Epilepsia Journal

Trials including participants with high SF could include either fewer participants or shorter maintenance phase.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #antiepilepticdrugs #clinicaltrials #Lrelationship #timetoevent

The DAME score predicts the risk of epilepsy in patients with autoimmune encephalitis-associated NORSE.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #autoimmuneencephalitis #etiology #NORSE #statusepilepticus

Epilepsia is pleased to welcome our new Associate Editors. We thank them for their willingness to serve and for the expertise they bring to the journal.

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Prolonged ASM exposure increased malformation risk, and valproate- or some lamotrigine-based dual therapies showed higher malformation risks associated with these combinations.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #AntiSeizureMedications #Pregnancy #FetalOutcomes #DrugSafety

For optimal uptake, AI should be used as a tool that complements human-centered care and clinical judgment.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #AIethics #computationalintelligence #datascience #deeplearning #IGAP #machineintelligence #machinelearning #syntheticintelligence

New in Epilepsia – January 10, 2026
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#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

A 1-unit serum S100B increase (in μg/L) after traumatic brain injury was associated with a 46% higher epilepsy risk.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #epidemiology #observationalstudy #posttraumatic #S100B #TBI

The symmetrical claustrum sign demonstrates high specificity in FIRES diagnosis and is considered a potential diagnostic marker.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #SCS #FIRES #claustrum #prognosis

Combining MRI and interictal iEEG abnormalities significantly improved outcome differentiation.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #epilepsysurgery #graymatter #iEEG #multimodal #superficialwhitematter

Carbamazepine was associated with increased interictal activity, while valproate–lamotrigine was associated with reduced activity in the IGEs.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #ambulatory #EEG #antiseizuremedication #IGE #interictalepileptiformdischarges #vEEG

Cluster analysis based on electronic medical records reveals dynamic phenotypic clustering reflecting the evolving nature of SCN8A-related disorders throughout the first 10 years of childhood.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #EMRs #ASM #developmentalskills #pediatric

New in Epilepsia – December 13, 2025
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#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

Prioritization of candidate genes reveals high-quality candidates that are known to influence neurodevelopment and synaptic plasticity and be druggable.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #drugtargetprioritization #genomewideassociationstudy #multispeciesanalysis #systemsbiology

The updated ILAE seizure classification proved fully applicable at secondary referral centers.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #applicability #feasibility #seizureclassification

This study establishes that early symptoms such as dysphagia, neurodevelopmental concerns, seizures, and hyperkinetic movement disorders are consistent and early clinical biomarkers of the GABRG2 p.(Ala106Thr) GoF variant.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #GABAAreceptor

Largest reported series highlighting rare but serious sEEG-related pseudoaneurysms and the need for prompt imaging and treatment.
doi.org/10.1002/epi....

#epilepsy #ILAE #epilepsia #complication #epilepsysurgery #SEEG

Medial pulvinar entropy changes during seizures predict clinical response to deep brain stimulation in drug-resistant epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #DBS #permutationentropy #pulvinar #SEEG

Acute PHM is a clinically heterogeneous disorder with significant diagnostic and therapeutic challenges and a poor prognosis.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #cardiacarrest #LanceAdamssyndrome #myoclonicstatusepilepticus #perampanel #postanoxicmyoclonus

Theory of Mind appears preserved in juvenile myoclonic epilepsy after accounting for cognitive and mood factors, highlighting broader vulnerabilities.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #cognition #executivefunction #neuropsychologicaltests #psychology

A new method called ME-MAGMA is designed to identify genes influenced by epigenetic regulators associated with epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #epigenetics #geneticgeneralizedepilepsy #GWAS #MAGMA #transcriptomics

Interrater agreement of retrospective chart reviews is highly dependent upon documentation quality.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #datareporting #drugresistantepilepsy #interraterreliability #neuromodulation #vagusnervestimulation

In 62.6% of patients with FDS, there were no red flags to indicate co-occurring epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #comorbidity #diagnosticlevelofevidence #functionalneurologicaldisorder #psychogenicnonepilepticseizures #subjective #PNES

SEEG offers a unique framework for prospective white matter functional mapping in epilepsy patients.
doi.org/10.1111/epi....

#epilepsy #ilae #epilepsia #epilepsysurgery #SEEG #whitematter #anatomy

New in Epilepsia – December 6, 2025
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#epilepsy #epilepsia #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch

Risks can be minimized by avoiding bright flashing lights, covering one eye, wearing dark glasses, and staying far back from screens.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #guidelines #patternsensitiveseizures #photoparoxysmalresponse #photosensitiveseizures #reflexepilepsy

PIPs for antiseizure medications have mainly focused on focal seizures so far. Limited compliance and incomplete trials represent ongoing challenges in pediatric antiseizure drug development.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #antiseizuremedication #drugdevelopment #seizure

This study evaluated the implementation and clinical effectiveness of a mental health care workflow for inpatients with epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #antidepressants #anxiety #comorbidities #depression #healthrelatedqualityoflife #psychotherapy #seizurefrequency

Combining polygenic risk scores with rare variant data has potential to refine diagnostic accuracy and improve genetic counseling.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #DEE #genetics #penetrance #polygenic #PRS

This is the first placebo-controlled cenobamate efficacy study to use the globally approved cenobamate titration schedule.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #antiseizuremedication #efficacy #refractory #titration #cenobamate

Cenobamate demonstrates sustained seizure freedom and a favorable safety profile in patients with drug-resistant epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #antiepileptic #cenobamate #drugresistantepilepsy #seizurefreedom