bit.ly/4sFhNx6.

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16 hours ago
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#gfe2026 @gfeev.bsky.social PhD Award goes to Tatiana Lebedeva 🎉 for Tatiana's thesis investigating the role of β-catenin in specifying germ layers in one of my favourite organisms, the starlet sea anemone, Nematostella.

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21 hours ago
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6/ What we found in the Cell paper:

Figure 2:

When subjects pick between two options, each associated with reward magnitude and probability, vmPFC embeds these options as “locations” in a 2D choice attribute space and represents the trajectory between these options with a hexagonal periodic code

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21 hours ago
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A cognitive map for value-guided choice in the ventromedial prefrontal cortex Value-based decision-making can be conceptualized as navigation within a cognitive map of choice values. During choice, the ventromedial prefrontal cortex (vmPFC) compositionally builds cognitive maps...

1/n

With Cosyne around the corner, I thought I would:

a) make a thread about our “A cognitive map for value-guided choice in the vmPFC” Cell paper (i'm a bit late). shorturl.at/DBA3H

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5 days ago
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Shona Murray: Powerful countries no longer bother with international norms Europe appears to have accepted the law of the jungle supplanted by Donald Trump and Benjamin Netanyahu, writes Shona Murray

If 176 children were slaughtered in their classrooms in Dublin, Brussels, Berlin, Tel Aviv or Texas by a foreign adversary, the world would rightfully be at a standstill.

- Shona Murray

www.irishexaminer.com/opinion/colu... @shonamurray.bsky.social

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21 hours ago
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Report: RFK Jr.’s anti-vaccine agenda curbed as GOP realizes it's unpopular Meanwhile, Kennedy's allies want all vaccine recommendations eliminated.

Report: RFK Jr.’s anti-vaccine agenda curbed as GOP realizes it's unpopular arstechnica.com/health/2026/...

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21 hours ago

It's Cosyne time!!

Here are some contributions from my lab and some of my close collaborator labs (Thomas Akam, @melgaby.bsky.social, Steve Kennerley, @sameershethmd.bsky.social )

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22 hours ago
View Boris Gamazaychikov’s  graphic link
Boris GamazaychikovBoris Gamazaychikov
   • 1stVerified • 1st
Head of AI Sustainability @ SalesforceHead of AI Sustainability @ Salesforce
32m • Edited •  32 minutes ago • Edited • Visible to anyone on or off LinkedIn

The gas-powered data center craze has come to Europe.

Yesterday, a 110MW off-grid AI data center outside of Dublin was switched on - and it's powered entirely by fossil fuels.

Developers went with natural gas engines (specifically RICE) to bypass the grid connection queue. They claim the engines "could" be switched to HVO, and that the project will attempt to connect to the grid "when possible".

What does this mean for Ireland's climate goals? According to my estimates, this single project will increase the entire country's annual GHG emissions by ~1%.

Assumptions:
- The project seems to be using Rolls Royce (mtu) 4000 Series RICE which have an electrical efficiency of 44% https://lnkd.in/eRX4PRuf
- Modifying the NREL life cycle gas emissions factor with this efficiency yields 656.75 gCO2e/kWh https://lnkd.in/gfgs2X6P
- Assuming a 90% capacity factor because AI hyperscale data centers run near 24/7 to recoup massive GPU costs
- Ireland’s 2024 GHG emissions = 53.8 million tCO2e https://lnkd.in/ejjRgRpE

hashtag#DataCenters hashtag#Sustainability hashtag#ArtificialIntelligence Royce (mtu) 4000 Series RICE (natural gas)
Al Data Center

Ireland's new fossil-fuelled #Petrotech data center will increase Ireland's **total** (everything, not just the power sector) emissions by ~1%

Absolutely nuts. A 1% national increase - for what? Come on boosters, explain why this is worth it 🫠

www.linkedin.com/posts/bgamaz...

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21 hours ago

I note “development” and “evolution” don’t appear! Y’all are missing a trick…

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21 hours ago
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Bridging developmental and statistical approaches to variation and evolution | PNAS Phenotypic variation is the raw material for evolutionary diversification and adaptation. However, a critical gap remains in evolutionary theory be...

How does development shape the variation evolution can act on?

In our new paper in @pnas.org , we bridge developmental dynamics and quantitative genetics, linking dynamical models of phenotype formation with the statistical parameters used to study evolutionary change

www.pnas.org/doi/10.1073/...

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23 hours ago
Original post on mastodon.social

TIL that "carbon footprint" is a campaign started by Brittish petroleum (BP) in order to distract attention away from coporate responsibility and culpability towards individual responsibility and culpability.

https://www.publishersweekly.com/9781541700116

If you are concerned about your carbon […]

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1 day ago
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Tiny, transparent, and now charted! Our brain atlas of adult Danionella cerebrum includes >200 annotated regions, 29 whole-brain in situs, and male/female reference volumes – openly available, versioned and extendable. Work by @nkadobyansky.bsky.social and team.
www.biorxiv.org/content/10.6...

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1 day ago

Predictive forgetting. What a fantastic choice of words. It conveys so much, so succinctly.

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1 day ago
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Deconstruction of a memory engram reveals distinct ensembles recruited at learning - Nature Neuroscience Pouget et al. identified distinct CA1 neuron ensembles active during specific moments of fear learning and uncovered the core engram essential for memory formation.

How does the brain build a memory?
A common assumption is that the neurons activated during an experience collectively form the memory engram.
In our new Nature Neuroscience paper (finally out!), we show that this is not the case.
www.nature.com/articles/s41...

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4 days ago

A thoughtful response from @dermotcasey.bsky.social to an interview with @utafrith.bsky.social about the expansion of the diagnostic category of "autism"

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23 hours ago

Don't miss @maxschwabe.bsky.social's poster this evening (our master's student and presenter awardee 🎉) on decomposing RNN dynamics during naturalistic decision-making! It was a joint work with @armanbehrad.bsky.social and @roxana-zeraati.bsky.social!

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1 day ago

One thing that radicalized me on this was following golden rice, as a friend of mine was working on it in the 00s. People in the Philippines destroyed a trial crop because of propaganda from rich countries with no vitamin A deficiencies, especially from Greenpeace and existing grain producers.

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1 day ago

Really great work demonstrating the importance of task-based responses in characterizing the functional organization of the brain. Congrats to @carobellum.bsky.social and the rest of the team!

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1 day ago
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Can injured adult CNS axons regenerate by recapitulating development? Summary: This Review highlights the mechanisms underlying CNS developmental axon growth and adult regeneration failure, exploring the hypothesis that adult central neurons can regenerate by recapitula...

Neuronal axons in the mammalian central nervous system usually do not regenerate upon injury. The third #gfe2026 keynote, Frank Bradke, reveals key roles for cytoskeletal dynamics, vesicles and scarring in regeneration – a great example of how #devbio has informed treatment for spinal cord injury.

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1 day ago
Father Dougal
Looking out the window saying “looks like rain Ted”

Everyone in ireland right now

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1 day ago

I know we’re ODing on ‘end of the American empire’ bellwethers, but ‘Italy is better than us at baseball’ might be the most decisive one yet

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1 day ago

It is extremely difficult to construct a practical case against this position. Net Zero is now as much about patriotism as it is about climate change.

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