Melissa Lechner's group at UCLA identified both CD4+ (Tfh) and CD8+ (Tc1) T cells as drivers of the autoimmune diabetes that arises after anti-PD1 therapy, and showed the nonspecific JAK inhib ruxolitinib could prevent it! Wow. My suspicion is that targeting IFNg-STAT1 alone probably is enough.
09.07.2025 17:16 — 👍 3 🔁 1 💬 1 📌 0
One the many advances in this incredible paper by Columbia's Milner and Izar labs shows that GOF variants in PIK3CD are not all that rare, including p.M285T that occurs in 1/8000, and is correlated with autoimmune diseases. There are many more APDS patients lurking out there! #IEI #raredisease
21.06.2025 14:47 — 👍 4 🔁 2 💬 0 📌 0
New antifungals are much needed -- 41 of these patients receiving olorofim had coccidioidomycosis. #valleyfever
18.06.2025 16:06 — 👍 4 🔁 1 💬 0 📌 0
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
⚠️ Effective Monday 2/10/25, NIH indirect rate capped at 15%. Applies to existing & future grants.
—> Deep budget cuts & program closures coming to a university near you.
Is this the break the glass moment for university administrators who have been silent so far about the attack on science?
07.02.2025 23:33 — 👍 2172 🔁 846 💬 102 📌 269
Please add me to your next pack. My lab studies inborn errors of immunity and T cells.
28.11.2024 14:35 — 👍 2 🔁 0 💬 0 📌 0
Advancing our understanding of human autoimmunity and transforming patient lives through bold, collaborative, and translational science.
Learn more: www.coltonconsortium.org
Medical Oncology Resident at the University Hospital of Pisa, Italy. Focused on clinical and translational research on gastrointestinal cancers.
Reporter at the national environmental magazine Grist covering climate politics and the intersection of climate change and human health.
Signal username: zoyateirstein.58
postdoc with Mark Daly at Broad Institute & MGH - curious about (large) chromosome alterations & (deep) human pedigrees + immunity, cancer & their interplay :)
High-quality, topflight, and clinically impactful basic and translational research representative of all biomedical specialties and physician-scientists: https://insight.jci.org/
UCLA Law Professor. Civil rights, police accountability, civil procedure. Author of Shielded: How the Police Became Untouchable (2023). Learn more at: joannaschwartz.net
Law prof @ UCLA. I study equality and oligarchy.
Most recent book @ https://anti-oligarchy.com
Researchers at the University of Birmingham, Centre for Liver and Gastrointestinal Research, UK
Principal Scientist Bioinformatics @ Gilead Sciences, Oxford UK
MD/PhD – Postdoc Brigham/Harvard Med
Immunology. Kidneys. Autoimmune Disorders. Basketball. Jazz.
50% of the @immunoboys.bsky.social
md/phd candidate at columbia // t cell engineering
precision psychiatry & psychiatric genetics
postdoc @ massgen | harvard med | broad institute
Assistant Professor @ UCLA. Chemical probes, bacterial biology and biochemistry, diagnostics, infectious diseases. Opinions my own.
🇬🇧 in 🇺🇲. Immunologist studying glioblastoma at Duke. Grimsby Town fan. Crochet & knitting enthusiast. She/her.
Diabetes UK and Breakthrough T1D RD Lawrence fellow in Exeter
Diabetes/autoimmunity/genetics.
The Freedom Writers Collaborative is a multi-state Indivisible Group and a grass roots operation providing messaging and social media content inspired by our progressive allies.
https://freedomwriterscollaborative.org
Bioinformatics / Genomics
@INMEGEN Mexico City
biology + computers + a leavening of snark | 👨👨👧👧🏳️🌈| nanomedicine | cancer genomics 🧬 | ML | biomaterials | #compchem #matsky #chemsky #ai4science #materialsinformatics #md | startups | @Cal 🐻 @Stanford @UniversityOfOxford @OxfordNano (swimsf on the Bad Place)
Physician, Physicist, Hematologist, with deep interest in Genomics, Bioinformatics, Biostatistics, Academics, LLMs, and potential applications of AIs to cognitive medicine, 'approach which values the physician's ability to synthesize information' (Copilot)
