Sandeep J. Joseph's Avatar

Sandeep J. Joseph

@sandeep-j-joseph.bsky.social

Public health Scientist at @CDCSTD . #Microbialgenomics #genomicepidemiology #STDgenomics #husband #dad. All thoughts are my own. https://scholar.google.com/citations?user=yZCT5TwAAAAJ&hl=en https://github.com/CDCgov/neissflow

80 Followers  |  244 Following  |  7 Posts  |  Joined: 10.04.2025  |  1.6083

Latest posts by sandeep-j-joseph.bsky.social on Bluesky

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An AI system to help scientists write expert-level empirical software The cycle of scientific discovery is frequently bottlenecked by the slow, manual creation of software to support computational experiments. To address this, we present an AI system that creates expert...

Just spotted this paper saying their tree search/genetic algorithm writes better bioinformatics software than SOTA. Does batch correction of scRNAseq, and covid hospitalisation estim.

Noth outside my wheelhouse. Does anyone have expertise and energy to look at it?

arxiv.org/abs/2509.06503

09.09.2025 20:54 โ€” ๐Ÿ‘ 12    ๐Ÿ” 4    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 1
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Efficient sequence alignment against millions of prokaryotic genomes with LexicMap - Nature Biotechnology LexicMap uses a fixed set of probes to efficiently query gene sequences for fast and low-memory alignment.

Sometimes you meet absolutely incredible bioinfo-magicians.
It was a huge privilege when @shenwei356.bsky.social
joined our group for a year on an @embl.org sabbatical.
While here, he developed a new way of aligning to
millions of bacteria, called LexicMap 1/n
www.nature.com/articles/s41...

10.09.2025 09:12 โ€” ๐Ÿ‘ 189    ๐Ÿ” 98    ๐Ÿ’ฌ 5    ๐Ÿ“Œ 4
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Racing against antibiotic resistanceย  โ€” Harvard Gazette Scientists fear funding cuts will slow momentum in their war with evolving bacteriaโ€” one of Americaโ€™s most urgent healthcare problems.

โ€œI think of antibiotics as infrastructureโ€ @yhgrad.bsky.social interviewed for the Harvard Gazette, 'Racing against antibiotic resistance'. Read it here at bit.ly/47PdOqv

28.08.2025 16:12 โ€” ๐Ÿ‘ 4    ๐Ÿ” 4    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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AllTheBacteria - all bacterial genomes assembled, available and searchable The bacterial sequence data publicly available via the global DNA archives is a vast potential source of information on the evolution of bacteria. However, most of this sequence data is unassembled, o...

Wow, more than 2.4M of assembled bacteria in the new release of ABT! We plan to index these using our efficient colored De Bruijn graph index, Fulgor. We recently conducted experiments with nearly 1M genomesโ€ฆgetting there :)
www.biorxiv.org/content/10.1...

28.08.2025 12:16 โ€” ๐Ÿ‘ 67    ๐Ÿ” 30    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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๐Ÿ’ฅ Excited to introduce Bacformer ๐Ÿฆ  - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the โ€œgrammarโ€ of how genes are arranged, interact and evolve.

Preprint ๐Ÿ“: biorxiv.org/content/10.1...

๐Ÿงต 1/n

21.07.2025 09:55 โ€” ๐Ÿ‘ 91    ๐Ÿ” 59    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 2
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HHS reverses hundreds of CDC firings The Trump administration has reversed the firings of hundreds of staffers at the CDC.

www.statnews.com/2025/06/11/h...

12.06.2025 01:02 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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STI Outbreak in Alaska Alaska is seeing a dangerous gonorrhea outbreak, while the CDC's STD lab and field staff have been cut. What happens to sexual health when states lose their first line of defense?

www-psychologytoday-com.cdn.ampproject.org/c/s/www.psyc...

07.05.2025 15:16 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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The Cruelty of the OMB Budget Proposal: An Advocacy Guide to Public Health True priorities are revealed in a budget.

open.substack.com/pub/healthsc...

01.05.2025 23:56 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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RFK Jr.โ€™s cuts to CDC eliminate labs tracking STIs, hepatitis outbreaks The only lab in the U.S. capable of testing for and tracking antibiotic-resistant gonorrhea, or โ€œsuper gonorrhea,โ€ was effectively shut down by layoffs.

www.washingtonpost.com/health/2025/...

18.04.2025 15:38 โ€” ๐Ÿ‘ 0    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Trump Layoffs Shut Down Key CDC Sexually Transmitted Diseases Lab The Trump Administration has reportedly cut all 28 full-time employees and 10 fellows from the CDC Sexually Transmitted Diseases Laboratory Reference and Research Branch.

www.forbes.com/sites/brucel...

12.04.2025 17:37 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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It's STI Awareness Monthโ€”So Why Did They Just Shut Down This CDC STI Lab? The Quiet Closure of a Crucial CDC Lab Reveals a Dangerous Shift: From Public Health Priority to Moral Judgment

It's STI Awareness Monthโ€”So Why Did They Just Shut Down This CDC STI Lab?
open.substack.com/pub/emilydep...

11.04.2025 22:01 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Statement from ASTDA on Cuts to the CDCโ€™s Division of STD Prevention | ASTDA

www.astda.org/statement-fr...

10.04.2025 18:30 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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This campaign needs you now Protect the CDC's National STD Reference Laboratory

The CDC's Sexually Transmitted Diseases Reference Laboratory is the only one of its kind in the US. It is a key resource for keeping Americans healthy. Sign the petition to rescind its unjustified closure. chng.it/pxjfWmRm2w

10.04.2025 14:58 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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