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Michael Hoffman

@michaelhoffman.bsky.social

Chair, Computational BIology and Medicine Program, Princess Margaret Cancer Centre, University Health Network. Associate Professor, Medical Biophysics, University of Toronto. Disclosures: https://github.com/michaelmhoffman/disclosure/

16,515 Followers  |  1,720 Following  |  5,472 Posts  |  Joined: 30.04.2023  |  1.8322

Latest posts by michaelhoffman.bsky.social on Bluesky

I want AI to improve my life in ways I don't notice or think about. Like satellites or MSG. It would make traffic lights more intelligent. it would diagnose illness more effectively. It shouldnt be forced on me like that stupid feature that no one likes that makes everything look shit on smart TVs

28.01.2026 12:33 โ€” ๐Ÿ‘ 140    ๐Ÿ” 19    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 3

He's not actually a cool cow from 1994, you know

28.01.2026 21:10 โ€” ๐Ÿ‘ 5    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Wow, some really scary "rioters" that ICE is "protecting" us from.

28.01.2026 21:09 โ€” ๐Ÿ‘ 19    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

I am hearing that RFK Jr.โ€™s minions are going to go after HPV vaccines. Iโ€™ve got problems with these people and now youโ€™re going to hear about them, first from a personal perspective and then from a professional one.

It all boils down to this: WE HAVE A SAFE VACCINE THAT PREVENTS CANCER.

28.01.2026 19:52 โ€” ๐Ÿ‘ 3159    ๐Ÿ” 1106    ๐Ÿ’ฌ 98    ๐Ÿ“Œ 85
Uppsala in late autumn

Uppsala in late autumn

Join us at the Evolutionary Biology Centre at Uppsala University. Weโ€™re searching for an Assistant Professor in Biology. www.uu.se/en/about-uu/...

28.01.2026 20:28 โ€” ๐Ÿ‘ 79    ๐Ÿ” 97    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 3

Fair.

28.01.2026 21:04 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

While not disagreeing with your theory more generally, I don't think desiring alone time makes someone a maladjusted weirdo.

28.01.2026 20:52 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
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Amazing how uniform these emails are these days. The last three all arrived within three minutes!

28.01.2026 20:42 โ€” ๐Ÿ‘ 17    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Output management specification could be through comma separation e.g.

bedtools intersect --pieces=inverse,none g.fai a.bed b.bed

28.01.2026 20:19 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

I would suggest an interface like

bedtools intersect [OPTIONS] GENOMEFILE INTERVALFILE...

You might not want to bake in an assumption of only two sets of intervals from the start. Could easily see the utility of more for something like intersect.

28.01.2026 20:09 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

We're having a lab tech talk on this now. Really happy to see this, and it seems very nice!

Since you have the opportunity to change the interface dramatically, would you consider further to a more standard Unix command-line interface? Required "options" make my eyelid twitch ๐Ÿ˜†

28.01.2026 20:02 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

I assume Parks still has responsibility because it would cost money for Transportation to take the responsibility that could not be easily offset by a cut in Parks expenditure, as Parks still needs to clear the interior.

Parks seems to have much lower standards for clearing though. V. annoying.

28.01.2026 18:32 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Bilbo looking at his phone top

on bottom is ChatGPT

After all, why not? Why shouldn't I keep it?

You're absolutely right โ€” you found it, it's been with you a long while, and it's only natural to feel fond of something that's served you so well, especially when someone like Gandalf suddenly seems to want it for himself.

Bilbo looking at his phone top on bottom is ChatGPT After all, why not? Why shouldn't I keep it? You're absolutely right โ€” you found it, it's been with you a long while, and it's only natural to feel fond of something that's served you so well, especially when someone like Gandalf suddenly seems to want it for himself.

28.01.2026 01:51 โ€” ๐Ÿ‘ 24769    ๐Ÿ” 6823    ๐Ÿ’ฌ 7    ๐Ÿ“Œ 147
Screenshot of tweet from Huberman that reads: โ€œThe other is that dog breeds w/different shaped heads are predictive of their demeanor and intelligence. And while I donโ€™t! believe in Phrenology I now do pay some attention to how the shapes of peoples heads relates to their intellect and steadiness, or lack thereof.โ€

Screenshot of tweet from Huberman that reads: โ€œThe other is that dog breeds w/different shaped heads are predictive of their demeanor and intelligence. And while I donโ€™t! believe in Phrenology I now do pay some attention to how the shapes of peoples heads relates to their intellect and steadiness, or lack thereof.โ€

In response to announcement that he will be a new CBS contributor, Andrew Huberman tweeted โ€œIโ€™ve always gone issue-by-issue on health & science, spoken to experts w/a range of takes & presented where I see the center of (data) mass pointed. Iโ€™ll do the same with @CBSNewsโ€. In Sept he posted this:

28.01.2026 01:44 โ€” ๐Ÿ‘ 7283    ๐Ÿ” 1848    ๐Ÿ’ฌ 514    ๐Ÿ“Œ 677
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The one about 40 min away here has been stuck for 9:38 according to @transsee.bsky.social.

28.01.2026 02:18 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
28.01.2026 00:07 โ€” ๐Ÿ‘ 571    ๐Ÿ” 121    ๐Ÿ’ฌ 5    ๐Ÿ“Œ 6

Anyone who doesn't think this is funny has humoral immunity.

28.01.2026 01:41 โ€” ๐Ÿ‘ 3    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Caroline is a natural killer.

28.01.2026 01:38 โ€” ๐Ÿ‘ 4    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

One thing I see liberal outlets giving ground on that I feel the need to correct: itโ€™s impossible to โ€œdoxโ€ a paid public official
By simply reporting their name, institutional role, and political affiliations

28.01.2026 00:05 โ€” ๐Ÿ‘ 3594    ๐Ÿ” 714    ๐Ÿ’ฌ 30    ๐Ÿ“Œ 37
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Video from this morning shows ICE agents deploying tear gas outside a Minneapolis preschool as parents shout, โ€œThis is a preschool! Thereโ€™s kids here!โ€

27.01.2026 17:53 โ€” ๐Ÿ‘ 7706    ๐Ÿ” 4143    ๐Ÿ’ฌ 484    ๐Ÿ“Œ 929

it reveals pretty plainly that "merit-based hiring" means "you belong to the correct class and hold the right set of identities"

27.01.2026 21:43 โ€” ๐Ÿ‘ 5441    ๐Ÿ” 1099    ๐Ÿ’ฌ 119    ๐Ÿ“Œ 18

I was maybe 2.5 years into my position as an Assistant Professor when my phone rang, and it was Kirsty Duncan, the new federal science minister, calling out of the blue. I had never met her. She asked me what she could do for early career investigators. /1

26.01.2026 22:51 โ€” ๐Ÿ‘ 95    ๐Ÿ” 23    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0
Preview
Former Liberal cabinet minister Kirsty Duncan dies at 59 OTTAWA โ€” Former Liberal cabinet minister Kirsty Duncan has died at the age of 59 following a years-long battle with cancer. Born on Oct.

Gutted to learn of the passing of Dr Kirsty Duncan.

She was a tireless fighter for the people she served, not only her local community in Toronto but others, especially the science & research &
athletics communities too.

She championed equity, diversity, inclusion and made change happen.

๐Ÿค๐Ÿ™๐Ÿป

26.01.2026 22:28 โ€” ๐Ÿ‘ 110    ๐Ÿ” 27    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 5

It is an improvement. The Common CV was such a bad waste of time, that thousands of researchers signed a petition to eliminate it and replace it with something like this. Thankfully, the Tri-Agencies listened!

27.01.2026 20:41 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

In 100% agreement with both of these posts. 2FA is essential for anything important, and yet there are so many crappy implementations of it.

But also dear lord I shouldn't have to go through the rigmarole of it to view the soup menu

27.01.2026 20:37 โ€” ๐Ÿ‘ 6    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Very few people are in favor of any sort of change ever.

27.01.2026 20:33 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

One of the rare Common CV fans here?

27.01.2026 20:21 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Because I haven't paid for TransSee Premium

27.01.2026 19:27 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

If Democrats haven't announced their proposal for the Donald Trump No Guns in Public bill by the end of the day, they're missing an easy shot

27.01.2026 18:06 โ€” ๐Ÿ‘ 7502    ๐Ÿ” 1924    ๐Ÿ’ฌ 233    ๐Ÿ“Œ 93

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