#FluorescenceFriday & Erythroblast
Erythroblast stimulated with CXCL12, stained for CXCR4 (green) and nuclei (blue).
Captured via Correlative Light & Electron Microscopy by
@jemimaburden.bsky.social
Learn more: scim.ag/4kTxFZz
@antalpedro.bsky.social
@jffoley.bsky.social
@science.org
Congratulations! such a great picture too!
Enjoyed a fantastic WHRI Review Day yesterday and the Dufton Group came away with not one, but two, Poster Prizes! Congrats to Dr Josh Dignam and Ms Christina Gkantsinikoudi 🏆 @qmulwhri.bsky.social
Fantastic to see a paper I played a small part of get highlighted on the Science website. Congrats to the amazing Dr Julia Gutjarh and the whole of Prof Antal Rot’s team at @qmulwhri.bsky.social @science.org
In our science.org/doi/10.1126/... we describe the hitherto overlooked erythroblast expression of CXCR4, which do not migrate in response to CXCR4 ligation by CXCL12. Instead, in these cells CXCR4 localises to the nucleus and mediates alternative cell responses in maturation and triggers enucleation
Only #CLEM allowed us to explain the mechanism of #CXCR4 transfer from the cell membrane into the nucleus and map its localization within (i.e. led us to the "discovery" (for ourselves) of the #nucleoplasmic reticulum). Thank you so much for this collaboration, Jemima. We are forever in your debt!
CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells
www.science.org/doi/10.1126/...
Yesterday.. our #CLEM with Julia Gutjahr and Antal Rot was featured in the main Science webpage....☺️ Nice to see #correlativemicroscopy and #volumeEM up front and centre.
www.science.org/doi/10.1126/...
