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Epilepsia® – A Journal of the ILAE Epilepsia® is the world's leading journal of original scientific research and commentary in epileptology. Impact Factor: 6.6. Epilepsia® publishes original articles on all aspects of epilepsy, clinical and experimental. T
Trials including participants with high SF could include either fewer participants or shorter maintenance phase.
doi.org/10.1002/epi....
#epilepsy #ILAE #epilepsia #antiepilepticdrugs #clinicaltrials #Lrelationship #timetoevent
The DAME score predicts the risk of epilepsy in patients with autoimmune encephalitis-associated NORSE.
doi.org/10.1002/epi....
#epilepsy #ILAE #epilepsia #autoimmuneencephalitis #etiology #NORSE #statusepilepticus
Epilepsia is pleased to welcome our new Associate Editors. We thank them for their willingness to serve and for the expertise they bring to the journal.
View the full editorial team - onlinelibrary.wiley.com/page/journal...
Prolonged ASM exposure increased malformation risk, and valproate- or some lamotrigine-based dual therapies showed higher malformation risks associated with these combinations.
doi.org/10.1002/epi....
#epilepsy #ILAE #epilepsia #AntiSeizureMedications #Pregnancy #FetalOutcomes #DrugSafety
For optimal uptake, AI should be used as a tool that complements human-centered care and clinical judgment.
doi.org/10.1002/epi....
#epilepsy #ILAE #epilepsia #AIethics #computationalintelligence #datascience #deeplearning #IGAP #machineintelligence #machinelearning #syntheticintelligence
New in Epilepsia – January 10, 2026
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#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
A 1-unit serum S100B increase (in μg/L) after traumatic brain injury was associated with a 46% higher epilepsy risk.
doi.org/10.1002/epi....
#epilepsy #ILAE #epilepsia #epidemiology #observationalstudy #posttraumatic #S100B #TBI
The symmetrical claustrum sign demonstrates high specificity in FIRES diagnosis and is considered a potential diagnostic marker.
doi.org/10.1002/epi....
#epilepsy #ILAE #epilepsia #SCS #FIRES #claustrum #prognosis
Combining MRI and interictal iEEG abnormalities significantly improved outcome differentiation.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #epilepsysurgery #graymatter #iEEG #multimodal #superficialwhitematter
Carbamazepine was associated with increased interictal activity, while valproate–lamotrigine was associated with reduced activity in the IGEs.
doi.org/10.1002/epi....
#epilepsy #ILAE #epilepsia #ambulatory #EEG #antiseizuremedication #IGE #interictalepileptiformdischarges #vEEG
Cluster analysis based on electronic medical records reveals dynamic phenotypic clustering reflecting the evolving nature of SCN8A-related disorders throughout the first 10 years of childhood.
doi.org/10.1002/epi....
#epilepsy #ILAE #epilepsia #EMRs #ASM #developmentalskills #pediatric
New in Epilepsia – December 13, 2025
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#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
Prioritization of candidate genes reveals high-quality candidates that are known to influence neurodevelopment and synaptic plasticity and be druggable.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #drugtargetprioritization #genomewideassociationstudy #multispeciesanalysis #systemsbiology
The updated ILAE seizure classification proved fully applicable at secondary referral centers.
doi.org/10.1002/epi....
#epilepsy #ILAE #epilepsia #applicability #feasibility #seizureclassification
This study establishes that early symptoms such as dysphagia, neurodevelopmental concerns, seizures, and hyperkinetic movement disorders are consistent and early clinical biomarkers of the GABRG2 p.(Ala106Thr) GoF variant.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #GABAAreceptor
Largest reported series highlighting rare but serious sEEG-related pseudoaneurysms and the need for prompt imaging and treatment.
doi.org/10.1002/epi....
#epilepsy #ILAE #epilepsia #complication #epilepsysurgery #SEEG
Medial pulvinar entropy changes during seizures predict clinical response to deep brain stimulation in drug-resistant epilepsy.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #DBS #permutationentropy #pulvinar #SEEG
Acute PHM is a clinically heterogeneous disorder with significant diagnostic and therapeutic challenges and a poor prognosis.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #cardiacarrest #LanceAdamssyndrome #myoclonicstatusepilepticus #perampanel #postanoxicmyoclonus
Theory of Mind appears preserved in juvenile myoclonic epilepsy after accounting for cognitive and mood factors, highlighting broader vulnerabilities.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #cognition #executivefunction #neuropsychologicaltests #psychology
A new method called ME-MAGMA is designed to identify genes influenced by epigenetic regulators associated with epilepsy.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #epigenetics #geneticgeneralizedepilepsy #GWAS #MAGMA #transcriptomics
Interrater agreement of retrospective chart reviews is highly dependent upon documentation quality.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #datareporting #drugresistantepilepsy #interraterreliability #neuromodulation #vagusnervestimulation
In 62.6% of patients with FDS, there were no red flags to indicate co-occurring epilepsy.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #comorbidity #diagnosticlevelofevidence #functionalneurologicaldisorder #psychogenicnonepilepticseizures #subjective #PNES
SEEG offers a unique framework for prospective white matter functional mapping in epilepsy patients.
doi.org/10.1111/epi....
#epilepsy #ilae #epilepsia #epilepsysurgery #SEEG #whitematter #anatomy
New in Epilepsia – December 6, 2025
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#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
Risks can be minimized by avoiding bright flashing lights, covering one eye, wearing dark glasses, and staying far back from screens.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #guidelines #patternsensitiveseizures #photoparoxysmalresponse #photosensitiveseizures #reflexepilepsy
PIPs for antiseizure medications have mainly focused on focal seizures so far. Limited compliance and incomplete trials represent ongoing challenges in pediatric antiseizure drug development.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedication #drugdevelopment #seizure
This study evaluated the implementation and clinical effectiveness of a mental health care workflow for inpatients with epilepsy.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antidepressants #anxiety #comorbidities #depression #healthrelatedqualityoflife #psychotherapy #seizurefrequency
Combining polygenic risk scores with rare variant data has potential to refine diagnostic accuracy and improve genetic counseling.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #DEE #genetics #penetrance #polygenic #PRS
This is the first placebo-controlled cenobamate efficacy study to use the globally approved cenobamate titration schedule.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedication #efficacy #refractory #titration #cenobamate
Cenobamate demonstrates sustained seizure freedom and a favorable safety profile in patients with drug-resistant epilepsy.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiepileptic #cenobamate #drugresistantepilepsy #seizurefreedom