⏳ Deadline Extended! ⏳

The deadline to submit your abstract for the #CIS2026 Annual Meeting is now Monday, December 15th.

Don't miss your chance to present in New Orleans. Share your science with the world!
🔗 Submit today: https://cis.clinimmsoc.org/education/meetings/am26/abstracts

#CIS2026

⏳ Extended Deadline Today!

The application deadline for the CIS–Grifols AIM Workshop is Today, December 8th

Acceptance to the AIM Program comes with:
✈️ Round-trip airfare
🏨 3 nights lodging
🍽️ All meals

Don't miss your chance. Apply now!
👉 https://clinimmsoc.org/.../2025-CISGrifols-AIM-Program.htm

🌟 Time is running out to nominate the next generation of CIS leaders!
We're seeking nominations for:
🔹 One Councilor (3-year)
🔹 NEW Junior Councilor (2-year) for early-career professionals.

Deadline: December 7!
https://clinimmsoc.org/CIS/About/Leadership/Council-Nominations.htm

⏳ Deadline Approaching!

The deadline to submit your abstract for the #CIS2026 Annual Meeting is Monday, December 8th.
Don't miss your chance to present in New Orleans. Share your science with the world!
Submit today: https://cis.clinimmsoc.org/education/meetings/am26/abstracts
#ClinicalImmunology

Kilic, Zhao et al. report a child w/ a homozygous TBK1 mutation previously linked to #autoinflammation, suggesting its role in recurrent severe viral infections; the patient died from acute disseminated #encephalomyelitis. rupress.org/jhi/article/...

@casanovalab.bsky.social
@clinimmsoc.bsky.social

⏳ Extended Deadline Approaching!
The application deadline for the CIS–Grifols AIM Workshop is now December 8th
Acceptance to the AIM Program comes with:
✈️ Roundtrip airfare
🏨 3 nights lodging
🍽️ All meals

Don't miss your chance. Apply now!
👉 https://clinimmsoc.org/.../2025-CISGrifols-AIM-Program.htm

It’s Giving Tuesday—a day to support the causes you care about. You can show support by publicly honoring a mentor who offered you guidance and opened doors.
Honor Your Mentor Here: https://clinimmsoc.org/CIS/About/Foundation/Recognize-a-Mentor.htm

Novel de novo dominant PSMB10 variants in three patients with immune deficiency and liver disease. New study from Benjamin Fournier @hopitalnecker.bsky.social, Léa Poirier, Jean-Pierre de Villartay, Frédéric Ebstein @univ-nantes.fr and colleagues: rupress.org/jhi/article/...

#InbornErrorsOfImmunity

Genotypes truncating the intracellular tail of human pre-TCR⍺: From amorphic to isomorphic. New report from Marie Materna, Vivien Béziat @vbeziat.bsky.social and colleagues: rupress.org/jhi/article/...

@hopitalnecker.bsky.social @institutimagine.bsky.social
#TcellDeficiencies

Automated data extraction model for the USIDNET registry: Bigger, faster, and better data collection. New study from Vaibhavi Vichare @childrensphila.bsky.social, Kathleen Sullivan ( Icahn School of Medicine at Mount Sinai) and colleagues: rupress.org/jhi/article/...

@clinimmsoc.bsky.social

Human inborn errors of the alternative NF-κB pathway. New review from Tom Le Voyer, Jean-Laurent Casanova @casanovalab.bsky.social, and Anne Puel @anne-puel.bsky.social: rupress.org/jhi/article/...

#InbornErrorsOfImmunity

This Thanksgiving, we want to express our gratitude to this amazing community. Thank you for your contributions and for the collaborative spirit that makes CIS so special.

Recognize a mentor you are thankful for!

The Clinical Immunology Society (CIS) Foundation invites you to participate in its "Recognize a Mentor" program. This is an initiative to celebrate the mentors who guide and inspire us.

Honor Your Mentor Here: https://lnkd.in/gQSUxmuR

Leniolisib reduced lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome. New study from Chopie Hassan, Kevin S. Thorneloe (Pharming Group) and colleagues: rupress.org/jhi/article/...

#InbornErrorsOfImmunity

Application Deadline Extended!
The application deadline for the CIS–Grifols AIM Workshop is now December 8th.

Acceptance to the AIM Program comes with:
✈️ Roundtrip airfare
🏨 3 nights lodging
🍽️ All meals

Apply now!
👉 https://clinimmsoc.org/CIS/Meetings/2025-CISGrifols-AIM-Program.htm

Our search for diagnostic tools for primary immune regulatory disorders (PIRD) continues. Join us in reading this outstanding article by Harris et al.: “T-cell and autoantibody profiling for primary immune regulatory disorders”

https://www.jacionline.org/article/S0091-6749(25)00649-9/abstract

New review from Voyer, @casanovalab.bsky.social, & @anne-puel.bsky.social synthesizes human inborn errors of the alternative NF-κB pathway, highlighting their shared and distinct effects on lymphoid development, immune dysregulation, and mTEC-mediated tolerance rupress.org/jhi/article/...

⏳ TIME IS RUNNING OUT! ⏳

The deadline to submit your abstract for the #CIS2026 Annual Meeting is December 8th.

Don't miss your chance to present in New Orleans.

🔗 Submit today: https://cis.clinimmsoc.org/education/meetings/am26/abstracts

#ClinicalImmunology #Abstracts #MedicalResearch

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. - YouTube

See a short video summary of the study by Kristine Jeganathan: youtu.be/7Kut4zWWTuk

New study from Hassan et al. examines the efficacy of leniolisib, a selective PI3Kδ inhibitor, in a murine model of ALPS, illustrating a reduction in lymphoproliferation and disease-associated biomarkers such as elevated double-negative T cells. rupress.org/jhi/article/...

#InbornErrorsOfImmunity

IRF4 haploinsufficiency in a multiplex family with Whipple's disease. New report from Sinem Ünal, Stéphanie Dublanc, Jacinta Bustamante, Jérémie Rosain (@jrosain.bsky.social) and colleagues @hopitalnecker.bsky.social: rupress.org/jhi/article/...

#InbornErrorsOfImmunity

Fournier @hopitalnecker.bsky.social, Poirier, Ebstein et al. report that novel dominant PSMB10 variants cause severe combined immunodeficiency and life-threatening liver disease in three pediatric patients. rupress.org/jhi/article/...

#InbornErrorsOfImmunity #SevereImmunodeficiencies

In a new research letter, Materna, @vbeziat.bsky.social et al. identified six individuals with homozygous truncating variants in the pre-TCRα intracellular tail, revealing hypomorphic and neutral alleles. rupress.org/jhi/article/...

@casanovalab.bsky.social
@esidsociety.bsky.social

@childrensphila.bsky.social @clinimmsoc.bsky.social

⏳ Time is running out!

The application deadline for the CIS–Grifols AIM Workshop is November 24.

Acceptance to the AIM Program comes with:
✈️ Roundtrip airfare
🏨 3 nights lodging
🍽️ All meals

Don't miss your chance. Apply now!
👉 https://clinimmsoc.org/CIS/Meetings/2025-CISGrifols-AIM-Program.htm

Ünal, Dublanc, Bustamante, @jrosain.bsky.social et al. @hopitalnecker.bsky.social report two patients with Whipple’s disease caused by autosomal dominant IRF4 deficiency. rupress.org/jhi/article/...

@esidsociety.bsky.social
#InbornErrorsOfImmunity

ORAI1 mutation with mixed loss- and gain-of-function properties causes #immunodeficiency and HLH, say Lucile Noyer (@Lucilenoyer.bsky.social) , Stefan Feske (@stefanfeske.bsky.social) and colleagues (NYU Grossman School of Medicine): rupress.org/jhi/article/...

#InbornErrorsOfImmunity

Jeganathan, Pham-Huy et al. @uottawa.ca report that standard newborn screening using T cell receptor excision circles (TRECs) failed to detect delayed-onset ADA deficiency in two cases. But retrospective MS/MS analysis showed diagnostic deoxyadenosine elevation at birth. rupress.org/jhi/article/...

Nirmatrelvir/ritonavir use reduces risk for #longCOVID in patients with #immunodeficiency. New study from Karen Gilbert, Mei-Sing Ong, Jocelyn Farmer (Lahey Hospital) and colleagues: rupress.org/jhi/article/...

#InbornErrorsOfImmunity #COVID19 #SARSCoV2

The landscape is changing, and industry collaboration is key. Don't miss your chance to join the CIS–Grifols AIM Program for a Clinical-Industry-Career Development Workshop this January in Austin, TX!
Deadline is November 24th.
👉 https://clinimmsoc.org/CIS/Meetings/2024-CISGrifols-AIM-Program.htm