Abhishek Trivedi

'Congress has your back': US senators tell scientists they want to protect NIH budget Attendees at a meeting of a US Senate appropriations committee on 31 July: from left, Patty Murray, a Democrat from Washington state; Susan Collins, a Republican from Maine; and Mitch McConnell, a Republican from Kentucky.Credit: Tom Williams/CQ-Roll Call via Getty...

'Congress has your back': US senators tell scientists they want to protect NIH budget
->Nature | #Science | More info from EcoSearch

Stay safe.

Antagonism as a foraging strategy in microbial communities In natural habitats, nutrient availability limits bacterial growth. We discovered that bacteria can overcome this limitation by acquiring nutrients by lysing neighboring cells through contact-dependen...

🄰🅆🄴🅂🄾🄼🄴
Stubbusch et al 𝘚𝘊𝘐𝘌𝘕𝘊𝘌

Bacteria 🦠 repurpose Type VI Secretion Systems based on environmental cues:

Nutrient-rich environments ➜ kill competitors

Under starvation ➜ lyse neighbors to scavenge their nutrients

Even “non-pathogens” shift from competition to predation as a survival strategy

A molecular conveyor belt-associated protein controls the rotational direction of the bacterial type 9 secretion system | mBio The type 9 secretion system (T9SS) is fundamental to bacterial gliding motility, pathogenesis, and surface colonization. Our findings reveal that the C-terminal region of the conveyor belt-associated protein GldJ functions as a molecular switch which is ...

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This adds a new layer to how bacteria control their motility and behavior. Learn more in our latest paper:
journals.asm.org/doi/full/10....
#Microbiology #MolecularMachines #Bacteria #T9SS

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We discovered a switch protein that can flip the direction of this rotary motor—clockwise or counterclockwise—like shifting gears in a car. It's the first known example of such control in T9SS! 🔄⚙️

Did you know some bacteria can move by spinning tiny motors embedded in their outer membrane? These motors are part of the Type 9 Secretion System (T9SS), which helps them glide and secrete proteins. 🚶‍♂️🦠

A molecular conveyor belt-associated protein controls the rotational direction of the bacterial type 9 secretion system | mBio The type 9 secretion system (T9SS) is fundamental to bacterial gliding motility, pathogenesis, and surface colonization. Our findings reveal that the C-terminal region of the conveyor belt-associated protein GldJ functions as a molecular switch which is ...

We identified a switch protein that controls the rotational direction of the bacterial T9SS motor a molecular gear shift in Flavobacterium

A molecular conveyor belt-associated protein controls the rotational direction of the bacterial type 9 secretion system | mBio journals.asm.org/doi/full/10....

Krista Freeman et al 𝘊𝘌𝘓𝘓

stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm

can inform precise targeted phage therapies for TB and NTM infections

www.cell.com/cell/fulltex...

The link provides access to the article for another 2 weeks before a paywall goes up. Use it or lose it.

U.S. early-career researchers struggling amid chaos Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard

U.S. early-career researchers struggling amid chaos | Science | AAAS www.science.org/content/arti...

a poster that says if life gives you lemon make lemonade on it ALT: a poster that says if life gives you lemon make lemonade on it

ATTENTION (PLEASE SHARE)

If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.

There are lots of talented and accomplished people who may be looking for new opportunities.

Deeply saddened by the passing of Prof. Mike Sheetz, a true leader in Mechanobiology. His groundbreaking work on Kinesin, membrane organization, and mechanotransduction has left an indelible mark. A tremendous loss to science. #Mechanobiology #Science #LaskerAward

KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid - Nature Microbiology Structural and single-molecule analyses show the CTPase, KorB, is a sliding DNA clamp that interacts with a clamp-locking protein KorA to inhibit gene expression over distances of more than 1 kb in th...

OUT NOW: KorB is a DNA clamp which slides along DNA to mediate long-range gene silencing upon interaction with the clamp-locking KorA protein

by Tung Le & co @johninnescentre.bsky.social

www.nature.com/articles/s41...

A profile picture of Douglas Prasher from Martin Chalfie's Nobel Lecture

Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇