Antal Rot

#FluorescenceFriday & Erythroblast

Erythroblast stimulated with CXCL12, stained for CXCR4 (green) and nuclei (blue).

Captured via Correlative Light & Electron Microscopy by
@jemimaburden.bsky.social

Learn more: scim.ag/4kTxFZz
@antalpedro.bsky.social
@jffoley.bsky.social
@science.org

Congratulations! such a great picture too!

Enjoyed a fantastic WHRI Review Day yesterday and the Dufton Group came away with not one, but two, Poster Prizes! Congrats to Dr Josh Dignam and Ms Christina Gkantsinikoudi 🏆 @qmulwhri.bsky.social

Intracellular and nuclear CXCR4 signaling promotes terminal erythroblast differentiation and enucleation CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells.

This has a corrupted link! please use this one www.science.org/doi/10.1126/...

Fantastic to see a paper I played a small part of get highlighted on the Science website. Congrats to the amazing Dr Julia Gutjarh and the whole of Prof Antal Rot’s team at @qmulwhri.bsky.social @science.org

In our science.org/doi/10.1126/... we describe the hitherto overlooked erythroblast expression of CXCR4, which do not migrate in response to CXCR4 ligation by CXCL12. Instead, in these cells CXCR4 localises to the nucleus and mediates alternative cell responses in maturation and triggers enucleation

Only #CLEM allowed us to explain the mechanism of #CXCR4 transfer from the cell membrane into the nucleus and map its localization within (i.e. led us to the "discovery" (for ourselves) of the #nucleoplasmic reticulum). Thank you so much for this collaboration, Jemima. We are forever in your debt!

CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells
www.science.org/doi/10.1126/...

Intracellular and nuclear CXCR4 signaling promotes terminal erythroblast differentiation and enucleation CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells.

🧪 In Science Signaling, Julia Gutjahr, Antal Rot, and colleagues show that CXCL12-CXCR4 signaling in bone marrow erythroblasts drives their differentiation and the production of red blood cells in mice, suggesting that this pathway might be targeted to treat erythrocyte pathologies.

Yesterday.. our #CLEM with Julia Gutjahr and Antal Rot was featured in the main Science webpage....☺️ Nice to see #correlativemicroscopy and #volumeEM up front and centre.

www.science.org/doi/10.1126/...

Intracellular and nuclear CXCR4 signaling promotes terminal erythroblast differentiation and enucleation CXCL12-stimulated intracellular and nuclear CXCR4 signaling mediates erythroblast enucleation to generate red blood cells.

With the right link:
www.science.org/doi/10.1126/...