Alex Lippert

Summary figure for study of psilocybin's effect on cortical network connectivity.

New preprint + thread 🧵

#Psychedelics induce the formation of new synapses, but where do they connect?

Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks.

www.biorxiv.org/content/10.1...

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Chiral Induction and Memory via Supramolecular Deracemization The helical chirality of a dynamic crown-ether switch can, by light- or redox-switching to a prochiral state, be erased and subsequently stereoselectively re-formed by relaxation in the presence of a...

🔥Hot of the press: Chiral induction and chiral memory via host-guest binding now published in
@angewandtechemie.bsky.social! One of my favourite projects and a super rewarding collaboration with @sidlereric.bsky.social, Yohan and @feringalab.bsky.social!
onlinelibrary.wiley.com/doi/10.1002/...

This illustration shows consecutive stages during operation of a molecular catenating machine.

This week in Science, researchers report an artificial molecular motor that can twist a molecular thread to form a mechanically interlocked molecule. The approach creates opportunities to fabricate mechanically interlocked molecules with precise structural control.

Learn more: scim.ag/40FboGP

Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2) - Psychedelic Alpha In this second Dispatch from the inaugural Neurobiology of Psychedelics Gordon Research Conference, Dr. Alaina Jaster recaps Days 2 through 4, highlighting cutting-edge research on neuroplasticity…

Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2)

Reporting by @jasteralaina.bsky.social.

The entire Dispatch is now free to read.

psychedelicalpha.com/news/dispatc...

My opinion on animal models of psychedelic drug actions It's complicated

My take on the head-twitch response to test #psychedelic drugs in animals:
open.substack.com/pub/zendudes...

Curved molecule bottles sunlight and releases it as heat Liquid anthracene morphs into high-energy isomer to store solar heat for use on demand hours later

Comment on @gracegdhan.bsky.social recent work on energy storage molecules in @cenmag.bsky.social

cen.acs.org/energy/solar...

Effects of a Single Atom Substitution on the Physical Properties, Excited State Dynamics, and Iodine Capture Performance of Emissive Covalent Organic Frameworks Emissive urea/thiourea-based covalent organic frameworks: A single-atom alteration causes distinct variations in charge transfer characteristics and I2 adsorption kinetics.

A long time in the making but finally delighted to share our efforts to understand how slight differences in the monomers can affect the properties of resulting COFs.. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

My department at Colgate University is hiring a tenure-stream assistant professor in Organic Chemistry this fall. Please feel free to reach out with questions, and please repost. We're an undergraduate university with a strong focus on research. @chemjobber.bsky.social

apply.interfolio.com/170152

See fireballs and meteors crisscross the night sky over the next month - The Weather Network The Perseid and delta Aquariid meteor showers are both ramping up towards the end of July.

The delta Aquariid and Perseid meteor showers are ramping up towards the end of July, producing overlapping displays in the sky.
#astronomy #space #meteorshower

www.theweathernetwork.com/en/news/scie...

Very grateful I had the opportunity to attend the first #GRCPsychedelics and connect with others in the field!

Had several great discussions at my poster #GRCPsychedelics

Looking forward to building future collaborations :)

Excited to attend Neurobiology of Psychedelics GRC this week! Looking forward to deep dives into the mechanism of action of psychedelics and how they modulate neuroplasticity, cognitive flexibility, and adaptive decision-making—across behavior and neural dynamics. 🧠🍄
#GRCPsychedelics

So happy the first #GRCPsychedelics was such a success. It was great to see everyone and share all the amazing science and community. Thank you to all the speakers and congratulations to the travel awardees!!

Had a blast at the first ever #GRCPsychedelics - thanks so much to Chairs @alexkwan.bsky.social @vyazovskiy.bsky.social & Vice Chairs @melissaherman.bsky.social @viditavaidya.bsky.social for bringing our community together 🫶

Per usual, I took no pics - but luckily Missy had it covered for me 😂

The polypharmacology of psychedelics reveals multiple targets for potential therapeutics Jain et al. profiled 41 classical psychedelics across 318 GPCRs, revealing activity at serotonin, dopamine, and adrenergic receptors. All compounds activated multiple 5-HT2AR signal transduction pathw...

EVERYTHING YOU EVER WANTED TO KNOW ABOUT #PSYCHEDELICS AND THINGS YOU NEVER THOUGHT ABOUT!
www.cell.com/neuron/abstr...

Attending the first psychedelic GRC organized by @alexkwan.bsky.social & @vyazovskiy.bsky.social was surreal. The internationally representative panels ensure we are collectively/efficiently advancing our understanding of psychedelics. Special thanks to
@mayoonthebrain.bsky.social for bringing me ❤️

So happy I got to attend the first #GRCPsychedelics conference. Such an amazing opportunity to connect with other researchers & learn about the newest findings in the field.

The inaugural #GRCPsychedelics was a success! I am honored to have been one of a few chosen to receive a travel award and be able to share the stage with the leaders in the field. 🙏 to the organizers! @alexkwan.bsky.social @vyazovskiy.bsky.social @melissaherman.bsky.social @viditavaidya.bsky.social

Somehow we got almost all the students and postdocs in one photo!!

Until next time #GRCPsychedelics 🫡

#GRCPsychedelics is squad goals !!

I learned so much, laughed even more, and slept even less

Grateful for the new connections, strengthening of old ones and for the opportunity to view my favorite topics from a different lens.

This image montage shows the image and the spectrum of a star and an exoplanet as seen with the NACO adaptive optics instrument on ESO’s Very Large Telescope. In the spectrum (right) several artefacts from the instrument are seen, such as internal reflections, or “ghosts”, and diffraction rings. Similarly, the image of the star (left) suffers from several diffraction artefacts, which should not be confused with the real signal of the exoplanet. Credit: ESO/M. Janson

A Spectra-cular Milestone: More than 1,000 exoplanet spectra in the #NASAExoArchive Atmospheric Spectroscopy table, including transmission, eclipse, and direct imaging spectra. 75% were observed from space (mostly HST/JWST), and 25% from the ground!

exoplanetarchive.ipac.caltech.edu/cgi-bin/atmo...

A proposed classification of psychedelics "Move over Beethoven"

in the spirit of the recent #psychedelic GRC which is heretofore known as the 'WOODSTOCK OF PSYCHEDELIC SCIENCE' I propose a new definition in which every psychedelic is 'classical'!!
open.substack.com/pub/zendudes...

Delighted to be part of the first Gordon Conference devoted to psychedelics #GRCPsychedlics. My message this morning: science is in this dark place now partly because we spend all of our time and effort in the lab. Get out and talk about your science with the public! Your science will benefit too!

Climbing with fellow scientists at Psychedelics GRC

Science together climb together - sneaked out with fellow #GRCPsychedelics attendees for a quick session 💪

I had a great time at #GCRpsychedelics, discussing our data on the non-hallucinogenic derivative of LSD, alongside a stellar panel of researchers! Very grateful to @alexkwan.bsky.social
and @vladvysotsky.bsky.social for inviting me and putting together a very exciting program!

New product idea:

Bars of soap with dendritic spine designs. Would be a hit at #grcpsychedelics.

@cllantz.bsky.social you in? 🧼

Poll of #GRCPsychedelics attendees….. not good.

NIH funding opportunities panel at the psychedelics GRC conference.

Thank you #NIMH #NIDA and #BrainInitiative for an informal panel at the #GRCPsychedelics to answer questions regarding grant funding. 🙏

#GRCPsychedelics 🔥🔥🔥🔥poster session and our first ever Honorary Best PI poster award to @zenbrainest.bsky.social 🤣🤣🤣