William (Bill) Grey

Chromatin Accessibility Shapes Developmental-Specific Lineage Plasticity in Hematopoiesis Cell differentiation is governed by dynamic changes in chromatin accessibility, and its dysregulation underlies multiple disease states. Prior to birth, development of the hematopoietic system constit...

Don’t miss our new preprint!
We mapped chromatin accessibility in human first-trimester HSPCs, revealing key fetal vs adult differences in hematopoiesis.
🔗 doi.org/10.64898/202...
#Hematopoiesis #StemCells #Chromatin #Epigenetics #LeukemiaResearch

Brian Huntly and I are looking to recruit a postdoc to investigate a promising novel therapeutic target in B-ALL @scicambridge.bsky.social. This new CRUK-funded project will involve collaboration with Prof Sir Steve Jackson's group @cruk-ci.bsky.social and the CRUK Functional Genomics centre.

The November Issue of #ExpHem is here! Explore the lineup, including Honoring giants in hematopoietic and progenitor cell biology www.exphem.org/article/S030...

This month on #SimplyBlood 🩸 we're featuring the Cancer and Bone Lab at The University of Sheffield, UK. Led by Alanna Green, the lab played a central role in developing a new drug to clinical trials for myeloma patients. Read more on iseh.org/Publications...

dave boucher PhD Projects, Programmes & Scholarships - 3 PhDs Listed FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucher. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.

Correct link: www.findaphd.com/phds/?Keywor...

3 PhD positions in the lab for British Students. Inflammasome, cell death and skin immunity, with fantastic colleagues. Check them out or share it with curious and motivated PhD students: www.findaphd.com/phds/?Keywor... @yorkshirebiodtp.bsky.social @ybri-uoy.bsky.social @biologyatyork.bsky.social

All #PhD adverts are now live with some deadlines upcoming: www.findaphd.com/phds/?Keywor...

Reach out to me at william.grey@york.ac.uk for any informal enquiries.

PhD: Targeting Therapy-Resistant Leukaemic Stem Cells in AML
Use proteomics, CRISPR & holotomographic imaging to expose how leukaemic stem cells evade therapy — and how to stop them.
🧠 Start Oct 2026
💫 Apply via DiMeN DTP
👉 Details: [https://www.dimen.org.uk]

PhD: Harnessing Proteostasis to Boost Blood Stem Cell Expansion for Transplantation
Combine proteomics, advanced microscopy & CRISPR to enhance HSC resilience — bridging discovery & clinical translation.
🧠 Start Oct 2026
💫 Apply via DiMeN DTP
👉 Apply: [https://www.dimen.org.uk]

PhD: Decoding Human Blood Stem Cells – Proteomics & Super-Resolution Imaging (STED, Elyra, CryoEM) of human HSCs & 3D culture systems.
🧠 Start Oct 2026
💫 Apply via Yorkshire Bioscience DTP
👉 Info: tinyurl.com/2xkzryx4

🚨 We have 3 fully funded PhD studentships open!
Join the Grey Lab & collaborators at @biologyatyork.bsky.social, @universityofleeds.bky.social & @ybri-uoy.bsky.social to explore stem cells, proteomics & leukaemia biology
📍Start Oct 2026 | 💡Apply via MRC & BBSRC
👇Details in thread 👇

A decade of progress and impact - Leukaemia UK This October marks ten years since Leukaemia UK launched its John Goldman Fellowship (JGF) programme. In this blog, and the next, we’ll explore its impact and successes.

A decade of bold ideas, brilliant minds & real impact. 💡

Our John Goldman Fellowships are driving progress in leukaemia research, from identifying new drug targets to repurposing existing medicines.

Read more: www.leukaemiauk.org.uk/stories/a-de...

Explore the October Issue of #ExpHem including the article Mer receptor expression promotes multiple myeloma disease development via a cell-extrinsic mechanism ➡️ www.exphem.org/current

Upfront Menin-inhibitor resistance in multiply pretreated leukemias 10% of acute leukemias carry rearrangements of the KMT2A gene (Mixed-Lineage Leukemia-1, MLL-1). More than 80 fusion partners have been identified, and differences in fusion partner have been linked t...

Surprising finding that standard chemo renders AML resistant to subsequent treatment with menin inhibitors. Published in @isehsociety.bsky.social journal Exp. Hem.: www.exphem.org/article/S030...

We all must take the responsibility and don’t just complaint about these problems. Take action and don’t be a spectator!

WS6 enables scalable ex vivo expansion and gene editing of epithelial basal stem cells Modeling human epithelial diseases and developing cell-based therapies require robust methods to expand and manipulate epithelial stem and progenitor cells in vitro. Basal stem/progenitor cells from s...

Our latest work is available on BioRxiv!

WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity.

www.biorxiv.org/content/10.1...

Mesenchymal stromal cells from JAK2V617F myeloproliferative neoplasms support healthy and malignant hematopoiesis in a humanized scaffold model in vivo Myeloproliferative Neoplasms (MPN) are malignancies of hematopoietic stem and progenitor cells (HSPCs) that lead to the overproduction of mature blood cells. These disorders include Essential Thrombo....

Humanized MPN xenograft model that offers valuable insights into how human BM MSCs interact with JAK2V617F mutant clone.

onlinelibrary.wiley.com/doi/10.1002/... @hemasphere-journal.bsky.social

New Preprint 🚨. Our latest work is now available in biorXiv: A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche. www.biorxiv.org/content/10.1...

Three researchers receive Barncancerfonden funding to investigate the causes of childhood leukemia Lund University. This spring Barncancerfonden, the Swedish Childhood Cancer Foundation, awarded SEK 64 million to 29 researchers across the country. The funding includes positions of up to six years f...

Congratulations to everyone!
It’s incredibly exciting to see our lab getting recognition with the postdoc grant to Keiki.

www.stemcellcenter.lu.se/article/thre...

Ontogeny-specific induction of the KMT2A::AFF1-fusion drives development of a distinct CD24 positive pre-leukemic state - Leukemia Leukemia - Ontogeny-specific induction of the KMT2A::AFF1-fusion drives development of a distinct CD24 positive pre-leukemic state

Thrilled to share our latest research just published in Leukemia. www.nature.com/articles/s41...
Grateful to all co-authors for their dedicated effort and collaboration. @lundstem.bsky.social @lunduniversity.bsky.social

A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis Beta-secretase 1 promotes the spread of lung cancers to the brain through epidermal growth factor receptor signaling.

Excited to share our collaborative work with Sheila Singh's lab: we performed an in vivo genome-wide CRISPRa screen using a lung TRACERx PDX model to uncover drivers of brain metastasis. BACE1 - already investigated as target in Alzheimer's - was as a key hit.

www.science.org/doi/10.1126/...

Post-transcriptional control of gene expression by β-catenin: expanding the non-canonical ARMoury - Oncogene Oncogene - Post-transcriptional control of gene expression by β-catenin: expanding the non-canonical ARMoury

Following on from our recent paper showing novel post-transcriptional roles for B-catenin in leukaemia cells, a very well done to Drs Sevim & Park for writing a superb review in @natureportfolio.nature.com Oncogene summarising our current understanding of this field.

www.nature.com/articles/s41...

Interested in innate immunity and inflammation? Join us in September for a great meeting! Superb lineup of speaker and lots of opportunities for Ecrs to present!

Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations confer a fitness advantag...

Excited to see the first commentary in Experimental Hematology (@isehsociety.bsky.social)! Kudos to Aishwarya, Linde ‪@lindemileslab.bsky.social, and Grant @challenlab.bsky.social for highlighting recent papers in Exp Hem on cell-extrinsic factors in Tet2-mutant clonal hematopoiesis!! bit.ly/4k3pEAI

Is the bone marrow microenvironment the hidden catalyst in malignant haematopoiesis? - Leukemia Leukemia - Is the bone marrow microenvironment the hidden catalyst in malignant haematopoiesis?

Excited to share our perspective just out in @leukemia journal! What is bone marrow niche doing in shaping clonal dynamics in MDS and Leukemias.

www.nature.com/articles/s41...

We're excited to see the launch of the TARGET study, co-led by @billgrey.bsky.social, to tackle AML relapse by targeting chemo-resistant stem cells.

This could mean oral treatments at home, fewer side effects, and safer options for all. 🧡

A new research study @leedsth.nhs.uk and @york.ac.uk is set to transform treatments for one of the most aggressive and hard-to-treat blood cancers.

Read ▶️ www.leedsth.nhs.uk/news/new-res...

@leukaemiauk.bsky.social @bloodcanceruk.bsky.social @cbr-uoy.bsky.social

PhD Studentship: Structure and function of tyrosine fusion kinases in leukaemia and their regulation by the HSP90 molecular chaperone at University of Sussex Discover a PhD Studentship: Structure and function of tyrosine fusion kinases in leukaemia and their regulation by the HSP90 molecular chaperone on jobs.ac.uk. Apply now and explore other PhD opportun...

📢 New PhD Opportunity

🧬🧪 Excited to share a fully funded PhD studentship is available in my lab @gdsc-sussex.bsky.social

📅 Deadline: 2nd May 2025

👉 www.sussex.ac.uk/study/fees-f...

Please share with anyone who might be interested.

Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies Summary: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.

🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social!

We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo.

doi.org/10.1242/jcs....