Very happy to host Fred Antson (University of York) today for a seminar! Stunning structures and functional insights into phage/virus capsids and DNA loading.
Fabian was quicker :) But yes, we have an open postdoc position in bacterial bioenergetics and membrane biology, using on B. subtilis as the model. Come join us! @cbcb-newcastle.bsky.social is a great place to work, and we are a friendly, international lab. Visa+IHS fees covered. #microsky
Happy holidays everyone from a not very wintry Newcastle!
Congratulations Laura, the latest CBCB PhD graduate heading for a science career!
Today, we are lucky to have Imane El Meouche from IAME, France to give a MCM seminar @medicalsciencesncl.bsky.social (chaired by @henrikstrahl.bsky.social) on antibiotics tolerance in E. Coli
Big congratulations Neha!
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells.
See the original preprint-thread for a summary of our findings.
www.nature.com/articles/s41...
#microsky
Transcription in malaria Plasmodium organelles: Mechanisms and drug targets. Supervised by Yulia Yuzenkova and @nishaphilip.bsky.social.
www.findaphd.com/phds/project...
Global pathogen, local impact: Genomic and functional dissection of S. infantis in Peru. Supervised by Matt Bawn and @jomcinerney.bsky.social.
www.findaphd.com/phds/project...
Structural and functional analysis of drug resistance in tuberculosis via a novel MmpL3 binding site. Supervised by @mycobacterium-ncl.bsky.social and @kshbeckham.bsky.social.
www.findaphd.com/phds/project...
Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy. Supervised by @kevindwhitley.bsky.social and @mycobacterium-ncl.bsky.social.
www.findaphd.com/phds/project...
Unexpected role of RNA polymerase in development of Methicillin-Resistance in S. aureus (MRSA). Supervised by Nikolay Zenkin and Simon Foster.
www.findaphd.com/phds/project...
Resensitisation of antibiotic-tolerant Staphylococcus aureus small colony variants. Supervised by @henrikstrahl.bsky.social, @kateduncan.bsky.social, and @mycobacterium-ncl.bsky.social.
www.findaphd.com/phds/project...
Targeting thioredoxin reductase to combat antifungal resistance in Candida spp. Supervised by @alesdantas.bsky.social, Janet Quinn, and Francesco Del Carratore. @nclfungalgroup.bsky.social
www.findaphd.com/phds/project...
Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils. Supervised by @ruamicro.bsky.social, Marie Phelan, and @jleslie1.bsky.social.
www.findaphd.com/phds/project...
Looking for a PhD opportunity in Microbiology? Consider joining one of the UK's leading microbiology research clusters at Newcastle University. See the thread for MRC DTP studentships currently advertised. @medicalsciencesncl.bsky.social @sagencl.bsky.social @cbcb-newcastle.bsky.social #microsky
You were already one of us. Now just under the same roof!
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
It was great to have Mark visit us today. Many great science discussions and hopefully new collaborations to start!
A new methods paper from us, this time with a focus on reliable monitoring membrane potential and cell lysis at different growth stages and cell densities. Also, note the surprisingly high level of background lysis in seemingly healthy B. subtilis cultures.
www.biorxiv.org/content/10.1...
Fascinating seminar by Prof @gebhardlab.bsky.social on ‘Building bacterial bridges – How an ancient bacterial trait can help us build the infrastructure of the future’ and visit at @cbcb-newcastle.bsky.social (hosted by @henrikstrahl.bsky.social) #bacillus #spores
Don’t miss your chance #Newcastle, tickets for #PINT25 are out! @pintofscience.uk @pintsworld.bsky.social
More info for venues and tickets here pintofscience.co.uk/events/newca...
Repost appreciated :)
The role of membrane perturbations in antibiotic resistant Gram-negative bacteria. Supervised by @davychang.bsky.social, Margarita Staykova, Mark Geoghegan and @adwol.bsky.social.
www.findaphd.com/phds/project...
New lysins for medically and environmentally important Mycobacteriales. Supervised by @lislowe.bsky.social and Paul James.
www.findaphd.com/phds/project...
Dissecting Gram-negative envelope biogenesis to understand drug delivery in Gram-negative pathogens. Supervised by Manuel Banzhaf, @thecopperdoctor.bsky.social and @henrikstrahl.bsky.social.
www.findaphd.com/phds/project...
Microbial metal-head: the integrated roles of metal homeostasis in host-pathogen interaction. Supervised by @ruamicro.bsky.social, @thecopperdoctor.bsky.social and Manuel Banzhaf.
www.findaphd.com/phds/project...
Adding functionality to C. difficile's armour; integrative structural biology studies of SlpA and CWPs. Supervised by @pssalgado.bsky.social, Peter Chivers, and Agnieszka Bronowska.
www.findaphd.com/phds/project...
Structure and functions of the novel type of RNA polymerases and their application in synthetic biology and biotechnology. Supervised by Nikolay Zenkin and Ehmke Pohl.
www.findaphd.com/phds/project...
Single-molecule analysis of the bacterial chromosome origin Basal Unwinding System (BUS). Supervised by @heathmurraylab.bsky.social and Aakash Basu.
www.findaphd.com/phds/project...
