David Finlay

10,000 people marched this weekend in Dublin, Ireland

10,000 people marched in Dublin this weekend. Ireland stands against genocide. Free Palestine.

Data‐driven discovery of associations between prescribed drugs and dementia risk: A systematic review Abstract Recent clinical trials on slowing dementia progression have led to renewed focus on finding safer, more effective treatments. One approach to identify plausible candidates is to assess whet...

A systematic review involving >130 million people and 1 million dementia cases found that anti-inflammatory medications, vaccinations, and antibiotics were associated with reduced dementia, whereas vitamins and supplements linked to higher risk
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Our paper on nurturing a #PositiveResearchCulture within your #research #team published by @wellcometrust.bsky.social gives useful tips for your lab. As well as making you a good team leader, nurturing culture pays off in building your science: 1/11

wellcomeopenresearch.org/articles/9-3...

Triacylglycerol mobilization underpins mitochondrial stress recovery - Nature Cell Biology Baker et al. show that mitochondrial stress recovery requires mobilization of lipid droplet triacylglycerol stores to facilitate cardiolipin biosynthesis and mitochondrial biogenesis.

Lots of interest in how to maintain healthy mitochondria for effective cell therapy, like #NKcells for cancer immunotherapy. Some interesting clues in this article.
#immunosky #immunometabolism

Triacylglycerol mobilization underpins mitochondrial stress recovery
www.nature.com/articles/s41...

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that...

Exciting work from Sue Kaech’s lab @tcellogic.bsky.social

Tissue specific metabolites like #BileAcids in #Liver affect #CD8Tcell tumour responses

#immunometabolism #immunosky

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer www.science.org/doi/10.1126/...

Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in macrophages The circadian clock, orchestrated by BMAL1, regulates the expression of Nlrp3 and Il1b in response to lipopolysaccharide (LPS), causing time-of-day production of pro-IL-1β. Mitochondria exhibit time-....

More nice research from Annie Curtis’ lab on the circadian rhythm and the
#immunometabolism of macrophages.

#immunosky #mitochondria #inflammasome

Time‐of‐day control of mitochondria regulates NLRP3 inflammasome activation in macrophages faseb.onlinelibrary.wiley.com/doi/10.1096/...

Metabolic reprogramming of macrophages by PKM2 promotes IL-10 production via adenosine TEPP-46 activates PKM2 by inducing a tetramer formation, which leads to a metabolic reprogramming in macrophages, resulting in an increase in ATP and IL-10 production. Toller-Kawahisa et al. showed th...

PKM2 has always been intriguing; complex roles in some cells, here involving adenosine in #macrophages, simple glycolytic enzyme in #NKcells (doi.org/10.7554/eLif...)
#immunometabolism #immunosky
Metabolic reprogramming of macrophages by PKM2 promotes IL-10 via adenosine www.cell.com/cell-reports...

La dolce vita: fueling chimeric antigen receptor (CAR) T... : Immunometabolism y of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immu...

Check out our new commentary on this interesting study by @justinaguerrero.bsky.social and team on Glut1 overexpressing CAR T cells. Excited to see what comes next for these metabolically enhanced T cells!
@davidfinlaytcd.bsky.social

La dolce vita: fueling chimeric antigen receptor (CAR) T... : Immunometabolism y of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immu...

La dolce vita: fueling chimeric antigen receptor (CAR) T... : Immunometabolism
#immunometabolism #immunosky #glucose #CAR-T

journals.lww.com/immunometabo...

Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes Lymph node swelling is a well-known symptom of infection. A shift in the chemoattractant code controls lymphocyte recruitment from blood into inflamed lymph nodes, allowing lymphocytes to accumulate so that even rare antigen-specific cells can encounter their activating antigen.

Interesting new oxysterol research from Jason Cyster’s lab.

EBI2 (GPR183) and oxysterol ligand 7α,25-HC are required for lymphocyte homing to inflamed LNs.
#immunology #oxysterols
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into LN www.cell.com/cell/fulltex...

An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses, but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this q...

📢Preprint alert! Very excited to share the first preprint from the lab spearheaded by stellar postdoc Eloïse Marques. An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo. 1/n
www.biorxiv.org/content/10.1...

Metabolic #plasticity to Slc1a5 loss involving upregulation of macropinocytosis.

Important also for #immune cells to support glutamine requirements?
#immunometabolism

“Macropinocytosis mediates resistance to loss of glutamine transport in TNBC” www.embopress.org/doi/full/10....

Glutamine sensing licenses cholesterol synthesis | The EMBO Journal imageimageWhether cholesterol biosynthesis can be adjusted to the availability of input carbon sources remains unclear. This study demonstrates that glutamine is directly sensed by and required for ac...

“Glutamine sensing licenses cholesterol synthesis”

#glutamine interacts with SCAP to alter the ER to Golgi trafficking needed to activate #SREBP transcriptional response.

www.embopress.org/doi/full/10....

Is this relevant to #immunometabolism, such as SREBP-dependent #NKcell responses?

Another important example of lactylation controlling metabolic pathways; stabilisation of TFEB to increase lysosomal activity.

Will be interesting to see if this mechanism plays a role in #immunometabolism #immunology responses.

rupress.org/jcb/article/...

Metformin targets mitochondrial complex I to lower blood glucose levels Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.

Authors use an elegant transgenic model to demonstrate that acute oral administration of metformin targets mitochondrial complex I to lower blood glucose.

A crucial contribution to the debate about the mechanisms of action of #metformin.

#metabolism #glucose

doi.org/10.1126/scia...

Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3 The intersection between cellular metabolism and innate immunity lacks understanding. Here, Rao and Qin et al. report that the metabolic enzyme, CTP synthetase 1, deamidates IRF3 to limit interferon induction, independent of its role in pyrimidine synthesis. This reveals how a key metabolic enzyme directly regulates innate immune activation.

#Immunometabolism role for Pyrimidine synthesis enzyme CTP synthetase-1.
CTPS1 deaminates IRF3 and suppresses IFN response; important implications for antiviral #immunology?

Yes indeed…. authors show that loss of CTPS1 elevates antiviral immune response in

www.cell.com/immunity/ful...

AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress - Nature Cell Biology Zhai, Yang et al. report a central role for AMPK in regulating aldolase B-mediated glycerol synthesis and excretion under hypoxia as a mechanism to balance the trade-off between reductive and energy s...

AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress www.nature.com/articles/s41...

Natural killer loops: pyruvate in, lactate out Nature Metabolism - Resting human CD56Dim natural killer cells utilize exogenous pyruvate to support energy metabolism. A new study shows that these cells take up exogenous pyruvate, which...

Full text of commentary available here: rdcu.be/d5ps4

Natural killer loops: pyruvate in, lactate out - Nature Metabolism Resting human CD56Dim natural killer cells utilize exogenous pyruvate to support energy metabolism. A new study shows that these cells take up exogenous pyruvate, which regenerates cytosolic NAD+ via ...

Interesting new research from Antoine Marçais’ lab showing a central role for pyruvate and the Citrate-Malate Shuttle (non-canonical TCA cycle) in human NK cells.

#immunology #NKcells #Immunometabolism

doi.org/10.1038/s422...

See our commentary article here:

www.nature.com/articles/s42...

Vaccines still don´t cause autism

Autism is still totally incorrectly associated with vaccinations (it is genetic). Autism was first described by a Russian doctor in 1926 (Dr. G. E. Ssucharewa). This was before any vaccines were distributed to children

link.springer.com/article/10.1...

Vaccines don’t cause autism.

ImmunoTea Episode 24 - Innate Immunity and Immunometabolism ImmunoTea: Your Immunology Podcast · Episode

Had great fun talking all things immunological to Lara and Vyanka on their ImmunoTea Podcast.

open.spotify.com/episode/2YqS...

Asparagine availability controls germinal center B cell homeostasis Asparagine metabolism is a critical regulator of germinal center B cell function.

This week in #ScienceImmunology: Germinal Center B cells require asparagine (Asn) #metabolism for their function. GC B cells can acquire exogenous Asn from their local environment, but when Asn is limited, they utilise the enzyme asparginine synthetase. @ajclarke.bsky.social @yfy1.bsky.social

This week @eimearrryan.bsky.social from our lab will present the second story from her PhD (only started year 3!) on human MAIT cells metabolism

And from National University of Ireland Maynooth (NUIM), Eimear Ryan from @andyhogan82.bsky.social lab will present her work at the December @immunometforum.bsky.social on #MAITcell #metabolism.

#immmunosky #immunoology #immunometabolism

From Leiden in the Netherlands, @thiagoapatente.bsky.social from Bart Everts lab will present work at the December @immunometforum.bsky.social on #DCs and #Tregs.

#immmunosky #immunoology #immunometabolism

From Madrid in Spain, Gillian Dunphy from the @sancholab.bsky.social lab will present her work c on #macrophages and #mitochondria.

#immmunosky #immunoology #immunometabolism

The Immunometabolism forum logo, sponsored by Agilent and Sitryx

The December @immunometforum.bsky.social will
take place this Friday with three great early career researcher presenting:
🧵1/4

#immmunosky #immunoology #immunometabolism

New review article written by Cristhiane Favero de Aguiar and Carrie Corkish from my lab. They did a great job.

www.nature.com/articles/s41...

#SingleCell #Immunometabolism
#ImmunoSky

Approaches to investigate tissue-resident innate lymphocytes metabolism at the single-cell level

Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses Intracranial tumors present unique challenges for immunotherapy. These can include both local and systemic modes of immune suppression whose mechanistic underpinnings are incompletely understood. Here...

New insight into the challenges for immunotherapy to treat Glioblastoma.
#GBM #catecholamines

www.biorxiv.org/content/10.1...